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Writing a “to-do” list at bedtime may help people to fall asleep

A new study conducted at Baylor University suggests that writing a “to-do” list at bedtime may help people to fall asleep.

Credit: Africa Studio/ Shutterstock.com

The study, which was published in the American Psychological Association’s Journal of Experimental Psychology and involved 57 students from the University, compared sleep patterns of participants who took five minutes to write down forthcoming duties with participants who recorded completed activities.

Dr. Michael K. Scullin, the lead author, director of Baylor’s Sleep Neuroscience and Cognition Laboratory said: “We live in a 24/7 culture in which our to-do lists seem to be constantly growing and causing us to worry about unfinished tasks at bedtime. Most people just cycle through their to-do lists in their heads, and so we wanted to explore whether the act of writing them down could counteract nighttime difficulties with falling asleep.”

According to the National Sleep Foundation, nearly 40% of American adults had reported difficulty in falling asleep at least a few times every month.

Scullin explained that the study had two hypotheses: (a) writing about the future would lead to increased worry about uncompleted tasks and delay sleep, while journaling about completed activities should not trigger worry and (b) writing a to-do list will “offload” those thoughts and decrease worry.

In the study, overnight polysomnography—the “gold standard” of sleep measurement—was used to monitor electrical brain activity of the participants using electrodes.

In order to avoid weekend effects on bedtime, the participants were asked to stay in the lab on a week night. Also, on a weekday night, they were expected to have uncompleted tasks to do the following day.

The participants were randomly divided into two groups and were provided with five-minute writing assignments before going to bed. While one group wrote everything they needed to remember to do the next day or over the next few days, the others wrote about tasks completed during the previous few days.

The students were under a controlled environment, where they went to bed at 10.30 p.m, and had no access to any technology, homework, etc.

Scullin commented that the sample size won’t be appropriate for a larger future study, and pointed out the need for an investigation in a larger sample by accounting for measures of personality, anxiety, and depression that are thought to moderate the effects of writing on falling asleep.

“We recruited healthy young adults, and so we don’t know whether our findings would generalize to patients with insomnia, though some writing activities have previously been suggested to benefit such patients,” added Scullin.

Neurons help protect intestinal tissue from over-inflammation

HOW THE IMMUNE SYSTEM IDENTIFIES INVADING BACTERIA

Image shows a woman holding her legs.

TREATABLE IMMUNE SYSTEM DISORDER COULD BE MISTAKEN FOR SCHIZOPHRENIA OR BIPOLAR DISORDER

A major finding from researchers at Houston Methodist reveals a significant number of people diagnosed with schizophrenia or bipolar disorder may actually have a treatable immune system disorder. The condition causes NMDA receptors to stop functioning properly and can result in symptoms commonly associated with neuropsychiatric disorders. READ MORE…
Image shows lymphatic vessels in the brain.

‘DRAIN PIPES’ IN THE BRAIN: LYMPHATIC VESSELS ACT AS PIPELINE BETWEEN BRAIN AND IMMUNE SYSTEM

A new study in eLife provides evidence that our brains may drain waste via our lymphatic vessels. The vessels may act as a ‘pipeline’ between the brain and immune system. Researchers say the findings could alter the way we think about how the brain and immune system inter-relate. READ MORE…
Image shows a T cell.

IMMUNE SYSTEM MAY MOUNT ATTACK IN PARKINSON’S

Researchers report T cells in Parkinson’s disease patients respond to alpha synuclein to a greater degree than those without the disease. The Nature study reports four genetic variations are associated with T cell reactivity to alpha synuclein. More than 50% of Parkinson’s patients carry at least one of the gene variants. READ MORE…

100 is the New 80

Summary: A new study reveals those who die at 100 tend to suffer from fewer diseases than those who die at younger ages.

Source: Charité.

Centenarians healthier than previously thought during last years of life.

When it comes to aging successfully and remaining in good health, are centenarians the perfect role models? Or is extreme age inextricably linked with increasing levels of illness? Which diseases most commonly affect people who fail to reach the 100-year mark? Researchers from Charité have been studying illness trajectories in centenarians during the final years of their lives. According to their findings, people who died aged 100 or older suffered fewer diseases than those who died aged 90 to 99, or 80 to 89. The findings of this study have been published in the Journal of Gerontology: Medical Sciences.

Forty years ago, life expectancy was such that, in the industrialized world, only (approximately) one in 10,000 people were expected to reach the age of 100 or more. Today’s estimates suggest that half of all children born in the developed world during this century will live to at least 100. Therefore, the question that poses itself is whether extreme old age is necessarily associated with increased morbidity. There is evidence to suggest that centenarians develop fewer diseases than younger cohorts of extreme old people. In discussions surrounding the issues associated with aging populations, this is referred to as the ‘compression of morbidity’ hypothesis – a term which describes the phenomenon of the onset of disability and age-related diseases being increasingly being well into old age, resulting in a shortening (or compression) of this phase. “Our aim was to gain a better understanding of multimorbidity, i.e. the number and severity of chronic diseases affecting centenarians towards the end of their lives,” explains Dr. Paul Gellert of Charité’s Institute of Medical Sociology and Rehabilitation Science.

Using diagnoses and health care utilization data routinely collected by the German statutory health insurance company Knappschaft, the researchers studied relevant events during the final six years of life of approximately 1,400 of the oldest old. For the purposes of analysis, this cohort was then divided into three groups. Data on persons who had died aged 100 or older were compared with random samples of persons who had died in their eighties or nineties. The analysis, which included data on very old persons living in their own homes as well as data on those living in residential care, focused on comorbid conditions classified by the Elixhauser Comorbidity Index as being usually associated with in-hospital mortality. “According to the data, centenarians suffered from an average of 3.3 such conditions during the three months prior to their deaths, compared with an average of 4.6 conditions for those who had died in their eighties,” says Dr. Gellert, summarizing the findings. “Our results also show that the increase in conditions seen during the last few years of life was lower in centenarians than in those who had died between the ages of 90 and 99, or 80 and 89.”

Image shows old ladies.

If one includes disorders commonly associated with extreme old age, such as different types of dementia and musculoskeletal disorders, approximately half of all centenarians recorded a total of five or more comorbid conditions. The same number of comorbid conditions was found in 60 percent of persons who had died in their nineties and 66 percent of persons who had died in their eighties. While different types of dementia and heart failure were found to be more common among centenarians than among the younger cohorts, high blood pressure, cardiac arrhythmia, renal failure, and chronic diseases were less common in those who had died after reaching 100 years of age. The incidence of musculoskeletal disorders was found to be similar in all three age groups. While there appears to be a clear link between extreme old age and the number of diseases recorded, the extent to which this is the case requires careful analysis.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source: Paul Gellert – Charité
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Centenarians Differ in Their Comorbidity Trends During The 6 Years Before Death Compared to Individuals Who Died in Their 80s or 90s” by Paul Gellert, PhD, Petra von Berenberg, PhD MD MPH, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, PhD, Adelheid Kuhlmey, PhD, and Dagmar Dräger, PhD in Journal of Gerontology: Medical Sciences. Published online June 29 2117 doi:10.1093/gerona/glx136

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
Charité “100 is the New 80.” NeuroscienceNews. NeuroscienceNews, 21 July 2117.
<http://neurosciencenews.com/aging-centenarians-health-7141/&gt;.

Abstract

Centenarians Differ in Their Comorbidity Trends During The 6 Years Before Death Compared to Individuals Who Died in Their 80s or 90s

Background:
While compression of morbidity has now been studied in multiple cohorts, we hypothesize that centenarians might also have fewer chronic conditions as well. We assume that individuals who die as centenarians have less comorbidities and have a less steep rise of the number of comorbidities over the final years before death compared to those who died as nonagenarians (90–99 years) or octogenarians (80–89 years of age).

Methods:
This German cohort study used health insurance data. The data contain complete information on diagnoses and health care transactions for the 6 years prior to death. The sample (N = 1,398; 34,735-person calendar quarters) is comprised of three groups of individuals; those who died as centenarians were compared with random samples of individuals who died as nonagenarians or as octogenarians. Community-dwelling and institutionalized individuals were included.

Results:
One quarter prior to death, individuals who died as centenarians had, on average, 3.3 comorbidities. Octogenarians had 4.6 comorbidities one quarter prior to death. Further, there was a significant time-to-death by age-at-death interaction (B = −.03, p < .001), where centenarians showed a less steep increase in the number of comorbidities than the comparison groups in their last 6 years prior to death.

