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Selenium Protects a Specific Type of Interneuron in the Brain

Selenium Protects a Specific Type of Interneuron in the Brain

Summary: A new study reveals selenium is essential for the postnatal development of a specific type of interneuron.

Source: Helmholtz.

Exactly 200 years ago, the Swedish scientist Jöns Jacob Berzelius discovered the trace element selenium, which he named after the goddess of the moon, Selene. Besides its industrial applications (chemical industry, production of semiconductors and toners), selenium is an essential trace element and indispensable for humans, many animals and some bacteria. A team led by Dr. Marcus Conrad, research group leader at the Institute of Developmental Genetics (IDG) at Helmholtz Zentrum München, showed for the first time why selenium is a limiting factor for mammals.

Scientific ‘by-catch’ solves decades-old mystery

The scientists have been investigating for years the processes of a novel type of cell death, known as ferroptosis. In this context, the enzyme GPX4, which normally contains selenium in the form of the amino acid selenocysteine, plays an important role.

In order to better understand the role of GPX4 in this death process, we established and studied mouse models in which the enzyme was modified,” said study leader Conrad. “In one of these models, we observed that mice with a replacement of selenium to sulfur in GPX4 did not survive for longer than three weeks due to neurological complications.”

In their search for the underlying reasons, the researchers identified a distinct subpopulation of specialized neurons in the brain, which were absent when selenium-containing GPX4 was lacking. “In further studies, we were able to show that these neurons were lost during postnatal development, when sulfur- instead of selenium-containing GPX4 was present,” stated first author of the study, Irina Ingold.

half moons

Furthermore, the scientists were able to show that ferroptosis is triggered by oxidative stress, which is known to occur for instance during high metabolic activity of cells and high neuronal activity. “Our study demonstrates for the first time that selenium is an essential factor for the postnatal development of a specific type of interneurons,” said Dr. José Pedro Friedmann Angeli, a scientist at the IDG, describing the results. “Selenium-containing GPX4 protects these specialized neurons from oxidative stress and from ferroptotic cell death.”

Thus, the study explains why certain selenoenzymes are essential in some organisms, including mammals, whereas they are dispensable in other organisms, such as fungi and higher plants. In future investigations, study leader Marcus Conrad and his team aim to investigate how ferroptosis is triggered in cells. As a long-term goal, he wants to elucidate the role of ferroptosis in various disease conditions in order to be able to alleviate diseases, such as cancer or neurodegeneration, which are currently difficult to tackle.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

GPX4 stands for the enzyme glutathione peroxidase 4, one of 25 selenoproteins in humans. In the enzyme, selenium is an integral part of the 21st amino acid selenocysteine. The enzyme plays a decisive role in ferroptosis. The word ferroptosis, which means a type of programmed cell death dependent on iron, is derived from the Greek ptosis: fall and Latin ferrum: iron. Ferroptosis has not yet been completely elucidated, but the importance of cellular suicide has already been impressively confirmed, for example, by apoptosis, which has been more extensively studied.

Source: Marcus Conrad – Helmholtz
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Ingold et al., Cell.
Original Research: Abstract for “Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis” by Irina Ingold, Carsten Berndt, Sabine Schmitt, Sebastian Doll, Gereon Poschmann, Katalin Buday, Antonella Roveri, Xiaoxiao Peng, Florencio Porto Freitas, Tobias Seibt, Lisa Mehr, Michaela Aichler, Axel Walch, Daniel Lamp, Martin Jastroch, Sayuri Miyamoto, Wolfgang Wurst, Fulvio Ursini, Elias S.J. Arnér, Noelia Fradejas-Villar, Ulrich Schweizer, Hans Zischka, José Pedro Friedmann Angeli, and Marcus Conrad in Cell. Published online December 28 2017 doi:10.1016/j.cell.2017.11.048

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Helmholtz “Selenium Protects a Specific Type of Interneurons in the Brain.” NeuroscienceNews. NeuroscienceNews, 29 December 2017.
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Abstract

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Highlights
•Selenium-containing GPX4 is necessary for full viability of mice
•The GPX4-Cys variant is highly susceptible to hydroperoxide-induced inactivation
•Hydroperoxide induces ferroptosis in Gpx4cys/cys cells
•GPX4-Cys bypasses the requirement of selenoproteins for cell viability

Summary
Selenoproteins are rare proteins among all kingdoms of life containing the 21st amino acid, selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of selenium for sulfur. Yet the actual advantage of selenolate- versus thiolate-based catalysis has remained enigmatic, as most of the known selenoproteins also exist as cysteine-containing homologs. Here, we demonstrate that selenolate-based catalysis of the essential mammalian selenoprotein GPX4 is unexpectedly dispensable for normal embryogenesis. Yet the survival of a specific type of interneurons emerges to exclusively depend on selenocysteine-containing GPX4, thereby preventing fatal epileptic seizures. Mechanistically, selenocysteine utilization by GPX4 confers exquisite resistance to irreversible overoxidation as cells expressing a cysteine variant are highly sensitive toward peroxide-induced ferroptosis. Remarkably, concomitant deletion of all selenoproteins in Gpx4cys/cys cells revealed that selenoproteins are dispensable for cell viability provided partial GPX4 activity is retained. Conclusively, 200 years after its discovery, a specific and indispensable role for selenium is provided.

“Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis” by Irina Ingold, Carsten Berndt, Sabine Schmitt, Sebastian Doll, Gereon Poschmann, Katalin Buday, Antonella Roveri, Xiaoxiao Peng, Florencio Porto Freitas, Tobias Seibt, Lisa Mehr, Michaela Aichler, Axel Walch, Daniel Lamp, Martin Jastroch, Sayuri Miyamoto, Wolfgang Wurst, Fulvio Ursini, Elias S.J. Arnér, Noelia Fradejas-Villar, Ulrich Schweizer, Hans Zischka, José Pedro Friedmann Angeli, and Marcus Conrad in Cell. Published online December 28 2017 doi:10.1016/j.cell.2017.11.048

Posted byconnie dello buonoJuly 18, 2018Posted inanti-agingTags:brain, seleniumLeave a comment on Selenium Protects a Specific Type of Interneuron in the Brain

Asparagus soup

CREAM OF ASPARAGUS SOUP

 

1 Freestyle Points 81 caloriesTOTAL TIME: 25 minutes

 

I LOVE cream of asparagus soup, it’s pure comfort in a bowl and so simple to make. This recipe is made with just 5 ingredients, not counting salt and pepper and is ready under 25 minutes!

Skinnytastes.com

My senior client loves it too and helps him with his lung cancer and constipation.

Connie of Motherhealth caregivers 408-854-1883

INGREDIENTS:

  • 2 lbs asparagus (2 bunches), tough ends snapped off
  • 1 tbsp unsalted butter
  • 1 medium onion, chopped
  • 6 cups reduced sodium chicken broth
  • 2 tbsp low fat sour cream
  • kosher salt and fresh pepper, to taste

DIRECTIONS:

  1. Melt butter over low heat in a large pot. Add onion and sauté until soft, about 2-minutes.
  2. Cut the asparagus in half and add to the pot along with chicken broth and black pepper, to taste. Bring to a boil, cover and cook low about 20 minutes or until asparagus is very tender.
  3. Remove from heat, add sour cream and using your hand held blender, puree until smooth (or in two batches in a large blender).

