Photo post by @momdancer40.
When math algo takes a stand in court
Stretching at work
Stretching at work
Pomegranates, red rspberries, strawberries and walnuts anti-aging molecule
Your gut bacteria and molecule in pomegranates , oak-aged red wine, red raspberries, strawberries and walnuts have anti-aging properties (anti Alzheimer’s and anti Parkinson’s). Urolith…
Source: Pomegranates, red rspberries, strawberries and walnuts anti-aging molecule
Pomegranates, red raspberries, strawberries and walnuts anti-aging molecule
Your gut bacteria and molecule in pomegranates , oak-aged red wine, red raspberries, strawberries and walnuts have anti-aging properties (anti Alzheimer’s and anti Parkinson’s).
Urolithins are microflora human metabolites of dietary ellagic acid derivatives[1] such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate,[2] strawberries, red raspberries, walnuts or oak-aged red wine.[3]
During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans.[2][4] Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice,[5] leading to clinical studies of pomegranate juice or fruit extracts for efficacy against several diseases.
Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites. Urolithins are found in plasma mostly as glucuronides at low concentrations.[6]
Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella.[7]
30-min cross fit workout every day
I vow to do a 30-min cross fit workout every day so I joined and I completed my first 30min cross fit with coach Alex today. 4 rounds of 1min runs, squat and crunch and here are the results 1 min r…
Free health coach
Motivation is key in fitness
In group fitness and having a fitness coach, we are motivated to reach our fitness goals. What is your fitness goal. My GF last night had so many questions about her statins, mucle aches, diet, weight loss goals and more. In chatting with her, I was able to share my experience and research by others. So reach out to a health coach, fitness coach or a wellness buddy.
Free health coach
I give free health coaching in the bay area in return for:
-trying out NC.FIT for a month, 30-min of cross-fit workout with fitness coach 11:30am and 4:30am in the gym (mention Connie Dello Buono when joining) ; applicable to other gyms
– phone health coaching with me
– complete survey on Mobile Health Outpatient application (in development) , email motherhealth@gmail.com for survey copy
Gym with gym coach free in group setting
Fitness goal: I vow to do a 30-min cross fit workout every day so I joined http://nc.fit/ and I completed my first 30min cross fit with coaches, Alex, Brandon and Kory. I invite you to join, do mention my name. It is worth it, you get your energy back and at NC Fit you always have a coach (in team setting) to help you optimize the correct way of exercising at NC FIT in California –> http://nc.fit/
4 rounds of 1min runs, squat and crunch and here are the results
1 min runs: 11,12,12,11
1 min squat: 13,16,16,17 (Legs wide and outward)
1 min crunch: 9,9,9,9
And I started and warmed up with rowing and bike. You can do it too. I also will avoid overripe bananas and other fruits and consume more citrus.
Your voice in the health mobile app
Dear Readers, Please complete the survey above by clicking on anyone of the images. This will help us create a mobile health app that will help you and others reduce cost in chronic health care mon…
Your voice in the health mobile app
Inhaled soil bacteria causes AD/brain disease
Melioidosis is an infectious disease caused by a gram-negative bacterium, Burkholderia pseudomallei, found in soil and water. It is of public health importance in endemic areas, particularly in Thailand and northern Australia. It exists in acute and chronic forms. Signs and symptoms may include pain in chest, bones, or joints; cough; skin infections, lung nodules and pneumonia.
B. pseudomallei was previously classed as part of the Pseudomonas genus and until 1992, it was known as Pseudomonas pseudomallei. It is phylogenetically related closely to Burkholderia mallei which causes glanders, an infection primarily of horses, donkeys, and mules. The name melioidosis is derived from the Greek melis (μηλις) meaning “a distemper of asses” with the suffixes -oid meaning “similar to” and -osis meaning “a condition”, that is, a condition similar to glanders.[1]
This bacteria from the soil can be inhaled and travels from the nose to the brain. Seek a doctor for an antibiotic treatment when sympoms occur: fever, cough
Acute melioidosis
In the subgroup of patients where an inoculating event was noted, the mean incubation period of acute melioidosis was 9 days (range 1–21 days).[2] Patients with latent melioidosis may be symptom-free for decades; the longest period between presumed exposure and clinical presentation is 62 years.[3] The potential for prolonged incubation was recognized in US servicemen involved in the Vietnam War, and was referred to as the “Vietnam time-bomb”. A wide spectrum of severity exists; in chronic presentations, symptoms may last months, but fulminant infection, particularly associated with near-drowning, may present with severe symptoms over hours.
