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Lead and holistic detox ways

What are the Adverse Health Effects that Lead Exposure Can Have on Adults?

The toxic nature of lead is well documented. Lead affects all organs and functions of the body to varying degrees. The frequency and severity of symptoms among exposed individuals depends upon the amount of exposure. The list below shows many of the key lead-induced health effects.

  • Neurological Effects
    • Peripheral neuropathy
    • Fatigue / Irritability
    • Impaired concentration
    • Hearing loss
    • Wrist / Foot drop
    • Seizures
    • Encephalopathy
  • Gastrointestinal Effects
    • Nausea
    • Dyspepsia
    • Constipation
    • Colic
    • Lead line on gingival tissue
  • Reproductive Effects
    • Miscarriages/Stillbirths
    • Reduced sperm count & motility
    • Abnormal sperm
  • Heme Synthesis
    • Anemia
    • Erythrocyte protoporphyrin elevation
  • Renal Effects
    • Chronic nephropathy with proximal tubular damage
    • Hypertension
  • Other
    • Arthralgia
    • Myalgia

What Lead Levels are Considered Elevated in Adults?

  • At levels above 80 µg/dL, serious, permanent health damage may occur (extremely dangerous).
  • Between 40 and 80 µg/dL, serious health damage may be occuring, even if there are no symptoms (seriously elevated).
  • Between 25 and 40 µg/dL, regular exposure is occuring. There is some evidence of potential physiologic problems (elevated).
  • Between 10 and 25 µg/dL, lead is building up in the body and some exposure is occuring.

The typical level for U.S. adults is less than 10 µg/dL (mean = 3 µg/dL)

 


Heavy metals (including lead, cadmium, mercury, and the metalloid arsenic) are persistent in the environment and have documented potential for serious health consequences. Heavy metal toxicity may damage:

  • central nervous system
  • cardiovascular system
  • gastrointestinal system
  • lungs
  • kidneys
  • liver
  • endocrine glands
  • bones

Fortunately, integrative interventions like selenium and garlic have been shown to decrease the buildup and increase the excretion of toxic heavy metals.

Risk Factors for Toxic Metal Exposure

Lead:

  • Lead-containing plumbing
  • Lead-based paints (in buildings built before 1978 and is the predominant source for children)
  • Foods grown in lead-rich soil

Mercury:

  • Eating fish or shellfish contaminated with methylmercury (includes shark, swordfish, king mackerel, tile fish, bass, walleye, pickerel)
  • Breathing contaminated workplace air or skin contact during use in the workplace
  • Release of mercury vapor from dental amalgam fillings

Cadmium

  • Tobacco smoke
  • Eating foods containing cadmium (levels are highest in grains, legumes, and leafy vegetables, fish and shellfish)
  • Contact with cadmium from household products (electric batteries and solar panels)

Signs and Symptoms

These can be similar to other health conditions and may not be immediately recognized as due to heavy metal toxicity:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Central nervous system dysfunction
  • Heart problems
  • Anemia

Diagnosis

  • Blood testing
  • Urine testing
  • Hair and nail analysis

Conventional Therapies

  • Chelation therapy, which enhances the elimination of metals (both toxic and essential) from the body, including:
    • DMPS, an oral medication for arsenic, cadmium, and mercury toxicity
    • Succimer (DMSA), an oral medication for mild-to-moderate lead, arsenic and mercury toxicity
    • Calcium-disodium EDTA for lead encephalopathy and lead poisoning

Novel and Emerging Therapies

  • Toxicogenomics, the study of gene expression changes by toxin exposure
  • New chelation therapies, including polygamma-glutamic acid-coated superparamagnetic nanoparticles that have a high specificity for metal toxins

Dietary and Lifestyle Changes

  • Avoid or replace mercury amalgam dental fillings with mercury-free composite material
  • Maintain nutrient sufficiency, as adequate intake of essential trace minerals may reduce toxic metal uptake
  • Limit consumption of high-mercury fish to no more than 1 serving/week

Integrative Interventions

  • Selenium: Selenium is an inhibitor of mercury accumulation and increases excretion of mercury and arsenic
  • Vitamin C: A free-radical scavenger that has been shown to reduce lead levels in humans
  • Folate: Higher blood folate levels in pregnant women were associated with lower blood mercury and cadmium levels
  • Garlic: Garlic lowered lead levels in the blood of industrial workers as effectively as the chelator d-penicillamine
  • Alpha-Lipoic Acid and Glutathione: In preclinical studies, these compounds reduced the adverse changes in blood parameters due to lead, cadmium, and copper

