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Washington Post 12-20-2017

Opinions

Tom Toles
Donald Trump has made his mark on Washington
  • By Tom Toles
Ann Telnaes
Paul Ryan says he’s staying where he is
  • By Ann Telnaes
Columns

I spoke my mind on guns. Then my Senate confirmation was put on hold.

I have no regrets. Our gun laws are insane.

  • Dean L. Winslow
  • ·
  • 1 hour ago

Cornel West, Ta-Nehisi Coates and the post-Obama black public intellectual

Christine Emba, Wesley Lowery and Karen Attiah discuss the row between Harvard philosopher Cornel West and best-selling author Ta-Nehisi Coates.

  • Christine Emba, Karen Attiah
  • ·
  • PostPartisan
  • ·
  • 2 hours ago
https://tpc.googlesyndication.com/safeframe/1-0-14/html/container.html

Trump’s $1.5 trillion bribe

There’s something inherently sleazy about borrowing for the express purpose of funding politically convenient tax cuts.

  • Robert J. Samuelson
  • ·
  • 5 hours ago

Trump’s little-noticed war on hidden taxes

His crusade against the regulatory state can help sustain the economic boom.

  • Marc A. Thiessen
  • ·
  • 9 hours ago

So we’re banning words now? Here’s my list.

“Awesome” isn’t anymore. And “snowflake” produces more ennui than insult.

  • Kathleen Parker
  • ·
  • 21 hours ago

Republicans have their own Obamacare now

Americans will blame everything they don’t like about taxes on this bill.

  • Dana Milbank
  • ·
  • 21 hours ago

Bye-bye Bannonism?

Trump’s national security strategy is a welcome rejection of the zero-sum Bannonism of the early administration.

  • David Von Drehle
  • ·
  • 21 hours ago

What North Korea told a U.N. envoy trying to prevent war

We’re still on the brink of conflict.

  • David Ignatius
  • ·
  • 21 hours ago
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The Post’s View

A win for the wealthy, the entitled and the irresponsible

The just-passed Republican tax bill will be seen as an ignominious moment for the GOP.

  • Editorial Board
  • ·
  • The Post’s View
  • ·
  • 4 hours ago

A blueprint for saving Metro — at last

On the eve of leaving office, Terry McAuliffe offers a blueprint for saving the transit system.

  • Editorial Board
  • ·
  • The Post’s View
  • ·
  • 21 hours ago

Ousting Peru’s president would do more harm than good

The incumbent is caught up in a massive corruption scandal, but there is no proof he has done anything illegal.

  • Editorial Board
  • ·
  • The Post’s View
  • ·
  • 21 hours ago
PostEverything
The GOP tax bill will make life easier for tax cheats. Here’s how.
House Ways and Means Committee Chair Kevin Brady (R-Texas) in the Capitol on Friday after signing the conference committee report to advance the GOP tax bill. (J. Scott Applewhite/AP)
House Ways and Means Committee Chair Kevin Brady (R-Texas) in the Capitol on Friday after signing the conference committee report to advance the GOP tax bill. (J. Scott Applewhite/AP)
The final bill cut two provisions that were pro-whistleblower.
  • By Stephen M. Kohn

How the GOP tax bill will wreck what’s left of Puerto Rico’s economy

By treating Puerto Rico as a foreign country, the bill will encourage U.S. companies to abandon the island.

  • Armando Valdés Prieto
  • ·
  • 6 hours ago

Let’s grade the State Department memo on balancing interests and values!

Somebody wrote a bad memo.

  • Daniel W. Drezner
  • ·
  • 9 hours ago

With this tax bill, the GOP has finally killed family-friendly conservatism

Republicans would rather reduce corporate taxes than let families with children keep more of their own money.

  • Jonathan Coppage
  • ·
  • 11 hours ago

Saudi Arabia is trying to contain the spread of Salafism. It won’t work.

The horses have long since left the barn.

  • Geneive Abdo, Abdallah Hendawy
  • ·
  • 11 hours ago

Yes, the Republicans are passing their awful tax plan. And yes, the people know what they’re up to, and they don’t like it.

Share a primal scream with me as the Republicans are passing their awful tax plan. Then get ready to repeal, replace, and resist.

  • Jared Bernstein
  • ·
  • 1 day ago

A Straussian national security strategy

There is a massive disconnect between Trump’s speech and his National Security Strategy. Why?

  • Daniel W. Drezner
  • ·
  • 1 day ago

Why hasn’t Trump fired Mueller yet? Because he’s better off not doing it.

Dumping Mueller wouldn’t end the Russia investigations.

  • Renato Mariotti
  • ·
  • 1 day ago

Let women have our Hallmark Christmas movies. We deserve them.

There’s relief in sharing entertainment with friends of all political persuasions, made about women for women.

  • Cassie Belek
  • ·
  • 2 days ago

The good, the bad, and the politics of The Last Jedi

A few political thoughts on ‘The Last Jedi’

  • Daniel W. Drezner
  • ·
  • 2 days ago

Our terribly distorted tax debate

This destructive, inequality-inducing tax plan was sold on false promises of trickle-down growth effects.

  • Jared Bernstein
  • ·
  • 2 days ago

In their own words: Americans assess Trump’s performance in 2017

Negative feelings have intensified since early in the presidency.

  • 4 days ago

The two expat bros who terrorized women correspondents in Moscow

Matt Taibbi and Mark Ames trafficked in hideous stereotypes and body-shaming.

  • Kathy Lally
  • ·
  • 5 days ago

Stop asking black women to ‘save America.’ Start organizing your own people.

After Alabama, white liberals need to talk to their friends and families, not thank black voters.

  • Brittney Cooper
  • ·
  • 5 days ago

The Fed’s playbook says raise rates. What if that’s an obsolete game plan?

As congressional Republicans prepare to pass their tax bill , the Federal Reserve is about to say goodbye to Janet Yellen as chair. She’s had a good run: The United States and the world recovered from…

  • Zachary Karabell
  • ·
  • 5 days ago

Clerkships are invaluable for young lawyers. They can also be a setup for abuse.

When things go wrong, too often law clerks — about half of whom are women — feel they have nowhere to turn.

  • Catherine Crump
  • ·
  • 5 days ago

America’s chaotic, crazy, challenging, great, tumultuous, horrible, disappointing year

A look back at the ups and downs of public opinion in 2017.

  • Scott Clement, Emily Guskin, Shelly Tan
  • ·
  • 5 days ago

Want to thank black voters for defeating Roy Moore? Tackle voter suppression.

Voter suppression tactics didn’t work in Alabama this time, but they could have.

  • Mikki Kendall
  • ·
  • 5 days ago

A three-tiered solution for Puerto Rico

This is a way to meet the challenges faced by our fellow citizens in Puerto Rico. Is there a will?