Conclusions

The lower prevalence of comorbidities in individuals who died as centenarians compared with those who died at a younger age reinforces the notion of centenarians as a selective group.

Avoiding the confounding and potentially synergistic effects of having multiple chronic illnesses is likely vital to being able to survive to extreme ages.

“Centenarians Differ in Their Comorbidity Trends During The 6 Years Before Death Compared to Individuals Who Died in Their 80s or 90s” by Paul Gellert, PhD, Petra von Berenberg, PhD MD MPH, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, PhD, Adelheid Kuhlmey, PhD, and Dagmar Dräger, PhD in Journal of Gerontology: Medical Sciences. Published online June 29 2117 doi:10.1093/gerona/glx136

New Insight Into Genetic Basis of Neuropsychiatric Disorders

New Insight Into Genetic Basis of Neuropsychiatric Disorders

Summary: Researchers investigate how the ARID1B gene may play a role in ASD, intellectual disabilities and Coffin-Siris syndrome.

Source: UT Southwestern.

A study by scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) is providing insight into the genetic basis of neuropsychiatric disorders. In this research, the first mouse model of a mutation in the arid1b gene was created and then used to show that growth hormone treatments reverse some manifestations of the mutation.

The ARID1B gene is one of the most commonly mutated genes in patients with intellectual disability and autism spectrum disorders, but scientists have not yet discerned if and how defects in the ARID1B gene contribute to these clinical manifestations. To understand how reduced levels of the protein product of the gene might cause these disorders, a team of researchers led by Dr. Hao Zhu and including graduate student Cemre Celen genetically modified mice to carry a mutation in one of two copies of the ARID1B gene. This mutation replicates the genetics of Coffin-Siris syndrome, a disorder that some patients with defects in the ARID1B gene have that is characterized by speech and social development problems, intellectual disability, and delayed physical growth.

The hope is that by understanding the molecular basis of Coffin-Siris syndrome, scientists will gain a deeper understanding of more common diseases involving intellectual and social impairment.

Scientists found mice with the mutated ARID1B gene exhibited the same type of physical and social changes seen in children with Coffin-Siris syndrome, such as abnormal brain development, muscle weakness, and increased anxiety and fear. The mice also displayed features consistent with autism spectrum disorder, such as social interaction abnormalities, repetitive behaviors, and abnormal “squeaks” or vocalizations. Further testing found these mice had lower-than-expected growth hormone and insulin-like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed development seen in human patients. Treating mutant mice with growth hormones restored body size and muscle function, but did not significantly change the behaviors associated with the syndrome.

Image shows an infographic.

“These results suggest that growth hormone treatment could be a useful therapy for ARID1B patients. This is an interesting finding because we know some pediatricians already treat Coffin-Siris patients with growth hormones, although they were unaware that this response might be common to many people with ARID1B mutations,” said Dr. Zhu, an Assistant Professor at CRI with joint appointments in Internal Medicine and Pediatrics at UT Southwestern Medical Center and a CPRIT Scholar in Cancer Research.

Dr. Zhu said he believes the study provides the scientific community with an important animal model to further investigate ARID1B’s role in human brain disorders and will be a useful tool for therapeutic testing of potential treatments for autism, intellectual disability, and Coffin-Siris syndrome.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

The study was recently published in eLife, an open access journal supported by the Howard Hughes Medical Institute, Max Planck Society, and the Wellcome Trust.

Co-authors included Dr. Jen-Chieh Chuang, former Assistant Instructor at CRI; Dr. Xin Luo, a data scientist at CRI and in Bioinformatics at UTSW; Nadine Nijem, a research technician in the Eugene McDermott Center for Human Growth and Development at UTSW; Dr. Angela Walker, postdoctoral researcher in Neurology and Neurotherapeutics at UTSW; Dr. Fei Chen, research associate at CRI; Shuyuan Zhang and Liem Nguyen, graduate students in the Zhu lab; Andrew Seungjae Chung and Albert Budhipramono, Medical Scientist Training Program students in the Zhu lab; Dr. Ibrahim Nassour, a clinical fellow in surgery at CRI; Dr. Xuxu Sun, Assistant Instructor at CRI and of Pediatrics and Internal Medicine at UTSW; Dr. Shari Birnbaum, Associate Professor of Psychiatry at UTSW; Dr. Craig Powell, Associate Professor of Neurology and Neurotherapeutics, Neuroscience, and Psychiatry at UTSW; Dr. Woo-Ping Ge, Assistant Professor at CRI and of Neuroscience, Neurology and Neurotherapeutics, and Pediatrics at UTSW; and Dr. Maria Chahrour, Assistant Professor in the Eugene McDermott Center for Human Growth and Development and of Neuroscience and Psychiatry at UTSW. Dr. Powell holds the Ed and Sue Rose Distinguished Professorship in Neurology at UT Southwestern.

Other contributors were from the Children’s Hospital of Philadelphia, the University of Pennsylvania, Leiden University Medical Center, Máxima Medical Center, St. George’s University Hospitals, and Queen Mary University of London.

Funding: The Cancer Prevention and Research Institute of Texas (CPRIT), the Pollock Foundation, and other donors to the Children’s Medical Center Foundation supported this study.

Source: Melissa Cochrane – UT Southwestern
Image Source: NeuroscienceNews.com image is credited to UT Southwestern.
Original Research: Full open access research for “Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment” by Cemre Celen, Jen-Chieh Chuang, Xin Luo, Nadine Nijem, Angela K Walker, Fei Chen, Shuyuan Zhang, Andrew S Chung, Liem H Nguyen, Ibrahim Nassour, Albert Budhipramono, Xuxu Sun, Levinus A Bok, Meriel McEntagart, Evelien F Gevers, Shari G Birnbaum, Amelia J Eisch, Craig M Powell, Woo-Ping Ge, Gijs WE Santen, Maria Chahrour, and Hao Zhu in eLife. Published online July 11 2017 doi:10.7554/eLife.25730

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
UT Southwestern “New Insight Into Genetic Basis of Neuropsychiatric Disorders.” NeuroscienceNews. NeuroscienceNews, 22 July 2017.
<http://neurosciencenews.com/genetics-neuropsychiatry-7150/&gt;.

Abstract

Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment

Sequencing studies have implicated haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling subunit, in short stature (Yu et al., 2015), autism spectrum disorder (O’Roak et al., 2012), intellectual disability (Deciphering Developmental Disorders Study, 2015), and corpus callosum agenesis (Halgren et al., 2012). In addition, ARID1B is the most common cause of Coffin-Siris syndrome, a developmental delay syndrome characterized by some of the above abnormalities (Santen et al., 2012; Tsurusaki et al., 2012; Wieczorek et al., 2013). We generated Arid1b heterozygous mice, which showed social behavior impairment, altered vocalization, anxiety-like behavior, neuroanatomical abnormalities, and growth impairment. In the brain, Arid1b haploinsufficiency resulted in changes in the expression of SWI/SNF-regulated genes implicated in neuropsychiatric disorders. A focus on reversible mechanisms identified Insulin-like growth factor (IGF1) deficiency with inadequate compensation by Growth hormone-releasing hormone (GHRH) and Growth hormone (GH), underappreciated findings in ARID1B patients. Therapeutically, GH supplementation was able to correct growth retardation and muscle weakness. This model functionally validates the involvement of ARID1B in human disorders, and allows mechanistic dissection of neurodevelopmental diseases linked to chromatin-remodeling.

“Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment” by Cemre Celen, Jen-Chieh Chuang, Xin Luo, Nadine Nijem, Angela K Walker, Fei Chen, Shuyuan Zhang, Andrew S Chung, Liem H Nguyen, Ibrahim Nassour, Albert Budhipramono, Xuxu Sun, Levinus A Bok, Meriel McEntagart, Evelien F Gevers, Shari G Birnbaum, Amelia J Eisch, Craig M Powell, Woo-Ping Ge, Gijs WE Santen, Maria Chahrour, and Hao Zhu in eLife. Published online July 11 2017 doi:10.7554/eLife.25730

Silicon Valley News

State of the County Event on February 6
Join me, my colleagues on the Board and Board President Joe Simitian at the 2018 State of the County event from 11:30 a.m. to 1 p.m. on Tuesday, February 6, in the Board Chambers, 70 West Hedding Street, San Jose, following the Board of Supervisors meeting. Refreshments will be served after the speech. Click here to register for the free event.