Fungal brain

Fungal (mold) infections to the brain were once relatively rare. Now they are becoming increasingly more common for many reasons including: 1) increases in the number of HIV/ AIDS patients, 2) increases in the number of patients with certain cancers like leukemia or lymphoma, 3) increases in patients on immunosuppressive therapy for organ or bone marrow transplants, and 4) increased numbers of patients on long term antibiotic therapy which can encourage mold overgrowth. The most common fungi to cause brain infections include filament-forming fungi like Aspergillus, Mucor and Rhizopus and yeast-type fungi such as Candida and Cryptococcus. Less common causes of fungal brain infections include Trichosporon, Blastomyces, Histoplasma, Coccidioides, Paracoccidioides and Penicillium marneffei.

The most common form of fungal brain infections are meningitis, although these infections cause also present as localized brain infections called abscesses.

Meningitis typically presents with fever, headache, eye problems, difficulty concentrating and seizures. Brain abscesses can present with a local brain defect- such as a localized seizure. Even with hospital treatment, fungal meningitis and abscesses cam have a high mortality rate of over 20%.

Fungal brain infections may be hard to detect at their early and highly treatable stages. Testing the blood for galactomannan or for mold cultures may detect some fungal brain infections. Lumbar puncture and brain imaging may also be useful in some cases.


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Systemic fungal infections are serious and sometimes life-threatening conditions, especially in immunocompromised patients such as those with cancer, AIDS, and other chronic illnesses. … Dr. James Konopka investigates Candida albicans, which can cause lethal systemic infections.Oct 23, 2012

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Oral cancer and fungus in the kitchen

Lead in lipstick and health issues

Lead is a highly toxic metal that was used for many years in products found in and around our homes. Lead may cause a range of health effects, from behavioral problems and learning disabilities, to seizures and death. Children 6 years old and under are most at risk, because their bodies are growing quickly.

Research suggests that the primary sources of lead exposure for most children are:

  • deteriorating lead-based paint
  • lead contaminated dust
  • lead contaminated residential soil

EPA is playing a major role in addressing these residential lead hazards. According to the Centers for Disease Control and Prevention (CDC), in 1978 there were 13.5 million children in the United States with elevated blood lead levels (i.e., 10µg/dl). By 2002, that number had dropped to 310,000 kids. While we still have a significant challenge, EPA is very proud of how federal, state, tribal, and private sector partners have coordinated efforts with the public to better protect our children.

Since the 1980’s, EPA and its federal partners have phased out lead in gasoline, reduced lead in drinking water, reduced lead in industrial air pollution, and banned or limited lead used in consumer products, including residential paint. States and municipalities have set up programs to identify and treat lead poisoned children and to rehabilitate deteriorated housing. Parents, too, have greatly helped to reduce lead exposures to their children by cleaning and maintaining homes, having their children’s blood lead levels checked, and promoting proper nutrition. The Agency’s Lead Awareness Program continues to work to protect human health and the environment against the dangers of lead by developing regulations, conducting research, and designing educational outreach efforts and materials.

Checking your family and home for lead – To reduce your child’s exposure to lead, get your child checked, have your home tested (especially if your home has paint in poor condition and was built before 1978), and fix any hazards you may have.

Your Family

  • Children’s blood lead levels tend to increase rapidly from 6 to 12 months of age, and tend to peak at 18 to 24 months of age.
  • Consult your doctor for advice on testing your children. A simple blood test can detect high levels of lead. Blood tests are important for:
    • Children at ages 1 and 2.
    • Children and other family members who have been exposed to high levels of lead.
    • Children who should be tested under your state or local health screening plan.
  • Your doctor can explain what the test results mean and if more testing will be needed.

Your Home – You can get your home checked in one of two ways, or both:

  • A paint inspection tells you the lead content of every different type of painted surface in your home. It won’t tell you whether the paint is a hazard or how you should deal with it.
  • A risk assessment tells you if there are any sources of serious lead exposure (such as peeling paint and lead dust). It also tells you what actions to take to address these hazards.

