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What are the side effects of drinking coffee every day?

What are the side effects of drinking coffee every day? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Coffee is a stimulant that creates an imbalance with cortisol hormones (stress hormone). It is better taken (fresh – with less added chemicals) in small cup (one) early morn before exercise. It may interfere with sleep.

What are the side effects of drinking coffee every day?

What are some innovative business catering to senior citizens?

What are some innovative business catering to senior citizens? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Caregiving at home, driving or companion to seniors, senior day care, care home for 6 seniors, cooked meals delivery and other healing ways.
I am looking for partners for a mobile health application that will reduce chronic care monitoring and management – see my blog at http://www.clubalthea.com . Email motherhealth@gmail.com

What are some innovative business catering to senior citizens?

What is the meaning of “Community Aged Care Packages” (CACPs)?

What is the meaning of "Community Aged Care Packages" (CACPs)? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

In Australia:
CACP, EACH and EACH Dementia Statistics Online
Aged care packages in the community 2007-08: a statistical overview presents key statistics on the provision of:
•Community Aged Care Packages (CACP), which provide support service for older people with complex care needs living at home who would otherwise be eligible for admission to low-level residential aged care
•Extended Aged Care at Home (EACH) packages, which aims to deliver care at home that is equivalent to high-level residential aged care, and
•Extended Aged Care at Home (EACH) Dementia packages, which are EACH packages for people who experience behaviours of concern and psychological symptoms associated with dementia. The first EACH Dementia packages were implemented in March 2006.
——
In the USA, based on your income you can ask Dept of Social Services for in home care.
It is usually out of pocket cost that you pay your own private in home care (caregivers) in the USA at rate of $250 or more for 24hr care. Email motherhealth@gmail.com if you need an in home health caregiver in the bay area or USA.

What is the meaning of "Community Aged Care Packages" (CACPs)?

Wife and I moved to another state but what can I do if my mom needs my help?

Wife and I moved to another state but what can I do if my mom needs my help? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

A senior concierge can help http://www.clubalthea.com
Motherhealth@gmail.com
Or hire neighbor as one of the caregivers.
Use delivery service of Whole foods or Safeway.
And Uber drivers as drivers.
But a caregiver who lives nearby can be very important.

Wife and I moved to another state but what can I do if my mom needs my help?

Is it possible to improve brain power and memory?

Is it possible to improve brain power and memory? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

There are many ways to improve brain power. We help grow more neurons when we are learning to dance, play musical instruments, sing or do some sports/exercise. Getting good sleep (calcium, magnesium, melatonin) and de-stressing helps. Brain foods (serotonin and dopamine rich are listed at http://www.clubalthea.com . It is in using our memory each waking moment that we can prevent from losing more of it. Avoidance of toxins, toxic environment and infections with a strong immune system helps.

Is it possible to improve brain power and memory?

Can percumin prevent Parkinson’s disease?

Can percumin prevent Parkinson's disease? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

No one knows what can prevent Parkinson if some of the multifactorial causes include: narcotics, OTC and prescription meds, metal toxins, infection, diabetes, blood pressure, stress, metabolic disorders (lack of probiotics and whole food diet), lack of magnesium and Vit B12, lack of exercise, exposure to toxic fumes, weak immune system and other unknowns.

Can percumin prevent Parkinson's disease?

Can people die sooner from Alzheimer’s or dementia?

Can people die sooner from Alzheimer's or dementia? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

When AD appears before the age of 60, the life span is shorter and for over 65, the person lives a little longer. Since AD is a Type 3 diabetes, the body's insulin and lipid levels are factors to consider. Over medicated seniors in care homes are more affected by AD. Those with good care from family and caregivers (massage, music, exercise, whole foods) live longer.

Can people die sooner from Alzheimer's or dementia?

Does having copper pipes contribute to Alzheimer’s and other diseases?