  • Jared Bernstein
  • ·
  • 6 days ago

Tell me how Trump’s North Korea gambit ends

I do not see a conceivable military option that would not lead to a catastrophic loss of life.

  • Daniel W. Drezner
  • ·
  • 6 days ago

Donald Trump cannot stop endorsing losers

Donald Trump’s losing streak in endorsements is now at three.

  • Daniel W. Drezner
  • ·
  • Dec 13
Load More
Outlook
America’s chaotic, crazy, challenging, great, tumultuous, horrible, disappointing year
A look back at the ups and downs of public opinion in 2017. (Shelly Tan/The Washington Post)
A look back at the ups and downs of public opinion in 2017. (Shelly Tan/The Washington Post)
A look back at the ups and downs of public opinion in 2017.
  • By Scott Clement, Emily Guskin and Shelly Tan

In their own words: Americans assess Trump’s performance in 2017

Negative feelings have intensified since early in the presidency.

  • 4 days ago

The two expat bros who terrorized women correspondents in Moscow

Matt Taibbi and Mark Ames trafficked in hideous stereotypes and body-shaming.

  • Kathy Lally
  • ·
  • 5 days ago

Five myths about bitcoin

No, the currency isn’t beyond the reach of the law, and it won’t replace cash.

  • Joseph Bonneau, Steven Goldfeder
  • ·
  • 5 days ago

The Fed’s playbook says raise rates. What if that’s an obsolete game plan?

As congressional Republicans prepare to pass their tax bill , the Federal Reserve is about to say goodbye to Janet Yellen as chair. She’s had a good run: The United States and the world recovered from…

  • Zachary Karabell
  • ·
  • 5 days ago
Local Opinions

Why does D.C. have so few public restrooms?

Options dwindle further at night.

  • Marcia Bernbaum
  • ·
  • 5 days ago

How to give Maryland workers sick leave without killing businesses

The finger-pointing from the legislature helps no one.

  • Larry Hogan
  • ·
  • 5 days ago

Virginia took a bold step in tolling I-66. And it’s likely to pay off.

Officials eschewed a Sisyphean strategy and tired something different to deal with intractable transportation problems in the region.

  • Robert Puentes
  • ·
  • 5 days ago

Let’s really open the roads in Montgomery County

Cars are here to stay, so traffic planning must focus on adding more routes for them.

  • Jason Neuringer
  • ·
  • Dec 8
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Campus rapes aren’t being reported to D.C. police, and that’s dangerous

Federal law mandates that universities share campus rape statistics with the Education Department but not with law enforcement.

  • K. Denise Rucker Krepp
  • ·
  • Dec 8
Posted byconnie dello buonoDecember 20, 2017Posted inPoliticsLeave a comment on Washington Post 12-20-2017

Top health and aging hacks 12-20-2017

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Eggplant and apple cider vinegar for skin cancer
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Signs of the preactive/ active phase of dying and medications for terminally ill
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Nitric Oxide Dump Exercise with nose breathing to lower blood pressure and thin blood
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DMSO, hydrogen peroxide and Vit C fight cancer cells
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Home page / Archives
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Non pasteurized beers have more health benefits
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MEDICATIONS TO AVOID that worse PD (Parkinson’s disease)
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Can Gout be cured permanently?
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Colors in iris of eyes
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Philippines Coconut Wine -Tuba
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What will happen if a person accidentally drinks kerosene/petrol/diesel?
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Anabolic and catabolic process, hormones and exercise
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Complications of Low Potassium and sodium and magnesium for balance
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FOXO3, a gene linked to intelligence and involved in insulin signalling that might trigger apoptosis
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Massage oil of fresh ginger and coconut oil relieves joint pain
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Gastroparesis, Betain HCL, diabetes and stomach health
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Blind services in California
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Vitamin B5 – Panthothenate – for Schizophrenia
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Clean up our lymps to reduce restless leg syndrome
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Toxins in green potatoes
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How diet can change your epigenome and affect cancer and chromatin of DNA
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Depression to Dementia
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Eat protein-rich food when drinking alcohol to protect your stomach
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Cardio-based body weight exercises
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Polio virus
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Foods to eat and avoid when you have Gout and leg pains
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Warren Buffett and Solar Energy
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Atopic dermatitis and psoriasis by Dr Mercola
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Why New Antidepressant Brintellix May Be a Killer
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Restore your vision naturally y Dr. Mercola
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Restless Legs Syndrome in Alzheimer’s and Parkinson’s Disease
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Thyme herb for toe fungus (guava and comfrey leaves and others)
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Serum vascular cell adhesion molecule-1 as predictor of Chronic Heart Failure
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Iodine prevents cancer growth; up avocado and reduce caffeine intake to prevent Thyroid cancer
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The Emergence of a New Dopamine Hypothesis of Schizophrenia
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Uncaria Tomentosa (“Cat’s Claw”); Anti Malaria
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Reducing belly fat
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Leaky gut, leaky brain, eat your garlic and pickles by C Guthrie
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Chlorine rich foods are cleansing (avocado, coconut, onions, parsnips)
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Growth hormone DHEA increases libido/anti-aging
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Fight VIRUS with Enzymes from pineapple and papaya, baking soda, alkaline food, calcium and magnesium from whole foods
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Personalized Diet ebook
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Fatigue and Red (bloodshot) eyes from WebMD
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Pneumonia, Liposomal Vit C, immune system
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Philippines president Dutarte asked each town to prepare a list of drug users and pushers
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Alzheimer’s, pork and food statistics
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What is your molecular age? P16 protein can ID your molecular age
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Nicotinamide Riboside converting 60yr old to 20yr old cells in mice, an anti-aging miracle (metabolic and brain issues)
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Anabolic and catabolic process, hormones and exercise
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Browning or caramelized sugar is a carcinogen
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Congested ears and nose
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Ionizing radiation may be confounding factor in Alzheimer’s disease
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Fasting, sun bathing ,Vit C, Lysine, turmeric, green tea, carrots and raw food diet to reduce tumor size
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What Coffee Does to the Heart, Brain, & Body – Dr. Alan Mandell D.C.
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Weird Facts about Tall and Short People by Lisa Collier Cool
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Paul Ryan and Mitch McConnell implicated in Russia-Trump
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Why Wonder Woman is the perfect hero for the Trump era
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MUSCLES AND BRAIN
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new business card motherhealth
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Psoriasis, immune system and nutrition
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Urea cycle disorder , brain and Alzheimer
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Washington Post 11-30-17
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The Toxin, Heavy Metal, and Thyroid Connection
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Signs of the preactive/ active phase of dying and medications for terminally ill
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Yohimbine and sleep apnea
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Parkinson and Exercises
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Instead of border walls, subsidized housing for teachers and solar panels
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Gut Bacteria Linked to Age Related Conditions
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Bay Area Belly Dance and Music this Sat in Los Altos
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Mobile Health News 7-28-2017
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Calm worries and increase cognitive flexibility with exercise and nutrition
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Hiatal Hernia, Pancreatitis, Pancreatic Cancer and the Western Diet
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Spices that boost testosterone
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Coconut Oil facts from Dr Mark Hyman
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Anti-aging and Parkinson/Alzheimer’s prevention: Enzymes and apple cider vinegar
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Detox your lungs from air pollution and metal toxins and for early lung cancer
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Not patentable anti-cancer plant-fruit , soursop or Guyabano fruit, Vitamins C and B-rich
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Shark oil for your skin, wound healing and overall health
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Back pain, high blood pressure, stroke and brain tumor
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Ionizing radiation may be confounding factor in Alzheimer’s disease
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Support your aging mechanisms , epigenetic way
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Nitric Oxide Dump Exercise with nose breathing to lower blood pressure and thin blood
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Support your aging mechanisms , epigenetic way
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Dopamine and Serotonin in Depression
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Quickly assesses live tissue cellular antioxidant levels
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Shampoo ingredients causing nerve damage
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Case Note Sample Narratives from visiting nurses, social workers and physical therapists for home care patients
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Quora highlights – answering your health related questions
Posted byconnie dello buonoDecember 20, 2017Posted inMenuLeave a comment on Top health and aging hacks 12-20-2017