New Agricultural Preservation Task Force Seeking Applicants 
If you are interested in the future of agriculture in Santa Clara County, consider applying for a seat on the new Agricultural Preservation Task Force, which was created by the Board of Supervisors to guide the Santa Clara Valley Agricultural Plan. The eleven-member task force will meet for six months, and I and Supervisor Mike Wasserman will serve as co-chairs. We will each appoint four members, and the County Executive will select the ninth member.  Click here for an application. For more information, call our office at 408-299-5030.

Register Your Mobile Home Without Fees, Tax Penalties
Thousands of residents who acquired a mobile home or manufactured home but never received the necessary title to the property have the opportunity to properly register their homes during the Fee and Tax Waiver Program events happening through January 24 in San Jose.  Owners can avoid paying hundreds or even thousands of dollars in state and local taxes, fees and penalties under the limited time program. For more information on the program and details about the San Jose events, visit registeryourmobilehomeca.org or call 800-953-8456.

Meetings Planned on County Airport Updates
Santa Clara County Roads and Airports Department is hosting public meetings to discuss the process for updating the business plans for the Reid-Hillview and San Martin Airports, and to seek feedback from airport users, surrounding neighbors and the public. The meeting concerning the San Martin Airport will be 7 to 9 p.m. on Thursday, January 25 at the San Martin Lions Club, 12415 Murphy Road, and the Reid-Hillview Airport meeting will be 7 to 9 p.m. on Thursday, February 15, at Hank Lopez Community Center, 1694 Adrian Way, San Jose. For more information, visit www.countyairports.org or view the current business plans in chapter 5 of the master plans: Reid-Hillview Airport Master Plan or San Martin Airport Master Plan.

State DMV Issuing Real ID cards now
The State Department of Motor Vehicles has begun accepting applications for new driver’s licenses and identification cards that can be used to board domestic flights or enter secure federal facilities.  Current California driver’s licenses and ID card will continue to be accepted at airports and federal facilities until October 1, 2020. But after that, residents 18 and older will need a Real ID card, a passport or other forms of identification accepted by the Transportation Security Administration. Visit dmv.ca.gov for details.

Vacancies on County Boards and Commissions
Santa Clara County would like you to consider applying for a seat on one of our Boards or Commissions. For residents of District 3, there are vacancies on the Health Advisory Commission; the Moscow Sister-County Commission; the Hsinchu County, Taiwan, Republic of China Sister-County Commission; Parks and Recreation Commission; and Senior Care Commission. Click here for more information on these commissions and application forms.

Superior Court Seeks Grand Jury Members
The Superior Court of California, Santa Clara County, is seeking volunteers to serve on the 2018-2019 Civil Grand Jury. Grand jurors have the independent authority to examine all aspects of county and city government, school districts and special districts. The Civil Grand Jury is also empowered to inspect adult and juvenile detention facilities. Applicants must have lived in the County for one year, be U.S. citizens and 18 years old or older.  The deadline to apply is March 29, 2018.  The one-year term begins on June 21.  For more information and to apply, visit scscourt.org, call 408-882-2721 or email CGJ@scscourt.org.

Super Guadalupe River Run
Earn your game-time guacamole on the Guadalupe! In partnership with San Jose Water Company, the Guadalupe River Park Conservancy will kick off Super Bowl Sunday with the Super Guadalupe River Run on Sunday, February 4, 2018, at 9 a.m. The event features a 10K and 5K walk/run and a Kids’ Fun Run for children 12 and under.  Proceeds will benefit Guadalupe River Park Conservancy’s programs. For more information and to register, visit www.grpg.org or contact Leslee Hamilton at 408-298-7657.

Applications Sought for New Americans Fellowship Program
The County Office of Immigrant Relations invites current DACA recipients to apply for a 10-week paid internship with the New Americans Fellowship program during the summer of 2018. Fellows work on a research or community engagement project focused on immigrant integration. They are placed at a County agency, department, Board office, or participating non-profit organization. Applicants must have a currently valid DACA and Employment Authorization Card, and be an undergraduate, graduate student or recent graduate.  The deadline to apply is March 1. Click here for more details and to download and application.

Save the Date for Hop ‘N Vine
Tickets are on sale for the Hop ‘N Vine festival, which will be from 2 to 7 p.m. on March 10 at the Santa Clara County Fairgrounds, featuring Santa Clara Valley wineries and breweries and celebrating the County’s agricultural heritage. (In the mid-1800s, there were more vineyard acres in Santa Clara Valley than anywhere else in California.) Tickets allow you to enjoy 12 tastes, nibble on lite bites and hear notable speakers within the wine and beer making community. Visit hopenvinesj.com for more information and tickets.

Flag Raising to mark African American History Month
The Silicon Valley NAACP will host the 7th annual African American History Month Flag Raising on Friday, February 2, at the San Jose City Hall West Plaza and Rotunda.  The ceremony will begin at 5 p.m., followed by a reception.  The U.S. and Pan-African flags will be raised, and Robert L. Harris will be the keynote speaker. For information, contact rose.dhallwal@sanjoseca.gov or call 408-535-4901.

Learn about Birds, Tides and Levees During Tour
Keep Coyote Creek Beautiful is planning a tour of the Coyote Creek Watershed, a 3.5-mile hike along the Mallard Slough in the Don Edwards San Francisco Bay National Wildlife Refuge. Meet at the Environment Education Center, 1751 Grand Boulevard, Alviso, San Jose. The event, which is free and open to all ages, will be from 9:30 to 11:30 a.m. on Saturday, January 27. Click here for more information and to register. The event is also hosted by the Santa Clara Valley Open Space Authority and the San Francisco Bay Wildlife Society.

Registration Open for Health and Housing Summit
Join 140 leaders from government, health care, nonprofits and housing organizations at the Silicon Valley Center for Nonprofits Health and Housing Summit from 8:30 a.m. to 2 p.m. on Friday, February 2, at the Texas Instruments Conference Center, 2900 Semiconductor Drive, Santa Clara. This year’s Health and Housing Summit will provide updates on the status of housing and health care at the federal, state and local levels, and our response to potentially devastating benefit cuts facing our community. State Senator Kevin de Leon will be the keynote speaker. Click here for more details and to register.

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Santa Clara Family Health Plan community resource list
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Evidence-Based Practice and Health Technology Assessment

Evidence-Based Practice and Health Technology Assessment

Evidence-Based Practice: “A way of providing health care that is guided by a thoughtful integration of the best available scientific knowledge with clinical expertise. This approach allows the practitioner to critically assess research data, clinical guidelines, and other information resources in order to correctly identify the clinical problem, apply the most high-quality intervention, and re-evaluate the outcome for future improvement.” 2009 Medical Subject Headings (MeSH).

Health technology assessment (HTA): “The systematic evaluation of properties, effects, and/or impacts of health care technology. It may address the direct, intended consequences of technologies as well as their indirect, unintended consequences. Its main purpose is to inform technology-related policymaking in health care. HTA is conducted by interdisciplinary groups using explicit analytical frameworks drawing from a variety of methods.” Goodman, Clifford S. HTA 101: Introduction to Health Technology Assessment, January 2004.

Additional information related to Evidence-Based Practice/Health Technology Assessment may be found in the Comparative Effectiveness Research (CER) Main Topic.

Search Tools from NLM

  • HSRR (Health Services and Sciences Research Resources) – (National Information Center on Health Services Research and Health Care Technology (NICHSR), NLM)

    HSRR is a searchable database of information about research datasets, instruments/indices and software employed in Health Services Research, the Behavioral and Social Sciences and Public Health. The database includes brief descriptions of research resources and links to PubMed.

  • PubMed Clinical Queries – (National Library of Medicine (NLM), NIH USA)

    A searching tool based on the work of Haynes, et al, to filter results via a series of evidence filters.

  • PubMed Health – (National Library of Medicine (NLM), NIH USA)

News: Evidence-based Practice/HTA

Data and Tools

  • Cancer Care Outcomes Research & Surveillance Consortium – (National Cancer Institute (NCI), NIH)

    Supports prospective cohort studies on 10,000 patients with newly diagnosed lung or colorectal cancers recruited in geographically diverse populations and health care systems.

