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Bipolar disorder have increased risk of Parkinson’s disease

Is bipolar disorder associated with increased risk of Parkinson’s disease

Summary: Study reveals patients with bipolar disorder have a significantly increased risk of developing Parkinson’s disease compared with the general population.

Source: JAMA

A new systematic review and meta-analysis combined the results of seven studies with 4.3 million participants to examine a potential association between bipolar disorder with a later diagnosis of Parkinson’s disease of unknown cause.

The findings suggest that a previous diagnosis of bipolar disorder was associated with an increased likelihood of a subsequent Parkinson’s disease diagnosis but subgroup analyses suggest the possibility of an overestimation of the magnitude of the associations.

The main limitation of the study is analysis that suggests a greater likelihood of a Parkinson’s disease diagnosis in shorter studies which raises concerns over misdiagnosis.

This shows a depressed woman

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source:
JAMA
Media Contacts:
Joaquim J. Ferreira – JAMA
Image Source:
The image is in the public domain.

Original Research: Open access
“Risk of Developing Parkinson Disease in Bipolar Disorder”. Joaquim J. Ferreira, M.D., Ph.D et al.
Neuron doi:10.1001/jamaneurol.2019.3446.

Abstract

Risk of Developing Parkinson Disease in Bipolar Disorder

Importance

Parkinson disease (PD) manifests by motor and nonmotor symptoms, which may be preceded by mood disorders by more than a decade. Bipolar disorder (BD) is characterized by cyclic episodes of depression and mania. It is also suggested that dopamine might be relevant in the pathophysiology of BD.

Objective
To assess the association of BD with a later diagnosis of idiopathic PD.

Data Sources
An electronic literature search was performed of Cochrane Controlled Register of Trials, MEDLINE, Embase, and PsycINFO from database inception to May 2019 using the terms Parkinson disease, bipolar disorder, and mania, with no constraints applied.

Study Selection
Studies that reported data on the likelihood of developing PD in BD vs non-BD populations were included. Two review authors independently conducted the study selection.

Data Extraction and Synthesis
Two review authors independently extracted study data. Data were pooled using a random-effects model, results were abstracted as odds ratios and 95% CIs, and heterogeneity was reported as I2.

Main Outcome and Measures
Odds ratios of PD.

Results
Seven studies were eligible for inclusion and included 4 374 211 participants overall. A previous diagnosis of BD increased the likelihood of a subsequent diagnosis of idiopathic PD (odds ratio, 3.35; 95% CI, 2.00-5.60; I2 = 92%). A sensitivity analysis was performed by removing the studies that had a high risk of bias and also showed an increased risk of PD in people with BD (odds ratio, 3.21; 95% CI, 1.89-5.45; I2 = 94%). Preplanned subgroup analyses according to study design and diagnostic certainty failed to show a significant effect.

Conclusions and Relevance
This review suggests that patients with BD have a significantly increased risk of developing PD compared with the general population. Subgroup analyses suggested a possible overestimation in the magnitude of the associations. These findings highlight the probability that BD may be associated with a later development of PD and the importance of the differential diagnosis of parkinsonism features in people with BD.

Increased inflammatory activity in patients with FTD dementia

Frontotemporal dementia is associated with alterations in immune system function

Summary: Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism’s symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.

Source: University of Eastern Finland

Recent research from the University of Eastern Finland revealed increased inflammatory activity in a subgroup of patients with frontotemporal dementia (FTD). Increased inflammation was associated with parkinsonism symptoms and more rapid disease progression. In addition, the results showed that cancer is rare in FTD, whereas some autoimmune diseases may be more common among FTD patients. These findings may indicate an overactive immune system in FTD.

FTD is the second most common cause of early-onset dementia. Currently, the precise mechanisms causing the disease are unknown, and there are no disease-modifying or curative treatments. Recent studies have indicated that inflammation and autoimmunity in the central nervous system and in peripheral blood may be linked to FTD. Additionally, the most common genetic cause of FTD, the C9orf72 repeat expansion mutation, has been associated with immune system regulation.