Have qualified professionals do the work – There are standards in place for certifying lead-based paint professionals to ensure the work is done safely, reliably, and effectively. Trained professionals use a range of methods when checking your home, including:

  • Visual inspection of paint condition and location.
  • A portable x-ray fluorescence (XRF) machine.
  • Lab tests of paint samples.
  • Surface dust tests.

Have a trained professional at Environmental Analytics test your home for lead. Call 520.290.6653 for more information.

Note: Home test kits for lead are available, but studies suggest that they are not always accurate. Consumers should not rely on these tests before doing renovations or to assure safety.

* The information provided above is referenced from: http://www.epa.gov/lead

 


Mold and Bacteria

MOLD – Overview – A particular type of fungus in the Fungi Kingdom.

Mold, or Fungi, has received much attention in the past decade or two from the various media sources. Phrases such as “black mold” and “toxic mold” have cluttered the internet and air waves with various definitions and levels of concern to the public. Environmental Analytics has put together a simple, accurate, up-to-date “punch list” of mold and what you should know and how it can affect you, giving you a grounded perspective on this thing called mold.

Mold (fungus): Molds, mildews, yeasts, mushrooms, and puffballs, a group of organisms lacking in chlorophyll (i.e. are not photosynthetic) and which are usually non-mobile, filamentous, and multicellular. Some grow in soil, others attach themselves to decaying trees and other plants whence they obtain nutrients. Some are pathogens, others stabilize sewage and digest composted waste1. Few places exist on earth that are completely “fungus free”.

Mold is a natural constituent of the environment, a major player that helps shape the very environment you live in. Without mold, many things, including you, would be significantly affected. The main responsibility of fungi existence is to recycle carbon. One of the most basic elements, carbon, is the “makeup” of virtually everything that exists today and in the past. At the most raw and basic stages of develop, whether it be animal, plant or thing, carbon is and was a significant material used. You are made from carbon, your chair is made from carbon, the trees outside are made of carbon.

Fungi helps to break down the environment, bio-degrading leaves, grass, wood, paper, cardboard, and other cellulose products that would otherwise not rot away.

Fungi is also important in the medical fields. Some of most effective antibiotics, penicillin, cephalosporin and griseofulvin, are produced by common fungi2. In general, fungi plays an important role in our eco-system.

Health Affects – While fungi serves to help the environment, it can also interact with the human population in adverse ways. For one, fungi is known to be an important agent of human disease. The Environmental Protection Agency (EPA) has offered the following information regarding mold and associated health affects:

(Following information obtained from: http://www.epa.gov/mold/append_b.html)

Health Effects and Symptoms Associated with Mold Exposure – When moisture problems occur and mold growth results, building occupants may begin to report odors and a variety of health problems, such as headaches, breathing difficulties, skin irritation, allergic reactions, and aggravation of asthma symptoms; all of these symptoms could potentially be associated with mold exposure.

All molds have the potential to cause health effects. Molds produce allergens, irritants, and in some cases, toxins that may cause reactions in humans. The types and severity of symptoms depend, in part, on the types of mold present, the extent of an individual’s exposure, the ages of the individuals, and their existing sensitivities or allergies.

Potential Health Effects Associated with Inhalation Exposure to Molds and Mycotoxins – Allergic Reactions (e.g., rhinitis and dermatitis or skin rash); Asthma; Hypersensitivity Pneumonitis; Other Immunologic Effects

Research on mold and health effects is ongoing. This list is not intended to be all-inclusive.

The health effects listed above are well documented in humans. Evidence for other health effects in humans is less substantial and is primarily based on case reports or occupational studies.

Specific reactions to mold growth can include the following:

  • Allergic Reactions – Inhaling or touching mold or mold spores may cause allergic reactions in sensitive individuals. Allergic reactions to mold are common – these reactions can be immediate or delayed. Allergic responses include hay fever-type symptoms, such as sneezing, runny nose, red eyes, and skin rash (dermatitis). Mold spores and fragments can produce allergic reactions in sensitive individuals regardless of whether the mold is dead or alive. Repeated or single exposure to mold or mold spores may cause previously non-sensitive individuals to become sensitive. Repeated exposure has the potential to increase sensitivity.
  • Asthma – Molds can trigger asthma attacks in persons who are allergic (sensitized) to molds. The irritants produced by molds may also worsen asthma in non-allergic (non-sensitized) people.
  • Hypersensitivity Pneumonitis – Hypersensitivity pneumonitis may develop following either short-term (acute) or long-term (chronic) exposure to molds. The disease resembles bacterial pneumonia and is uncommon.
  • Irritant Effects – Mold exposure can cause irritation of the eyes, skin, nose, throat, and lungs, and sometimes can create a burning sensation in these areas.
  • Opportunistic Infections – People with weakened immune systems (i.e., immune-compromised or immune-suppressed individuals) may be more vulnerable to infections by molds (as well as more vulnerable than healthy persons to mold toxins). Aspergillus fumigatus, for example, has been known to infect the lungs of immune-compromised individuals. These individuals inhale the mold spores which then start growing in their lungs. Trichoderma has also been known to infect immune-compromised children. Healthy individuals are usually not vulnerable to opportunistic infections from airborne mold exposure. However, molds can cause common skin diseases, such as athlete’s foot, as well as other infections such as yeast infections.

FOR MORE INFORMATION RELATING TO HEALTH AFFECTS VISIT: http://www.epa.gov/mold/append_b.html

Ten things you should know about mold (reducing amplification and exposure)

(Following information obtained from: http://www.epa.gov/mold/moldresources.html)

The EPA has come up with ten things you should know about mold to help minimize exposure and mold amplification:

  1. Potential health effects and symptoms associated with mold exposures include allergic reactions, asthma, and other respiratory complaints.
  2. There is no practical way to eliminate all mold and mold spores in the indoor environment; the way to control indoor mold growth is to control moisture.
  3. If mold is a problem in your home or school, you must clean up the mold and eliminate sources of moisture.
  4. Fix the source of the water problem or leak to prevent mold growth.
  5. Reduce indoor humidity (to 30-60% ) to decrease mold growth by: venting bathrooms, dryers, and other moisture-generating sources to the outside; using air conditioners and de-humidifiers; increasing ventilation; and using exhaust fans whenever cooking, dishwashing, and cleaning.
  6. Clean and dry any damp or wet building materials and furnishings within 24-48 hours to prevent mold growth.
  7. Clean mold off hard surfaces with water and detergent, and dry completely. Absorbent materials such as ceiling tiles, that are moldy, may need to be replaced.
  8. Prevent condensation: Reduce the potential for condensation on cold surfaces (i.e., windows, piping, exterior walls, roof, or floors) by adding insulation.
  9. In areas where there is a perpetual moisture problem, do not install carpeting (i.e., by drinking fountains, by classroom sinks, or on concrete floors with leaks or frequent condensation).
  10. Molds can be found almost anywhere; they can grow on virtually any substance, providing moisture is present. There are molds that can grow on wood, paper, carpet, and foods.

For more information regarding mold and what you can do to help prevent mold-problems in your home or office, call Environmental Analytics at 520.290.6653.

1-Referenced from: http://www.websters-online-dictionary.org/definition/fungus

2-Referenced from: “Bioaerosols: Assessment and Control.” ACGIH, Kemper Woods Center. 1999.

BACTERIA – Overview – Bacteria is abundant in air, water, and soil: in and on animals; on plant surfaces; and on man-made surfaces both indoors and outdoors. Bacteria may become airborne from any of these natural reservoirs1.

Bacteria were the only form of life on earth for 2 billion years. They were first observed by Antony van Leeuwenhoek in the 17th cent.; bacteriology as an applied science began to develop in the late 19th cent. as a result of research in medicine and in fermentation processes, especially by Louis Pasteur and Robert Koch 2.

Bacteria are remarkably adaptable to diverse environmental conditions: they are found in the bodies of all living organisms and on all parts of the earth-in land terrains and ocean depths, in arctic ice and glaciers, in hot springs, and even in the stratosphere. Our understanding of bacteria and their metabolic processes has been expanded by the discovery of species that can live only deep below the earth’s surface and by species that thrive without sunlight in the high temperature and pressure near hydrothermal vents on the ocean floor. There are more bacteria, as separate individuals, than any other type of organism; there can be as many as 2.5 billion bacteria in one gram of fertile soil2.