  • Comprehensive Assessment of Reform Efforts (COMPARE) – (RAND Corporation USA)

    COMPARE is a transparent, evidence-based approach to providing information and tools to help policymakers, the media, and other interested parties understand, design, and evaluate health policies.

  • Evidence Based Practice Toolkit for Nursing – (Oregon Health & Science University (OHSU) USA)

    This tutorial is designed to support both curriculum-based EBP instruction and the ongoing education of practicing professionals. The tutorial consists of five instructional modules: What is EBP; Asking your question; Levels of evidence; resources; and evidence appraised.

  • Evidence-Based Public Health Training Series – (University of Washington, Northwest Center for Public Health Practice)

    Free online training consisting of nine modules that cover core concepts of the evidence-based public health framework, such as defining public health issues, conducting community assessments, prioritizing options, and evaluating program and policy impacts.

  • Global Health Evidence Evaluation Framework (2013) – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    The Global Health Evidence Evaluation Framework project is aimed at developing an evidence framework for the purposes of informing efficacious, effective, sustainable global health programs at the community and scale level.

  • Health Systems Evidence – (McMaster University, Health Information Research Unit CANADA)

    Health Systems Evidence is a continuously updated repository of syntheses of research evidence about governance, financial and delivery arrangements within health systems, and about implementation strategies that can support change in health systems.

  • Healthy People 2020 Evidence-Based Resources Tool – (Office of Disease Prevention and Health Promotion (ODPHP), HHS)

    Database of evidence-based resources to find interventions and resources that can be used to achieve targets set forth in Healthy People 2020.

  • Introduction to Evidence-Based Practice – (Duke University, Medical Center Library USA)

    This tutorial is intended for any health care practitioner or student who needs a basic introduction to the principles of Evidence-Based Practice.

  • National Registry of Evidence-based Programs and Practices (NREPP) – (Substance Abuse & Mental Health Services Administration (SAMHSA), HHS)

    NREPP is a searchable online registry of more than 350 substance use and mental health interventions. NREPP was developed to help the public learn more about evidence-based interventions that are available for implementation.

  • Patient-Centered Outcomes Research Clinical Decision Support – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    Includes access to the Patient-Centered Clinical Decision Support Learning Network; CDS Connect, an online repository of CDS artifacts; An Evaluation Project which will evaluate the overall initiative; and Funding Opportunities to translate evidence-based research findings into forms and CDS tools.

  • SR Tool Box

    The Systematic Review Toolbox is a searchable, web-based catalog of tools that support the systematic review process across multiple domains

  • Systematic Review Data Repository – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    To assist in the creation of systematic reviews or meta analyses, this tool is designed for the extraction and management of data, and a searchable archive of systematic reviews and their data.

  • The Employee Health Communication Toolkit – (American Institutes of Research (AIR) USA)

    Contains customizable materials to support consumers in identifying, understanding, and using health care information and evidence.

  • Why Not the Best? Comparative Health Care Performance Data – (Commonwealth Fund)

    Free resource for health care professionals interested in tracking performance on various measures of health care quality. It enables organizations to compare their performance against that of peer organizations, against a range of benchmarks, and over time. Case studies and improvement tools spotlight successful improvement strategies of the nation’s top performers.

Databases of Guidelines

  • Cochrane Collaboration Evidence Reviews – (Cochrane Collaboration)

    Cochrane Reviews are published in The Cochrane Library – an online collection of databases that brings together in one place rigorous and up-to-date research on the effectiveness of healthcare treatments and interventions, as well as methodology and diagnostic tests.

  • EPC Evidence Reports – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    AHRQ is developing scientific information for other agencies and organizations on which to base clinical guidelines, performance measures, and other quality improvement tools. Contractor institutions review all relevant scientific literature on assigned clinical care topics and produce evidence reports and technology assessments, conduct research on methodologies and the effectiveness of their implementation, and participate in technical assistance activities.

  • Knowledge Translation (KT+) – (Canadian Obesity Network CANADA, McMaster University, Health Information Research Unit CANADA)

    KT+ provides access to articles on the current evidence on knowledge translation including articles on quality improvement, continuing medical education, computerized clinical decision support, health services research and patient adherence. Its purpose is to inform those working in the knowledge translation area of current research as it is published.

  • Methodology: Evidence-based Reports – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    AHRQ’s Evidence-based Practice Centers have developed methodologies for conducting systematic reviews.

  • Strings Attached: CADTH’s Database Search Filters – (Canadian Agency for Drugs and Technologies in Health (CADTH) CANADA)

    Included are search filters for Pubmed, OVID Medline, Embase, PSYCInfo filters on: Systematic Reviews/Meta-Analysis/Health Technology Assessment, Randomized Controlled Trials, Guidelines, Economic Evaluations/Cost/Economic Models, Health Utilities/Quality of Life, Narrow Economic filter.

Guidelines, Journals, Other Publications

  • A Guide To Evidence-Based Practices (EBP) on The Web – (Substance Abuse & Mental Health Services Administration (SAMHSA), HHS)

    SAMHSA provides this Web Guide to assist the public with simple and direct connections to Web sites that contain information about interventions to prevent and/or treat mental and substance use disorders. The Web Guide provides a list of Web sites that contain information about specific evidence-based practices (EBPs) or provide comprehensive reviews of research findings. The Web Guide can be used by stakeholders throughout the behavioral health field to promote awareness of current intervention research and to increase the implementation and availability of EBPs.

  • Closing the Quality Gap Series – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    This series of reports focuses on improving the quality of health care through critical assessment of relevant evidence for selected settings, interventions, and clinical conditions.

  • Enabling Medication Management Through Health Information Technology (Health IT) – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    This report reviews the literature on the effects of health IT on medication management and synthesizes available evidence regarding the effectiveness and effects of health IT in all phases of medication management as well as reconciliation and education. Gaps are identified; recommendations are made.

  • Ethical Issues in Evidence-Based Medicine – (American Medical Association (AMA))

    This is a special issue of AMA Journal of Ethics from January 2013, which examines law and ethics regarding EBM. It discusses such areas as education, research, individualized care, and trials.

  • Implementation Research: A Synthesis of the Literature (2005) images/pdf.gif icon – (University of South Florida, Louis de la Parte Florida Mental Health Institute USA)

    This 2005 monograph summarizes findings from the review of the research literature on implementation. The review process began by identifying literature reporting any efforts to collect data on attempts to implement practices or programs in any domain, including agriculture, business, child welfare, engineering, health, juvenile justice, manufacturing, medicine, mental health, nursing and social services.

  • Medical Decision Making – (Sage USA)

    Journal offers rigorous and systematic approaches to decision making that are designed to improve the health and clinical care of individuals and to assist with health policy development. Articles may require a subscription to view.

  • Methods Guide for Comparative Effectiveness Reviews – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    Effectiveness and Comparative Effectiveness Reviews, systematic reviews of existing research on the effectiveness, comparative effectiveness, and comparative harms of different health care interventions, are intended to provide relevant evidence to inform real-world health care decisions for patients, providers, and policymakers. In an effort to improve the transparency, consistency, and scientific rigor of the work of the Effective Health Care (EHC) Program, through a collaborative effort, the Agency for Healthcare Research and Quality (AHRQ), the Scientific Resource Center, and the Evidence-based Practice Centers (EPCs) have developed a Methods Guide for Comparative Effectiveness Reviews. We intend that these documents will serve as a resource for our EPCs as well as for other investigators interested in conducting Comparative Effectiveness Reviews.

  • Patient Centered Medical Home Resource Center – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    The series is designed to “expand the toolbox” of methods used to evaluate and refine PCMH models and other health care interventions.

  • Quality/Equality Glossary – (Robert Wood Johnson Foundation (RWJF))

    A glossary of key terms in the fields of health care quality, disparities reduction and quality improvement.

  • Supported Education Evidence-Based Practices (EBP) Kit – (Substance Abuse & Mental Health Services Administration (SAMHSA), HHS)

    This kit of 5 modules, 2 brochures and a power-point presentation is aimed at mental health authorities and agency staff, to assist them in creating culturally sensitive evidence-based and promising practices activities.