Inflammation is associated with more rapid disease progression

The association between systemic inflammation and clinical features of FTD was evaluated by analyzing several inflammatory markers such as cytokines and C-reactive protein (CRP) from FTD patients’ blood samples. The aim was to analyse whether the potential systemic inflammatory changes associated with specific features under the heterogeneous FTD spectrum, including psychotic symptoms, parkinsonism, and disease progression. Increased inflammation in the blood, which was indicated by elevated levels of cytokines that promote inflammation (MCP-1 and RANTES) and decreased levels of cytokine that reduces inflammation (IL-10), were associated with parkinsonism symptoms and more rapid cognitive and functional decline. These findings were recently published in Journal of Neurology.

Cancer is rare among FTD patients

Immune system activity in FTD was also studied by evaluating disease comorbidities in the FTD cohort. An extremely low prevalence of cancer was observed in FTD patients. This supports a recent theory about an inverse association between degenerative diseases and cancer. Previous genetic and immunological studies have indicated that this inverse association may be explained by the opposite genetic activities of cancer and degeneration, and additionally by opposite immunological pathways. Based on the present results, the low prevalence of cancer in FTD may thus be associated with overactive immune system.

This shows a brain

The prevalence of autoimmune diseases, in general, was not significantly higher in FTD compared to control groups. On the other hand, especially FTD patients with the C9orf72 repeat expansion mutation had a potential association with an autoimmune skin disease bullous pemphigoid, which was indicated by elevated autoantibody levels in 12.5% of the patients. Previous studies have indicated that autoimmune diseases are more common in FTD in general, but based on these results, the association likely differs between different autoimmune diseases and FTD genotypes.

“In all, this research provides novel insights into the potential contribution of immune system alterations to the pathogenesis and clinical features of FTD. This new information may be utilized in designing further studies and for identifying novel prognostic biomarkers or therapeutic strategies in FTD,” says Kasper Katisko, B.M., from the University of Eastern Finland, who presented the findings in a doctoral thesis focusing on the role of inflammation and immune system function in frontotemporal dementia.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source:
University of Eastern Finland
Media Contacts:
Kasper Katisko – University of Eastern Finland
Image Source:
The image is in the public domain.

Original Research: Open access
“Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion”. Katisko et al.
Journal of Neurology doi:10.1007/s00415-019-09552-1.

Abstract

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

In this study, our aim was to evaluate potential peripheral inflammatory changes in frontotemporal lobar degeneration (FTLD) patients carrying or not the C9orf72 repeat expansion. To this end, levels of several inflammatory markers (MCP-1, RANTES, IL-10, IL-17A, IL-12p, IFN-γ, IL-1β, IL-8, and hs-CRP) and blood cells counts in plasma and/or serum of FTLD patients (N = 98) with or without the C9orf72 repeat expansion were analyzed. In addition, we evaluated whether the analyzed peripheral inflammatory markers correlated with disease progression or distinct clinical phenotypes under the heterogenous FTLD spectrum. Elevated levels of pro-inflammatory RANTES or MCP-1 and decreased levels of anti-inflammatory IL-10 were found to associate with Parkinsonism and a more rapid disease progression, indicated by longitudinal measurements of either MMSE or ADCS-ADL decline. These findings were observed in the total cohort in general, whereas the C9orf72 repeat expansion carriers showed only slight differences in IL-10 and hemoglobin levels compared to non-carriers. Furthermore, these C9orf72 repeat expansion-associated differences were observed mostly in male subjects. The females in general showed elevated levels of several pro-inflammatory markers compared to males regardless of the C9orf72 genotype. Our study suggests that pro-inflammatory changes observed in the early symptomatic phase of FTLD are associated with distinct clinical profiles and a more rapid disease progression, and that the C9orf72 repeat expansion and gender may also affect the inflammatory profile in FTLD.

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More tremors with Parkinson’s medications

More tremors with Parkinson’s medications

  • Carbidopa-levodopa.
  • Carbidopa-levodopa infusion
  • Dopamine agonists
  • MAO B inhibitors
  • Catechol O-methyltransferase (COMT) inhibitors
  • Anticholinergics
  • Amantadine

What are the root causes of Parkinsons? As I massage the foot of my client with Parkinsons, I can tell from her lifestyle the missing link to giving her quality of life with Parkinsons.

I trained caregivers to use massage and healthy soups for Parkinsons. We use liquid melatonin for sleep and lots of hugs.

card mother

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Trained and monitored caring caregivers are important in home care

  • Empowered staff with their customer experience successes
  • Informed teams of areas for improvement as patient experiences unfold
  • Enabled management, with actionable insights, to drive operational changes

Motherhealth trains and monitors its bayarea caregivers to have consistent care matching the home care needs of clients. This is very important for Alzheimer’s and Parkinson’s clients.

card mother

Fight infection with glycan-rich foods – onions, asparagus, apples, kiwi, carrots

Analysis of Asn-linked glycans from vegetable foodstuffs: widespread occurrence of Lewis a, core alpha1,3-linked fucose and xylose substitutions.

