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What causes debilitating cramps? by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
Lack of magnesium, calcium and Vitamin C. I will detox with lemon water, red colored fruits and veggies, pickled veggies (prebiotic like raw garlic and raw carrots) and acidophilus. Reduce stress with Vitamin B complex and herbs (ginger, turmeric,rosemary,thyme).
Can PCOS be fully treated without western medicine? by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
PCOS is multifactorial in causes. Can you effect a change for what is innate? We can detox from plastics or EDCs by how much if we are exposed to it inside our mother’s womb. I have seen some lab results when I was a nutritionist for women who undergo hysterectomies. And the presence of many microbes suggest a probiotic/prebiotic regimen of whole foods, raw garlic and raw carrots and many other dietary supplementations.
Reprod Sci. 2016 Jun 23. pii: 1933719116654992. [Epub ahead of print]
Prenatal Exposure to Endocrine Disruptors: A Developmental Etiology for Polycystic Ovary Syndrome.
Hewlett M1, Chow E1, Aschengrau A2, Mahalingaiah S3.
Polycystic ovary syndrome (PCOS) is one of the most common and complex endocrinopathies among reproductive-age women. Polycystic ovary syndrome is characterized by symptomatology of oligomenorrhea and androgen excess, with or without presence of polycystic ovarian morphology. The etiology of PCOS is multifactorial, including genetic and environmental components. It has been previously established that prenatal androgen exposure results in a PCOS phenotype in experimental animal models and epidemiologic human studies. Investigators hypothesize that prenatal exposure to endocrine-disrupting chemicals (EDCs) may contribute to PCOS development. This review examines the emerging research investigating prenatal exposure to 3 major classes of EDCs-bisphenol A (BPA), phthalates, and androgenic EDCs-and the development of PCOS and/or PCOS-related abnormalities in humans and animal models. Highlights of this review are as follows: (1) In rodent studies, maternal BPA exposure alters postnatal development and sexual maturation;, (2) gestational exposure to dibutyl phthalate and di(2-ethylhexyl)phthalate results in polycystic ovaries and a hormonal profile similar to PCOS; and (3) androgenic EDCs, nicotine and 3,4,4′-trichlorocarbanilide, create a hyperandrogenic fetal environment and may pose a potential concern. In summary, prenatal exposure to EDCs may contribute to the altered fetal programming hypothesis and explain the significant variability in severity and presentation.
Data is lacking on the association of interpersonal stressors and social isolation with mental disorders and the mediating role of loneliness. Thus, we examined this association prospectively using community-based data.
Data on 6105 adults aged ≥50 years from the Irish Longitudinal Study on Ageing (TILDA) was analyzed. Mental health outcomes were assessed 2 years after baseline. Depressive and anxiety symptoms were evaluated with validated scales. Multivariable linear regression and mediation analyses were conducted.
Higher levels of spousal support, less strain from spouse and better social network integration were protective against depressive symptoms in men. Social support from friends and children was protective against depressive symptoms in both genders. Higher levels of social strain from children were positively associated with depressive symptoms in women. Loneliness was a significant mediator in the majority of these associations.
Santini ZI1, Fiori KL2, Feeney J3, Tyrovolas S4, Haro JM4, Koyanagi A4.
Nicole K Valtorta, Department of Health Sciences, University of York, Heslington, York YO10 5DD, UK; nicole.valtorta@york.ac.uk Background The influence of social relationships on morbidity is wid…
Source: Loneliness or social isolation increases risk of stroke/CHD
Nicole K Valtorta, Department of Health Sciences, University of York, Heslington, York YO10 5DD, UK; nicole.valtorta@york.ac.uk
Methods Sixteen electronic databases were systematically searched for longitudinal studies set in high-income countries and published up until May 2015. Two independent reviewers screened studies for inclusion and extracted data. We assessed quality using a component approach and pooled data for analysis using random effects models.
Results Of the 35 925 records retrieved, 23 papers met inclusion criteria for the narrative review. They reported data from 16 longitudinal datasets, for a total of 4628 CHD and 3002 stroke events recorded over follow-up periods ranging from 3 to 21 years. Reports of 11 CHD studies and 8 stroke studies provided data suitable for meta-analysis. Poor social relationships were associated with a 29% increase in risk of incident CHD (pooled relative risk: 1.29, 95% CI 1.04 to 1.59) and a 32% increase in risk of stroke (pooled relative risk: 1.32, 95% CI 1.04 to 1.68). Subgroup analyses did not identify any differences by gender.