NUTRITION INFORMATION

Yield: 6 servings, Serving Size: 1 1/4 cups

  • Amount Per Serving:
  • Freestyle Points: 1
  • Points +: 2
  • Calories: 81 calories
  • Total Fat: 3g
  • Saturated Fat: 2g
  • Cholesterol: 7mg
  • Sodium: 576mg
  • Carbohydrates: 10g
  • Fiber: 4g
  • Sugar: 1g
  • Protein: 6g
All images and text ©Gina Homolka for Skinnytaste

Read more at https://www.skinnytaste.com/cream-of-asparagus-soup-2/#QvWG3MWxVODuSWyJ.99

Cream of asparagus soup

Cream of asparagus soup
Cream of broccoli soup
Carrot soup
Leek soup
Mixed Vegetable Soup
Lentil soup
Squash soup

Cream of Asparagus Soup (Crème d’asperges) recipe | Epicurious.com

Cream of asparagus soup from www.epicurious.com
https://www.epicurious.com/…/cream-of-asparagus-soup-creme-dasperges&#8230;

 Rating: 3.5/4 – ‎311 reviews – ‎1 hr 10 min – ‎310 cal

Preparation. Cut tips from 12 asparagus; 1 1/2 inches from top and halve tips lengthwise if thick. Reserve for garnish. Cut stalks and all remaining asparagus into …

Cream of Fresh Asparagus Soup II Recipe – Allrecipes.com

Cream of asparagus soup from www.allrecipes.com
https://www.allrecipes.com/recipe/…/cream-of-fresh-asparagus-soup-ii/

 Rating: 4.7 – ‎527 reviews – ‎40 min – ‎196 cal

Directions. In a large saucepan, combine asparagus, chopped onion, and 1/2 cup chicken broth. Cover, and bring to a boil over high heat. In the same saucepan, melt the butter over medium-low heat. Stir in the flour, salt, and pepper. Put the sour cream in a small bowl, and stir in a ladleful of the hot soup.

Cream of Asparagus Soup Recipe | Skinnytaste

Cream of asparagus soup from www.skinnytaste.com
https://www.skinnytaste.com/cream-of-asparagus-soup-2/

 Rating: 5 – ‎22 reviews – ‎25 min – ‎81 cal

Mar 7, 2018 – Melt butter over low heat in a large pot. Add onion and sauté until soft, about 2-minutes. Cut the asparagus in half and add to the pot along with chicken broth and black pepper, to taste. Bring to a boil, cover and cook low about 20 minutes or until asparagus is very tender.

You visited this page on 7/18/18.

Cream of Asparagus Soup – Martha Stewart

Cream of asparagus soup from www.marthastewart.com
https://www.marthastewart.com/1143354/cream-asparagus-soup

50 min

Directions. Bring 6 cups water to a boil in a medium saucepan; season with 2 teaspoons salt. Add asparagus tips and blanch until bright green and just tender, 2 to 3 minutes. In another saucepan, heat olive oil over medium. Add sliced shallot and chopped garlic and cook until softened but not browned, about 5 minutes.

Cream of Asparagus Soup Recipe | Sunny Anderson | Food Network

Cream of asparagus soup from www.foodnetwork.com
https://www.foodnetwork.com/…/cream-of-asparagus-soup-recipe-19486&#8230;

 Rating: 4.6 – ‎125 reviews – ‎50 min

Get Cream of Asparagus Soup Recipe from Food Network.

Easy Cream of Asparagus Soup Recipe – How to Make Asparagus Soup

Cream of asparagus soup from www.delish.com
https://www.delish.com/cooking/recipe…/cream-of-asparagus-soup-recipe/

30 min

Mar 12, 2018 – This delicious cream of asparagus soup from Delish.com couldn’t be easier.

Winning Cream of Asparagus Soup | Taste of Home

Cream of asparagus soup from www.tasteofhome.com
https://www.tasteofhome.com/recipes/winning-cream-of-asparagus-soup/

 Rating: 4.8 – ‎20 votes – ‎30 min – ‎232 cal

I developed this recipe myself by substituting asparagus for broccoli in cream of broccolisoup. It’s a big favorite at our house! —Westelle Griswa, Monroe …

Cream of Asparagus Soup with Parmesan and Garlic – Cook the Story

Cream of asparagus soup from cookthestory.com
https://cookthestory.com/cream-of-asparagus-soup-with-parmesan-and-ga&#8230;

15 min

Sep 29, 2017 – Learn how to create a flavorful Cream of Asparagus Soup with the addition of Parmesan Cheese and Garlic. Best part, it’s ready in 15 minutes.

Asparagus Soup with Lemon and Parmesan – Once Upon a Chef

Cream of asparagus soup from www.onceuponachef.com
https://www.onceuponachef.com/…/asparagus-soup-with-lemon-and-parm&#8230;

 Rating: 5 – ‎121 votes – ‎162 cal

This delicate and creamy asparagus soup tastes wonderfully luxurious, yet it’s made without heavy cream — just vegetables, broth and a hint of cheese puréed …

Creamy Asparagus Soup Recipe | SimplyRecipes.com

Cream of asparagus soup from www.simplyrecipes.com
https://www.simplyrecipes.com/recipes/creamy_asparagus_soup/

 Rating: 4.6 – ‎67 reviews – ‎45 min

Apr 14, 2018 – A fresh and easy asparagus soup in a base of stock, cream, and onion, seasoned with thyme and dry vermouth.

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% Daily Value*
Total Fat 20 g 30%
Saturated fat 8 g 40%
Polyunsaturated fat 5 g
Monounsaturated fat 5 g
Cholesterol 54 mg 18%
Sodium 2,528 mg 105%
Potassium 873 mg 24%
Total Carbohydrate 40 g 13%
Dietary fiber 1.8 g 7%
Protein 15 g 30%
Vitamin A 29% Vitamin C 16%
Calcium 42% Iron 11%
Vitamin B-6 10% Vitamin B-12 20%
Magnesium 12%
*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

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Posted byconnie dello buonoJuly 18, 2018Posted inFoodTags:asparagus, cleansing, contipation, detox, fiber, lungs, soup, sulfurLeave a comment on Asparagus soup

Stress, fungus and weak immune system are path to cancer – vinegar, lemon and whole foods can fight cancer

 

stress and cancer

The use of vinegar (this particularly apple cider vinegar), has been effective in the treatment and the remission of many of these types of fungus.

Based on the stage of the condition and the general immunity system of the individual, whether the individual has the recuperative powers to recover with the assistance of the vinegar, the body can heal aided with less stress, adequate sleep and optimum nutrition.

High doses of Vitamin C, the use of lemon and other anti-oxidants (from whole foods) are primary cancer fighters that we can use.

Vinegar provides great benefit in countering most fungus types. Most cancer is a psychological condition, caused by free radicals within the system that have an effect upon the metabolism, creating a dissolving of the immunity system to allow these fungi, and other destructive elements (air pollution, metal toxins,stress,lack of sleep,poor nutrition, sugar) to grow in a destructive manner within the tissue.

Eggplant and garlic are rich in sulfur and other nutrients that can fight cancer.

Coramsine – Wikipedia

https://en.wikipedia.org/wiki/Coramsine

  1. Coramsine (SBP002) was an experimental cancer drug that was evaluated in preliminary … company in Vanuatu and markets it worldwide via the internet under the name Curaderm BEC5, a cream ofsolasodine rhamnosyl glycosides (BEC).

(PDF) Topical Solasodine Rhamnosyl Glycosides Derived From the …

https://www.researchgate.net/…/268285627_Topical_Solasodine_Rhamnosyl_Glycoside&#8230;

PDF | Solasodine rhamnosyl glycosides (BEC) are a new class of antineoplastics that show superior … and Cisplatin-Resistant Human Lung Cancer Cells,” Bio-.

ChamDrug therapy: Solamargine and other solasodine rhamnosyl …

https://www.researchgate.net/…/276045696_ChamDrug_therapy_Solamargine_and_oth&#8230;

rhamnosyl glycosides as anticancer agents … Solasodine rhamnosyl glycosides are secondary me- ….. the promise that BEC may be potent antineoplastic bio-.