Robert Mueller III stood up against corruption

via Robert Mueller III stood up against corruption

Posted byconnie dello buonoDecember 19, 2017Posted inMenuLeave a comment on Robert Mueller III stood up against corruption

Robert Mueller III stood up against corruption

rmuehler

Robert Swan Mueller III (/ˈmʌlər/; born August 7, 1944) is an American lawyer and civil servant who was the sixth Director of the Federal Bureau of Investigation from 2001 to 2013. A Republican, he was appointed by President George W. Bush and his original ten-year term was given a two-year extension by President Barack Obama, making him the longest-serving FBI director since J. Edgar Hoover. He is currently head of the Special Counsel investigation of Russian interference in the 2016 United States elections.

A graduate of Princeton University, Mueller served as a Marine Corps officer during the Vietnam War, receiving the Bronze Star Medal with Combat “V” for heroism and the Purple Heart Medal. After graduating from the University of Virginia School of Law in 1973, he worked at a private firm in San Francisco for three years until his appointment as an assistant U.S. Attorney in the same city. Prior to his appointment as FBI Director, Mueller served as a United States Attorney, as United States Assistant Attorney General for the Criminal Division and as Acting U.S. Deputy Attorney General.

In May 2017, Mueller was appointed by Acting Attorney General Rod Rosenstein as special counsel overseeing an ongoing investigation into foreign electoral intervention by Russia in the 2016 U.S. presidential election

Posted byconnie dello buonoDecember 19, 2017Posted inMenu, Politics1 Comment on Robert Mueller III stood up against corruption

Jade , Genocide and Burma

Images for jade genocide burma

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Taint of Burma’s genocide gems | News | The Times & The Sunday …

https://www.thetimes.co.uk/article/taint-of-burmas-genocide-gems-6mtz2c7pn

Dec 10, 2017 – Cartier’s Tutti Frutti collection features sapphires from Burma. Activists from the International Campaign for the Rohingya (ICR) plan next to target Bulgari, which advertises several necklaces and earrings featuring Burmese rubies, sapphires and jade. In May, the American model Bella Hadid wore a Bulgari …

What Happened to Myanmar’s Human-Rights Icon? | The New Yorker

https://www.newyorker.com/…/10/…/what-happened-to-myanmars-human-rights-icon

Oct 2, 2017 – When Myanmar’s military regime released Aung San Suu Kyi from house arrest, in 2010, she had been the world’s most famous political prisoner for nearly … Democratic movements did not always triumph—the Chinese government’s massacre of student protesters near Tiananmen Square is the grimmest …

Cartier: Don’t Sell Burmese Genocide Gems – Action Network

https://actionnetwork.org/…/cartier-dont-sell-burmese-genocide-gems?…burmese-gen…

Burma produces over 95% of the world’s rubies and over 99% of the world’s jadeite. Jadeite is superior quality jade, or “imperial jade.” In its 2015 report “Jade: Myanmar’s “Big State Secret,” Global Witness stated that this multi-billion dollar jade trade is “tightly controlled by … military elites, US-sanctioned drug lords and …

Washington begins to sour on Aung San Suu Kyi amid mounting …

https://www.washingtonpost.com/…burma/…/56184e5e-93db-11e7-8754-d478688d23b…

Sep 7, 2017 – Washington lawmakers who once enthusiastically supported Aung San Suu Kyi’s rise to power in Burma have shifted this week to criticism of her … Obama made two trips to the country, and last year his administration lifted the remaining economic sanctions, including on the import of jade and rubies.

Miners find giant £140 million jade stone in Burma | The Independent

http://www.independent.co.uk › News › World › Asia

Oct 16, 2016 – Miners in Burma have found one of the world’s most valuable pieces of jade. The stone is valued at £140 million and was discovered in a remote mine in Kachin State, in the north of the country. The stone is is 18ft long, 18ft wide and 9ft high and weighs approximately 175 tonnes.

Giant jade stone uncovered in Myanmar – BBC News

http://www.bbc.co.uk/news/world-asia-37670305

Oct 15, 2016 – A giant jade stone weighing 175 tonnes has been uncovered by miners in Myanmar.

Giant jade stone uncovered in Myanmar – BBC News – BBC.com

http://www.bbc.com/news/world-asia-37670305

Oct 15, 2016 – A giant jade stone weighing 175 tonnes has been uncovered by miners in Myanmar.

Secret Genocide: Voices of the Karen of Burma – Google Books Result

https://books.google.com/books?isbn=1908518308
Daniel Pedersen – 2015

Tay Lay told mehehad gone into the jade business, teaming up with SPDC Vice Chairman Maung Aye’s sister-in-law (apparently known to all as’Cherry’), selling jade internationally. One would assume hewas selling to China, where jade is highly coveted. Burma’s jade isconsidered the world’s finest, but evenif it is sold …

There’s Strong Evidence of a Genocide in Myanmar – Newsweek

http://www.newsweek.com/theres-strong-evidence-genocide-myanamar-393096

Nov 13, 2015 – A new report by Yale Law School says the UN should urgently investigate the fate of the Rohingy

————
Connie’s comments: Stop buying Jade ladies.
Posted byconnie dello buonoDecember 18, 2017December 19, 2017Posted inMenuLeave a comment on Jade , Genocide and Burma

Washington Post on Leadership 12-18-17

The last year has been an epic one for leadership stories: A combative, unrestrained, ego-driven president in the White House. A divided, dysfunctional Congress with little to show — other than this week’s likely tax reform bill. A watershed workplace moment with the wave of sexual harassment. A reckoning in the C-suite as some lost their jobs — while many others spoke out more on current social issues.