Conclusions Our findings suggest that deficiencies in social relationships are associated with an increased risk of developing CHD and stroke.
Recent studies report that diet can mediate the vasculoplastic reserve of the hippocampus. For example, consuming high levels of cocoa flavanols increased capillary density and enhanced dentate gyr…
Recent studies report that diet can mediate the vasculoplastic reserve of the hippocampus. For example, consuming high levels of cocoa flavanols increased capillary density and enhanced dentate gyrus-associated cognitive function in cognitively normal healthy subjects. This suggests an interaction between vasculoplasticity and neuronal plasticity during normal aging and dementia, but how this relationship is affected by lifestyle and vascular risk factors is currently unclear and should be investigated in future studies.
Growing evidence supports the benefits of a Mediterranean diet in protecting against dementia and prolonging one’s cognitive reserve during aging. Age-related cognitive decline was attenuated in individuals consuming a Mediterranean diet, as found in a recent study of the Mediterranean-Dietary Approach to Systolic Hypertension (DASH)
Diet intervention for neurodegenerative delay. In comparing Mediterranean and Western diets, the primary difference is the source and proportion of dietary fats, with olive oil specifically being the main fat consumed in the Mediterranean diet and high levels of saturated fatty acids and simple carbohydrates being consumed in Western diets. Microvascular dysfunction is evident in rodent models fed unhealthy diets, namely, those fed diets of Western culture [219], high fat [220], and high cholesterol [221]. An intact BBB is needed for proper cholesterol metabolism. In CSF, decreased cholesterol levels correlate with decreased Aβ42 and increased CSF APPα and APPβ (products of APP processing) levels, supporting an association between disrupted cholesterol metabolism and increased amyloidogenesis.
Resveratrol is a biologically active plant-derived phytoalexin. Resveratrol has been shown to cross BBB and regulate expression of MMPs, reduce pericyte loss, maintain integrity of BBB, and promote Aβ clearance. Treatment with resveratrol completely reversed diabetes-induced vascular dysfunction by reducing capillary leakage, pericyte degeneration, and VEGF protein expression in the murine retina. An earlier study has shown that resveratrol inhibits RAGE expression in vascular cells , which is implicated in Aβ transport into the brain and accelerated Aβ pathology in a mousemodel].
Furthermore, long-term consumption of resveratrol reduced oxidative stress and prevented behavioral deficits in a rat model with disrupted NVU.
Olive oil is high in essential omega-3 fatty acids, the major component of which is docosahexaenoic acid (DHA), and has long been reported to benefit cognition and overall brain health.
DHA cannot be synthesized by the body and thus must be consumed, and the primary transporter of DHA from blood-to-brain is the major facilitator superfamily domain containing 2A (MFSD2A) at the BBB. Individuals with AD have lower CSF DHA lipid levels, and those with mild dementia have lower CSF α-liolenic acid levels. Interestingly, reduced MFSD2A expression at the BBB can lead to a loss of its important functions, including maintenance of BBB integrity and omega-3 fatty acid transport into the brain.
Transgenic APOE4 mice also exhibit reduced uptake of DHA into the brain compared with transgenic APOE2 mice, but whether this is related to reduced Mfsd2a expression is currently unknown. Additional studies are needed elucidate the underlying mechanisms of MFSD2A and fatty acids in relation to dementia and AD.
Regular exercise and physical activity, particularly during midlife, are associated with improved cerebrovascular function and reduced rates of dementia and AD [236]. Individuals that exercised regularly for 28 days exhibited reduced plasma homocysteine levels and increased endothelial progenitor cells in peripheral blood, factors that protect against vascular damage and cognitive impairment .
Experimental studies in diabetic rats have shown that treadmill exercise maintains claudin-5 expression at the BBB compared to rats not receiving exercise.
Physical activity and cognitive stimulation in the form of enriched environment (e.g., tunnels, balls, ladders, and running wheel) accelerated Aβ enzymatic degradation and enhanced transvascular Aβ clearance, reducing Aβ accumulation in brains of AD transgenic mouse models.
Additionally, physical activity promoted Aβ clearance from brain to blood via upregulation of LRP1 and downregulation of RAGE at the BBB. Mice without access to a running wheel had decreased occludin tight junction levels and disrupted BBB integrity.
Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced naturally by several plants in response to injury or when the plant is under attack by pathogens such as bacteria or fungi. Food sources of resveratrol include the skin of grapes, blueberries, raspberries, mulberries, and senna.
Here are 5 foods that are great sources of resveratrol:
Grapes don’t have to be fermented to contain this antioxidant. It’s actually found in the skin of red grapes along with other nutrients, such as minerals manganese and potassium and vitamins K, C and B1.
Peanut butter is great for dressing up apples and celery, but it also contains some resveratrol (up to .13 mg per cup). Peanut butter is a great source of niacin and manganese.
In dark chocolate, resveratrol blends nicely with other antioxidants and also minerals, such as iron, copper and manganese. Who doesn’t like chocolate?
Used in Japan and China as a traditional herbal remedy for the prevention of heart disease and strokes, itadori tea: contains resveratrol, consequently, The Journal of Agricultural Food Chemistry studies state that, ”For people who do not consume alcohol, Itadori tea may be a suitable substitute for red wine.”
Blueberries don’t have quite as much resveratrol as grapes, but they are also a great source of other antioxidants, dietary fiber, vitamins C and K and manganese.
For all of the above, it would be wise to choose organic sources to reduce pesticides, especially for red grapes, peanut butter and chocolate.
Low doses of resveratrol improve cell survival as a component of cardio- and neuro-protection, while high doses increase cell death, so this is always something to keep in mind before purchasing supplements with the next greatest dose.
“Reports on the benefits of red wine are almost two centuries old,” said Lindsay Brown, associate professor in the School of Biomedical Sciences at The University of Queensland
* Resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection.
“It sounds contradictory that a single compound can benefit the heart by preventing damage to cells, yet prevent cancer by causing cell death, said Brown. “The most likely explanation for this, still to be rigorously proved in many organs, is that low concentrations activate survival mechanisms of cells while high concentrations turn on the in-built death signals in these cells.”
* Resveratrol may aid in the prevention of age-related disorders, such as neurodegenerative diseases, inflammation, diabetes, and cardiovascular disease.
“The simplest explanation is that resveratrol turns on the cell’s own survival pathways, preventing damage to individual cells,” said Brown. “Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells.”
* Low doses of resveratrol improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death.
“The key difference is probably the result of activation of the sirtuins in the nucleus,” said Brown. “Low activation reverses age-associated changes, while high activation increases the process of apoptosis or programmed cell death to remove cellular debris. Similar changes are seen with low-dose versus high-dose resveratrol: low-dose resveratrol produces cellular protection and reduces damage, while high-dose resveratrol prevents cancers.”
Source:
Amy R. Nelson, Melanie D. Sweeney, Abhay P. Sagare, Berislav V. Zlokovic
Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
Here are some of the ways employers can help their workforce to be healthy: provide healthy lunch meals, Vit C supplements and drinks, free 15min back massage, free trips to nature walks (Bus tours…
Here are some of the ways employers can help their workforce to be healthy: provide healthy lunch meals, Vit C supplements and drinks, free 15min back massage, free trips to nature walks (Bus tours with family during weekends), ergonomic standing desks and chairs, rewards for enrolling in healthy gym classes (cross fits, aerobics, yoga, dance lessons), rewards for losing extra weights, a grocery bag of farmer’s market veggies (once a month or week), affordable housing, free college, $15min wage per hr, access to family planning or planned parenthood, rewards for 2-child per household and subsidized day care in or near work location.
Connie Dello Buono
Not all Americans have access to the benefits of modern medicine. In fact, access to health care has seriously eroded over the last seven years. In 2006, 47 million people were uninsured, an increase of 8.6 million from 2000.7 The Institute of Medicine (IOM) has concluded that the most important determinant of access to health care is adequate health insurance coverage.
workers.9 Only 22 percent of adults under age 65 in families with incomes of $20,000 or less had coverage through an employer in 2006, down from 29 percent in 2000.
Employer-based coverage in the next higher income category—under $37,800 annually—declined from 62 percent in 2000 to 53 percent in 2006.
Failure to provide health insurance to all has a price—to both the health of Americans and to our economy. The IOM estimated that 18,000 deaths of adults ages 25 to 54 in 1999 occurred as a direct consequence of being uninsured.10 A more recent update of that study by Stan Dorn at the Urban Institute puts the toll in 2004 at 20,000 deaths, making it the fifth leading cause of death in the U.S. for working age adults.11
The IOM projected that the aggregate, annualized cost of uninsured people’s lost capital and earnings from poor health and shorter life spans falls between $65 billion and $130 billion for each year without coverage.
