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Will Smoking Pot Harm Your Heart? Experts Weigh In

Will Smoking Pot Harm Your Heart? Experts Weigh In

News Picture: Will Smoking Pot Harm Your Heart? Experts Weigh InBy Dennis Thompson
HealthDay Reporter

MONDAY, Jan. 22, 2018 (HealthDay News) — Anyone worried that smoking a lot of pot could lead to a heart attack or stroke will just have to keep worrying for the time being.

There’s not enough scientific evidence to say one way or the other how marijuana affects heart health, a new review has concluded.

“Our review found insufficient evidence to draw meaningful conclusions that marijuana use is associated with cardiovascular risk factors and outcomes,” said lead study author Dr. Divya Ravi, an internist with the Wright Center for Graduate Medical Education in Scranton, Pa.

For their review, Ravi and her colleagues pored through medical literature and found 24 studies that evaluated marijuana use and its effects on either heart health risk factors or actual health problems such as heart attack or stroke.

A few studies showed that pot use might benefit the heart, but these were contradicted by other studies that reported potential harmful effects, Ravi said.

For example, some studies linked marijuana use to less diabetes, lower blood sugar and higher levels of “good” HDL cholesterol, the researchers found. And despite anecdotal reports of marijuana bringing on the “munchies,” no studies have tied pot use to weight gainor obesity.

However, other studies found that smoking pot was associated with a greater risk for heart attack and death from heart disease.

“The evidence is insufficient to draw any conclusions,” Ravi said. “The association between marijuana and cardiovascular health has not been adequately studied to date.”

Two heart experts not involved with the study said they’re not surprised by the lack of evidence, given how difficult it is to conduct studies on marijuana use.

Results could become more definitive in the future, thanks to some states legalizing marijuana. That might make people more comfortable discussing their pot use with researchers, said Dr. Russell Luepker, a professor with the University of Minnesota’s School of Public Health.

The vast majority of states allow limited use of medical marijuana under certain circumstances. And eight states and Washington D.C. have legalized recreational pot use.

Dr. Satjit Bhusri, a cardiologist at Lenox Hill Hospital in New York City, said it’s very likely that smoking pot can harm heart health because you’re actively breathing in smoke.

“If you inhale a joint it’s like inhaling a cigarette — you’re putting toxins in your body,” Bhusri said.

On the other hand, it’s hard to say that eating or vaping marijuana produces the same heart risk, said Luepker, a spokesman for the American Heart Association.

“Like any smoked product, you inhale a variety of things, including carbon monoxide and other substances that you certainly don’t get if you eat it,” Luepker said.

Bhusri also expects that the more someone smokes pot, the more they’d increase their heart health risk.

“I wouldn’t be surprised if there is a dose relationship because of these toxins that are inhaled,” he said.

But because marijuana users don’t smoke at the same rate as those who smoke cigarettes, Luepker said, it’s not likely they will be doing themselves as much harm.

For instance, it’s hard to think of many people smoking two packs a day of pot, or lighting up first thing in the morning, he said.

Marijuana users are more akin to “social cigarette smokers who smoke a cigarette or two at a party, and they don’t seem to have any increased risk from that,” Luepker said.

Until more is known, though, pot users should use caution, Ravi concluded.

“At this juncture we have little data on potential harms or benefits associated with use to inform the counseling of marijuana users,” Ravi said. “It may be wise to proceed with caution until we have sufficient evidence to comment on the health effects of chronic marijuana use.”

The study is published in the Jan. 23 issue of Annals of Internal Medicine.

Adverse effects of anti-hypertensive medication – hypotension, heart failure

antihy 3antihy 2antihy 1

antihypertensive meds adverse effects

 

Beta blockers have a wide range of side-effects,
including bradycardia, wheezing or unmasking
of asthma, masking of hypoglycaemia, sleep
disturbances, fatigue, exercise intolerance, erectile
dysfunction, glucose intolerance, worsening of
peripheral vascular disease, drowsiness, Raynaud’s
phenomenon, heart failure, dyslipidaemia, and
precipitation of angina with sudden withdrawal.

 

Aldosterone antagonists can cause life-threatening
hyperkalaemia, especially in patients with chronic
kidney disease (CKD) and concomitant use of ACE
inhibitors and NSAIDs. Other side-effects include
gynaecomastia, breast tenderness, menstrual
irregularities, gastric ulcers, and erectile dysfunction.
Generally, these complications can be avoided by
using low doses (50 mg maximum), avoiding their
use in high-risk situations, e.g. in the presence of
CKD, and avoiding the use of NSAIDs.