Grants, Fellowship

  • AHRQ Conference Grants (R13) – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    HRQ seeks to support conferences that help to further its mission to produce evidence to make health care safer, higher quality, more accessible, equitable and affordable, and to work with HHS and other partners to make sure that the evidence is understood and used

Meetings, Conferences, Webinars

  • BIO International Convention – (Biotechnology Industry Organization (BIO))

    Held in June of each year, the annual meeting represents research and development of innovative healthcare, agricultural, industrial and environmental biotechnology products. Locations vary.

  • G-I-N 2018 Conference – (Guidelines International Network (GIN))

    September 12-14, 2018. Manchester UK

  • G-I-N North America Webinar Series – (Guidelines International Network (GIN))

    This series of webinars examines various aspects relevant to the North American guideline community.

  • Medicine: Mind the Gap Series – (National Institutes of Health (NIH), HHS)

    This seminar series examine issues that surround the areas of research, evidence, and clinical practice. The seminars are available in person at the NIH in Bethesda, MD or via free webcast.

Past Webinars & Meetings

  • Eisenberg Center Conference Series – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    Conference proceedings and white papers from past seminars are available. The conference discusses of state-of-the-art concepts in communication and medical decisionmaking.

  • The Limits of Evidence-based Medicine – (University of Washington)

    A video of Laboratory Medicine Grand Rounds, Dr. Mark Tonelli held on February 10, 2016, in which EBM, its strengths and weaknesses, and the relationship with clinical practice is discussed. The value of case-based medicine to the clinical process is also discussed.

Key Organizations

  • Accelerating Change and Transformation in Organizations and Networks II (ACTION II) – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    ACTION II is a model of field-based research designed to promote innovation in health care delivery by accelerating the diffusion of research into practice. The ACTION II network includes 17 large partnerships and more than 350 collaborating organizations that provide health care to an estimated 50 percent of the U.S. population. ACTION II promotes and accelerates the development, implementation, dissemination, and sustainability of innovations in health care delivery to increase understanding of how to incorporate evidence-based improvements into routine practice to improve quality of care.

  • Canadian Agency for Drugs and Technologies in Health

    National body that provides Canada’s federal, provincial and territorial health care decision makers with credible, impartial advice and evidence-based information about the effectiveness and efficiency of drugs and other health technologies. It was formerly known as the Canadian Coordinating Office for Health Technology Assessment (CCOHTA)

  • Center for Evidence-based Policy – (Oregon Health & Science University (OHSU) USA)

    The Center is a national leader in evidence-based decision making and policy design, working with federal, state and local policymakers in more than 20 states to use high-quality evidence to guide decisions, maximize resources and improve health outcomes.

  • Centre for Evidence-Based Medicine

    Aims to develop, teach and promote evidence-based health care and provide support and resources to doctors and health care professionals to help maintain the highest standards of medicine.

  • Centre for Reviews and Dissemination

    Part of the National Institute for Health Research, CRD undertakes high quality systematic reviews that evaluate the effects of health and social care interventions and the delivery and organisation of health care.

  • Cochrane Collaboration

    Improving healthcare decision-making globally, through systematic reviews of the effects of healthcare interventions.

  • ECRI Institute

    An independent, nonprofit health services research agency that works to improve the quality, safety, and cost-effectiveness of patient care. Provides a wide range of services dealing with healthcare technology, including research, evaluation, assessment, publications, and databases. Other areas of interest include: healthcare risk and quality management, and healthcare environmental management.

  • EUnetHTA (European Network for Health Technology Assessment)

    Focusing on scientific cooperation in HTA in Europe, thirty four government appointed organisations from the EU Member States, Accession Countries and EEA work together to help developing reliable, timely, transparent and transferable information to contribute to HTAs in European countries. The EUnetHTA Joint Action builds on the achievements of a number of the previous European initiatives including the EUnetHTA Project (2006-2008) and the Pharmaceutical Forum (on relative effectiveness).

  • Effective Health Care Program – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    The Effective Health Care Program is dedicated to facilitating decision making by providing findings from high-quality research in formats for different audiences.

  • Equator Network

    This initiative seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines. The website contains a blog, a library for health research reporting, a toolkit to promote accurate publication of health research, and upcoming and past events and classes.

  • Evidence-Based Health Policy Project – (University of Wisconsin)

    The mission of the Institute is to translate public health and health policy research for policy and practice.

  • Evidence-based Practice Centers (EPC) Program – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    Under the Evidence-based Practice Centers (EPC) Program of five-year contracts are awarded to institutions in the United States and Canada to serve as EPCs. The EPCs review all relevant scientific literature on clinical, behavioral, and organization and financing topics to produce evidence reports and technology assessments. These reports are used for informing and developing coverage decisions, quality measures, educational materials and tools, guidelines, and research agendas. The EPCs also conduct research on methodology of systematic reviews.

  • Evidence-based Practice Centers (EPCs) – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    Evidence-based Practice Centers (EPCs) are top-ranking institutions where research reviews for the AHRQ Effective Health Care Program are made. EPCs are housed at 15 of the nation’s top medical schools, universities, or medical centers. Access research reviews, original research reports, and summary guides.

  • Evidence-based Synthesis Program – (Health Services Research and Development Service (HSR&D), VA)

    The Evidence-based Synthesis Program (ESP) was established to provide timely and accurate syntheses of targeted health care topics of particular importance to VA managers and policy makers and to disseminate these reports broadly throughout VA. Access published reports as well as reports in progress.

  • Health Information Research Unit, HIRU, McMaster University

    Conducts research in the field of health information science and is dedicated to the generation of new knowledge about the nature of health and clinical information problems, the development of new information resources to support evidence-based health care, and the evaluation of various innovations in overcoming health care information problems.

  • Health Technology Assessment – (Washington State Health Care Authority USA)

    The primary purpose of HTA is to ensure medical treatments and services paid for with state health care dollars are safe and proven to work. HTA serves as a resource for state agencies purchasing health care. HTA contracts for scientific, evidence-based reports about whether certain medical devices, procedures, and tests are safe and work as promoted. An independent clinical committee of health care practitioners then uses the reports to determine if programs should pay for the medical device, procedure, or test.

  • Health Technology Assessment International (HTAi)

    Focuses uniquely on health technology assessment (HTA) and provides the key forum for all those from the worlds of health care, academia and business interested in the science, development and application of HTA. Health technology assessment (HTA) offers “supporting evidence based decision making in health care policy and practice”.

  • Healthcare Delivery Research Program – (National Cancer Institute (NCI), NIH)

    NCI’s work related to quality of care research and the translation of this research into practice is available through the links on this website.

  • Insitute of Health Economics – (Institute of Health Economics CANADA)

    The IHE strives to assist decision makers in health policy and practice with the results from economic evaluations, costing and cost-effectiveness analyses, and with syntheses of findings from research in health technology assessment.

  • International Society for Pharmacoeconomics and Outcomes Research (ISPOR)

    ISPOR promotes the science of pharmacoeconomics (health economics) and outcomes research (the scientific discipline that evaluates the effect of health care interventions on patient well-being including clinical outcomes, economic outcomes, and patient-reported outcomes) and facilitates the translation of this research into useful information for healthcare decision-makers to ensure that society allocates scarce health care resources wisely, fairly and efficiently. ISPOR embraces all health technology assessors, government health technology regulators & payers of health care including governments, insurers, and other health care payers who use health care outcomes research information in their decisions.

  • Joanna Briggs Institute

    Based within the University of Adelaide, Australia, the JBI promotes the synthesis, transfer and utilization of evidence by identifying effective healthcare practices to assist in the improvement of healthcare outcomes globally.

  • NExT – Nursing Experts: Translating the Evidence – (University of Illinois at Chicago (UIC))

    The NExT project website is a tool for learning about evidence based public health practice and a portal to evidence based practice resources. The site was developed with a primary audience of public health nurses but will be of interest to everyone interested in learning more about evidence based public health. The site includes a free online course which offers 3 free CEUs to nurses.

  • NHS Health Technology Assessment Programme – (University of Southampton UNITED KINGDOM)

    The HTA programme is part of the National Institute for Health Research (NIHR). It produces independent research information about the effectiveness, costs and broader impact of healthcare treatments and tests for those who plan, provide or receive care in the NHS.

  • National Institute for Health and Clinical Excellence (NICE)

    NICE produces guidance in health technologies with guidance on the use of new and existing medicines, treatments and procedures within the NHS clinical practice; and guidance on the appropriate treatment and care of people with specific diseases and conditions within the NHS.