High Performance Health System National Scorecard found that 63 percent of insured children had preventive visits in 2003, compared with 35 percent of uninsured children.
Investing in children’s health by ensuring access to care and insisting on high standards of care, such as regular screening for developmental and behavioral delays in young children, is important to detecting conditions early and helping children reach school age ready to learn.
Gaps in health insurance coverage and financial barriers to care are the most important reason children and adults fail to receive preventive care. But even insured adults and Medicare beneficiaries often fail to receive beneficial care. Less than half of
American adults age 50 and older are up to date with preventive care; the percent ranges from 50 percent in Minnesota to 33 percent in Idaho.16 If all states reached the levels achieved among the top-ranked states, almost 9 million more older adults would receive recommended preventive care. Control of chronic conditions also varies from state to state. If all states performed at the rate of the best states, almost 4 million more diabetics would receive care to help prevent disease complications. Ensuring that all Americans receive care from a regular source of care that is accountable for ensuring that patients receive all appropriate preventive care and care of chronic conditions would improve health and productivity, as well as reduce disparities in care.
In short, we often fail to realize the benefits of the best of American medicine.
Quality of care is highly variable across geographic regions and across different populations.
Currently, health spending in the U.S. is predicted to increase from $2 trillion to more than $4 trillion over the next 10 years, and to consume one of every five dollars of national income, as increases outpace income growth by a wide margin. According to the report’s estimates, it is possible to curb health care spending by $1.5 trillion over the next 10 years, and to simultaneously enhance the overall performance of the health care system.
The sooner policy changes addressed at reducing spending are enacted, the greater the cumulative savings for families, businesses, and public health insurance programs. In fact, even modest changes can quickly add up to billions of dollars.
However, in order to see real savings and higher value, policies must address overall health system costs and not simply shift cost from one part of the system to another.
Examples of Savings Over 10 Years:
With an initial increase in investment, $88 billion could be saved by accelerating health care providers’ adoption of health information technology to allow them to share patient health information with other providers involved in the patient’s care.
Investing in the knowledge needed to improve health care decision-making; incorporating information about relative clinical and cost effectiveness into insurance benefit design; and including incentives for providers, payers and consumers to use this information could save an estimated $368 billion over 10 years.
Increasing federal taxes on sugared soft drinks by one cent per 12-ounce drink, with revenues to support national and state obesity programs, could yield an estimated $283 billion savings over 10 years.
A “medical home” approach, including improving Medicare reimbursements to primary care physician practices to support enhanced primary care services such as care coordination, chronic care management, and easy access to care, could result in net health system savings of $194 billion over 10 years if all Medicare fee-for-service beneficiaries were enrolled. Estimated national savings would be larger if this approach were adopted by all payers.
Click to access senate_testimony_davis_03122008.pdf
Join Motherhealth in coming out soon mobile health application that will reduce health care costs where:
Email motherhealth@gmail.com to participate in the app to promote Health IT (web and mobile app).
What is the best way to prevent maternal death in childbirth? by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
Prenatal exam monthly with a nurse midwife or OB/doctor. Whole foods, positive and loving relationships, clean water/air and whole foods, avoidance of infection/strong immune system, one mile nature walk a day and a belief in the power of women to birth a healthy child with supporting environment.
What is the best way to prevent maternal death in childbirth?
Can the mind reject itself in the style of an immune disorder? by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
The mind is the brain in action. The brain gravitate towards a healthy state during sleep, in absence of toxins, in presence of whole foods, of positive emotions in the person and around her/him and other factors that contribute to a strong immune system.
Can the mind reject itself in the style of an immune disorder?
Why hasn't anything much changed about pregnancy? Particularly, why do women still carry th… by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
We know now that emotions of mothers affect the growing fetus. The spiritual and positive energy of parents during pregnancy, birth and first years of the child influence brain growth. Each cell in the newborn is affected by bonding and massage from both parents. We also know now that not only maternal but paternal genes can influence a child to have predisposition to mental health issues when the father is older and alcoholic while the mother is younger. And we also know now the effects of toxins before conception, during pregnancy and we can avoid stillbirth and other prenatal and postnatal health issues for the baby by avoiding medications (prescribed or OTC) before and during pregnancy.
A clinic in London, has this team goal for recovery plan:
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