 

Curcumin Improves Memory and Mood

Curcumin Improves Memory and Mood

Summary: Curcumin, a substance found in turmeric, improves both mood and memory in people with mild, age related memory loss, researchers report.

Source: UCLA.

Lovers of Indian food, give yourselves a second helping: Daily consumption of a certain form of curcumin — the substance that gives Indian curry its bright color — improved memory and mood in people with mild, age-related memory loss, according to the results of a study conducted by UCLA researchers.

The research, published online Jan. 19 in the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed curcumin supplement on memory performance in people without dementia, as well as curcumin’s potential impact on the microscopic plaques and tangles in the brains of people with Alzheimer’s disease.

Found in turmeric, curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance.

“Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimer’s disease and major depression,” said Dr. Gary Small, director of geriatric psychiatry at UCLA’s Longevity Center and of the geriatric psychiatry division at the Semel Institute for Neuroscience and Human Behavior at UCLA, and the study’s first author.

The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months.

All 40 subjects received standardized cognitive assessments at the start of the study and at six-month intervals, and monitoring of curcumin levels in their blood at the start of the study and after 18 months. Thirty of the volunteers underwent positron emission tomography, or PET scans, to determine the levels of amyloid and tau in their brains at the start of the study and after 18 months.

The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not, Small said. In memory tests, the people taking curcumin improved by 28 percent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.

The amygdala and hypothalamus are regions of the brain that control several memory and emotional functions.

tumeric

Four people taking curcumin, and two taking placebos, experienced mild side effects such as abdominal pain and nausea.

The researchers plan to conduct a follow-up study with a larger number of people. That study will include some people with mild depression so the scientists can explore whether curcumin also has antidepressant effects. The larger sample also would allow them to analyze whether curcumin’s memory-enhancing effects vary according to people’s genetic risk for Alzheimer’s, their age or the extent of their cognitive problems.

“These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years,” said Small, UCLA’s Parlow–Solomon Professor on Aging.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

The paper’s authors, in addition to Small, are Prabha Siddarth, Dr. Zhaoping Li, Karen Miller, Linda Ercoli, Natacha Emerson, Jacqueline Martinez, Koon-Pong Wong, Jie Liu, Dr. David Merrill, Dr. Stephen Chen, Susanne Henning, Nagichettiar Satyamurthy, Sung-Cheng Huang, Dr. David Heber and Jorge Barrio, all of UCLA.

Theravalues Corp. provided the curcumin and placebos for the trial, as well as funds for laboratory testing and for Small’s travel to present preliminary findings at the 2017 Alzheimer’s Association International Conference.

Funding: The study was supported by the Ahmanson Foundation, the Marshall and Margherite McComb Foundation, the McMahan Foundation, Bob and Marion Wilson, the Fran and Ray Stark Foundation Fund for Alzheimer’s Disease Research, the U.S. Department of Energy and the National Institutes of Health.

Source: Leigh Hopper – UCLA
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to UCLA.
Original Research: Open access research in The American Journal of Geriatric Psychiatry.
doi:10.1016/j.jagp.2017.10.010

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
UCLA “Curcumin Improves Memory and Mood.” NeuroscienceNews. NeuroscienceNews, 23 January 2018.
<http://neurosciencenews.com/curcumin-mood-memory-8346/&gt;.

Abstract

Preterm birth leads to hyper-reactive cognitive control processing and poor white matter organization in adulthood

Objective
Because curcumin’s anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored its impact on brain amyloid and tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography (FDDNP-PET).

Methods
Forty subjects (age 51–84 years) were randomized to a bioavailable form of curcumin (Theracurmin® containing 90 mg of curcumin twice daily [N = 21]) or placebo (N = 19) for 18 months. Primary outcomes were verbal (Buschke Selective Reminding Test [SRT]) and visual (Brief Visual Memory Test-Revised [BVMT-R]) memory, and attention (Trail Making A) was a secondary outcome. FDDNP-PET signals (15 curcumin, 15 placebo) were determined in amygdala, hypothalamus, medial and lateral temporal, posterior cingulate, parietal, frontal, and motor (reference) regions. Mixed effects general linear models controlling for age and education, and effect sizes (ES; Cohen’s d) were estimated.