[PDF]Topical Solasodine Rhamnosyl Glycosides Derived From the Eggplant …

https://www.scirp.org/journal/PaperDownload.aspx?paperID=7563

by BE Cham – ‎2011 – ‎Cited by 17 – ‎Related articles

Jul 20, 2011 – Solasodine rhamnosyl glycosides (BEC) are a new class of antineoplastics that ….. and Cisplatin-Resistant Human Lung Cancer Cells,” Bio-.

[PDF]CuradermBEC5 for Skin Cancers, Is It? An Overview – Semantic Scholar

https://pdfs.semanticscholar.org/a099/bc16ba613a5ce998132802f4be9d831cf6ac.pdf

by TR Chase – ‎2011 – ‎Cited by 9 – ‎Related articles

Keywords: Nonmelanoma Skin Cancers, Solasodine Rhamnosyl Glycosides, Curaderm, Solamargine, Solasonine. 1. …. BEC is a mixture of solasodine glycosides consisting of …… asodine Rhamnosyl Glycosides,” Research Journal Bio-.

Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do …

https://www.ncbi.nlm.nih.gov/pubmed/22399274
by BE Cham – ‎2012 – ‎Cited by 20 – ‎Related articles

Jan 13, 2012 – Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do they also prime the immune system resulting in long-term protection …

Missing: wiki ‎| ‎Must include: ‎wiki

Drug Therapy: Solamargine And Other Solasodine Rhamnosyl …

https://www.omicsonline.org/…/drug-therapy-solamargine-and-other-solasodine-rham&#8230;

In this presentation, the development of promising novel cytotoxic solasodine rhamnosyl glycosides will be addressed that offer not only gains in specificity and …

Missing: wiki ‎| ‎Must include: ‎wiki

[PDF]Intralesion and Curaderm BEC5 Topical Combination Therapies of …

http://www.curadermbec5.com/…/Intralesion-and-Curaderm-BEC5-Topical-Combination-T&#8230;

by BE Cham – ‎2012 – ‎Cited by 13 – ‎Related articles

Therapies of Solasodine Rhamnosyl Glycosides Derived from the … Solasodine rhamnosyl glycosides(SRGs) are chemotherapeutic agents for the treatment of cancer. SRGs in a ….. and Cisplatin-Resistant Human Lung Cancer Cells,” Bio-.

History of Curaderm BEC5 | Bionational Pharmaceuticals

http://www.bionational.com/History-of-Curaderm.html

These glycoside compounds were named BEC. … “Solasodine rhamnosyl glycosides specifically Bind cancer cell receptors and induce apoptosis and necrosis.

Dr. Oz revisited – Science-Based Medicine

https://sciencebasedmedicine.org/dr-oz-revisited/

Feb 27, 2012 – … present evidence that an eggplant extract can cure cancer, while a search of “solasodine glycosides” and “skin cancer” revealed only three.

Missing: wiki ‎| ‎Must include: ‎wiki

 

Posted byconnie dello buonoJuly 18, 2018Posted inanti-agingTags:apple cider vinegar, cancerLeave a comment on Stress, fungus and weak immune system are path to cancer – vinegar, lemon and whole foods can fight cancer

La Bella Condos in Tagaytay Philippines – own one – contact Madeline Sophie

made 0made 1

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Connect with Madeline at Facebook Messenger , Sophie Benedicto

or Email Connie at motherhealth@gmail.com

Earn monthly income by listing your condo at http://www.airbnb.com . Average rent from $50 and up per night.

La-Bella-Tagaytay condo for sale in the Philippines

Posted byconnie dello buonoJuly 17, 2018July 17, 2018Posted inhousingTags:condominium, Philippines, TagaytayLeave a comment on La Bella Condos in Tagaytay Philippines – own one – contact Madeline Sophie

Donald Trump is NOT to be trusted when meeting with Russia

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Chuck Schumer

Senator Chuck Schumer: 

“President Trump should not meet with President Putin alone.” 

Donald Trump is NOT to be trusted when meeting with Russia, especially Vladimir Putin. Do you agree with Chuck Schumer? 

I AGREE: NO MEETING WITH PUTIN


Senator Chuck Schumer knows that Donald Trump can’t be trusted with Russia and Vladimir Putin.

The president needs to remember that, as Commander-in-Chief, his duty is to protect the American people from foreign threats, not to sell out our democracy to Putin.
Paul Manafort - Trump's Campaign Manage IN JAIL National Security Advisor Michael Flynn LIED to the FBI Donald Trump being EXPOSED by Robert Mueller daily
If you agree that Trump can't be trusted to meet with Putin, sign your name:

Connie, Donald Trump is selling out our allies — like Germany and Canada.

All while praising and bowing down to Vladimir Putin at every turn.

We must be LOUD in opposition like Senator Schumer to stop Trump from meeting with Putin while alienating our allies.

CLICK HERE IF YOU AGREE >>

https://go.boldpac.com/Agree-With-Schumer

This is about our National Security, Connie. Nothing’s more important.

–BOLD Democrats

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Posted byconnie dello buonoJuly 13, 2018Posted inPoliticsLeave a comment on Donald Trump is NOT to be trusted when meeting with Russia

Kidney health factors by Dr Mercola

How to Prevent and Treat Kidney Problems With Food

  • Satisfying Southwestern Stuffed Sweet Potato Recipe
Satisfying Southwestern Stuffed Sweet Potato Recipe
Boost Your Lung Health and Other Surprising Benefits of Eating More Fiber
Boost Your Lung Health and Other Surprising Benefits of Eating More Fiber
Urine Color

Story at-a-glance

  • Poor kidney function is associated with diabetes, hypertension, and heart disease. Common signs of kidney problems include frequent urination, problems urinating, and constant thirst
  • Good kidney function is essential for maintaining homeostasis in your body, including your pH level and electrolyte balance; your kidneys also produce hormones that make red blood cells and regulate blood pressure
  • Most Americans consume three to five times more protein than they need, and two to four times more fructose than is safe. These two dietary factors places significant stress on your kidneys, promoting kidney disease and stones

By Dr. Mercola

Your kidneys — two bean-shaped organs — are located just below your rib cage one on either side of your spine. Positioned on top of each kidney are your adrenal glands. Each day, your kidneys filter up to 150 quarts of blood and flush out waste products through your urine.

One of the reasons why you need to drink enough water is to ensure healthy kidney function. In fact, chronic low-grade dehydration is one of the most common causes of kidney stones.

Poor kidney function is also associated with a number of other serious health problems, including diabetes, hypertension, and heart disease. Common signs of kidney problems include:

  • Frequent urination
  • Problems urinating
  • Pain or burning sensation during urination
  • Constant thirst

Good kidney function1 is essential for maintaining homeostasis in your body, starting with the composition of your blood. For example, your kidneys are responsible for maintaining proper pH level and electrolyte balance (the ratios of sodium, potassium and phosphates).

They also produce hormones that make red blood cells, and those that help regulate your blood pressure.

Dietary Factors That Threaten Kidney Health

Waste products removed by your kidneys and eliminated through your urine include urea and uric acid, produced from the breakdown of proteins and nucleic acids respectively.

Excessive protein intake increases urea, while uric acid is a byproduct of both protein and fructose metabolism. Fructose typically increases uric acid within minutes of ingestion.

I became fully aware of the dramatic and devastating impact fructose has on your uric acid levels when I interviewed Dr. Richard Johnson on this topic.

Most Americans consume three to five times more protein than they need, and two to four times (or more) fructose than is considered safe. These two dietary factors, alone and especially in combination, places significant stress on your kidneys and promote kidney disease and kidney stones.

Kidney stones are particularly linked to a diet high in processed fructose and other sugars, as sugar upsets the mineral relationships in your body by interfering with calcium and magnesium absorption. The phosphorus acid in soda also acidifies your urine, which promotes stone formation.

Analgesic drugs are also known to damage your kidneys when taken in excess, and/or over long periods of time. This includes aspirin, anti-inflammatory drugs (NSAIDs), ibuprofen, naproxen, and acetaminophen — especially when taken in combination with alcohol, even if the amount of alcohol is small.

