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A meta-analysis of 21 studies presented at this year’s annual meeting the European Association for the Study of Diabetes (EASD) shows that exposure to pesticides is associated with increased …
Source: Exposure to pesticides linked to 61% risk of diabetes
A meta-analysis of 21 studies presented at this year’s annual meeting the European Association for the Study of Diabetes (EASD) shows that exposure to pesticides is associated with increased risk of developing diabetes by 61%, with different types of pesticides showing varying levels of risk. The study is by Giorgos Ntritsos, University of Ioannina, Greece, and Dr Ioanna Tzoulaki and Dr Evangelos Evangelou, Imperial College London, UK, and colleagues.
A total of 21 studies were identified assessing the association between pesticides and diabetes, covering 66,714 individuals (5,066 cases/ 61,648 controls). Most studies did not report the specific diabetes type examined. In almost all of the studies analyses, pesticide exposure was determined by blood or urine biomarker analysis, one of the most accurate methods. The researchers found that exposure to any type of pesticide was associated with increased risk of any type of diabetes by 61%. In the 12 studies analysing only type 2 diabetes, the increased risk was 64% for those exposed to pesticides. For individual pesticides, increased risk was identified in association with exposure to chlordane, oxylchlordane, trans-nonachlor, DDT, DDE dieldrin, heptachlor and HCB.
The authors conclude: “This systematic review supports the hypothesis that exposure to various types of pesticides increases the risk of diabetes. Subgroup analyses did not reveal any differences in the risk estimates based on the type of studies or the measurement of the exposure. Analysing each pesticide separately suggests that some pesticides are more likely to contribute to the development of diabetes than others.”
The authors add that results need to interpreted with caution given the observational nature of the data which does not prove the causality of the observed associations. They are now performing additional analyses of the data and doing a further meta-analysis of pesticide exposure in relation to the other outcomes, including neurological outcomes and several cancers.
A large analysis of more than 100 studies from around the world shows that exposure to pesticides, or bug and weed killers, and solvents is likely associated with a higher risk of developing Parkinson’s disease. The research appears in the May 28, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology.
For the analysis, researchers reviewed 104 studies that looked at exposure to weed, fungus, rodent or bug killers, and solvents and the risk of developing Parkinson’s disease. Studies that evaluated the proximity of exposure, such as country living, work occupation and well water drinking were also included.
The research found that exposure to bug or weed killers and solvents increased the risk of developing Parkinson’s disease by 33 to 80 percent. In controlled studies, exposure to the weed killer paraquat or the fungicides maneb and mancozeb was associated with two times the risk of developing the disease.
“We didn’t study whether the type of exposure, such as whether the compound was inhaled or absorbed through the skin and the method of application, such as spraying or mixing, affected Parkinson’s risk,” said Cereda. “However, our study suggests that the risk increases in a dose response manner as the length of exposure to these chemicals increases.”
The study was supported by the Grigioni Foundation for Parkinson’s Disease and the IRCCS University Hospital San Matteo Foundation.
A University of Kentucky faculty member is a contributing author on a new study demonstrating a connection between a common solvent chemical and Parkinson’s disease. Dr. Franca Cambi of the UK Kentucky Neuroscience Institute collaborated with researchers from across the U.S. on a paper recently published in the Annals of Neurology.
The novel study looked at a cohort of human twins wherein one twin had been occupationally exposed to trichloroethylene (TCE) and other chemicals believed to be linked to development of Parkinson’s.
TCE has been previously linked to Parkinson’s disease through prior research by UK authors and others, including the 2008 paper, “Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity,” and the 2010 paper, “Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.” The 2008 paper was based upon a study of factory workers in a facility using chemicals that have been linked to development of Parkinson’s disease.
In the most recent paper, the authors demonstrated that in addition to TCE, increase in Parkinson’s disease risk is also associated with exposure to percholorethylene (PERC) and carbon tetrachloride (CCI4).
Occupational or environmental exposure to TCE, PERC and CCI4 is common due to the extensive use of the chemicals in dry-cleaning solutions, adhesives, paints, and carpet cleaners. Despite the Food and Drug Administration (FDA) banning the use of TCE as a general anesthetic, skin disinfectant, and coffee decaffeinating agent in 1977, it is still widely used today as a degreasing agent. In the U.S., millions of pounds of TCE are still released into the environment each year and it is the most common organic contaminant found in ground water, detected in up to 30 percent of drinking water supplies in the country.