These stories and more captivated our interest in 2017. Below, a look back at 10 highlights and lowlights of a monumental year for leading in Washington and managing America’s workplaces. Short edited excerpts of each story follow.

10. Why sexual harassment training doesn’t stop harassment

As a staggering wave of women and men divulge unwanted advances and illegal behavior in what seems like an epidemic of sexual harassment allegations, employers have been searching for solutions. From Hollywood to the halls of Congress, the topic of harassment training has taken center stage. Employment lawyers said they’ve heard from clients in droves who want to make sure their training and coaching are up to speed. “We’ve definitely had an uptick in requests for this kind of work in the last couple of months,” said Kevin O’Neill, a principal at the employment law firm Littler Mendelson who leads sexual harassment training.

Yet researchers don’t have much evidence that sexual harassment training is effective at certain key goals: reducing the number of incidents in a workplace; or helping to shift its culture toward one that takes the issue seriously. “In most cases, employers are creating these policies more to protect themselves than to protect employees,” said Lauren Edelman, a professor at the law school of the University of California at Berkeley. “We don’t know when harassment training is effective, and we have reason to believe that maybe it’s counterproductive in some cases.”

9. America’s most powerful woman is losing her job. What that means.

Federal Reserve Chair Janet L. Yellen earned widespread approval for her term at the helm of the U.S. central bank, a singularly powerful job in the global economy. On her watch, unemployment fell sharply, inflation stayed subdued, wages began to rise, and she managed a gradual start to the Fed’s unwinding of its $4.5 trillion balance sheet, a tricky task that could have undercut growth if mishandled. Yet despite all that, Trump said he would not name Yellen — the first woman to hold the post — for a second term when her tenure expires at the end of January, an unusual break with tradition.

His decision also, according to some female economists, sends a message to others who may want to follow in Yellen’s footsteps. “She set the bar so high, and as a result of her hard work she was ahead of the curve on so many things,” said Julia Coronado, president of MacroPolicy Perspectives and a former Fed staff member. “Despite that, she’s not getting the job back. What is a young woman economist supposed to make of that? That I can work harder than anybody else and be smarter than people around me and get fired? That’s a tough message.”

8. The iPhone is 10. Where does Apple go from here?

It was a high-stakes moment for a company 10 years after it released what was its most revolutionary product of the century: the original iPhone. In September, Apple introduced its 10th anniversary model, as tech enthusiasts and business analysts alike looked for a glimpse of Apple’s future. It was a test of its consumer tech dominance as it faced a bevy of challenges: Samsung had resumed its smartphone momentum with the new Galaxy Note 8, Apple trailed competitors such as Google in the home hub space, Siri’s artificial intelligence wasn’t as advanced as others, and it was losing to Amazon.com as an entertainment innovator.

Apple’s disruptive reputation was famously first forged by Cook’s predecessor, Steve Jobs, whose showmanship turned such product announcements into glimmering spectacles of consumer technology. While Cook’s tenure at Apple’s helm has been characterized by considerable financial success, many were — and still are — asking: Will this be the moment Apple reclaims its mantle as tech’s top innovator?

7. Trump’s business advisory councils disband as CEOs abandon president over Charlottesville views

President Trump’s relationship with the American business community suffered a major setback in August as the president was forced to shut down his major business advisory councils after corporate leaders repudiated his comments on the violence in Charlottesville. Trump announced the disbanding of the two councils amid a growing uproar by chief executives furious over his decision to equate the actions of white supremacists and protesters. According to people familiar with the CEOs’ thinking, those groups had already decided to dissolve on their own.

The dissolution was a remarkable moment for Trump, who had made his corporate experience and ability to leverage America’s business potential one of his chief credentials. It also marked a rapid descent for a president who has alternatively praised and attacked the decisions of corporate leaders, sometimes making unverified or false claims, and whose policy choices on issues such as immigration and climate change have been criticized as anti-business. He lashed out on Twitter at the first CEO to resign, Merck chief executive Ken Frazier; Frazier’s resignation was followed by a wide range of CEOs, including JP Morgan Chase CEO Jamie Dimon and Campbell Soup’s Denise Morrison.

6. How Trump’s speech to the Boy Scouts could put AT&T’s CEO in a tricky spot

AT&T chief executive Randall Stephenson was hardly the first corporate leader to have also been national president of the Boy Scouts of America. Secretary of State and former ExxonMobil CEO Rex Tillerson held the role from 2010 to 2012. The CEO of Dreyer’s Grand Ice Cream, Rick Cronk, did so in the mid-2000s.

But Stephenson was almost certainly the first to find himself in that role while the president of the United States made a political speech at a Boy Scout event at a time when his company faced a Justice Department antitrust review. At the time, AT&T was awaiting word on its proposed $85 billion takeover of Time Warner — putting Stephenson in a potentially difficult scenario as many parents and former Boy Scouts called for an apology about Trump’s speech. In November, the Department of Justice sued to block AT&T’s $85 billion bid for entertainment conglomerate Time Warner, setting the stage for one of the biggest antitrust cases in decades.

5. GE CEO Jeffrey Immelt to step down after 16 years

General Electric said in June that its longtime chief executive, Jeffrey R. Immelt, would retire, closing out a 16-year run at the helm of the industrial giant, which included a vast overhaul of the conglomerate’s portfolio but also an underperforming stock price that trailed well below market indexes and competitors.

On Immelt’s watch, GE, the only remaining member of the original Dow Jones industrial average, was the Dow’s worst performing stock among companies that hadn’t gone bankrupt or left the group of blue-chip stocks. His inability to move the stock price — it fell by more than a quarter during his tenure — was thought by many to be his undoing. “Why the change? Two words: stock price,” said Ivan Feinseth, chief investment officer at Tigress Financial Partners. “There is no question. The board and shareholders have given Jeff Immelt a long time. He was CEO for almost 16 years in one of the biggest upmarkets cycles in history and the stock has underperformed.”

4. Trump invited the CEO comparisons, and now he’s being held to them

On the campaign trail, Donald Trump never shied away from touting his business skills, running as the outsider whose supposed management acumen would bring executive sensibilities to Washington. As a result, one of the most popular genres for political and business news and op-ed writers has been the Trump-as-CEO comparison. But in May, following a stunning week of upheaval and self-inflicted crises in the White House, those comparisons were taken to their logical next step. Not one but two publications asked whether the CEO president was performing in a way that should let him keep the corner office.