Research2,3 shows that combining alcohol with acetaminophen raises your risk of kidney damage by 123 percent, compared to taking either of them individually. Long term alcohol consumption and smoking also take their toll on kidney function.

3 Dietary Keys to Protect Kidney Function

To protect your kidney function, keep the following three basic factors in mind:

•Restrict protein to just what your body needs. An ideal protein intake is likely around one-half gram of protein per pound of lean body mass, which for most is 40 to 70 grams a day.

The American Kidney Fund recommends restricting protein to a maximum of 50 grams if you have kidney disease4

•Restrict fructose to 25 grams per day (about 6 teaspoons), or less (especially if you’re insulin/leptin resistant)

•Drink pure, clean water. Simply swapping out sweetened beverages like sodas and fruit juices for pure water can go a long way toward improving your kidney function and overall health.

The best way to gauge your water needs is to observe the color of your urine (it should be light pale yellow) and the frequency of your bathroom visits (ideally, this is around seven to eight times per day).

How to Calculate Your Protein Requirement

Considering the fact that the majority of Americans are overweight or obese, I recommend calculating your individual protein requirement based on lean bodyweight (your total weight minus your fat) only.

For optimal health, I believe most adults need about 1 gram of protein per kilogram of lean body mass (not total body weight), or 0.5 gram of protein per pound of lean body mass.

In this formula, you must first determine your lean body mass. To do that, subtract your percent body fat from 100. For example, if you have 30 percent body fat, then you have 70 percent lean body mass.

Then multiply that percentage (in this case, 0.7) by your current weight to get your lean body mass in pounds or kilos. As an example, if you weigh 170 pounds; 0.7 multiplied by 170 equals 119 pounds of lean body mass.

Using the “0.5 gram of protein” rule, you would need 59.5 or just under 60 grams of protein per day.

100 – % of body fat = % of lean mass X actual weight X 0.5 gm protein = total grams of protein recommended

Example: A 170 lb individual with 30% fat mass

100% total weight – 30% fat mass = 70 % lean mass

0.70 X 170 = 119 X 0.5 = 60 grams of protein recommended

Translating Ideal Protein Requirements Into Foods

To determine whether you’re getting too much protein, simply calculate your lean body mass as described above, then write down everything you’re eating for a few days, and calculate the amount of daily protein from all sources.

Again, you’re aiming for one-half gram of protein per pound of lean body mass, which would place most people in the range of 40 to 70 grams of protein per day. If you’re currently averaging a lot more than that, adjust downward accordingly.

The chart below can give you a general idea of the protein content of many foods. I personally use Cronometer.com to enter everything I eat and carefully calculate my protein requirement to the gram.

Just be sure to enter the correct foods and amounts into the program, as the results will be inaccurate if you don’t enter the correct details.

Red meat, pork, and poultry average 6 to 9 grams of protein per ounce.

An ideal amount for most people would be a 3-ounce serving of meat (not 9 or 12 ounce steaks!), which will provide about 18 to 27 grams of protein

Eggs contain about 6 to 8 grams of protein per egg.

So an omelet made from two eggs would give you about 12 to 16 grams of protein.

If you add cheese, you need to calculate that protein in as well (check the label of your cheese)

Seeds and nuts contain on average 4 to 8 grams of protein per quarter cup Cooked beans average about 7 to 8 grams per half cup
Cooked grains average about 5 to 7 grams per cup Most vegetables contain about 1 to 2 grams of protein per ounce

Interestingly, while fish is typically considered a good source of protein, most fish contain only HALF of the protein found in beef and chicken. The reduced protein content in fish may actually be one reason why the Mediterranean diet is linked to life extension and reduced risk for chronic disease.5 In essence, those who eat more fish than red meat are automatically getting far less protein.

Other Dietary Dos and Don’ts If You Have Kidney Disease and/or Stones

If you have kidney disease, you also need to reduce consumption of foods rich in phosphorous, as they may promote the formation of kidney stones. On the other hand, if you have problems urinating but don’t yet have kidney disease, try adding more potassium-rich foods (primarily vegetables and seeds) to your diet. Depending on the type of kidney stone you have, you may also need to modify your diet in other ways:

•Struvite stones: Found more often in women, these are almost always the result of urinary tract infections

•Cystine stones: Represent a very small percentage of kidney stones. These are the result of a hereditary disorder that causes your kidneys to excrete massive amounts of certain amino acids (cystinuria)

•Uric acid stones: These are a byproduct of protein and fructose metabolism, and are commonly seen with gout. Cutting your protein and fructose consumption is essential for preventing and treating these types of stones. Taking potassium citrate (which lowers urine acidity and reduces urine excretion of calcium) may also help prevent uric acid stones6

•Calcium oxalate stones:7 These are the most common. About 80 percent of kidney stones are calcium based, and about 80 percent of those are calcium oxalate stones. Typically, they are the result of insufficient water intake and dietary factors, including excessive oxalate, protein, and processed salt consumption

Oxalate is found in some fruits and vegetables, but your liver produces most of your oxalate. If you are found to have oxalate stones, your physician may recommend avoiding oxalate-rich foods. Also, make sure you’re getting enough magnesium, as magnesium helps prevent calcium from combining with oxalate to form stones8

If you have calcium oxalate stones, rather than reducing your calcium intake you’ll want to minimize the amount of oxalates in your body. Soy and beer are two primary culprits that should be avoided. For reasons that are unclear, grapefruit juice has been shown to increase the risk of kidney stones9 and is therefore best avoided. Other foods that contain high levels of oxalate10 that you’ll want toavoid if you have calcium oxalate kidney stones include:

Spinach Rhubarb Chocolate
Parsley Beetroot Most legumes,11 including green beans
Wheat and other grain-based flours12 Pepper Nuts13

Potassium and Kidney Health

Potassium is a nutrient that receives a great deal of attention when you have kidney disease. On the one hand, potassium (a mineral and electrolyte) is essential for your cells, tissues, and organs to function properly. It plays a vital role in heart health, digestive, and muscular function, bone health, and more.

While potassium is found in many foods commonly consumed in the U.S. — including fruits, vegetables, dairy products, salmon, sardines, and nuts — only 2 percent of U.S. adults get the recommended daily amount of 4,700 milligrams (mg).

This can be problematic because potassium needs to be kept in proper balance with sodium in your blood. If you consume too much sodium, which is common if you eat many processed foods, you’ll have an increased need for potassium. Others who are at particular risk of low potassium (hypokalemia) are those with chronic malabsorption syndromes, such as Crohn’s disease, or those taking heart medicine (particularly loop diuretics).

However, anyone who eats a poor diet — an excess of processed foods and not enough fresh, whole foods — is potentially at risk of inadequate potassium levels.

All of that said, if you have severe kidney impairment, you typically need to restrict your intake of high-potassium foods.14 Why? Because your kidneys are responsible for maintaining the proper amount of potassium in your body, and when they’re not working well, your levels could become excessively elevated.

Potassium helps maintain a regular heart rhythm and plays a role in muscle function, and when your potassium level gets too high, it can lead to irregular heartbeat and/or a heart attack.

Recommended Potassium Intake Varies Depending on the Health of Your Kidneys

If your kidneys are working well, the recommended amount of potassium is about 4,700 mg per day,15 which also needs to be balanced with sodium. As a general rule, your potassium to sodium ratio should be around 5:1. The easiest way to achieve this ratio is to eat REAL food (lots of fresh vegetables), ideally organically and locally grown to ensure optimal nutrient content.

This type of whole food diet will naturally provide much larger amounts of potassium in relation to sodium, whereas a processed food diet is virtually guaranteed to provide you with an upside-down ratio. Juicing your vegetables is a good way to ensure you’re getting enough potassium.