The current epidemiological study, led by Drs. Samuel Goldman and Caroline Tanner of The Parkinson’s Institute in Sunnyvale, Ca., investigated exposure to TCE, PERC and CCI4 as they related to risk of developing Parkinson’s disease. The team interviewed 99 twin pairs from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort in which one twin had Parkinson’s and one didn’t, inquiring about lifetime occupations and hobbies. Lifetime exposures to six specific solvents previously linked to Parkinson’s in medical literature — n-hexane, xylene, toluene, CCl4, TCE and PERC — were inferred for each job or hobby typically involving exposure to the chemicals.
While prior research has indicated a link between TCE exposure and Parkinson’s disease, the current findings are the first to report a statistically significant association — a more than six-fold increased risk. Researchers also found that exposure to PERC and CCI4 tended toward significant risk of developing the disease.
This study focused on occupational exposures, but the solvents under investigation are pervasive in the environment. Lead author Goldman concluded: “Our findings, as well as prior case reports, suggest a lag time of up to 40 years between TCE exposure and onset of Parkinson’s, providing a critical window of opportunity to potentially slow the disease process before clinical symptoms appear.”
The National Institute of Neurological Disorders and Stroke (NINDS) estimates that as many as 500,000 Americans have Parkinson’s disease and more than 50,000 new cases are diagnosed annually. While there is much debate regarding the causes of Parkinson’s disease, studies suggest that genetic and environmental factors likely trigger the disease — which is characterized by symptoms such as limb tremors, slowed movement, muscle stiffness, and speech impairment. Several studies have reported that exposure to solvents may increase risk of Parkinson’s, but research assessing specific agents is limited.
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The above post is reprinted from materials provided by University of Kentucky
Patients with type 2 diabetes have a 20 percent increased risk of developing blood cancers, such as non-Hodgkin lymphoma, leukemia and myeloma, according to a new meta-analysis led by researchers a…
Patients with type 2 diabetes have a 20 percent increased risk of developing blood cancers, such as non-Hodgkin lymphoma, leukemia and myeloma, according to a new meta-analysis led by researchers a…
Patients with type 2 diabetes have a 20 percent increased risk of developing blood cancers, such as non-Hodgkin lymphoma, leukemia and myeloma, according to a new meta-analysis led by researchers at The Miriam Hospital. The findings, published online in the journal Blood, the journal of the American Society of Hematology, add to the growing evidence base linking diabetes and certain types of cancer.
“I think when most people think about diabetes-related illnesses, they think of heart disease or kidney failure, but not necessarily cancer,” said lead author Jorge Castillo, M.D., a hematologist/oncologist with The Miriam Hospital. “But when you consider that more than 19 million Americans have been diagnosed with diabetes — not to mention the millions more who are either undiagnosed or will be diagnosed in the future — a 20 percent increased risk of blood cancer is quite significant.”
While diabetes has been previously associated with other types of cancer, such as liver and pancreatic cancer, there have been few connections to blood cancers. Researchers are still unclear what causes the vast majority of these malignancies, which include cancers of the blood, bone marrow, and lymph nodes and affect more than 100,000 Americans each year.
Castillo and colleagues analyzed 26 previously published research articles on the association between type 2 diabetes — the most common form of the disease — and the incidence of lymphoma, leukemia and myeloma. The meta-analysis included more than 17,000 cases of type 2 diabetes and blood cancer worldwide.
They concluded patients with type 2 diabetes have increased odds of developing leukemia, myeloma and non-Hodgkin lymphoma, as well as a subtype of non-Hodgkin lymphoma known as peripheral T-cell lymphoma. They did not find any associations with Hodgkin lymphoma.
Interestingly, researchers also say the odds of lymphoma, leukemia and myeloma appear to differ depending on the geographic region of the original report. For example, the odds of non-Hodgkin lymphoma were higher in Asia and Europe, while there was an increased leukemia risk in the United States and Asia.
Although the study did not identify a cause for any of these associations, the findings suggest type 2 diabetes could be associated with approximately five percent of all incidents of leukemia, myeloma non-Hodgkin lymphoma.
“It’s important to remember that type 2 diabetes can, to some degree, be prevented and controlled through lifestyle modification, such as diet and exercise,” Castillo said. “So by preventing the onset of type 2 diabetes, we could also prevent blood cancer.”
The researchers say additional studies are needed to explain the potential relationship between type 2 diabetes and blood cancers. In particular, Castillo believes future research should focus on the role of behavioral factors like obesity, physical activity and smoking, which have been linked to both diabetes and cancer.