Characteristics – Bacteria are grouped in a number of different ways. Most bacteria are of one of three typical shapes-rod-shaped (bacillus), round (coccus, e.g., streptococcus), and spiral (spirillum). An additional group, vibrios, appear as incomplete spirals. The cytoplasm and plasma membrane of most bacterial cells are surrounded by a cell wall; further classification of bacteria is based on cell wall characteristics .They can also be characterized by their patterns of growth, such as the chains formed by streptococci. Many bacteria, chiefly the bacillus and spirillum forms, are motile, swimming about by whiplike movements of flagella; other bacteria have rigid rodlike protuberances called pili that serve as tethers2.

Some bacteria (those known as aerobic forms) can function metabolically only in the presence of free or atmospheric oxygen; others (anaerobic bacteria) cannot grow in the presence of free oxygen but obtain oxygen from compounds. Facultative anaerobes can grow with or without free oxygen; obligate anaerobes are poisoned by oxygen2.

Nutrition – Most bacteria are heterotrophic, living off other organisms. Most of these are saprobes, bacteria that live off dead organic matter. The bacteria that cause disease are heterotrophic parasites. There are also many non-disease-causing bacterial parasites, many of which are helpful to their hosts. These include the “normal flora” of the human body.

Autotrophic bacteria manufacture their own food by the processes of photosynthesis and chemosynthesis (see autotroph). The photosynthetic bacteria include the green and purple bacteria and the cyanobacteria. Many of the thermophilic archaebacteria are chemosynthetic autotrophs2.

Beneficial Bacteria – Harmless and beneficial bacteria far outnumber harmful varieties. Because they are capable of producing so many enzymes necessary for the building up and breaking down of organic compounds, bacteria are employed extensively by humans-for soil enrichment with leguminous crops for preservation by pickling, for fermentation (as in the manufacture of alcoholic beverages, vinegar, and certain cheeses), for decomposition of organic wastes (in septic tanks, in some sewage disposal plants, and in agriculture for soil enrichment) and toxic wastes, and for curing tobacco, retting flax, and many other specialized processes. Bacteria frequently make good objects for genetic study: large populations grown in a short period of time facilitate detection of mutations, or rare variations 2.

Pathogenic Bacteria – Bacterial parasites that cause disease are called pathogens. Among bacterial plant diseases are leaf spot, fire blight, and wilts; animal diseases caused by bacteria include tuberculosis, cholera, syphilis, typhoid fever, and tetanus. Some bacteria attack the tissues directly; others produce poisonous substances called toxins. Natural defense against harmful bacteria is provided by antibodies. Certain bacterial diseases, e.g., tetanus, can be prevented by injection of antitoxin or of serum containing antibodies against specific bacterial antigens; immunity to some can be induced by vaccination; and certain specific bacterial parasites are killed by antibiotics.

New strains of more virulent bacterial pathogens, many of them resistant to antibiotics, have emerged in recent years. Many believe this to be due to the overuse of antibiotics, both in prescriptions for minor, self-limiting ailments and as growth enhancers in livestock; such overuse increases the likelihood of bacterial mutations. For example, a variant of the normally harmless Escherichia coli has caused serious illness and death in victims of food poisoning. See also drug resistance 2.

1-Referenced from: “Bioaerosols: Assessment and Control.” ACGIH, Kemper Woods Center. 1999.

2-Referenced from: “Bacteria.” Columbia Electronic Encyclopedia. Columbia University Press. 15 Sep. 2007. Reference.comhttp://www.reference.com/browse/columbia/bacteria.

The sun can kill germs

Effect of Natural Sunlight on Bacterial Activity and Differential …

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[PDF]Chapter 5. Treatment Efficiency……………….. – World Health Organization

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Mesolimbic pathway in the brain and drug addiction

Neurobiologic Processes in Drug Reward and Addiction – NCBI – NIH

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For the reward system which contains this pathway, see Reward system. The mesolimbic pathway can be seen here as the green projections from the VTA to the nucleus accumbens. The mesolimbicpathway, sometimes referred to as the reward pathway, is a dopaminergic … Addiction, schizophrenia, and depression all involve distinct structural …

Mesolimbic pathway – an overview | ScienceDirect Topics

Mesolimbic pathway – transports dopamine from the VTA to the nucleus accumbens, … that themesolimbic pathway is involved in conditions such as addiction and … A dopaminergic system deficit in MDD may be related to defective reward …

4: The reward pathway | National Institute on Drug Abuse (NIDA)

Understanding Drug Abuse and Addiction: What Science Says … important to understanding the effects of drugs on the brain is called the reward pathway.