“If Donald Trump were a CEO, he’d probably be fired today,” blared the headline of a story in The New Yorker. And Bloomberg News editor-in-chief John Micklethwait, writing in the cover story titled “If America were a company, would you keep this CEO?,” suggested the White House was “more like a court than a company, with the king retiring to bed with a cheeseburger and spontaneously tweeting orders.” The CEO-as-president analogy, in other words, has not worn well.

3. Uber’s CEO says ‘I need leadership help.’ What should it look like?

The first step to solving a problem is admitting you have one. And in March, then-Uber CEO Travis Kalanick did just that, making an unusually public call for help after a dashcam video of a heated exchange with one of his company’s drivers went viral online. “This is the first time I’ve been willing to admit that I need leadership help and I intend to get it,” Kalanick wrote in a post on the company’s web site to employees, titled “A profound apology.”

In the weeks and months that followed, Kalanick’s cry for assistance, a rare admission of vulnerability from the top of a booming start-up, can be seen in hindsight as a warning sign. The company lost a slew of top-ranked executives, found itself under investigation by the U.S. Justice Department, fired 20 employees after a workplace investigation turned up harassment and bad behavior, and as a result, committed to 47 changes suggested by investigators. In June, Kalanick took a leave of absence, and resigned shortly thereafter.

2. The cost of silence: Why more CEOs are speaking out in the Trump era

More and more, consumers and employees expect the companies they buy from or work for to take a stand on social issues. And increasingly, CEOs have responded. American companies emerged as a force for social change earlier this year and were among the most vocal critics of Trump’s executive order to temporarily ban migrants from seven Muslim-majority countries. In the days after Trump’s travel ban was issued, more than a dozen top executives at rival companies in Silicon Valley traded a flurry of candid emails to discuss the response. And although Silicon Valley led the opposition, companies as diverse as Chobani, Nike, Ford, Goldman Sachs and MasterCard all said they were against the order or expressed concerns about it.

The risks for companies in speaking out can cut both ways. Doing so can alienate consumers who disagree with the company’s views. But not doing enough doesn’t work either. “Silence used to be the default posture,” said Duke University professor Aaron Chatterji, but political polarization, Facebook and Twitter have changed that. “It’s a choose-a-side mentality. The middle is harder to occupy. And with the proliferation of social media, it’s kind of like a microphone that’s always on. If you’re not speaking out, it’s more conspicuous.”

1. In his dark ‘America First’ inaugural address, Trump has a message for the world

Inaugural speeches tend to be remembered for their soaring rhetoric aimed at unifying a nation after it’s endured the divisions that emerge in a campaign season. And indeed, until Trump’s inaugural address — one that sounded to rhetoric scholars more like a stump speech to his campaign supporters — that has been their most common purpose, to articulate shared values in a democracy.

But the outside world is another audience for the inaugural speech that often gets less attention. Unlike the State of the Union address, presidents have used their inaugural speeches to send a signal to the world community about the new presidency. Trump did not shy away from that audience, speaking to the broader world not only with his opening, but with a thread of nationalism that ran throughout his campaign and his speech. He derided the enriching of “foreign industry at the expense of American industry” and subsidizing “the armies of other countries” in the speech. “Every decision on trade, on taxes, on immigration, on foreign affairs will be made to benefit American workers and American families,” Trump said in the address. “We will follow two simple rules: buy American and hire American.”


More on leadership in Washington:

*Omarosa Manigault’s departure highlights lack of diversity in Trump White House (The Washington Post)

*Paul Ryan sees his wild Washington journey coming to an end (Politico)

*Trump assails FBI leadership, touts loyalty to police (The Washington Post)

*A checklist for when it’s time to quit a job, from the ethics chief who walked out under Trump (Quartz)

Posted byconnie dello buonoDecember 18, 2017Posted inPoliticsLeave a comment on Washington Post on Leadership 12-18-17

The World’s Top Call-Center Nation Has a People Problem

call piThe World’s Top Call-Center Nation Has a People Problem

By

Ditas B Lopez

and

Siegfrid Alegado
  • Philippine industry group to create roadmap to boost skills
  • Half of outsourced jobs at risk from automation, study shows

Since the early 2000s, the Philippines added more than a million jobs as foreign companies outsourced customer support and sales tasks to the Southeast Asian nation.

Northern Lights Technology Development’s call center in Cebu, Philippines.

Photographer: Kuni Takahashi/Bloomberg

Now a looming wave of automation is threatening employment at call centers and forcing the industry to retrain workers to meet the demand for higher skilled jobs in areas such as healthcare, banking, finance and insurance.

“The biggest challenge is people,” Jojo Uligan, president of the Contact Center Association of the Philippines or CCAP, said in an interview at his office in Manila on Wednesday. “We lack people with enough technical expertise and experience to service emerging needs.”

Top 69 call center in the Philippines March 2012 | The Summit Express

http://www.thesummitexpress.com/2012/08/top-69-call-center-in-philippines-march.html

Aug 2, 2012 – It also seems that BPO jobs are one of the priority options for most newly college graduates. Here is the list of top 69 call centers in the Philippines released March 2012. Rank Name of Company 1 TI (Philippines), Inc. 2 Accenture, Inc. 3 Teletech Customer Care Management Phils. Inc 4 Convergys Phils.

List of Filipino & India Call Centers: Manila, Cebu, Mumbai, Delhi …

http://www.123outsource.net/call_center_outsourcing.htm

Find call centers anywhere in the world. Africa, Costa Rica, Europe, India, Philippines, and more!

Where can I find an UP TO DATE list of call centers in the …

https://www.quora.com/Where-can-I-find-an-UP-TO-DATE-list-of-call-centers-in-the…

Here is a good and up-to-date list of call centers in the Philippines (Manila): Find Filipino Call Centers in Cebu, Manila, Davao,Quezon City You may want to directly message Magellan Solutions — one of the leading call centers in the Philippines…

Top 36 BPO (Call Center) Companies in the Philippines in Terms of …

mattscradle.com/top-36-bpo-call-center-companies-in-the-philippines-in-terms-of-rev…

Jan 15, 2017 – top call center company philippines. image credits to the owner. Do you want to start your career in the Business Process Outsourcing (BPO) and Call Center industry? Below are the top 36 BPO companies that you should target when applying for a job. Although the list is based on their respective revenue …

[Updated] The TOP Call center companies in the Philippines for 2017

https://auxbreak.com/top-call-center-companies-philippines-2/

Aug 15, 2017 – Working in the BPO industry consumes so much of your time and energy, so make sure it’s all worth it. JP Morgan Chase. This shouldn’t ccome as a surprise. ANZ. If you hate working at night, this is one place where you should be. Convergys Philippines. Accenture. American Express.