Research reported in this publication was supported by the National Center for Research Resources of the National Institutes of Health under award number UL1RR025752, the National Center for Advancing Translational Sciences and The Marilyn Fishman Grant for Diabetes Research from the Endocrine Fellows Foundation. Study co-authors include Nihkil Mull, M.D., John L. Reagan, M.D., and Saed Nemr, M.D., from The Miriam Hospital and Joanna Mitri, M.D., from Tufts Medical Center.T
One preventive measures of knowing about your health is a blood test. Shown above is an example of a woman’s blood test panel. Chemistry Panel (metabolic panel with lipids) – The…
Source: Blood test panel, women
One preventive measures of knowing about your health is a blood test.
Shown above is an example of a woman’s blood test panel.
C-reactive protein (High sensitivity) – CRP measures general levels of inflammation in your body, but cannot show where the inflammation is located or what is causing it. Uncontrolled, systemic inflammation places you at risk for many degenerative diseases like heart disease and stroke.
TSH (Thyroid stimulating hormone) – TSH is produced by the pituitary gland, and stimulates your thyroid to produce thyroid hormones T3 and T4. TSH can be used to screen for thyroid disease and other thyroid imbalances.
Vitamin D, 25-Hydroxy – Known as the sunshine vitamin, vitamin D is important to every cell and tissue throughout the body. From proper immune function and bone density to heart health and mood disorders, vitamin D is critical for optimal health.
Hemoglobin A1C (HbA1C) – HbA1C shows the average level of blood sugar (glucose) over the previous 3 months. HbA1C is a useful indicator of how well blood glucose is being controlled, and is also used to monitor the effects of diet, exercise, and drug therapy in diabetic patients.
Liver cancer is the fifth most common cancer in men and the ninth in women. An estimated 782,500 new liver cancer cases occurred in the world during 2012, with China alone accounting for about 50% …
Source: Liver cancer , China has 50% of worldwide cases, Molds in food
Liver cancer is the fifth most common cancer in men and the ninth in women. An estimated 782,500 new liver cancer cases occurred in the world during 2012, with China alone accounting for about 50% of the total. Rates are more than twice as high in men as in women. Liver cancer rates are the highest in Central America, West and Central Africa, and East and Southeast Asia.
Aflatoxins are among the most potent mutagenic and carcinogenic substances known. Differential potency of aflatoxin among species can be partially attributed to differences in metabolism; however, current information on competing aspects of metabolic activation and detoxification of aflatoxin in various species does not identify an adequate animal model for humans. Risk of liver cancer is influenced by a number of factors, most notably carriage of hepatitis B virus as determined by the presence in serum of the hepatitis B surface antigen (HBsAg+ or HBsAg-). About 50 to 100% of liver cancer cases are estimated to be associated with persistent infection of hepatitis B (or C) virus.
The potency of aflatoxin in HBsAg+ individuals is substantially higher (about a factor of 30) than the potency in HBsAg- individuals. Thus, reduction of the intake of aflatoxins in populations with a high prevalence of HBsAg+ individuals will have greater impact on reducing liver cancer rates than reductions in populations with a low prevalence of HbsAg+ individuals. The present analysis suggests that vaccination against hepatitis B (or protection against hepatits C), which reduces prevalence of carriers, would reduce the potency of the aflatoxins in vaccinated populations and reduce liver cancer risk.
This research has led to potential chemopreventative strategies for liver cancer in populations at high risk for aflatoxin exposure. “Aflatoxin is a very lipid soluble molecule so that when we ingest it, it’s rapidly absorbed. And it goes first to the liver where there are enzymes that will chemically biotransform it into a very reactive chemical, which attacks with very high preference, our DNA, causing damage to that DNA, mutations, perhaps in genes that enhance our susceptibility to cancer production. Aflatoxin is also a very cytotoxic molecule so it will directly kill some of our liver cells creating a void, if you will, that causes the remaining liver cells to replicate and perhaps grow at a faster rate than we would like. The combination of DNA damage and cell proliferation triggers the liver cancer process.”
Mold-contaminated crops can be a serious problem especially in countries where proper storage facilities are limited.
Professor Kensler explains their clinical trials in which chlorophyllin was administered as a therapy and the resultant levels of aflatoxin DNA damage products present in urine samples.