  • National Quality Forum (NQF)

    Not-for-profit membership organization created to develop and implement a national strategy for health care quality measurement and reporting.

  • Quality Enhancement Research Initiative (QUERI) – (Health Services Research and Development Service (HSR&D), VA)

    Works to improve the quality of healthcare for veterans by implementing research findings into routine clinical practice. The QUERI centers focus on nine high-risk and/or highly prevalent diseases or conditions among veterans.

  • SnowMed International

    Formerly the International Health Terminology Standards Development Organisation (IHTSDO), this organization is a not-for-profit association that develops and promotes use of SNOMED CT to support safe and effective health information exchange. SNOMED CT is a clinical terminology and is considered to be the most comprehensive, multilingual healthcare terminology in the world.

  • Swedish Council on Technology Assessment in Health Care (SBU)

    SBU presents the scientific evidence on the benefits, risks, and costs associated with different interventions. SBU identifies methods that offer the greatest benefits and the least risk, focusing on the most efficient ways to allocate healthcare resources. However, SBU also identifies methods currently in use that provide no benefits, have not been assessed, or are not cost effective.

  • Technology Assessment Program – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    This program provides technology assessments for the Centers for Medicare & Medicaid Services (CMS). AHRQ’s technology assessment program uses state-of-the-art methodologies for assessing the clinical utility of medical interventions. Technology assessments are based on a systematic review of the literature, along with appropriate qualitative and quantitative methods of synthesizing data from multiple studies.

  • The 6|18 Initiative: Accelerating Evidence into Action – (Centers for Disease Control and Prevention (CDC), HHS)

    This initiative from the CDC targets six common and costly health conditions – tobacco use, high blood pressure, healthcare-associated infections, asthma, unintended pregnancies, and diabetes – and 18 proven specific interventions that formed the starting point of discussions with purchasers, payers, and providers. Key actions of this initiative include bringing together health care purchasers, payers, and providers with CDC researchers, economists, and policy analysts to offer opportunities to improve health and control costs with the 6|18 interventions.

Health Technology Assessment

Health Technology Assessment items.

Data, Tools, and Statistics

  • AccessGUDID – (National Library of Medicine (NLM), NIH USA)

    Global Unique Device Identification Database (GUDID) contains key device identification information submitted to the FDA about medical devices that have Unique Device Identifiers (UDI).

  • Diffusion of Medical Procedures And Technology – (Dartmouth Institute for Health Policy & Clinical Practice USA)

    A publicly available source providing researchers, payers, regulators, and innovators with metrics quantifying the temporal and regional patterns of diffusion of medical interventions.

  • Equity-Oriented Toolkit for Health Technology Assessment (HTA) – (World Health Organization Centre for Knowledge Translation and Health Technology Assessment in Health Equity)

    The Equity-Oriented Toolkit is a needs-based health technology assessment model used to provide methods to match the identified health needs of a population, to the most appropriate interventions. It provides tools that explicitly consider health equity at the following steps of health technology assessment: Burden of illness, community effectiveness, economic evaluation, and knowledge translation and implementation.

  • Health Technology Assessment Database – (Cochrane Collaboration)

    Brings together details of completed and ongoing health technology assessments (studies of the medical, social, ethical, and economic implications of healthcare interventions) from around the world. The aim of the HTA Database is to improve the quality and cost-effectiveness of health care.

  • Horizon Scan – (Agency for Healthcare Research and Quality (AHRQ), HHS)

    Horizon Scan examines emerging health care technologies and innovations to better inform patient-centered outcomes research.

  • ISPOR International Digest of Databases – (International Society for Pharmacoeconomics and Outcomes Research (ISPOR) USA)

    Electronic index (Digest) of 400 databases from 45 countries. The Digest consists of key attributes of health care databases. It is grouped by country and allows both key word searches and searches by type of database.

Guidelines, Journals, Other Publications

  • Health Services/Technology Assessment Text (HSTAT) – (National Library of Medicine (NLM), NIH USA)

    Health Services/Technology Assessment Text is a searchable collection of large, full-text practice guidelines (including the Guide to Community Preventive Services), technology assessments and health information.

  • Health Technology Assessment of Medical Devices (2011) images/pdf.gif icon – (World Health Organization (WHO))

    WHO has developed a reference document to provide an introduction to the concept and programme of health technology assessment (HTA) around the world and to highlight the contribution that HTA can make to informed policy and decision-making, particularly in developing and emerging countries. It further aims to describe strategic actions that countries can take for introducing HTA into their health systems.

  • HTA Glossary – (Health Technology Assessment International (HTAi) CANADA)

    Provides a common vocabulary for work in HTA. Entries in this glossary have been created by selecting terms from existing glossaries (eg. Dr. Clifford Goodman’s guide HTA 101) and from terms and sources suggested by many individuals working in the field of HTA.

  • HTAI Global Policy Forum (free) – (Health Technology Assessment International (HTAi) CANADA)

    HTAI has created a subscription journal, which will allow non-members to access policy papers and news/events.

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OMB Control Number: 0925-0648.
Expiration Date: March 31, 2018Public reporting burden for this collection of information is estimated to average 1 minute per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a currently valid OMB control number. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to: NIH, Project Clearance Branch, 6705 Rockledge Drive, MSC 7974, Bethesda, MD 20892-7974, ATTN: PRA (0925-0648). Do not return the completed form to this address.

Placental Accumulation of Flame Retardant Chemical Alters Serotonin Production in Rat Offspring

Placental Accumulation of Flame Retardant Chemical Alters Serotonin Production in Rat Offspring

Summary: A new study reports on a link between exposure to a flame retardant mixture used in foam based furniture and the disruption of normal placenta function in rats. The placental disruption alters the production of serotonin in offspring, researchers report.

Source: NC State University.

A North Carolina State University-led research team has shown a connection between exposure to a widely used flame retardant chemical mixture and disruption of normal placental function in rats, leading to altered production of the neurotransmitter serotonin. Evidence of endocrine, inflammatory and neurotransmitter signaling pathway disruption was also identified in the placentas. These data show, for the first time, that flame retardants can have sex-specific effects on placental functions critical for brain development.

FireMaster 550 (FM550) is a flame-retardant mixture used in foam-based baby products and furniture. First identified by collaborating researchers at Duke University nearly a decade ago, it was developed to replace PBDEs, a class of fire retardants being phased out of use because of safety concerns. The interuniversity research team recently demonstrated that FM 550 is an endocrine disruptor, with developmental exposure affecting anxiety- and hyperactivity-related behaviors in rats in sex-specific ways. They also showed that three of the FM 550 components dose-dependently accumulate in placenta, with levels higher in male-associated placentas.

Heather Patisaul, professor of biology at NC State, and her graduate student, Kylie Rock, wanted to know if FM 550 could sex-specifically impact the developing brain by altering placental function. They exposed pregnant female rats to 0, 300, or 1,000 micrograms of the chemical mixture per day for 10 days during gestation. The team used a variety of tools, including metabolomics and high throughput RNA sequencing, to examine the placentas and the developing brains of the offspring to identify possible pathways impacted by the chemical mixture. The dose levels used were all below the 50 milligrams per day currently considered safe.

In rat offspring exposed to 300 or 1,000 micrograms of FM550, the researchers found dose-dependent upregulation of multiple genes related to inflammatory and endocrine processes. Some were sex-specific. For example, levels of estrogen and androgen receptors were upregulated in female-associated placentas while inflammatory markers associated with increased risk of behavioral disorders were upregulated in placentas from both sexes. Additionally, the ratio of the serotonin metabolite 5-HIAA to serotonin was reduced in female placentas and fetal forebrains compared to the control group, demonstrating disruption of neurotransmitter production in the placenta and developing brain.

Image shows the structure of serotonin.

“We found that exposure to FM 550 can impact multiple placental pathways critical for early brain development, which is particularly concerning given that it is commonly found in baby products and furniture,” Patisaul says. “Most intriguingly, we found some evidence that placental serotonin production is altered. This is important because in early development the placenta is the sole source of serotonin for the developing forebrain.”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Collaborating efforts were led by Heather Stapleton at Duke University and Susan Sumner at UNC Chapel Hill.

Funding: The work was funded by the National Institute of Environmental Health Sciences (grants R56ES022957, P30ES025128 and T32ES021432).