Results
SRT Consistent Long-Term Retrieval improved with curcumin (ES = 0.63, p = 0.002) but not with placebo (ES = 0.06, p = 0.8; between-group: ES = 0.68, p = 0.05). Curcumin also improved SRT Total (ES = 0.53, p = 0.002), visual memory (BVMT-R Recall: ES = 0.50, p = 0.01; BVMT-R Delay: ES = 0.51, p = 0.006), and attention (ES = 0.96, p < 0.0001) compared with placebo (ES = 0.28, p = 0.1; between-group: ES = 0.67, p = 0.04). FDDNP binding decreased significantly in the amygdala with curcumin (ES = −0.41, p = 0.04) compared with placebo (ES = 0.08, p = 0.6; between-group: ES = 0.48, p = 0.07). In the hypothalamus, FDDNP binding did not change with curcumin (ES = −0.30, p = 0.2), but increased with placebo (ES = 0.26, p = 0.05; between-group: ES = 0.55, p = 0.02).

Conclusions
Daily oral Theracurmin may lead to improved memory and attention in non-demented adults. The FDDNP-PET findings suggest that symptom benefits are associated with decreases in amyloid and tau accumulation in brain regions modulating mood and memory.

Cognitive Training Helps Regain a Younger-Working Brain

Cognitive Training Helps Regain a Younger-Working Brain

Summary: Researchers report specialized cognitive training can help make the brain more energy efficient as we age.

Source: Center for BrainHealth.

Relentless cognitive decline as we age is worrisome, and it is widely thought to be an unavoidable negative aspect of normal aging. Researchers at the Center for BrainHealth at The University of Texas at Dallas, however, say their research could provide new hope for extending our brain function as we age.

In a randomized clinical study involving adults age 56 to 71 that recently published in Neurobiology of Aging, researchers found that after cognitive training, participants’ brains were more energy efficient, meaning their brain did not have to work as hard to perform a task.

Dr. Michael Motes, senior research scientist at the Center for BrainHealth and one of the lead authors of the study, said, “Finding a nonpharmacological intervention that can help the aging brain to perform like a younger brain is a welcome finding that potentially advances understanding of ways to enhance brain health and longevity. It is thrilling for me as a cognitive neuroscientist, who has previously studied age-related cognitive decline, to find that cognitive training has the potential to strengthen the aging brain to function more like a younger brain.”

To investigate changes in brain efficiency, the research team studied neural activity while the participant performed a task. For the study, 57 cognitively normal older adults were randomly assigned to a cognitive training group, a wait-listed control group, or physical exercise control group. The cognitive training utilized the Strategic Memory Advanced Reasoning Training (SMART) program developed at the Center for BrainHealth.

Cognitive training strategies included how to focus on the most relevant information and filter out the less relevant; ways to continually synthesize information encountered in daily life to encourage deeper thinking; and how to inspire innovative thinking through generating diverse interpretations, solutions and perspectives. Because aerobic exercise has been shown to lead to improvements in processing speed and functional changes within the frontal and other brain regions, it was included as one of the study groups.

The cognitive training was conducted over the course of 12 weeks. Participants in the active control physical exercise program exceeded physical activity guidelines of 150 minutes per week for the 12 weeks.

Using functional magnetic resonance imaging (fMRI), an imaging technique that measures brain activity, researchers examined all three groups at the beginning (baseline), middle, and end of the study while participants performed computer-based speed tasks in the scanner.

The fMRI results provided evidence that cognitive training improved speed-related neural activity. While all groups showed faster reaction times across sessions, the cognitive training group showed a significant increase in the association between reaction time and frontal lobe activity. After training, faster reaction times were associated with lower frontal lobe activity, which is consistent with the more energy-efficient neural activity found in younger adults.

brain scans

In contrast to the cognitive training group, the wait-listed and physical exercise groups showed significant decreases across sessions in the association between reaction time and frontal lobe activation.

“This discovery of neural efficiency profiles found in the SMART-trained older adults is promising,” said Dr. Sandra Bond Chapman, one of the lead authors, Center for BrainHealth founder and chief director. “If replicated, this work paves the way for larger clinical trials to test the ability to harness the potential of the aging mind and its ability to excel – by working like a younger brain with all the rich knowledge and expertise accrued over time. To counteract the pattern of age-related losses and even enhance the brain’s inner workings by ‘thinking’ in smarter ways is an achievable and highly desirable goal.”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Funding: This work was supported by a grant from the National Institutes of Health (RC1-AG035954, 2009; R01-NS067015, 2010; R01- AG033106; 2009) and by grants from the Lyda Hill Foundation, T. Boone Pickens Foundation, and the Dee Wyly Distinguished University Endowment.