It has been estimated that the DNA in each cell of the body suffers 10,000 oxidative hits per day, leading to the formation of more than 20 different oxidative DNA lesions.108 Human studies show lifestyle and other environmental influences may profoundly modify outcomes of aging.109,110
It is not just environmental toxins (e.g., cigarette smoke, coal dust, and diesel emission particles) that pose a concern. Foods cooked at high temperatures also inflict cellular damage. Deep-fried foods along with well-done beef steak, hamburgers, and bacon cause the formation of gene-mutating heterocyclic amines.111,112 Even so-called healthy foods contain small amounts of undesirable substances.113
Chlorophyllin has been shown to have DNA-protective and antioxidant properties, inhibiting DNA adduction.101,114-116 Chlorophyllin also quenches all major oxygen species and acts to protect mitochondria.117-119 Chlorophyllin also has a role in preventing unavoidable dietary exposure to aflatoxin, a naturally occurring mycotoxin, by reducing its oral bioavailability.120
Keywords: John Hopkins bloomberg school of public health, liver toxicity, environmental health sciences, food and drug administration, liver cancer, aflatoxin, grain product, school of public health, hepatitis b, strict guidelines, department of agriculture, biomarkers, carcinogen, metabolite, food supply, byproduct
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women (not counting skin cancer). In men, prostate cancer is more common, while in women breast can…
Source: Lung Cancer deaths from 55-70
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women (not counting skin cancer). In men, prostate cancer is more common, while in women breast can…
Source: Lung Cancer deaths from 55-70
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Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women (not counting skin cancer). In men, prostate cancer is more common, while in women breast cancer is more common. About 14% of all new cancers are lung cancers.
The American Cancer Society’s estimates for lung cancer in the United States for 2016 are:
Lung cancer is by far the leading cause of cancer death among both men and women; about 1 out of 4 cancer deaths are from lung cancer. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined.
Lung cancer mainly occurs in older people. About 2 out of 3 people diagnosed with lung cancer are 65 or older, while less than 2% are younger than 45. The average age at the time of diagnosis is about 70.
Overall, the chance that a man will develop lung cancer in his lifetime is about 1 in 14; for a woman, the risk is about 1 in 17. These numbers include both smokers and non-smokers. For smokers the risk is much higher, while for non-smokers the risk is lower.
Black men are about 20% more likely to develop lung cancer than white men. The rate is about 10% lower in black women than in white women. Both black and white women have lower rates than men, but the gap is closing. The lung cancer rate has been dropping among men over the past few decades, but only for about the last decade in women.
Statistics on survival in people with lung cancer vary depending on the stage (extent) of the cancer when it is diagnosed. For survival statistics based on the stage of the cancer, see “Non-small cell lung cancer survival rates by stage.”
Despite the very serious prognosis (outlook) of lung cancer, some people with earlier stage cancers are cured. More than 430,000 people alive today have been diagnosed with lung cancer at some point.
Other cancers in increasing trend in the West:
Connie’s notes: How can we detect cancer early?
My brother’s friend has adenocarcinoma and was detected late already when the pain in the hip and other areas in the body was dismissed and was not pursued to have a deeper origin. There was a skin disorder on the chest last month and now he has 3months to live with his tongue slowly deteriorating in movement and the hip pain unbearable. He is 64 yrs of age, over weight and on meat diet. His wife works as a nurse at Kaiser. He is a scientist. His father died of Parkinson, 10 yrs ago, at 70 yrs of age. He lives in Northern California.
My answer to What are the best ways to grow a high volume of grey matter in my brain?Answer by Connie b. Dellobuono:Exercise, training your body to learn new movement, exposing your body in the sun…
Source: What are the best ways to grow a high volume of grey matter in my brain?
My answer to What are the best ways to grow a high volume of grey matter in my brain?
Answer by Connie b. Dellobuono:
Exercise, training your body to learn new movement, exposing your body in the sun (before 10am and after 3pm) with sunscreen, avoiding toxins such as molds, omega 3, fish (wild and not farm), sulfur rich foods (garlic), avocado/walnut/coconut (good fats), massage,sleep,nurturing,pickled veggies (probiotics),avoidance of medications/OTC or prescribed,avoidance of too much alcohol/cigarettes,avoidance of caffeine(more than one cup in the morn only),green tea,parsley,cilantro,red colored veggies and fruits (not overripe),avoidance of toxic fumes/formaldehyde,avoidance of plastics/Endocrine disrupting substances and more.
If I am pregnant and wanted my baby to have high IQ, I will seek care of a midwife,breastfed,massage baby,sleep with them,talk with them in positive ways (not saying NO all the time),nurture them and expose them to environment conducive to learning new things,music and be street smart.
If I am on my 50s, I will love more, be forgiving,get massage every week,nature walks,eat whole foods, do cross fit, learn new dance steps,learn new skills,read more,stay away from toxins such as drugs,alcohol,cigarettes and do cross fit training (strength training).
If I am a teenager, I will not be a vegan but eat whole foods, fish, eggs and hormone free food products, natural form , wild and not farmed, avoiding plastics, sleep well,surround myself wit positive people and influences, learn new skills and travel to see other cultures and learn from them.
What are the best ways to grow a high volume of grey matter in my brain?
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