Wilson IB, et al. Glycobiology. 2001.

From: https://www.ncbi.nlm.nih.gov/m/pubmed/11358875/

The N-glycans from 27 “plant” foodstuffs, including one from a gymnospermic plant and one from a fungus, were prepared by a new procedure and examined by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). For several samples, glycan structures were additionally investigated by size-fractionation and reverse-phase high-performance liquid chromatography in conjunction with exoglycosidase digests and finally also (1)H-nuclear magnetic resonance spectroscopy. The glycans found ranged from the typical vacuolar “horseradish peroxidase” type and oligomannose to complex Le(a)-carrying structures. Though the common mushroom exclusively contained N-glycans of the oligomannosidic type, all plant foods contained mixtures of the above-mentioned types.

Apple, asparagus, avocado, banana, carrot, celery, hazelnut, kiwi, onion, orange, pear, pignoli, strawberry, and walnut were particularly rich in Le(a)-carrying N-glycans.

Although traces of Le(a)-containing structures were also present in almond, pistachio, potato, and tomato, no such glycans could be found in cauliflower. Coconut exhibited almost exclusively N-glycans containing only xylose but no fucose. Oligomannosidic N-glycans dominated in buckwheat and especially in the legume seeds mung bean, pea, peanut, and soybean. Papaya presented a unique set of hybrid type structures partially containing the Le(a) determinant.

These results are not only compatible with the hypothesis that the carbohydrate structures are another potential source of immunological cross-reaction between different plant allergens, but they also demonstrate that the Le(a)-type structure is very widespread among plants.

 

FRom: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005082/

The dense microbial community (microbiota) that is established in the human intestine shortly after birth has a profound effect on health and physiology, providing benefits such as modulation of immune development, digestion of recalcitrant dietary nutrients, and inhibition of pathogen colonization. However, abnormalities in microbiota composition (dysbiosis) have been implicated in several disease states, including inflammatory bowel disease (IBD), colon cancer, antibiotic-associated colitisand obesity. Dysbiosis is postulated to result when a typically healthy microbial community becomes unbalanced, due to either increased abundance of potentially harmful microorganismsor increased flux through harmful metabolic pathways. The normal composition of the gut microbiota, both at single time points and over longer periods of human life, has only been deeply probed within the last several years. Current investigations seek to define the dominant forces shaping the microbiota in order to better understand the causes of dysbiosis and develop strategies to restore a healthy community.

One major factor shaping the composition and physiology of the microbiota is the influx of glycans into the intestine, mostly from diet and host mucosal secretions. Humans consume dozens of different plant and animal-derived dietary glycans, most of which cannot be degraded by enzymes encoded in the human genome. Microbial fermentation transforms these indigestible glycans into short chain fatty acids (SCFA), which serve as nutrients for colonocytes and other gut epithelial cells. Gut microorganisms therefore play a pivotal symbiotic role in helping humans access calories from otherwise indigestible nutrients. Individual microorganisms prefer different glycans. Thus, selective consumption of these nutrients can influence which microbial groups proliferate and persist in the gastrointestinal tract, pointing to dietary glycans as a non-invasive strategy with which humans can directly influence the balance of species in the gut.

In addition to dietary glycans, which fluctuate in composition and abundance, some members of the microbiota are able to degrade glycans found in host mucus secretions or shed epithelial cells. These endogenous glycans provide consistent sources of nutrients to the microbiota, despite potentially drastic changes in diet. Endogenous host glycans are presented to bacteria in the intestinal lumen as O-linked glycans attached to secreted or cell-associated mucin glycoproteins (the major component of mucus), or as N-linked glycans present in shed epithelial cells. Some proportion of endogenous glycans are likely to be concentrated directly adjacent to host tissue in the protective mucus layer. The ability of certain microorganisms to penetrate and degrade mucus as a nutrient source positions them in close proximity to host cells. As a consequence, species that are adept at utilizing these endogenous glycans may exert a disproportionate effect on colonic health, especially during states of dysbiosis.