If you have kidney disease, you need to pay careful attention to your potassium level and dietary intake. Most who are being treated for kidney disease will monitor their potassium level by measuring it monthly, and potassium- restricted diets typically recommend keeping potassium intake to about 2,000 mg per day.

Kidney-Friendly Superfoods

Besides monitoring your protein and sugar/fructose intake and drinking plenty of water, adding the following foods to your diet can also help promote optimal kidney function.16,17,18,19,20

Red bell peppers: low in potassium, rich in vitamins A, B6, C, folic acid and fiber Cherries: rich in antioxidants and phytochemicals
Cabbage: low in potassium, rich in vitamins C and K, and fiber, and phytochemicals that protect against free radical damage Red and purple grapes: rich in antioxidants; the skin is particularly rich in resveratrol
Cauliflower: high in vitamin C, folate and fiber Watermelon: rich in water, with diuretic properties, allowing you to produce more urine to flush out toxins
Garlic: antioxidant, anti-inflammatory, and anti-clotting properties Lemon juice: helps reduce kidney stone formation
Onion: low in potassium, rich in antioxidants, particularly quercetin, which has natural antihistamine properties Pumpkin seeds: rich in antioxidants, vitamins and minerals, especially magnesium, which helps reduce the risk of kidney stones
Apples: high in fiber, antioxidants, and anti- inflammatory compounds. Raw organic apple cider vinegar is helpful for the prevention of kidney stones Kale: lower in potassium, good source of vitamins A and C, rich in iron — the latter of which is important for kidney health. Many with kidney disease are also iron deficient21
Berries,22 including blueberries, raspberries, and strawberries Sweet potatoes: rich in beta-carotene, vitamins A and C, and fiber, and a good source of B6 and potassium

Herbal Kidney Cleansers

A number of herbs also have kidney-cleansing properties, including the following:

Ginger: purifies the blood and kidneys of toxins Red clover: diuretic that stimulates waste removal from the kidneys
Turmeric: has antiseptic and anti-inflammatory properties that help prevent and treat kidney infections and inflammation Chanca Piedra: Used in South America to break up kidney stones (its Spanish name actually means “stone breaker”)
Dandelion: a natural diuretic that helps strengthen the kidneys and soothe urinary tract problems Hydrangea root: Native American remedy for kidney stones
Nettle: natural diuretic that helps purify blood and treat urinary tract infections; also high in iron, making it beneficial for building blood Uva ursi root: helps treat urinary and bladder problems
Marshmallow root: natural diuretic that helps treat urinary tract infections, kidney stones, and bladder infections Gravel root (Joe-Pye weed): Indian remedy for urinary tract and kidney health
Juniper: improves kidney function and helps treat urinary tract infections and kidney and/or bladder stones.

Avoid juniper berry if you have a kidney infection and/or are pregnant. Also don’t take continuously for more than four weeks

Goldenrod root: Native American remedy traditionally used to support urinary tract and kidney health
Yarrow root: a natural diuretic with antiseptic and anti-inflammatory properties; helpful for urinary tract infections
Posted byconnie dello buonoJuly 13, 2018Posted inanti-agingTags:kidneysLeave a comment on Kidney health factors by Dr Mercola

Washington Post evening edition

Mueller probe indicts 12 Russians for hacking Democrats in 2016
The suspects “covertly monitored the computers, implanted hundreds of files containing malicious computer code, and stole emails and other documents,” Deputy Attorney General Rod Rosenstein said as he detailed the charges against Russian intelligence officers.
By Devlin Barrett and Matt Zapotosky  •  Read more »
Spotlight intensifies on Roger Stone after latest charges in Russia inquiry
The longtime Trump adviser has acknowledged exchanging Twitter direct messages in 2016 with Guccifer 2.0, who claimed to be a Romanian hacker. Stone has said there is no proof the account was connected to the Russians.
By Rosalind S. Helderman and Manuel Roig-Franzia  •  Read more »
The Fix: Indictment lands days before Trump is to meet with Putin
The development in the Russia investigation — coming days before a planned summit with Vladimir Putin — could force President Trump’s hand on something he has seemed loath to do: Confront the Russian leader about election meddling.
By Amber Phillips  •  Read more »
Trump’s tough words for Merkel and May raise questions about his relationships with female leaders
President Trump’s attacks on the British prime minister and German chancellor prompted diplomats to ask why a president who prizes his “great chemistry” with world leaders seems to go out of his way to damage two powerful female allies.
By Greg Jaffe, Mary Jordan and Josh Dawsey  •  Read more »
Trump walks back critical interview, says May is ‘doing a terrific job’
President Trump, in a news conference with British Prime Minister Theresa May, tried to ease tensions after the publication of an interview in which he questioned May’s handling of Brexit, praised one of her political foes and threatened to upend the trade relationship between their countries.
By Seung Min Kim, Josh Dawsey and William Booth  •  Read more »
‘In all reality, there were three shooters’: When ‘good guys with guns’ foil an active shooter
Bryan Whittle, left, and Juan Carlos Nazario have been hailed as heroes for confronting an attacker in Oklahoma City over Memorial Day weekend. But the incident was complex, and the two men know it could have ended in so many different ways.
By Frances Stead Sellers and Mark Berman  •  Read more »
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Perspective
How to keep going after a mass shooter kills your husband
Reporter John McNamara went into the Capital Gazette in Annapolis on a Thursday. The rest has been a daze for his widow.
By Andrea Chamblee  •  Read more »
White House declares War on Poverty ‘largely over’ amid push to revamp social programs
The administration argues that there are few truly poor Americans and that people on government aid should be pushed toward private employment. Poverty experts say President Trump’s team understates the scope of economic hardship.
By Jeff Stein and Tracy Jan  •  Read more »
At Wimbledon, Anderson outlasts Isner in second-longest Grand Slam match ever
Kevin Anderson won, 7-6, 6-7, 6-7, 6-4, 26-24, in a semifinal that lasted 6 hours 35 minutes, denying John Isner the chance to become the first American man to reach a Grand Slam final since 2009.
By Liz Clarke  •  Read more »
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Inside the risky effort to save the soccer team trapped in a Thai cave
As the world watched, expert divers executed a desperate plan they assumed would mean the death of some of the 12 young players, who were stuck in the cave along with a coach. Instead it ended in triumph.
By Shibani Mahtani, Steve Hendrix and Timothy McLaughlin  •  Read more »
Boil-water zone reduced in Northeast and Northwest Washington
Initially, about 34,000 residences and businesses were affected. The lingering impact as of lunchtime was mainly in Brookland, Mount Pleasant, Columbia Heights, Foxhall and parts of Georgetown.
By Dana Hedgpeth  •  Read more »
Rare rhinos were moved to help their species. But things went horribly wrong.
Eight black rhinos were taken last month to a sanctuary in a Kenyan national park, where officials said they might have been poisoned by the saltier water in their new home.
By Karin Brulliard  •  Read more »
Pioneering film ‘Akira’ resonates 30 years after its debut
With intricate, futuristic cityscapes and an evocative tale of telepathic power that influenced a generation of works to come, Katsuhiro Otomo’s cyberpunk movie served as an entry point into Japanese animation for many Westerners.
By Hau Chu  •  Read more 
Posted byconnie dello buonoJuly 13, 2018Posted inPoliticsLeave a comment on Washington Post evening edition

Washington Post 7-13-2018

 

Tom Toles
The cave rescue of the kids is anything but a model
  • By Tom Toles
Ann Telnaes
Cartoons: Trump’s Russia connections, illustrated
  • By Ann Telnaes
Columns

I quarantined myself to watch the World Cup. Seriously.

Time to reenter the real world, but Qatar 2022 isn’t far off.

  • David Hirshey
  • ·
  • 30 minutes ago

Republicans are sabotaging D.C.’s self-rule. Send them packing.