The Philippines has become the call-center capital of the world – LA …

http://www.latimes.com/business/la-fi-philippines-economy-20150202-story.html

Feb 1, 2015 – Today, it’s the job of choice for many young people here. More than 1 million Filipinos now work at call centers and in related outsourcing businesses, mostly serving American companies. The combination of cheap labor and specialized skills has made the Filipino workforce invaluable to a growing list of …

List of Outsourcing Companies in the Philippines | Staff.com Blog

https://blog.staff.com/list-of-philippine-outsourcing-companies/

Jul 3, 2014 – Based on my research they just don’t offer online jobs but they are also operating a call center in the Philippines of the same city where some of the outsourcing companies on your list is located like Live2sell and Taking you Forward. I just cant find reviews about them. I was wondering if you have one?

List of all call centers in the Philippines – Tsikot

https://www.tsikot.com › … › The Pitstop Cafe › Politics, Economy and Religion Talk

Oct 2, 2005 – 9 posts – ‎7 authors

Meron ba kayong alam na website na may list ng call centers here in the Philippines or kahit Metro Manila lang? Thanks in advance!

Philippine Call Centers in Manila – Philippine Country Guide

http://www.philippinecountry.com/philippine_call_centers/manila.html

24X7 Communications Inc URL: http://www.24x7communications.com/. 24X7 Communications Inc MakatiPeak Tower Makati City, Philippines. 24X7 Communications Inc ManilaChamp Building, Anda Circle, Port Area, Manila, Philippines Tel no.: (63) 02-495-0243. 2. 2GO (an Aboitiz company) URL: http://www.2go.com.ph/.

Call Center Companies in Philippines – Call Center Jobs in …

https://call-center-bpo.jobstreet.com.ph/call-center-industry/call-center-companies.htm

Search call center jobs in Philippines. Offering call center job openings, call center agent, call centerdirectory, BPO jobs, interview questions and training.

—————
Connie’s comments: Email motherhealth@gmail.com as I will be in the Philippines (between Dec 26 to Jan 4,2018) to search for a  Philippines call center to work for sustainable – renewable energy project based in California.

The Philippines is the world’s top call center destination with companies like Accenture Plc and American Express Co. among those that have set up shop in the Southeast Asian nation. They’ve been lured by cheaper wages, Filipinos’s cultural affinity with the West, and a 100 million population that’s mostly fluent in English.

With technology constantly advancing, machines are now able to replicate some of the tasks that people do, including customer relations. More than half of outsourced jobs could be lost in a few years unless significant retraining is done, according to a study by Tholons Capital, a New York-based consultancy.

In India, robots are now replacing warehouse workers, for example.

Click to read: Butler, a stubby, orange robot, crawls along the aisles to fetch everything from smartphones to shampoos from warehouse shelves.

Leaders of some of the biggest outsourcing companies in the world will meet this month in the Philippines to craft fresh strategies to counter the impact of automation, Uligan said.

Companies are increasingly seeking workers who are college educated, experienced, have technical expertise and can easily be retrained, he said.

“There is a lot of complex work now,” Uligan said. “It’s no longer mere directory assistance or taking orders.”

These concerns are tempering the outlook for the industry. The CCAP estimates that revenue will grow as much as 8 percent this year until 2022, compared with growth rates exceeding 10 percent in the past.

“People don’t evolve as fast as technology,” Uligan said.

Posted byconnie dello buonoDecember 18, 2017Posted inMenuLeave a comment on The World’s Top Call-Center Nation Has a People Problem

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Posted byconnie dello buonoDecember 15, 2017Posted inMenuLeave a comment on Top health and aging hacks 12-15-17

Washington Post 12-15-17

Opinions

  • The Post’s View
  •  Local Opinions
  •  PostEverything
  •  Letters to the Editor
  •  Global Opinions
Tom Toles
Donald Trump says Happy Tax Holiday to all his friends and loved ones
  • By Tom Toles
Ann Telnaes
Two scoops with PDB sprinkles
  • By Ann Telnaes
Columns

Trent Franks rescinded my internship when I wouldn’t come to his house

I didn’t speak up, but you should.

  • Melissa Richmond
  • ·
  • 16 minutes ago

Democrats should be heartbroken that Roy Moore lost

“Sen. Moore (R-Ala.)” would have been the gift that kept on giving.

  • Marc A. Thiessen
  • ·
  • 8 hours ago

All men should be facing the mirror on sexual harassment

None of us can be disinterested bystanders if things are going to change.

  • Ari Wilkenfeld
  • ·
  • 11 hours ago

To save the GOP, Republicans have to lose

The Alabama election was like looking into the abyss.

  • Michael Gerson
  • ·
  • 21 hours ago

What Trumpists should really worry about

Alabama could be a sign of things to come.

  • Eugene Robinson
  • ·
  • 21 hours ago

A feast for regulatory parasites

The GOP tax proposal is stunningly complex on the corporate side, meaning lawyers and accountants would make out like bandits.

  • Catherine Rampell
  • ·
  • 21 hours ago

How Trump can win the GOP’s great war of ideas

He must make the case for a new conservatism.

  • Christopher Buskirk
  • ·
  • 21 hours ago

Newtonian physics will crush the GOP

The harder Trump fights women and minorities, the harder they will push back.

  • Joe Scarborough
  • ·
  • 21 hours ago
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The Post’s View

Congress should help Puerto Rico — not hurt it

The situation is more dire than we know.

  • Editorial Board
  • ·
  • The Post’s View
  • ·
  • 21 hours ago

Corruption makes Ukraine even more vulnerable to Russia

As long as the country fails to embrace the rule of law, it is in danger.

  • Editorial Board
  • ·
  • The Post’s View
  • ·
  • 21 hours ago

The Supreme Court gets a second chance to quash gerrymandering

A new case challenges extreme partisan redistricting.

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  • ·
  • 21 hours ago
PostEverything
The CIA tailors its briefings so it doesn’t anger Trump. That’s good.
The CIA reportedly tailors its briefings to avoid enraging President Trump. (MICHAEL REYNOLDS/EPA-EFE/REX/Shutterstock)
Intelligence officials have always adjusted their briefings to suit a president’s style. It’s changing their conclusions that’s dangerous.
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The two expat bros who terrorized women correspondents in Moscow

Matt Taibbi and Mark Ames trafficked in hideous stereotypes and body-shaming.

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Stop asking black women to ‘save America.’ Start organizing your own people.

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Want to thank black voters for defeating Roy Moore? Tackle voter suppression.

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A three-tiered solution for Puerto Rico

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Donald Trump cannot stop endorsing losers

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The Republicans have momentum on the tax cut. How did it come to this?