A patient with active melioidosis usually presents with fever. Pain or other symptoms may be suggestive of a clinical focus, which is found in around 75% of patients. Such symptoms include cough or pleuritic chest pain suggestive of pneumonia, bone or joint pain suggestive of osteomyelitis or septic arthritis, or cellulitis. Intra-abdominal infection (including liver and/or splenic abscesses, or prostatic abscesses) do not usually present with focal pain, and imaging of these organs using ultrasound or CT should be performed routinely. In one series of 214 patients, 27.6% had abscesses in the liver or spleen (95% confidence interval, 22.0% to 33.9%). B. pseudomallei abscesses may have a characteristic “honeycomb” or “swiss cheese” architecture (hypoechoic, multiseptate, multiloculate) on CT.[4][5]
Regional variations in disease presentation are seen: parotid abscesses characteristically occur in Thai children, but this presentation has only been described once in Australia.[6] Conversely, prostatic abscesses are found in up to 20% of Australian males, but are rarely described elsewhere. An encephalomyelitis syndrome is recognised in northern Australia.
Patients with melioidosis usually have risk factors for disease, such as diabetes, thalassemia, hazardous alcohol use, or renal disease, and frequently give a history of occupational or recreational exposure to mud or pooled surface water.[7] However, otherwise healthy patients, including children, may also get melioidosis.
Do not eat over ripe bananas
What would be the effects of naturally high dopamine levels (not due to drugs)?
What would be the effects of naturally high dopamine levels (not due to drugs)? by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
High levels of dopamine lead to high levels of motor activity, more sexual arousal and less prolactin (pituitary hormones = sex, food cravings, sleep, stress mgt).
Dopamine inhibits prolactin which is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation and nursing. Prolactin stimulates cells responsible for the formation of myelin coatings on axons in the CNS. When there is less myelin coatings, neurons could not connect to another neurons.
What would be the effects of naturally high dopamine levels (not due to drugs)?
Does Dopamine Beta-Hydroxylase Deficiency increase risks of Parkinson’s?
Does Dopamine Beta-Hydroxylase Deficiency increase risks of Parkinson's? by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
DBS is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla.
https://en.wikipedia.org/wiki/Dopamine_beta-hydroxylaseYes.
1. Reduced levels of CSF amyloid beta 1-42 were associated with more rapid cognitive decline in Lewy body dementia patients. Future prospective studies should include larger samples, centralized CSF analyses, longer follow-up, and biomarker-pathology correlation. © 2016 International Parkinson and Movement Disorder Society.2. A staged pipeline, starting from our previous proteomic profiling followed by high-throughput targeted mass spectrometry (MS), to identify peptides in human cerebrospinal fluid (CSF) for PD diagnosis and disease severity correlation
A panel of five peptides (derived from SPP1, LRP1, CSF1R, EPHA4, and TIMP1) was identified to provide an area under curve (AUC) of 0.873 (sensitivity = 76.7%, specificity = 80.0%) for PD versus healthy controls in the training set. The performance was essentially confirmed in the validation set (AUC = 0.853, sensitivity = 82.5%, specificity = 82.5%). Additionally, this panel could also differentiate the PD and AD groups (AUC = 0.990, sensitivity = 95.0%, specificity = 97.4%). Furthermore, a combination of two peptides belonging to proteins TIMP1 and APLP1 significantly correlated with disease severity as determined by the Unified Parkinson's Disease Rating Scale motor scores.
http://www.ncbi.nlm.nih.gov/pubmed/255562333.In Parkinson's disease, cerebrospinal fluid dopamine beta-hydroxylase was markedly diminished (16.3 +/- 2.9 versus 31.3 +/- 1.4 ng/ml, P < 0.001) and rose by 58 +/- 21% (P = 0.02) after adrenal-to-caudate chromaffin cell autografts. In congenital dopamine beta-hydroxylase deficiency, lack of detectable dopamine beta-hydroxylase immunoreactivity in cerebrospinal fluid or plasma suggests absent enzyme (rather than a catalytically defective enzyme) as the origin of the disorder.
http://www.ncbi.nlm.nih.gov/pubmed/25556233
Does Dopamine Beta-Hydroxylase Deficiency increase risks of Parkinson's?