Mesolimbic Dopamine System – Alcohol Rehab

https://alcoholrehab.com › Educate Yourself with Articles on Addiction

In addition to pleasure and reward, the mesolimbic dopamine system is associated … with themesolimbic pathway to produce addictive and rewarding effects.

2-Minute Neuroscience: Reward System – YouTube

Feb 13, 2015 – Uploaded by Neuroscientifically Challenged

In this video, I cover the reward system. … I discuss dopamine’s role in reward as well as the mesolimbic

Brain Reward Pathways – Neuroscience Department | Icahn School of …

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… Models of. Addiction & Depression · Molecular Mechanisms of Adaptation … The most importantreward pathway in brain is the mesolimbic dopamine system.

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Jan 16, 2015 – The term reward system refers to a group of structures that are activated by rewarding or reinforcing stimuli (e.g. addictive drugs). … The mesolimbic dopamine pathway is thought to play a primary role in the reward system.

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Jan 5, 2016 – Uploaded by khanacademymedicine

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Our bodies maintain a chemical balance

Our bodies maintain a chemical balance

By Connie Dello Buono

Each food, herb or medicine, sunshine, lack of sleep, stress, anxiety, and gene affect each of us differently. This is because our blood, tissues and organs have varying levels of life matters or chemistry. These life matters include skin, bones, chemistry, hormones, microbiota, fluids, fats, urines, toxins and other matters that make up our human body.

Fifteen years ago, when my father died of stage 4 lung cancer at age 64, I kept on searching the cure for cancer and the ingredients for longevity. His doctor said he had 3 months to live and we juiced green papaya and apples and he lived 6 more months. We also have my mom and sister massage his body and my brother carried him to his appointment to a spiritual healer to pray for him and burn incense. This happened in the Philippines. He only have 2 oxygen tanks beside him and has no pain killer. He said that the pain during the last month is like living in hell while still on earth. Did we make a mistake of not taking the path of chemo and surgery? Can we do more aside from what we know then?

After that event, I am a regular caregiver at bedside with senior clients who hired us as their caregivers during the last months of their lives. We massage them and I train other caregivers how to care for hospice clients with massage oil and other holistic means. When they expire, we cried, said our prayer and burned incense.  Many years have passed, and we are still connected to their love ones keeping them as friends and support system.

Someone emailed me about his quest for a cure for his brain cancer. And I said, I do not have an answer to details about the use of hydrogen peroxide and Vitamin C.  But, do start with probiotics, fresh carrot juice, fresh, garlic , anti parasite tinctures, detox metals with cilantro and other, greens, liquid melatonin and calcium with magnesium. Exercise, adequate sleep, whole foods. Without knowing his own body chemistry, I do not know what is missing in his body. I know that microbes from gut can travel to the brain that is why, I want to start with fighting them.

Another at QUORA, ask me this:  Is there more to heart disease management than taking medicine, eating healthy and exercising?

Avoid vigorous exercise, work to exhaustion, emotional stress, heat from too much exposure to sun’s radiation, standing all day with no hydration, pollution, not clean water and not eating whole foods. But most important is avoiding bacteria and virus from entering the body esp, mouth, teeth and other point of entry including the skin (largest organ in the body). Deep breathing, avoiding sugar and too much alcohol and infection. Do not over medicate, know drug interactions. Up Vitamin C intake, eating orange peels, parsley and onion-family (sulfur rich foods – colored ones). Take acidophilus and eat pickled veggies. Have good vowel and sunshine in the morn before 9am. Sleeping well and eating between 5am to 5pm. Drinking water when thirsty in the middle of the night. And a love one nearby to know of any ominous signs of heart issues.

We do not know our end, but we can fight the bugs that kills our cells if we know how to balance our chemistry.

Hope all is well.