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Who belongs in the anti-Trump coalition?

Those in political opposition need all the political allies they can muster.

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I don’t like the GOP tax bill, but now my life depends on beating it

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Four thoughts on the story that almost broke the #ToddlerinChief thread

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Why doesn’t Apple make its devices as carefully as it’s making Apple Park?

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  • ·
  • 4 days ago

Weary of the Internet, I went back to mail. 108 letters later, here’s what I learned.

I wrote one letter every day, to someone I knew or used to know or wanted to know better.

  • Tim Johnson
  • ·
  • 4 days ago

There are dolls for all Barbie’s weddings. Here are the ones for her divorces.

Barbie is the plastic Larry King — she’s had more weddings than anybody could hope to keep track of. Mattel is exceedingly talented at mashing up the words “bride” and “Barbie.” There’s Barbie…

  • Amy Collier, Susan Burghart
  • ·
  • Dec 8

This is how nuclear war with North Korea would unfold

In one all-too-plausible worst-case scenario, millions die from mistakes and a tweet.

  • Jeffrey Lewis
  • ·
  • Dec 8
Load More
Outlook
America’s chaotic, crazy, challenging, great, tumultuous, horrible, disappointing year
A look back at the ups and downs of public opinion in 2017. (Shelly Tan/The Washington Post)
A look back at the ups and downs of public opinion in 2017. (Shelly Tan/The Washington Post)
A look back at the ups and downs of public opinion in 2017.
  • By Scott Clement, Emily Guskin and Shelly Tan

The two expat bros who terrorized women correspondents in Moscow

Matt Taibbi and Mark Ames trafficked in hideous stereotypes and body-shaming.

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Campus rapes aren’t being reported to D.C. police, and that’s dangerous

Federal law mandates that universities share campus rape statistics with the Education Department but not with law enforcement.

Posted byconnie dello buonoDecember 15, 2017Posted inPoliticsLeave a comment on Washington Post 12-15-17

New York Times 12-15-17

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  1. LETTER

    An Israeli View on Peace

    Israel’s consul general in New York responds to an editorial.

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  2. LETTERS

    The Effects of Ending Net Neutrality

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    Dec. 15, 2017
  3. LETTER

    How #MeToo Threatens Equality

    A reader argues that not distinguishing between different forms of harassment — a clumsy advance versus an assault — “diminishes women.”

    Dec. 15, 2017
  4. LETTER

    The Tax Bill: ‘This Abomination’

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  6. Defeat in Alabama

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  8. OP-ED CONTRIBUTOR

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  9. CONTRIBUTING OP-ED WRITER

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Posted byconnie dello buonoDecember 15, 2017Posted inPoliticsLeave a comment on New York Times 12-15-17

Prostate flush and masturbation

Why Men Should Masturbate 21 Times A Month According To Science …

http://www.iflscience.com/health…/masturbating-frequently-reduces-risk-of-prostate-cancer/

Jul 6, 2017 – Masturbating frequently may actually result in a significantly lower risk of prostate cancer. … It is currently unconfirmed why, but some scientists believe a successful orgasm may flush out cancer-determining toxins that build up in the prostate. Around one in seven men will experienceprostate cancer in the …

Frequent ejaculation may decrease prostate cancer risk – National …

https://www.ncbi.nlm.nih.gov/…/2017-07-06-frequent-ejaculation-may-decrease-pros…

Jul 6, 2017 – Despite any lurid tales you may have heard growing up, masturbation is entirely safe. So if you want to do it as a … The Sun’s claim that “having 21 orgasms a month could be the key to preventing CANCER in men because it helps the prostate ‘flush out toxins'” is unsupported. The claim that it flushesout …

Science Says Men Should Masturbate 21 Times A Month — Here’s …

https://www.huffingtonpost.com/…/science-says-men-should-masturbate-21-times-a-…

Jul 13, 2017 – Beyond the prostate flush, Dr. Kerner says masturbation comes with a whole slew of benefits, such as giving a dude the chance to experience pleasure and relaxation. “It’s an opportunity to engage in self-care,” he explains. “Masturbation can also be a healthy distraction mechanism and a natural way of …

Happy news! Masturbation actually has health benefits

theconversation.com/happy-news-masturbation-actually-has-health-benefits-16539

Dec 4, 2013 – For men, masturbation helps reduce risk of prostate cancer, probably by giving theprostate a chance to flush out potential cancer-causing agents. Masturbation also improves immune functioning by increasing cortisol levels, which can regulate immune functioning in small doses. It also reduces depression …

prostate health and ejaculation – WebMD

https://www.webmd.com › Prostate Cancer › News

Apr 6, 2004 – April 6, 2004 — Frequent ejaculation, whether it happens during sexual intercourse,masturbation, or a dream, isn’t likely to increase men’s risk of prostate cancer. In fact, new research suggests it may have the opposite effect and help protect the prostate. Researchers say it’s too soon to recommend that …

Masturbation and Prostate Cancer Risk – WebMD

https://www.webmd.com › Prostate Cancer › News

Jan 27, 2009 – Frequent masturbation is a sign of higher prostate cancer risk in younger men, but a sign of lower risk in older men, a U.K. study shows.

Masturbating may protect against prostate cancer | New Scientist

https://www.newscientist.com/…/dn3942-masturbating-may-protect-against-prostate-c…

Jul 16, 2003 – Frequent ejaculation by men may cut the risk by a third – the flushing out of carcinogens is one possible explanation.

Re: Masturbation flushes toxins, cuts cancer risk at News Forum …

https://www.curezone.org/forums/am.asp?i=588340

3 posts – ‎2 authors

not so fast. there is much more to this than meets the eye. first of all, the best thing to do is to not ingest the toxins to begin with. secondly, staying well hydrated and doing physical activity which stimulates circulation, particularly the kind that makes the lymph system flow, will flush not only the prostate but also the rest of the …

10 benefits of masturbating – Men’s Fitness

https://www.mensfitness.com/women/sex-tips/12-benefits-0

A 2004 Harvard study found that men who ejaculated 21 times per month were less likely to faceprostate cancer compared to those who ejaculated four to seven times a month. The exact link betweenmasturbation and prostate cancer risk is unclear, but flushing the prostate of carcinogens that could cause problems is the …

You Won’t Go Blind: Men’s Health.com

https://www.menshealth.com/sex-women/health-and-sexual-benefits-of-masturbation

May 24, 2012 – Learn the sexual benefits and health benefits of masturbation, from Men’s Health. … A 2003 Australian study found that men who ejaculated more than five times a week were a third less likely to develop prostate cancer. Regularly flushing your system, so to speak, keeps your semen healthy and prevents …

Posted byconnie dello buonoDecember 15, 2017Posted inMenuTags:masturbation, prostate cancerLeave a comment on Prostate flush and masturbation

Disrupted Internal Clocks Play Role in Liver Disease

via Disrupted Internal Clocks Play Role in Liver Disease

Posted byconnie dello buonoDecember 15, 2017Posted inMenuLeave a comment on Disrupted Internal Clocks Play Role in Liver Disease

Disrupted Internal Clocks Play Role in Liver Disease

It’s About Time: Disrupted Internal Clocks Play Role in Disease

Study uncovers circadian disruption as risk factor in alcoholic liver disease.