This review explores the role of glycans in shaping the microbiota by first considering its assembly from birth to adulthood and how this process is catalyzed by changes in glycan availability. We then consider the glycan acquisition mechanisms that have been evolved by some of the most abundant (and therefore successful) members of the human gut microbiota. Finally, we consider how the spatial abundance and diversity of glycans in different gut regions (i.e., lumen versus mucosa, proximal versus distal) may select for regional sub-populations, some of which may be of particular interest in pathologies resulting from dysbiosis.

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A place for your employees in the bay area with corporate landlord

A place for your employees in the bay area with corporate landlord

Motherhealth will now accept requests from corporations in the bay area looking for house for rent for their employees. We will furnish the place and prepare them for your employees. Profits will support affordable senior home care and housing in the bay area.

Email Connie at motherhealth@gmail.com

card mother

What are the treatment options for chronic wounds?

What are the treatment options for chronic wounds?

Created: October 17, 2006; Last Update: June 14, 2018; Next update: 2021.

At first, chronic wounds are regularly cleaned and covered using wound dressings and bandages. If a wound still hasn’t healed after a long time despite this wound care, special treatments such as vacuum-assisted closure or skin grafts are used.

If someone has a wound for more than eight weeks without any signs of it healing, it’s considered to be a chronic wound. These kinds of wounds usually arise as a result of poor blood circulation, diabetes or a weak immune system. Open wounds on the lower leg are also known as venous leg ulcers.

As well as treating the underlying condition and tending to the wound, pain relief is important. Some people with complex, poorly healing wounds find psychological support helpful too.

Cleaning the wound

The wound is often cleaned when the dressing is changed, normally using a saline (salt) solution. Overall, though, not enough is known about the advantages and disadvantages of the various solutions that are used to clean wounds, and how they affect the healing process. It’s also not yet clear whether tap water could be used for the medical cleaning of wounds.

Debridement

When treating chronic wounds, doctors or nurses often remove dead or inflamed tissue. This is known as . The tissue is removed using instruments such as tweezers, a sharp spoon-like instrument called a curette, or a scalpel. An enzyme-based gel is sometimes applied too, to help clean the wound.

The wound can also be cleaned using a high-pressure water jet. Another form of  involves the use of a certain species of maggots (fly larvae) that are specially bred for medical purposes. The maggots are placed on the wound, either as they are or in a pouch. They remove dead tissue and fluid from the wound.

Because  is often painful, a local anesthetic is used to numb the wound beforehand, for instance using an ointment. If more severe pain is expected, painkillers can also be taken before treatment. Larger wounds are sometimes cleaned under general anesthetic. There is not enough good research on the advantages and disadvantages of the various debridement techniques to be able to say how effective they are.

Wound dressings

Once the wound has been cleaned, it is covered with a dressing. Most wounds are kept moist, for instance with moist compresses. But the following kinds of dressings can be used instead:

  • Films
  • Gauze
  • Hydrogel dressings
  • Hydrocolloid dressings
  • Dressings containing silver or alginates
  • Foam dressings

The dressings are used to remove excess fluid from the wound and protect it from infection. They are usually left on the wound for several days. Dressings should be changed if it’s clear that they can’t soak up any more wound secretions, if they slip out of place, or if fluid leaks out of the bandage. It’s not yet possible to tell which types of wound dressings are most suitable for different kinds of wounds because there isn’t enough good research in this area.

There are also dressings that contain substances called growth factors. These hormone-like substances are meant to help the healing process by promoting the growth of the body’s cells. But there aren’t enough good studies to be able to say whether treatment with growth factors is more effective than conventional wound care for diabetic foot ulcers and other kinds of chronic wounds.

Honey has traditionally been used in wound care. But applying specially prepared honey before dressing the wound probably doesn’t have any advantages. The effect of using honey in the treatment of leg wounds has so far only been tested in people with venous leg ulcers, though.

Compression stockings and compression bandages

If poor blood circulation is what caused the chronic wound, then compression stockings or compression bandages can help it to heal faster. The pressure from the stockings and bandages helps the veins to carry blood back to the heart and improves circulation.

Antibiotics

Wounds are even less likely to heal well if they are infected with . Depending on how severe the infection is,  may be considered. They can either be applied to the wound using an ointment or placed on the wound using a compress. Initial study results show that wounds in people with diabetic foot syndrome heal faster as a result. It’s not yet clear whether this also applies to wounds caused by other underlying diseases.