Does having copper pipes contribute to Alzheimer's and other diseases? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

From http://www.ncbi.nlm.nih.gov/pubmed/19466673
This review reports current knowledge regarding the roles that cadmium (Cd), mercury (Hg), arsenic (As), lead (PB), manganese (Mn), and zinc (Zn) play as endocrine-disrupting chemicals (EDCs). The influence of these metals on the endocrine system, possible mechanisms of action, and consequent health effects were correlated between experimental animals and humans. Analysis of the studies prompted us to identify some critical issues related to this area and showed the need for more rigorous and innovative studies. Consequently, it was recommended that future studies need to: (1) identify the mechanisms of action, because at the present time only a few have been elucidated-in this context, the possible presence of hormesis need to be determined, as currently this was reported only for exposure Cd and As; (2) study the possible additive, synergistic, or antagonistic effects on the endocrine system following exposure to a mixture of metals since there is a lack of these studies available, and in general or occupational environments, humans are simultaneously exposed to different classes of xenobiotics, including metals, but also to organic compounds that might also be EDCs; (3) assess the potential adverse effects on the endocrine system of low-level exposures to metals, as most of the information currently available on EDCs originates from studies in which exposure levels were particularly high; and (4) assess the effects on the endocrine and reproductive systems of other metals that are present in the general and occupational environment that have not yet been evaluated.
——
Do a heavy metal detox. Include cilantro and other whole foods (sulfur rich foods, probiotics).

Does having copper pipes contribute to Alzheimer's and other diseases?

Alzheimer's Disease, a Type 3 Diabetes

Metabolic correction

This approach is based on the prominent aspect of Alzheimer’s disease, which is common for many other neurodegenerative diseases: energy deficit. It has first been noted for the case of insulin insufficiency in the brain of Alzheimer’s patients. Because of that Alzheimer’s disease has been called “Type 3 diabetes” [14] and the insulin modification therapies are in pharmaceutical’s pipelines.

Angiotensin receptor blockers

A retrospective analysis of five million patient records with the US Department of Veterans Affairs system found that different types of commonly used anti-hypertensive medications had very different AD outcomes. Those patients taking angiotensin receptor blockers (ARBs) were 35—40% less likely to develop AD than those using other anti-hypertensives.[17]

Antibiotic therapy

Only one clinical trial is being done (at McMaster University) to investigate the efficacy of antibiotic therapy.[18] The authors of the study indicated that it was effective in delaying the progress of the disease: “In conclusion, a 3-month course of doxycycline and rifampin reduced cognitive worsening at 6 months of follow-up in patients with mild to moderate AD.”[19] A re-examination of the same data using: “…AUC analysis of the pooled index showed significant treatment effect over the 12-month period”.[20]

Several studies using minocycline and doxycycline, in an animal model of Alzheimer’s Disease, have indicated that minocycline[21][22] and doxycycline[23][24] exerts a protective effect in preventing neuron death and slowing the onset of the disease.

Antiviral therapy

The possibility that AD could be treated with antiviral medication is suggested by a study showing colocation of herpes simplex virus with amyloid plaques.[25]

Cannabinoids

The endocannabinoid system may have a role in AD.[26][27] For instance, THC, one of the active ingredients in marijuana, has been show to reduce amyloid beta plaque formation through inhibition of acetylcholinesterase (AChE).[28

Biomarkers

From gene expression patterns obtained in microarray datasets, correlation between cellular physiology and diseases can be revealed. Divergence studies (e.g. Jensen-Shannon divergence computations which interprets difference in gene expression and probability of distribution patterns) reveals gene expression distribution difference between AD and normal aging brains.[80] That is, expressed genes that are negatively correlated with normal aging brain but are positively correlated with AD brains are possible biomarkers for AD diagnosis and treatment. Combining KEGG and PATHWAY studio, ATP5C1, COX6A1, NDUFV2, PLCB1, and PPP3CA are metabolism and mitochondrial-related genes that have been shown to be reduced in AD samples.[81][82][83] Furthermore, metabolic dysregulations such as calcium homeostasis [84] and insulin signaling have also been identified to contribute to the onset of AD. Genes that are associated with calcium and insulin signaling are found using GATHER (online bioinformatics tool for analyzing genomic signatures).[80] In fact, insulin signaling impairment and AD has been considered to be related in many levels. Functional protein sequence alignments (e.g. ClustalW, MUSCLE) and phylogenetic analysis (e.g. Phylip, Mega) demonstrate that acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are highly linked in these two diseases.[85] Increased BChE contributes altered lipoprotein metabolism and insulin insensitivity,[86] and is positively correlated to hypertension and diabetes in correlation studies.[87] AChE allows stabilization of neurotransmitter, acetylcholine (ACh), which is one of the main target for AD treatment. However, recent in silico pharmacological study examined drug-disease interaction showed that AChE inhibitors may not be the answer to AD treatment. PKC, ARG, HDAC, and GSK3 inhibitors that regulate calcium homeostasis and genetic modification of cell cycle and apoptosis may be the future targets of AD medication.[88]