Thirty percent of severe alcoholics develop liver disease, but scientists have not been able to explain why only a subset is at risk. A research team from Northwestern University and Rush University Medical Center now has a possible explanation: disrupted sleep and circadian rhythms can push those vulnerable over the edge to disease.

The team studied mice that essentially were experiencing what shift workers or people with jet lag suffer: their internal clocks were out of sync with the natural light-dark cycle.

Another group of mice had circadian disruption due to a faulty gene. Both groups were fed a diet without alcohol and next with alcohol, and the team then examined the physiological effects.

The researchers found the combination of circadian rhythm disruption and alcohol is a destructive double hit that can lead to alcoholic liver disease.

The study was published last month by the journal PLOS ONE.

“Circadian disruption appears to be a previously unrecognized risk factor underlying the susceptibility to or development of alcoholic liver disease,” said Fred W. Turek, the Charles E. and Emma H. Morrison Professor of Biology at Northwestern’s Weinberg College of Arts and Sciences and one of the senior authors of the paper.

“What we and many other investigators are doing is bringing time to medicine for the diagnosis and treatment of disease,” Turek said. “We call it circadian medicine, and it will be transformative. Medicine will change a great deal, similar to the way physics changed when Einstein brought time to physics.”

The image shows the different stages of liver damage.

A number of years ago, Ali Keshavarzian, M.D., a gastroenterologist at Rush University Medical Center who has worked with and studied patients with gastrointestinal and liver diseases, had a hunch disrupted circadian rhythms could be a contributing factor to the disease.

Keshavarzian had noticed that some patients with inflammatory bowel disease (inflammation in the intestine and/or colon) had flare-ups of symptoms when working nights, but they could control the disease when working the day shift. He sought out Turek, director of Northwestern’s Center for Sleep and Circadian Biology, to help investigate the relationship between circadian rhythms and the disease.

The two investigators and their groups first studied the effect of circadian rhythm disruption in an animal model of colitis and noted that disruption of sleep and circadian rhythms (caused by modeling shift work and chronic jet lag in the animals) caused more severe colitis in mice.

Keshavarzian has been studying the effect of “gut leakiness” (the intestinal lining becomes weak and causes dangerous endotoxins to get into the blood stream) to bacterial products in gastrointestinal diseases for two decades. Because the mouse model of colitis is associated with leaky gut, he proposed that disruption of circadian rhythms from shift work could make the intestine more susceptible to leakiness. He wanted to test its effect in an animal model of alcoholic liver disease — where a subset of alcoholics develop gut leakiness and liver disease — in order to find out whether shift work is the susceptibility factor that promotes liver injury.

“Non-pathogen-mediated chronic inflammation is a major cause of many chronic diseases common in Western societies and developing countries that have adopted a Western lifestyle,” said Keshavarzian, one of the senior authors of the paper. He is director of the Division of Digestive Diseases and the Josephine M. Dyrenforth Chair of Gastroenterology.

Crohn’s and ulcerative colitis, Parkinson’s disease, diabetes, multiple sclerosis, autoimmune disease and cardiovascular disease are examples of these diseases, to name just a few.

“Recent studies have shown that intestinal bacteria are the primary trigger for this inflammation, and gut leakiness is one of the major causes,” Keshavarzian said. “The factor leading to gut leakiness is not known, however. Our study suggests that disruption of circadian rhythms and sleep, which is part of life in industrial societies, can promote it and explain the susceptibility.”

In the study, the Northwestern and Rush researchers used two independent approaches, studying both genetic and environmental animal models. The circadian rhythms of one group of mice were disrupted genetically: Each animal had a mutant CLOCK gene, which regulates circadian rhythms. The second group’s circadian rhythms were disrupted environmentally: The animals’ light-dark cycle was changed periodically, leading to a state similar to chronic jet lag.

Mice in both groups, prior to ingesting alcohol, showed an increase in gut leakiness.

Next, both groups of mice were fed alcohol. After only one week, animals in both groups showed a significant additional increase in gut leakiness, compared to control mice on an alcohol-free diet. At the end of the three-month study, mice in both groups were in the early stages of alcoholic liver disease.

“We have clearly shown that circadian rhythm disruption can trigger gut leakiness, which drives the more severe pathology in the liver,” said Keith Summa, a co-first author of the study and an M.D./Ph.D. candidate working in Turek’s lab.

“For humans, circadian rhythm disruption typically is environmental, not genetic, so individuals have some control over the behaviors that cause trouble, be it a poor sleep schedule, shift work or exposure to light at night,” he said.

Sleep and circadian rhythms are an integral part of biology and should be part of the discussion between medical doctors and their patients, the researchers believe.

“We want to personalize medicine from a time perspective,” Turek said. “Our bodies are organized temporally on a 24-hour basis, and this needs to be brought into the equation for understanding health and disease.”

Notes about this circadian rhythm and health research

The paper, titled “Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Pathology and Inflammation,” is available online.

In addition to Turek, Keshavarzian and Summa, other authors of the paper are co-first author Robin M. Voigt, Christopher B. Forsyth, Maliha Shaikh and Yueming Tang, of Rush University Medical Center; Martha Hotz Vitaterna and Kate Cavanaugh, of Northwestern; and Shiwen Song, of the American Society for Clinical Pathology.

Contact: Megan Fellman – Northwestern University
Source: Northwestern University press release
Image Source: The liver damage image is credited to the NIH and is in the public domain.
Original Research: Full open access research for “Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation” by Keith C. Summa, Robin M. Voigt, Christopher B. Forsyth, Maliha Shaikh, Kate Cavanaugh, Yueming Tang, Martha Hotz Vitaterna, Shiwen Song, Fred W. Turek and Ali Keshavarzian in PLOS ONE. Published online June 18 2013 doi:10.1371/journal.pone.0067102

Posted byconnie dello buonoDecember 15, 2017Posted inMenuTags:alcohol, autoimmune, disease, liver, sleep1 Comment on Disrupted Internal Clocks Play Role in Liver Disease

Trump’s untruth is damaging to our democracy

via Trump’s untruth is damaging to our democracy

Posted byconnie dello buonoDecember 15, 2017Posted inMenuLeave a comment on Trump’s untruth is damaging to our democracy

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