Source: Heather Patisaul – NC State University
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Molecular Effects of Developmental FM 550 Exposure in Wistar Rat Placenta and Fetal Forebrain” by Kylie R Baldwin, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather Stapleton and Heather Patisaul in Endocrine Connections. Published online January 2018 doi:10.1530/EC-17-0373

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NC State University “Placental Accumulation of Flame Retardant Chemical Alters Serotonin Production in Rat Offspring.” NeuroscienceNews. NeuroscienceNews, 22 January 2018.
<http://neurosciencenews.com/flame-retardant-serotonin-8340/&gt;.

Abstract

Molecular Effects of Developmental FM 550 Exposure in Wistar Rat Placenta and Fetal Forebrain

Firemaster 550 (FM 550) is a flame retardant (FR) mixture that has become one of the most commonly used FRs in foam-based furniture and baby products. Human exposure to this commercial mixture, comprised of brominated and organophosphate components, is widespread. We have repeatedly shown that developmental exposure can lead to sex-specific behavioral effects in rats. Accruing evidence of endocrine disruption and potential neurotoxicity have raised concerns regarding the neurodevelopmental effects of FM 550 exposure, but the specific mechanisms of action remains unclear. Additionally, we observed significant, and in some cases sex-specific, accumulation of FM 550 in placental tissue following gestational exposure. Because the placenta is an important source of hormones and neurotransmitters for the developing brain, it may be a critical target of toxicity to consider in the context of developmental neurotoxicity. Using a mixture of targeted and exploratory approaches, the goal of the present study was to identify possible mechanisms of action in the developing forebrain and placenta. Wistar rat dams were orally exposed to FM 550 (0, 300, or 1,000 µg/day;) for 10 days during gestation and placenta and fetal forebrain tissue collected for analysis. In placenta, evidence of endocrine, inflammatory, and neurotransmitter signaling pathway disruption was identified. Notably, 5-HT turnover was reduced in placental tissue and fetal forebrains indicating that 5-HT signaling between the placenta and the embryonic brain may be disrupted. These findings demonstrate that environmental contaminants, like FM 550, have the potential to impact the developing brain by disrupting normal placental functions.

“Molecular Effects of Developmental FM 550 Exposure in Wistar Rat Placenta and Fetal Forebrain” by Kylie R Baldwin, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather Stapleton and Heather Patisaul in Endocrine Connections. Published online January 2018 doi:10.1530/EC-17-0373

Reduced Attention to Audiovisual Synchrony in Infancy Predicts Autism Diagnosis

Reduced Attention to Audiovisual Synchrony in Infancy Predicts Autism Diagnosis

Summary: Infants who pay little attention to synchronous sights and sounds could have an elevated risk of being diagnosed with autism, researchers report.

Source: Uppsala University.

An ability to integrate information from different sensory modalities is important for infants’ development and for their perception of the environment. A new study suggests that infants who pay little attention to synchronous sights and sounds may be at elevated risk for developing autism spectrum disorder (ASD). This knowledge about early development in ASD may contribute to earlier detection and intervention in the future.

The findings were recently published in the Journal of Child Psychology and Psychiatry. The researchers let the infants observe a computer screen on which half of the screen showed objects that moved in synchrony with a sound and the other half showed objects that moved without any relation to the sound. The participants who fulfilled criteria for ASD at three years of age looked equally long at both sides, while children with typical development showed a strong preference for audiovisual synchrony, defined as changes in object velocity happening at the same time as changes in sound volume.

“We expected an effect in this direction, but were nevertheless surprised to see that the group differences were so large,” says Terje Falck-Ytter, Associate Professor at the Department of Psychology, Uppsala University, and Principal Investigator for the study. “We believe the findings are important because they point to a rather basic function that has not been studied much earlier in this context.”

The study is a part of the larger project Early Autism Sweden (EASE), which is a collaboration between Uppsala University and the Center of Neurodevelopmental Disorders at Karolinska Institutet (KIND). The project includes younger siblings of children with ASD, ADHD or language disorder. The infants are followed longitudinally from five months of age until they reach six years. The participants in the current experiment were 10 months old when their visual preferences were examined and were followed until three years, when the diagnostic evaluation was conducted. In total, 33 infants with an older sibling with ASD took part in the study, of whom thirteen met criteria for ASD at follow-up. The study also included a control group consisting of fourteen infants at low (average) risk for ASD.

 Image shows a mom and baby.

“Currently, ASD cannot be reliably diagnosed before 2-3 years of age, and despite a lot of research we still know too little about the causes. Even if twin studies suggest that genetic factors play an important role, we still do not know enough about which specific genes are involved and how they affect the developing brain to cause ASD. Our philosophy is that studying the early development of ASD will help clarify the picture,” Falck-Ytter explains.

The results demonstrated significant group differences, but it is too early to say whether the method in its current form can facilitate early detection in a clinical context.

“We used eye tracking to measure the infants’ gaze, and the experiment lasted only a few minutes. It is of course fascinating and promising that one can forecast with some degree of accuracy how a child will develop based on such a short measurement of gaze patterns. At the same time it is important to bear in mind that significant results at the group level do not imply that one can take this eye tracking ‘test’ and get accurate results on an individual level,” says Falck-Ytter.

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Source: Terje Falck-Ytter – Uppsala University
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Terje Falck Ytter.
Original Research: Abstract in Journal of Child Psychology and Psychiatry.
doi:10.1111/jcpp.12863

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Uppsala University “Reduced Attention to Audiovisual Synchrony in Infancy Predicts Autism Diagnosis.” NeuroscienceNews. NeuroscienceNews, 23 January 2018.
<http://neurosciencenews.com/autism-audiovisual-synchrony-8345/&gt;.

Abstract

Reduced orienting to audiovisual synchrony in infancy predicts autism diagnosis at 3 years of age

Background
Effective multisensory processing develops in infancy and is thought to be important for the perception of unified and multimodal objects and events. Previous research suggests impaired multisensory processing in autism, but its role in the early development of the disorder is yet uncertain. Here, using a prospective longitudinal design, we tested whether reduced visual attention to audiovisual synchrony is an infant marker of later-emerging autism diagnosis.

Methods
We studied 10-month-old siblings of children with autism using an eye tracking task previously used in studies of preschoolers. The task assessed the effect of manipulations of audiovisual synchrony on viewing patterns while the infants were observing point light displays of biological motion. We analyzed the gaze data recorded in infancy according to diagnostic status at 3 years of age (DSM-5).

Results
Ten-month-old infants who later received an autism diagnosis did not orient to audiovisual synchrony expressed within biological motion. In contrast, both infants at low-risk and high-risk siblings without autism at follow-up had a strong preference for this type of information. No group differences were observed in terms of orienting to upright biological motion.

Conclusions
This study suggests that reduced orienting to audiovisual synchrony within biological motion is an early sign of autism. The findings support the view that poor multisensory processing could be an important antecedent marker of this neurodevelopmental condition.

Will Smoking Pot Harm Your Heart? Experts Weigh In

Will Smoking Pot Harm Your Heart? Experts Weigh In

News Picture: Will Smoking Pot Harm Your Heart? Experts Weigh InBy Dennis Thompson
HealthDay Reporter

MONDAY, Jan. 22, 2018 (HealthDay News) — Anyone worried that smoking a lot of pot could lead to a heart attack or stroke will just have to keep worrying for the time being.

There’s not enough scientific evidence to say one way or the other how marijuana affects heart health, a new review has concluded.

“Our review found insufficient evidence to draw meaningful conclusions that marijuana use is associated with cardiovascular risk factors and outcomes,” said lead study author Dr. Divya Ravi, an internist with the Wright Center for Graduate Medical Education in Scranton, Pa.

For their review, Ravi and her colleagues pored through medical literature and found 24 studies that evaluated marijuana use and its effects on either heart health risk factors or actual health problems such as heart attack or stroke.

A few studies showed that pot use might benefit the heart, but these were contradicted by other studies that reported potential harmful effects, Ravi said.

For example, some studies linked marijuana use to less diabetes, lower blood sugar and higher levels of “good” HDL cholesterol, the researchers found. And despite anecdotal reports of marijuana bringing on the “munchies,” no studies have tied pot use to weight gainor obesity.

However, other studies found that smoking pot was associated with a greater risk for heart attack and death from heart disease.

“The evidence is insufficient to draw any conclusions,” Ravi said. “The association between marijuana and cardiovascular health has not been adequately studied to date.”