Neuronal plasticity is a key player in cognitive function that cannot be ignored in study of AD progression. Microarray studies found that NEFM, NEFL, and SV2B are highly downregulated in samples obtained from severe AD patients. NEFL is a neurofilament gene that has been shown to be related to hypotrophy of axons in motorneurons when mutated.[89] However, both neurofilaments (NEFL and NEFM) have been documented to be involved in neurological disease, Charcot-Marie-Tooth,[90][91] instead of AD, which demonstrate possible unknown connections of AD to other neurological diseases. SV2B is another gene that is downregulated in AD and has been shown to be related to neurodegeneration, particularly synaptic calcium-regulated exocytosis.[92] The downregulation of genes responsible for neural synapse and neuroplasticity is related to another family of protein that has been found to be related to AD pathogenesis, EGR (early growth response).[93] This EGR is regulated by upregulated FOXO1 (Forkhead Box O1) through PI3K/Akt pathway,[94] which is listed as one of the pathway for future in anti-AD medication.[88] These findings using computational methods allow for the connection of different studies and facilitate the understanding of disease complexity as well as directing to new possible biomarkers of AD.


Comments:

Can exercise, Vit D from the sun, sleep, massage to destress and whole foods prevent Alzheimer?

Most drug companies halted their drug development to treat Alzheimer.

Recent studies point to our aging as related to how our mother’s aged.

Are toxins such as copper and other prescriptions contribute to Alzheimer?

How are these healing ways affecting the slow progression of Alzheimer ( massage, whole foods, sleep, exercise, social interaction and care)?

Can in home caregiver (24/7 care) slow the progression of Alzheimer?

 

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Why can smoking lead to hypertension and atherosclerosis?

Why can smoking lead to hypertension and atherosclerosis? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

From Wiki:
Adrenal medulla
Effect of nicotine on chromaffin cells.
By binding to ganglion type nicotinic receptors in the adrenal medulla, nicotine increases flow of adrenaline (epinephrine), a stimulating hormone and neurotransmitter. By binding to the receptors, it causes cell depolarization and an influx of calcium through voltage-gated calcium channels. Calcium triggers the exocytosis of chromaffin granules and thus the release of epinephrine (and norepinephrine) into the bloodstream. The release of epinephrine (adrenaline) causes an increase in heart rate, blood pressure and respiration, as well as higher blood glucose levels.[

Why can smoking lead to hypertension and atherosclerosis?

Can physical pain be useful in the long run?

Can physical pain be useful in the long run? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

A laboring mother endures pain delivering her baby naturally without medications for healthy reasons. Our body has our own pain killers. The effect is a natural process of healing for mothers and babies.

Can physical pain be useful in the long run?

Is there any scientific evidence that scalp massages increase hair growth?

Is there any scientific evidence that scalp massages increase hair growth? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Massage helps our cells grow. I massage from children whenever they are sick. A 90 yr old Alzheimer's client is being massaged in her head by her daughter daily. She still eats and smiles often even when her body is already rigid, cannot be moved without the help of caregivers 24/7 in a care home. Our hair falls due to stress. Massage is a great stress reliever. For hair nutrient, eat raw (hormone free) eggs which are rich in Biotin.

Is there any scientific evidence that scalp massages increase hair growth?