It’s also not clear whether antibiotic tablets can help: Studies haven’t shown that they have any advantages in wound healing compared to other treatments.

Hyperbaric oxygen therapy

In hyperbaric oxygen therapy, the person with the wound goes into a special chamber to breathe in oxygen under high pressure. This is meant to increase the oxygen concentration in their blood and improve the blood supply to the wound area.

Research suggests that hyperbaric oxygen therapy can improve the healing of wounds in people with diabetic foot syndrome.

Ultrasound and electromagnetic therapy

Ultrasound therapy involves treating chronic wounds using sound waves. The sound waves make the tissue warmer. But ultrasound therapy hasn’t been proven to help the wound heal faster.

The same is true of electromagnetic therapy, where weak electromagnetic waves are applied to the wound using pillows or mats that have magnets in them.

Vacuum-assisted closure therapy

In vacuum-assisted closure therapy (VAC therapy), the wound is covered with an airtight dressing that is connected to a pump by a thin tube.

The pump continuously sucks fluid out of the wound, creating negative pressure across the surface of the wound. The aim is to increase the flow of blood to the wound. It helps keep the wound moist too, which is also meant to improve the healing process.

Vacuum systems are used in some hospitals to treat chronic or large open wounds, for example following skin grafts. But they can also be used at home. The negative pressure is either applied to the wound around the clock or at regular time intervals.

But the pump, which is constantly attached, limits your mobility and makes noise. Some people find this annoying. Changing the dressing and tube can also be painful and cause a small amount of bleeding.

It’s not possible to say whether vacuum-assisted therapy can help in people with chronic wounds because there’s a lack of good studies in this area. It’s also not clear whether shockwave, ozone or light therapy can help.

Skin grafts

Skin grafts are considered as a treatment option if a wound is so large that it can’t close on its own. In this procedure, skin is taken from another part of your body – usually your thigh – and transplanted onto the wound.

There are also grafts that are made from human cell products and synthetic materials. Studies have shown that these increase the chances of poorly healing venous leg ulcers closing faster.

The wounds healed completely within six months in

  • 40 out of 100 people who had conventional treatment using wound dressings, and in
  • 61 out of 100 people who had a skin graft.

Chronic foot wounds also healed faster after a skin graft than after standard treatment.

What are the pain management options?

Painful chronic wounds can be a burden in daily life and also prevent you from getting a good night’s sleep. Constant pain can really wear you down, making you feel quite low or even depressed after a while.

Drugs like acetaminophen (paracetamol) or ibuprofen can help ease mild to moderate pain. If they aren’t effective enough, the doctor can prescribe a stronger painkiller.

Wound dressings that contain ibuprofen are also available. There’s not enough research to be able to say how effectively they can relieve pain caused by chronic wounds.

People who have chronic pain can benefit from psychological support. Psychological treatments for pain management aim to help people cope better with the pain in everyday life.

Sources


Connie’s story: My client has been losing toes as Kaiser uses the honey mesh to cover his infection.  He might have an internal infection that doesn’t go away such as MRSA. I have suggested zinc and vitamin C lozenges in the past. He is bed-ridden. And was given few months to live and still lives with our home care for the past 2 years.

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Top health hacks 8-20-2019

Choline rich foods to prevent Alzheimers and Parkinsons

Eggs, liver, and peanuts, are especially rich in choline. Major contributors to choline in the American diet are meat, poultry, fish, dairy foods, pasta, rice, and egg-based dishes. Spinach, beets, wheat, and shellfish are also good sources of the choline metabolite, betaine.

Summary: Taking dietary choline supplements may help to protect the brain from Alzheimer’s disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer’s. Choline also helps block the production of amyloid plaques.

Common nutrient supplement choline may hold the answers to combating Alzheimer’s

Source: Arizona State University

Mice, rabbit and cat’s poop and Alzheimer

A new report warns a parasite commonly found in cat feces alters the chemistry of the human brain, making it fertile ground for the disease to take hold. It builds on previous studies that linked the parasite – Toxoplasma gondii – to increased risk of brain cancer, anxiety, and schizophrenia.

Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Infections with …. Ingestion of cat feces containing oocysts: This can occur through ….. Intracranial injection of brain and spinal cord samples into mice, rabbits and rats ….. Latent infection has been linked to Parkinson’s disease and Alzheimer’s disease.