Two heart experts not involved with the study said they’re not surprised by the lack of evidence, given how difficult it is to conduct studies on marijuana use.

Results could become more definitive in the future, thanks to some states legalizing marijuana. That might make people more comfortable discussing their pot use with researchers, said Dr. Russell Luepker, a professor with the University of Minnesota’s School of Public Health.

The vast majority of states allow limited use of medical marijuana under certain circumstances. And eight states and Washington D.C. have legalized recreational pot use.

Dr. Satjit Bhusri, a cardiologist at Lenox Hill Hospital in New York City, said it’s very likely that smoking pot can harm heart health because you’re actively breathing in smoke.

“If you inhale a joint it’s like inhaling a cigarette — you’re putting toxins in your body,” Bhusri said.

On the other hand, it’s hard to say that eating or vaping marijuana produces the same heart risk, said Luepker, a spokesman for the American Heart Association.

“Like any smoked product, you inhale a variety of things, including carbon monoxide and other substances that you certainly don’t get if you eat it,” Luepker said.

Bhusri also expects that the more someone smokes pot, the more they’d increase their heart health risk.

“I wouldn’t be surprised if there is a dose relationship because of these toxins that are inhaled,” he said.

But because marijuana users don’t smoke at the same rate as those who smoke cigarettes, Luepker said, it’s not likely they will be doing themselves as much harm.

For instance, it’s hard to think of many people smoking two packs a day of pot, or lighting up first thing in the morning, he said.

Marijuana users are more akin to “social cigarette smokers who smoke a cigarette or two at a party, and they don’t seem to have any increased risk from that,” Luepker said.

Until more is known, though, pot users should use caution, Ravi concluded.

“At this juncture we have little data on potential harms or benefits associated with use to inform the counseling of marijuana users,” Ravi said. “It may be wise to proceed with caution until we have sufficient evidence to comment on the health effects of chronic marijuana use.”

The study is published in the Jan. 23 issue of Annals of Internal Medicine.

Adverse effects of anti-hypertensive medication – hypotension, heart failure

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antihypertensive meds adverse effects

 

Beta blockers have a wide range of side-effects,
including bradycardia, wheezing or unmasking
of asthma, masking of hypoglycaemia, sleep
disturbances, fatigue, exercise intolerance, erectile
dysfunction, glucose intolerance, worsening of
peripheral vascular disease, drowsiness, Raynaud’s
phenomenon, heart failure, dyslipidaemia, and
precipitation of angina with sudden withdrawal.

 

Aldosterone antagonists can cause life-threatening
hyperkalaemia, especially in patients with chronic
kidney disease (CKD) and concomitant use of ACE
inhibitors and NSAIDs. Other side-effects include
gynaecomastia, breast tenderness, menstrual
irregularities, gastric ulcers, and erectile dysfunction.
Generally, these complications can be avoided by
using low doses (50 mg maximum), avoiding their
use in high-risk situations, e.g. in the presence of
CKD, and avoiding the use of NSAIDs.

 

Curcumin Improves Memory and Mood

Curcumin Improves Memory and Mood

Summary: Curcumin, a substance found in turmeric, improves both mood and memory in people with mild, age related memory loss, researchers report.

Source: UCLA.

Lovers of Indian food, give yourselves a second helping: Daily consumption of a certain form of curcumin — the substance that gives Indian curry its bright color — improved memory and mood in people with mild, age-related memory loss, according to the results of a study conducted by UCLA researchers.

The research, published online Jan. 19 in the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed curcumin supplement on memory performance in people without dementia, as well as curcumin’s potential impact on the microscopic plaques and tangles in the brains of people with Alzheimer’s disease.

Found in turmeric, curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance.

“Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimer’s disease and major depression,” said Dr. Gary Small, director of geriatric psychiatry at UCLA’s Longevity Center and of the geriatric psychiatry division at the Semel Institute for Neuroscience and Human Behavior at UCLA, and the study’s first author.

The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months.

All 40 subjects received standardized cognitive assessments at the start of the study and at six-month intervals, and monitoring of curcumin levels in their blood at the start of the study and after 18 months. Thirty of the volunteers underwent positron emission tomography, or PET scans, to determine the levels of amyloid and tau in their brains at the start of the study and after 18 months.

The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not, Small said. In memory tests, the people taking curcumin improved by 28 percent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.

The amygdala and hypothalamus are regions of the brain that control several memory and emotional functions.

tumeric

Four people taking curcumin, and two taking placebos, experienced mild side effects such as abdominal pain and nausea.

The researchers plan to conduct a follow-up study with a larger number of people. That study will include some people with mild depression so the scientists can explore whether curcumin also has antidepressant effects. The larger sample also would allow them to analyze whether curcumin’s memory-enhancing effects vary according to people’s genetic risk for Alzheimer’s, their age or the extent of their cognitive problems.

“These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years,” said Small, UCLA’s Parlow–Solomon Professor on Aging.

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The paper’s authors, in addition to Small, are Prabha Siddarth, Dr. Zhaoping Li, Karen Miller, Linda Ercoli, Natacha Emerson, Jacqueline Martinez, Koon-Pong Wong, Jie Liu, Dr. David Merrill, Dr. Stephen Chen, Susanne Henning, Nagichettiar Satyamurthy, Sung-Cheng Huang, Dr. David Heber and Jorge Barrio, all of UCLA.

Theravalues Corp. provided the curcumin and placebos for the trial, as well as funds for laboratory testing and for Small’s travel to present preliminary findings at the 2017 Alzheimer’s Association International Conference.

Funding: The study was supported by the Ahmanson Foundation, the Marshall and Margherite McComb Foundation, the McMahan Foundation, Bob and Marion Wilson, the Fran and Ray Stark Foundation Fund for Alzheimer’s Disease Research, the U.S. Department of Energy and the National Institutes of Health.

Source: Leigh Hopper – UCLA
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to UCLA.
Original Research: Open access research in The American Journal of Geriatric Psychiatry.
doi:10.1016/j.jagp.2017.10.010

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UCLA “Curcumin Improves Memory and Mood.” NeuroscienceNews. NeuroscienceNews, 23 January 2018.
<http://neurosciencenews.com/curcumin-mood-memory-8346/&gt;.

Abstract

Preterm birth leads to hyper-reactive cognitive control processing and poor white matter organization in adulthood

Objective
Because curcumin’s anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored its impact on brain amyloid and tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography (FDDNP-PET).

Methods
Forty subjects (age 51–84 years) were randomized to a bioavailable form of curcumin (Theracurmin® containing 90 mg of curcumin twice daily [N = 21]) or placebo (N = 19) for 18 months. Primary outcomes were verbal (Buschke Selective Reminding Test [SRT]) and visual (Brief Visual Memory Test-Revised [BVMT-R]) memory, and attention (Trail Making A) was a secondary outcome. FDDNP-PET signals (15 curcumin, 15 placebo) were determined in amygdala, hypothalamus, medial and lateral temporal, posterior cingulate, parietal, frontal, and motor (reference) regions. Mixed effects general linear models controlling for age and education, and effect sizes (ES; Cohen’s d) were estimated.

Results
SRT Consistent Long-Term Retrieval improved with curcumin (ES = 0.63, p = 0.002) but not with placebo (ES = 0.06, p = 0.8; between-group: ES = 0.68, p = 0.05). Curcumin also improved SRT Total (ES = 0.53, p = 0.002), visual memory (BVMT-R Recall: ES = 0.50, p = 0.01; BVMT-R Delay: ES = 0.51, p = 0.006), and attention (ES = 0.96, p < 0.0001) compared with placebo (ES = 0.28, p = 0.1; between-group: ES = 0.67, p = 0.04). FDDNP binding decreased significantly in the amygdala with curcumin (ES = −0.41, p = 0.04) compared with placebo (ES = 0.08, p = 0.6; between-group: ES = 0.48, p = 0.07). In the hypothalamus, FDDNP binding did not change with curcumin (ES = −0.30, p = 0.2), but increased with placebo (ES = 0.26, p = 0.05; between-group: ES = 0.55, p = 0.02).

Conclusions
Daily oral Theracurmin may lead to improved memory and attention in non-demented adults. The FDDNP-PET findings suggest that symptom benefits are associated with decreases in amyloid and tau accumulation in brain regions modulating mood and memory.