Connie

Chlorophyll can help prevent cancer

Papaya for anti-cancer: How to eat papaya to fight cancer

How to Use Papaya Leaves for Cancer: A Homemade Treatment

Green papaya and leaves to fight cancer

PAPAYA
Also Known As:
Banane de Prairie, Caricae Papayae Folium, Chirbhita, Erandachirbhita, Erand Karkati, Green Papaya, Mamaerie, Melon Tree, Melonenbaumblaetter, Papaw,Papaya Fruit, Papayas, Papaye, Papaye Verte, Papayer, Papita, Paw Paw, Pawpaw.
CAUTION: See separate listings for Papain and American Pawpaw.
Scientific Name:
Carica papaya, synonyms Papaya carica, Carica peltata, Carica posoposa, Paw Paw,Pawpaw.
Family: Caricaceae.
People Use This For:
Orally, papaya is used orally for preventing and treating gastrointestinal tract disorders, intestinal parasite infections, dengue fever, and aging skin. Papaya is also used for preventing cancer, treating diabetes, and preventing persistent human papilloma virus (HPV). It is also used as a sedative and diuretic.
Topically, papaya is used for periodontitis, wound healing, neuralgia, and elephantoid growths.
Safety:
LIKELY SAFE …when used orally in amounts commonly found in foods. Papaya has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE …when used orally and appropriately in medicinal amounts (6).
POSSIBLY UNSAFE …when used orally in excessive amounts. Papaya latex contains papain, which can cause esophageal perforation (6, 93083). …when used topically. Papaya latex (raw papain) is a severe irritant and vesicant (6).
PREGNANCY: POSSIBLY UNSAFE …when used orally; avoid using. Crude papain shows evidence that it is teratogenic and embryotoxic (6); however, this might be due to extraneous substances rather than papain (11). Some evidence also shows that high doses of extract of papaya seeds has abortifacient activity and can adversely affect fetal development (67870); theoretically, eating large amounts of papaya seeds may have similar effects.
LACTATION: Insufficient reliable information available; avoid using.
Effectiveness:
INSUFFICIENT RELIABLE EVIDENCE to RATE

Cancer. Some population research has found that eating papaya fruit might prevent some types of cancer. In one population study, eating papaya fruit was associated with a 66% lower odds of developing gallbladder cancer (67871). In another population study, papaya fruit consumption was associated with a 42% lower odds of developing colorectal cancer (67941).
Diabetes. Preliminary clinical research suggests that consuming fermented papaya fruit 3 grams once daily for 2 months can reduce fasting and postprandial blood sugar levels by 13.3% and 10%, respectively, compared to baseline in patients with type 2 diabetes (67902).
Human papilloma virus (HPV). Some population research has found that people who eat papaya fruit at least once weekly have a 70% lower odds of persistent HPV infection compared to people who never eat papaya fruit (67881).
Periodontitis. Preliminary clinical research shows that applying fermented papaya gel 7 grams into intragingival pockets for 15 minutes daily for 10 days reduces bleeding after 7 days, plaque after 14 days, and gingivitis after 14 days compared to baseline in patients with moderate to severe periodontitis. Gingival pocket depth is reduced after 45 days (93090).
Wound healing. Preliminary clinical research shows that applying a wound dressing containing partially ripe papaya fruit 200 grams to the edges of gaped wound for 48 hours reduces the time needed for granulation tissue to develop by 3.7 days, reduces the duration of hospitalization by 6.3 days, and decreases the percentage of patients requiring post-surgical wound debridement by about 94% compared to treatment with hydrogen peroxide dressing in patients with postoperative wound gape (93091).
More evidence is needed to rate papaya for these uses.

Mechanism of Action:
The applicable part of papaya is the leaf. Papaya leaf contains 2% papain and carpain (6). Papain is a mixture of enzymes that degrade protein, carbohydrates, and fats (515). Papain is unstable in digestive juices, which raises questions about whether it can be effective when used orally (515). Carpain is thought to be amebicidal. It might cause bradycardia (4009) or have central nervous system depressant or paralytic effects.
Adverse Reactions:
Ingestion of large amounts of papain might cause esophageal perforation. Severe allergic reactions can occur in individuals sensitive to papain (6, 515). Papaya may cause hypersensitivity reactions, which occur more commonly in people who are allergic to latex (6197, 7853).
Interactions with Herbs & Supplements:
HERBS AND SUPPLEMENTS WITH HYPOGLYCEMIC POTENTIAL: Clinical research suggests that daily consumption of fermented papaya can decrease fasting and postprandial blood glucose levels (67902). Concomitant use with other herbs and supplements with hypoglycemic potential might increase the risk of blood glucose levels becoming too low. Some herbs and supplements with hypoglycemic potential include devil’s claw, fenugreek, guar gum, Panax ginseng, and Siberian ginseng.
PAPAIN: Concomitant use of papain and papaya can increase the effects and adverse effects of papain.
Interactions with Drugs:

AMIODARONE (Cordarone, Nexterone, Pacerone)

Interaction Rating = Moderate Be cautious with this combination.