District residents should mobilize to fight anti-home-rule riders in the 2019 D.C. appropriations bill.

  • Colbert I. King

Conservation isn’t winning. Extinction is.

For many species, we’re already past the point of no return.

It’s clear why Republicans interrogated Peter Strzok

But by all means let’s hear more about the affair.

Better relations with Russia are a worthy goal. But at what price?

Trump seems unaware that he may be seen as rewarding Vladimir Putin for bad behavior.

  • David Ignatius

Ronald’s out. Donald’s in.

At home and abroad, Trumpism is replacing Reaganism.

China will learn its lesson — just not the one Trump wants

China can fight back in the trade war even without tariffs.

Europe needs to start planning for a future with no U.S.

If Trump isn’t bluffing on NATO, it’s time for Europe to consider alternatives.

Trump and Putin may be about to make a terrible deal on Syria

A bad deal would worsen conditions for the Syrian people, the region and America’s security.

The social media mob is a danger to society

In our thin-skinned culture, no utterance goes unchallenged.

The Trump administration kidnapped children. Someone should go to jail.

The policy means some of these kids will never again see their parents.

Trump is a bully. Brett Kavanaugh will stand up to him.

The president’s Supreme Court nominee is fair-minded and unfailingly decent.

A timely reminder that Putin is no friend of ours

The country — and all its leaders — must recognize that the Russian government meddled in the nation’s democratic process and plans to do so again.

Migrant families’ nightmare is far from over

The government missed a deadline to reunite small children with their parents. Now comes a much tougher deadline.

The Strzok hearing damaged our democracy

Peter Strzok’s testimony also pokes huge holes in the idea that he and others worked to upend the president’s election campaign.

PostEverything
Can truth survive this president? An honest investigation.
Five books grapple with the era of ‘alternative facts.’
  • By Carlos Lozada

My tweet story went viral. It began when I met a stranger on a railway platform.

“Are you all right?” I asked the old woman. What happens when family, community and government fail you.

Trump thinks NATO is just about Russia. It’s about Germany, too

The alliance was meant to contain a powerful, destructive force. The president risks unleashing it.

As Trump taunts allies, a French village remembers a downed GI and his rescuers

A tail gunner was the sole survivor of the crash of his Flying Fortress during World War II. On the 75th anniversary, the families gather to honor his comrades and their own.

How to keep going after a mass shooter kills your husband

John went into the Capital Gazette on a Thursday. The rest is a daze.

Mueller could subpoena Trump. But it’s not worth the chaos that would follow.

Past presidents avoided constitutional battles to protect the rule of law. Would Trump?

I saw NATO’s flaws up close in combat. Trump’s bullying can’t fix them.

NATO needs to change, but disparaging our allies won’t do it.

Trump says there’s a crisis at NATO. He’s right. And the crisis is him.

Another meeting with allies, another emergency caused by the U.S. president’s behavior.

Plastic straw bans are the latest policy to forget the disability community

Laws, rules and regulations developed without input from people with disabilities often end up penalizing us.

Contrary to popular wisdom, automation is not a job killer in U.S. manufacturing

Many economists argue that automation is the reason for job losses in manufacturing. Here’s why they’re wrong.

Books on the Russia scandal focus on the news. What they need is more history.
Businessman standing on a pile of books
It’s impossible to understand Russia’s motivations and tactics without looking backward.
  • By Carlos Lozada

Five myths about the Supreme Court

No, the justices don’t always have the final word.

Trump thinks NATO is just about Russia. It’s about Germany, too

The alliance was meant to contain a powerful, destructive force. The president risks unleashing it.

How to keep going after a mass shooter kills your husband

John went into the Capital Gazette on a Thursday. The rest is a daze.

Mueller could subpoena Trump. But it’s not worth the chaos that would follow.

Past presidents avoided constitutional battles to protect the rule of law. Would Trump?

The new face of medical advice: the online pregnancy forum

Expecting moms are turning to the Internet for issues they can’t or won’t discuss with their doctors.

What it’s like to be trapped in a cave

The experience can be harrowing, even when you know what you’re doing

Five myths about the Beatles

Why did producer George Martin actually take on the band? As punishment.

I’m a boomer who didn’t get Marvel films. Now I rock a ‘Black Panther’ backpack.

My millennial students are on to something.

Richmond is gagging progressive local governments

Virginia Republicans don’t believe government should be closest to the people.

Loving the lotus along the Anacostia

An annual festival at Kenilworth reminds me of my great hypothetical failure.

Stop killing the Potomac’s snakehead

This fish is not going to ruin the ecosystem.

Give online sales tax revenue back to Marylanders

A recent Supreme Court ruling doesn’t address an inherent unfairness.

The Capital Gazette is the Annapolis community

It’s the area’s paper of record. That’s why the attack last month feels so personal.

Posted byconnie dello buonoJuly 13, 2018Posted inPoliticsLeave a comment on Washington Post 7-13-2018

New York Times 7-13-2018

  1. CREDITT.J. KIRKPATRICK FOR THE NEW YORK TIMES

    The Real F.B.I. Election Culprit

    Hint: It’s not Peter Strzok.

    32m agoBy GARRETT M. GRAFF

  2. Photo
    CREDITT.J. KIRKPATRICK FOR THE NEW YORK TIMES

    What Friday’s Indictments Mean

    The allegations of subverting American democracy are troubling in themselves. They also spell trouble for the president.

    19m agoBy NORMAN L. EISEN and NOAH BOOKBINDER

  3. Photo
    CREDITDOUG MILLS/THE NEW YORK TIMES

    ‘Evil Has Won’

    Pro-American Germans feel betrayed.

    5h agoBy MICHELLE GOLDBERG

  4. Photo
    CREDITT.J. KIRKPATRICK FOR THE NEW YORK TIMES

    Does Brett Kavanaugh Spell the End of Voting Rights?

    If he is confirmed for the Supreme Court, we will see the most extreme court on civil rights since the era of Jim Crow.

    5h agoBy ARI BERMAN

  1. Photo

    Boris Johnson, Donald Trump and the Rise of Radical Incompetence

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    The Quiet Death of Racial Progress

  3. OP-ED COLUMNIST

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    For Trump, Failure Is the Only Option

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    Susan Rice: Trump Must Not Capitulate to Putin

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    Trump Got From NATO Everything Obama Ever Asked For

Editorials

More in Editorials »

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    Ocasio-Cortez Isn’t Spelled C-r-o-w-l-e-y

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    Is the G.O.P. Following Jim Jordan Over a Cliff?

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    Someone Should Tell Donald Trump About America’s High Tariffs

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    You’re Welcome, Trump Tells His Base

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    There’s So Much You Don’t Know About Brett Kavanaugh

Op-Ed Columnists

More in Op-Ed Columnists »

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    Brexit Is the New Obamacare

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    Football Isn’t Coming Home After All

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    It Just Got Harder to Fire Mueller

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    Just Confirm Kavanaugh

  5. Photo

    We May Be Able to Get Kevin Cooper Off Death Row

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Posted byconnie dello buonoJuly 13, 2018Posted inanti-aging, PoliticsLeave a comment on New York Times 7-13-2018

Red Hot Congressional Strzok Fest 2018

Posted byconnie dello buonoJuly 13, 2018Posted inanti-agingLeave a comment on Red Hot Congressional Strzok Fest 2018

Former FBI official on GOP’s sham hearing: Only person enjoying this ‘travesty’ is Putin 