Source: Emily Bywaters – Center for BrainHealth
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Michael A. Motes, et. al., Neurobiology of Aging, 2018.
Original Research: Open access research in Neurobiology of Aging.
doi:10.1016/j.neurobiolaging.2017.10.003

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
Center for BrainHealth “Cognitive Training Helps Regain a Younger-Working Brain.” NeuroscienceNews. NeuroscienceNews, 23 January 2018.
<http://neurosciencenews.com/cognitive-training-brain-aging-8350/&gt;.

Abstract

Higher-order cognitive training effects on processing speed–related neural activity: a randomized trial

Higher-order cognitive training has shown to enhance performance in older adults, but the neural mechanisms underlying performance enhancement have yet to be fully disambiguated. This randomized trial examined changes in processing speed and processing speed–related neural activity in older participants (57–71 years of age) who underwent cognitive training (CT, N = 12) compared with wait-listed (WLC, N = 15) or exercise-training active (AC, N = 14) controls. The cognitive training taught cognitive control functions of strategic attention, integrative reasoning, and innovation over 12 weeks. All 3 groups worked through a functional magnetic resonance imaging processing speed task during 3 sessions (baseline, mid-training, and post-training). Although all groups showed faster reaction times (RTs) across sessions, the CT group showed a significant increase, and the WLC and AC groups showed significant decreases across sessions in the association between RT and BOLD signal change within the left prefrontal cortex (PFC). Thus, cognitive training led to a change in processing speed–related neural activity where faster processing speed was associated with reduced PFC activation, fitting previously identified neural efficiency profiles.

Mike Pence laughably defends Trump against credible reports of an affair with a porn star 

Do you support Planned Parenthood?

REUTERS: Trump administration “revokes Obama-era Planned Parenthood protection”!
This is BAD: The Trump administration just made it easier for states to defund Planned Parenthood!

From statehouses and governors’ mansions to Congress and the White House, Republicans at every level have shown that they’ll stop at NOTHING to defund Planned Parenthood. If we don’t stop them, they’ll trample women’s rights and leave thousands of women across the country without access to health care.

Every time Republicans have come after Planned Parenthood, committed grassroots Democrats like you have fought back. That’s why we need to hear from 6,500 Dems to help set our strategy for 2018. Take the one-question survey:

INSTANT POLL
Do you support Planned Parenthood?

Your wishes for end-of-life care

Starter Kits

The Conversation Project is dedicated to helping people talk about their wishes for end-of-life care. We developed the original Conversation Starter Kit as a useful tool to help people have conversations with their family members or other loved ones about their wishes regarding end-of-life care. Since then, we have translated the Starter Kit into several languages, and developed additional Starter Kits listed below. All are available to download for free.

Check out our updated How to Talk To Your Doctor guide below.


Printing These Materials

  • You are welcome to download or print any of the Starter Kits below.
  • Note: Be sure to save the Starter Kit to your desktop before filling it in. Otherwise, anything you type in it will not be saved.
  • To print or view in larger font, click here.
  • To purchase printed copies of our materials, or add your logo and contact information, visit our Mimeo Marketplace. 

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Conversation Starter Kit

Talking with your loved ones openly and honestly, before a medical crisis happens, gives everyone a shared understanding about what matters most to you at the end of life. You can use this Starter Kit whether you are getting ready to tell someone else what you want, or you want to help someone else get ready to share their wishes.

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How to Choose a Health Care Proxy & How to Be a Health Care Proxy

In addition to having the conversation, it’s important to choose a health care proxy – the person who will make decisions about your medical care if you become unable to make them for yourself. This new user-friendly guide offers facts and tips necessary to make sound decisions about choosing, and being, a health care proxy.

 

 

  • Co-branded version: For organizations planning to distribute the Health Care Proxy Kit, we have a version to which you can add your logo and local contact information. Available for purchase here.

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Conversation Starter Kit for Families and Loved Ones of People with Alzheimer’s Disease or Other Forms of Dementia

This Starter Kit is specifically designed to help families and loved ones of people with Alzheimer’s disease or another form of dementia who want guidance about “having the conversation.” We appreciate the difficulty — and the importance — of having these conversations.

 

 

  • Co-branded version: For organizations planning to distribute the Starter Kit for Families and Loves Ones of People with Alzheimer’s, we have a version to which you can add your logo and local contact information. Available for purchase here.

 

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How To Talk To Your Doctor

After you’ve had the conversation with your loved ones, the next step is talking to your doctor or nurse about your wishes. Don’t wait for a medical crisis; talking with your doctor or nurse now makes it easier to make medical decisions when the time comes.

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Pediatric Starter Kit: Having the Conversation with Your Seriously Ill Child

This Starter Kit is specifically designed to help parents of seriously ill children who want guidance about “having the conversation” with their children.

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