Severity = Moderate • Occurrence = Probable • Level of Evidence = D

Animal research shows that concomitant administration of amiodarone 50 mg/kg body weight orally plus papaya extract 1230 mg/kg body weight orally delays the maximum plasma concentration of amiodarone from being achieved, but does not affect systemic exposure to amiodarone. Therefore, this interaction is probably not clinically significant. However, taking papaya extract 1230 mg/kg body weight orally for 14 days prior to taking a single dose of amiodarone 50 mg/kg body weight increases the extent of systemic amiodarone exposure by 60% to 70% (93093). Theoretically, repeated intake of papaya extract along with amiodarone may increase the effects and adverse effects of amiodarone.

ANTIDIABETES DRUGS

Interaction Rating = Moderate Be cautious with this combination.

Severity = Moderate • Occurrence = Probable • Level of Evidence = B

Clinical research shows that daily consumption of fermented papaya can decrease fasting and post-prandial blood glucose levels in type 2 diabetic patients using glybenclamide, necessitating a dose adjustment of glybenclamide in approximately 36% of the patients (67902). Monitor blood glucose levels in diabetic patients using fermented papaya, as dose adjustments of antidiabetes drugs may be needed. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

LEVOTHYROXINE (Synthroid, Levothroid, Levoxyl, and others)

Interaction Rating = Moderate Be cautious with this combination.

Severity = Moderate • Occurrence = Possible • Level of Evidence = D

A case of hypothyroidism has been reported for a 37 year-old man who was taking levothyroxine. The patient, who had undergone total thyroidectomy 5 years earlier, had been stably euthyroid with levothyroxine treatment. When questioned about possible changes to his diet, the patient reported eating five or six papaya fruits daily while on a recent vacation. Forty-five days after discontinuing papaya consumption, the patient’s serum thyrotropin levels returned to normal without adjusting levothyroxine dose (93087). Theoretically, concomitant use of papaya can interfere with levothyroxine or hypothyroid therapy.

WARFARIN (Coumadin)

Interaction Rating = Moderate Be cautious with this combination.

Severity = High • Occurrence = Possible • Level of Evidence = B

Concomitant use might potentiate the effects of warfarin increasing the international normalization ratio (INR) (613, 6048, 49621).

Interactions with Foods:
None known.
Interactions with Lab Tests:
INTERNATIONAL NORMALIZED RATIO (INR): Papain, which is in papaya leaf, can increase INR in people maintained on warfarin (Coumadin) (613).
Interactions with Diseases or Conditions:
DIABETES: Fermented papaya can reduce blood glucose and have additive effects with diabetes medications in patients with type 2 diabetes (67902). Advise patients to closely monitor glucose levels after starting papaya. Dose adjustments to diabetes medications may be necessary.
HYPOGLYCEMIA: In healthy adults, consuming fermented papaya for 2 months can decrease postprandial blood glucose levels and can cause hypoglycemia in some individuals (67902). Theoretically, fermented papaya might increase the risk of blood glucose levels becoming too low in individuals who are already hypoglycemic.
HYPOTHYROIDISM: Theoretically, eating large amounts of papaya fruit might exacerbate hypothyroidism or interfere with therapy (93087).
LATEX ALLERGY: People who are allergic to latex should avoid eating papaya or taking papaya-containing products because of the possibility of cross hypersensitivity between latex and papaya (6197, 7853, 23831, 23832, 57497).
PAPAIN ALLERGY: Papaya contains papain. Theoretically, papaya may cause allergic reactions in individuals who are allergic to papain. If you are allergic to papain, avoid eating papaya or taking products that contain papaya.
SURGERY: Fermented papaya can reduce blood glucose levels (67902). Theoretically, papaya might interfere with blood glucose control during and after surgical procedures. Tell patients to discontinue papaya at least 2 weeks before elective surgical procedures.
Dosage/Administration:
ORAL: People typically use papaya with enzyme chewable tablets which contain 250 mg of papaya powder, 150 mg of dried pineapple juice powder, and 10 mg of papain (5024). One tablet is chewed up to three times daily, preferably after a meal(5024).
TOPICAL: No typical dosage.
Editor’s Comments:
Fermenting papaya leaves may make more potent, richer brewed teas (515).

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