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  • Want to beat some Republicans? You don’t need to wait til November. Chip in $3 to Democrat Danny O’Connor in this summer’s OH-12 special election!
  • Despite apparent financial struggles, Michael Cohen bought a $6.7 million condo from Trump pals
  • Mitch McConnell colluding to destroy democracy one nomination at a time
  • Former FBI official on GOP’s sham hearing: Only person enjoying this ‘travesty’ is Putin
  • ‘By decree,’ Sessions and Nielsen could send thousands of asylum seekers back to their deaths
  • Sign this petition: Investigate police involved killings and harassment of African Americans now!
  • Asylum Seekers can enter without legal documentation
  • Army veteran and his wife, happily married, considering divorce to afford daughter’s healthcare
  • Black unemployment rates in Kansas City show Trump should really stop bragging about what he’s done
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Posted byconnie dello buonoJuly 13, 2018Posted inanti-aging, PoliticsLeave a comment on Former FBI official on GOP’s sham hearing: Only person enjoying this ‘travesty’ is Putin 

Vitamin C inhibits synthesis of a molecule essential for bacteria survival

Vitamin C inhibits the synthesis of a molecule essential for bacteria survival

That vitamin C, an anti-oxidant agent, boosts and strengthens immunity is well known. Its ability to speed-up recovery from tuberculosis and impede the TB causing bacteria from causing disease, and even kill the bacteria in culture at high concentration are also known. Now, a study by a team of researchers at the Indian Institute of Science (IISc), Bengaluru has found the molecular mechanism by which vitamin C impedes and even kills Mycobacterium smegmatis, a non-pathogenic bacterium that belongs to the same genus as the TB-causing mycobacteria. The results were published in the journal FEMS Microbiology Letters.

Stress response

During times of stress or hostile conditions, such as increased temperature and presence of antibiotics, bacteria tend to come together and form a biofilm to protect themselves. The stress response pathway is crucial for bacteria to survive during hostile conditions. So blocking this pathway is a sure way of killing the bacteria.

In mycobacterium, the (p)ppGpp (Guanosine pentaphospahte or Guanosine tetraphosphate) is a key molecule in the stress response pathway. The (p)ppGpp is synthesised by Rel protein, which in turn is made by the Rel gene.

The team led by Dipankar Chatterji from the Molecular Biophysics Unit at IISc looked at the effects of vitamin C on the stress response pathway. “We chose vitamin C because its structure is similar to (p)ppGpp,” says Prof. Chatterji. “So we hypothesised that vitamin C should be competing to bind to the Rel enzyme and inhibiting (p)ppGpp synthesis.”

To test their hypothesis, the researchers conducted experiments using M. smegmatis. M. smegmatis is used as a model organism for TB-causing Mycobacterium tuberculosis.

Role of vitamin C

In vitro studies showed “significant” inhibition of (p)ppGpp synthesis in the presence of vitamin C. The inhibition level was seen to increase as the vitamin C concentration increased. The more the vitamin C concentration, the greater the possibility of vitamin C binding to the Rel enzyme, thus inhibiting (p)ppGpp synthesis. At about 10 mM concentration, the synthesis of (p)ppGpp molecule was completely inhibited.

The binding of vitamin C to the Rel enzyme is weak and this explains why high concentration of vitamin C is needed to inhibit (p)ppGpp synthesis.

“Using Mycobacterial cells we found that 1 mM of vitamin C produced 50% inhibition in (p)ppGpp synthesis. Vitamin C is able to get inside cells and inhibit (p)ppGpp synthesis,” says Kirtimaan Syal from IISc, the first author of the paper.

When 2 mM of vitamin C was added, “significant” defect in biofilm formation was seen. There was more than 50% reduction in viability of cells in a matter of four days when M. smegmatis was treated with 2mM of vitamin C. The viability of cells reduced even further with time, raising the possibility of therapeutic implications.


In the early literature, vitamin C deficiency was associated with pneumonia. After its identification, a number of studies investigated the effects of vitamin C on diverse infections. A total of 148 animal studies indicated that vitamin C may alleviate or prevent infections caused by bacteria, viruses, and protozoa. The most extensively studied human infection is the common cold. Vitamin C administration does not decrease the average incidence of colds in the general population, yet it halved the number of colds in physically active people. Regularly administered vitamin C has shortened the duration of colds, indicating a biological effect. However, the role of vitamin C in common cold treatment is unclear. Two controlled trials found a statistically significant dose–response, for the duration of common cold symptoms, with up to 6–8 g/day of vitamin C. Thus, the negative findings of some therapeutic common cold studies might be explained by the low doses of 3–4 g/day of vitamin C. Three controlled trials found that vitamin C prevented pneumonia. Two controlled trials found a treatment benefit of vitamin C for pneumonia patients. One controlled trial reported treatment benefits for tetanus patients. The effects of vitamin C against infections should be investigated further.

Vitamin C Has Effects on the Immune System

Vitamin C levels in white blood cells are tens of times higher than in plasma, which may indicate functional roles of the vitamin in these immune system cells. Vitamin C has been shown to affect the functions of phagocytes, production of interferon, replication of viruses, and maturation of T-lymphocytes, etc. in laboratory studies [1,23,42,43,44]. Some of the effects of vitamin C on the immune system may be non-specific and in some cases other antioxidants had similar effects.

The Diverse Biochemical, Physiological, and Psychological Effects of Vitamin C

Biochemistry textbooks usually mention the role of vitamin C in collagen hydroxylation. However, the survival time of vitamin C deficient guinea pigs was extended by carnitine [45] and by glutathione [46], which indicates that scurvy is not solely explained by defects in collagen hydroxylation, and it is not clear whether hydroxylation is important at all in explaining scurvy [6]. Vitamin C participates in the enzymatic synthesis of dopamine, carnitine, a number of neuroendocrine peptides, etc. [6,47,48,49,50]. Vitamin C is also a powerful antioxidant, as mentioned above.

Experimentally induced vitamin C deficiency leads to depression and fatigue [11,51]. Recently, vitamin C was reported to improve the mood of acutely hospitalized patients [52,53]. Such effects cannot be explained by collagen metabolism, and vitamin C effects on the immune system are not plausible explanations either. Instead, the effects of vitamin C on the neuroendocrine system or carnitine metabolism might explain such effects. Thus, if vitamin C has beneficial effects on patients with infections, that does not unambiguously indicate that these effects are mediated by the immune system per se.

The Effects of Antioxidants against Infections May Be Heterogeneous

It is quite a common assumption that the effects of vitamins are uniform. Thus, if there is benefit, it is often assumed that the same benefit applies to all people. However, it seems much more likely that the effects of vitamins, including vitamin C, vary between people depending on biology and their lifestyle. Thus, it is possible that there are benefits (or harms) restricted to special conditions or to particular people. In the case of vitamin E, there is very strong evidence for the heterogeneity in its effects on pneumonia [54,55] and on the common cold [56]. Although the factors modifying the effects of vitamin E cannot be extrapolated to vitamin C, it seems probable that there is comparable heterogeneity in the effects of vitamin C.

Posted byconnie dello buonoJuly 12, 2018Posted inanti-agingTags:bacteria, cancer, kill, microbes, Vitamin CLeave a comment on Vitamin C inhibits synthesis of a molecule essential for bacteria survival

Motherhealth caregivers cook healthy dishes based on health issues of seniors

The key to health lies in what we prepare as dishes and stored in our kitchen. With caring hands from Motherhealth caregivers, bay area seniors get gourmet cooking and loving hands for massaging aching bodies that are bed-bound with illness.

Do sit upright when eating and have a good bed bath with massage after. These are some of the instructions from Motherhealth caregivers.

If you want gourmet cooking and massage, hire Motherhealth caregivers. 408-854-1883 for discount for 24-hour care.

Our case managers are monitoring and training each caregiver daily to match care needs of clients. We treat seniors like family.

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Posted byconnie dello buonoJuly 12, 2018Posted inanti-agingLeave a comment on Motherhealth caregivers cook healthy dishes based on health issues of seniors

Heal your cells with amino acids from protein-rich whole foods

The Real Deal on Amino Acids in a Plant-Based Diet

Luckily, all foods contain a little protein, and a large variety of plant-based foods provide many of the essential amino acids once believed to only exist within animal-based foods. Essential amino acids are amino acids that are the building blocks of protein that our body can’t produce by itself. In other words, if we don’t eat them, we won’t get enough of them. But steak, beef, chicken, eggs, pork, and milk are not the only sources of essential amino acids; plants have plenty of them our bodies can use the same way.

Out of the 22 amino acids that exist, nine are essential and 11 are non-essential. Below are a list of the nine essential amino acids and plant-based foods that are good sources of each. Some sources of amino acids, like chia and hemp seeds, also offer all essential amino acids, making them a complete protein, though remember that all plant-based foods can form complete proteins within the body once ingested.

Here’s what each essential amino acid does and where to find it:

1. Leucine

Leucine is one of the best essential amino acids for stimulating muscle strength and growth, and also referred to as a BCAA (brand-chain amino acid). Leucine helps regulate your blood sugar by moderating insulin into the body during and after exercise and can even help prevent and treat depression by the way it acts on neurotransmitters in the brain.

Good plant-based sources include: seaweed, pumpkin, peas and pea protein, whole grain rice, sesame seeds, watercress, turnip greens, soy, sunflower seeds, kidney beans, figs, avocados, raisins, dates, apples, blueberries, olives and even bananas. Don’t limit yourself to one food of these choices, and aim for a serving of either seaweed, leafy greens, hemp seeds, chia seeds, grains, legumes, seeds, or beans at each meal to be sure you get enough high-quality plant protein.

2. Isoleucine

Isoleucine is another BCAA similar to leucine, however with a few different responsibilities. It is an isolated form of leucine that specifically helps the body produce energy and hemoglobin. It’s also vital assisting in nitrogren growth within the muscle cells, especially in children.

Plant-based sources include: rye, soy, cashews, almonds, oats, lentils, beans, brown rice, cabbage, hemp seeds, chia seeds, spinach, pumpkin, pumpkin seeds, sunflower seeds, sesame seeds, cranberries, quinoa, blueberries, apples, and kiwis.

Chocolate Chip Hemp Protein BarsIsoleucine is another BCAA similar to leucine, however with a few different responsibilities. It is an isolated form of leucine that specifically helps the body produce energy and hemoglobin. It’s also vital assisting in nitrogren growth within the muscle cells, especially in children.Plant-based sources include: rye, soy, cashews, almonds, oats, lentils, beans, brown rice, cabbage, hemp seeds, chia seeds, spinach, pumpkin, pumpkin seeds, sunflower seeds, sesame seeds, cranberries, quinoa, blueberries, apples, and kiwis.

3. Lysine

Lysine is responsible for proper growth and in the production of carnitine (a nutrient responsible for converting fatty acids into fuel to lower cholesterol).  It also helps the body absorb calcium for even further bone strength and also aids in collagen production. It’s vital to get enough of this amino acid since deficiency can lead to nausea, depression, fatigue, muscle depletion and even osteoporosis. Good plant-based sources of lysine include: beans (the best), watercress, hemp seeds, chia seeds, spirulina, parsley, avocados, soy protein, almonds, cashews, and some legumes with lentils and chickpeas being two of the best.

4. Methionine

Methionine helps form cartilage in the body through the use of sulfur. Sulfur is a mineral essential to the production of bone cartilage and no other amino acids contain sulfur aside from methionine. People who don’t eat enough sulfur-containing foods to produce methionine in the body may suffer arthritis, damaged tissue, and poor healing. Methionine also aids in the production of muscle growth and formation of creatine, needed for optimal cellular energy.

Good plant-based sources of sulfur include: sunflower seed butter and sunflower seeds, hemp seeds, chia seeds, Brazil nuts, oats, seaweed, wheat, figs, whole grain rice, beans, legumes, onions, cacao, and raisins.

5. Phenylalanine

This amino acid comes in three forms: L-phenalynaline (a natural form found in protein) and D-phenalynaline (a form produced by a laboratory), and DL phenalynaline (a combination of both forms). Always eat food-based sources before choosing supplements or enriched food products with a lab-derived version of this amino acid. Phenylalanine is important in the body because it turns into tyrosine once ingested, which is another amino acid that’s needed to make proteins, brain chemicals, and thyroid hormones. Not obtaining enough of this amino acid can result in brain fog, lack of energy, depression, lack of appetite, or memory problems.Good sources include: spirulina and other seaweed, pumpkin, beans, rice, avocado, almonds, peanuts, quinoa, figs, raisins, leafy greens, most berries, olives, and seeds.

6. Threonine

Threonine supports a healthy immune system, heart, liver, and central nervous system health. It also helps maintain a balance of proteins within the body to assist in overall repair, energy, and growth. This amino acid also helps the body’s connective tissues and joints in good health by producing glycine and serine in the body, two essential amino acids needed for healthy bones, skin, hair, and nails. In the liver it helps with fatty acid digestion to prevent fatty acid build-up and liver failure.The highest sources of this amino acid are: watercress and spirulina (which even exceed meat), pumpkin, leafy greens, hemp seeds, chia seeds, soybeans, sesame seeds, sunflower seeds and sunflower butter, almonds, avocados, figs, raisins, quinoa, and wheat . Sprouted grains are also excellent sources of this amino acid as well.7.

Tryptophan

Known as the relaxing amino acid, tryptophan is vital to a healthy nervous system and brain health, along with sleep, muscle growth and repair, and overall neurotransmitter function. It’s one of the most prominent amino acids found in turkey, milk, and cheese that cause those foods to make you feel sleepy and relaxed. Tryptophan also converts to serotonin once in the brain, which creates a happy feeling tied to lower levels of stress and depression. It’s best not to consume milk and cheese sources (or turkey) for your tryptophan content whenever you get the chance. Animal foods promote inflammation and there are tons of plant-based sources you can choose instead.

Plant-based sources that include high amounts of tryptophan include: oats and oat bran, seaweed, hemp seeds, chia seeds, spinach, watercress, soybeans, pumpkin, sweet potatoes, parsley, beans, beats, asparagus, mushrooms, all lettuces, leafy greens, beans, avocado, figs, winter squash, celery, peppers, carrots, chickpeas, onions, apples, oranges, bananas, quinoa, lentils, and peas.

8. Valine

Valine is another BCAA needed for optimal muscle growth and repair. It’s also responsible for endurance and the overall maintenance of good muscle health.

High sources of valine include: beans, spinach, legumes, broccoli, sesame seeds, hemp seeds, chia seeds, soy, peanuts, whole grains, figs, avocado, apples, sprouted grains and seeds, blueberries, cranberries, oranges, and apricots.

9. Histidine

This amino acid helps transport neurotransmitters (chemical messengers) to the brain and also helps overall muscle health within each muscle cells. It even helps detoxify the body by producing red and white blood cells needed for overall health and immunity. Not obtaining enough histidine can result in arthritis, sexual disfunction, and even deafness. It can also make the body more susceptible to the AIDS virus.

Good plant-based sources of histidine include: rice, wheat, rye, seaweed, beans, legumes, cantaloupe, hemp seeds, chia seeds, buckwheat, potatoes, cauliflower and corn.

How Much Do You Need?

So how much protein do you need? Everyone is different depending on their training goals or overall lifestyle goals. If you’re eating a vegan diet, use this handy online calculator to see how much is enough and to find out the best sources and see the Vegetarian Resource Group for more information on protein in a vegan diet.

Overall, eating a wide variety of whole, plant-based foods will provide you with all the essential amino acids your body needs for optimal growth, repair, and health. Feel free to make your own vegan protein bars, and even skip those store bought protein powders by making your own at home. Getting protein in a vegan diet is versatile and easy, so take advantage of these foods however you can.

Posted byconnie dello buonoJuly 12, 2018Posted inanti-agingLeave a comment on Heal your cells with amino acids from protein-rich whole foods

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