Heartburn Drugs in Pregnancy Tied to Asthma in Babies

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Taking heartburn medicines during pregnancy may increase the risk for asthma in the baby, a review of studies has found.

The analysis, in the Journal of Allergy and Clinical Immunology, combined data from eight studies that included more than 1.6 million patients. Follow-up ranged from five to 14 years.

Researchers found that H2 blockers, such as Pepcid or Tagamet, were associated with a 46 percent increased risk for childhood asthma. Taking proton pump inhibitors, such as Prilosec or Nexium, was linked to a 30 percent increase in risk. There was also some data suggesting an increased risk for skin allergies.

The reason for the connection is unclear, but animal studies suggest the drugs may interfere with digestion, leaving undigested food allergens that are then passed on to the fetus.

None of the studies accounted for all of the many factors that may influence asthma onset, and the authors acknowledge that no causal connection can be proven.

“Gastric reflux is common in pregnancy,” said the lead author, Dr. Aziz Sheikh, a professor of primary care at the University of Edinburgh, “and in the majority of women, it can be managed with lifestyle or diet changes.”

Where medicine is required, he said, “Milder treatments like chewable antacid tablets are the preferred option.”


  1. Taking Fish Oil During Pregnancy Is Found to Lower Child’s Asthma Risk

  2. Heartburn Drugs Tied to Dementia Risk

    Heartburn Drugs Tied to Kidney Problems

No grains, dairy, processed foods and sugars for active Crohn’s disease and ulcerative colitis

In a first-of-its-kind study published today in the Journal of Clinical Gastroenterology, researchers from Seattle Children’s and Children’s Healthcare of Atlanta, led by Dr. David Suskind, a Seattle Children’s gastroenterologist, found that diet alone can bring pediatric patients with active Crohn’s disease and ulcerative colitis (UC) into clinical remission.

In the small, prospective study, patients were put on a special diet called the specific carbohydrate diet (SCD) for 12 weeks as the sole intervention to treat their active Crohn’s or UC. SCD is a nutritionally balanced diet that removes grains, dairy, processed foods and sugars, except for honey. The diet promotes only natural, nutrient-rich foods, which includes vegetables, fruits, meats and nuts.

At the end of the 12 weeks, eight out of the 10 patients who finished the study showed significant improvement and achieved remission from the dietary treatment alone.

“This changes the paradigm for how we may choose to treat children with inflammatory bowel disease,” said Suskind.

To date, there have only been a few case reports where a whole food diet, like SCD, has been used as a potential treatment for inflammatory bowel disease (IBD). This study is the first to show, not just anecdotally, that the diet is safe and effective in treating pediatric patients with IBD.

IBD refers to several related illnesses that affect the digestive tract. Crohn’s and UC are two forms of IBD.

“For decades or longer, medicine has said diet doesn’t matter, that it doesn’t impact disease,” said Suskind. “Now we know that diet does have an impact, a strong impact. It works, and now there’s evidence that it can move patients into remission.”

At most centers across the country, treatment for IBD is usually limited to either treating patients with medications or steroids, which can often lead to life-long side effects. Another concern with these traditional treatments is that they only suppress the immune system, which doesn’t treat the underlying issue of the microbiome, the bacteria that lives in the digestive tract. Researchers believe that IBD occurs when something goes awry between a person’s genetic makeup, their immune system and their microbiome.

“Each person’s disease is unique, just as each person is unique,” said Suskind. “SCD is another tool in our tool box to help treat these patients. It may not be the best treatment option for everyone, but it is an effective treatment for those who wish to try a dietary therapy.”

Traumatic Head Injuries Should Be Treated By Cooling The Patients

Summary: Therapeutic hypothermia following a TBI significantly improves survival rate, a new study reports.

Source: Royal Holloway.

New research from Royal Holloway published today in Critical Care Medicine shows that lowering the body temperature of people who have suffered a traumatic brain injury (TBI) as soon as possible after the trauma may significantly improve chances of survival in adults.

Therapeutic Hypothermia (TH) involves reducing the body temperature of a person to protect neurons from being killed off or damaged. Neurons are part of the central nervous system and carry signals to and from the brain.

Protecting neurons

Researchers from Royal Holloway, Ashford and St Peters Hospital, and Imperial College London looked at how successful Therapeutic Hypothermia is and found that adults subjected to medically induced hypothermia are significantly less likely to die or suffer serious cognitive impairment due to damaged neurons.

“Lowering the body temperature to treat people with TBI is a controversial treatment, but one that our latest research has shown to reduce deaths and long-term injury,” said Professor Pankaj Sharma, Director of the Institute of Cardiovascular Research at Royal Holloway. “We have undertaken the largest such analysis of data on the use of therapeutic hypothermia and have found that patients have an 18% better chance of surviving and a 35% improvement in neurological outcome if they are given this treatment.”

TBIs: a world-wide problem

The World Health Organisation has predicted that traumatic brain injury (TBI) will become a major cause of death and disability across the world. TBIs can be caused by many things, including car accidents, but most are caused by falls. Currently there are around 5 million people in the US and 7.7 million people in Europe living with a TBI-related injury. Around 50% of those affected are unable to return to work, costing the economy $56 billion annually in the US alone.

American Football has recently come under the spotlight after research suggested that 40 percent of NFL players have suffered a TBI.

Good for adults, bad for children

Researchers looked at around 3,100 cases of TBI in adults and around 450 cases in children. They found that cooling the brain to a temperature of 33c for 72 hours, and then allowing the patient to return to their normal temperature of 37c at their natural speed is the most effective treatment.

Image shows a brain in blue and pink.

“Whilst cooling adults is effective at providing the best possible outcome, cooling children instead can prove fatal. In children between the ages of 3 months and 18 years, cooling provoked a 66% increase in mortality,” said Professor Sharma.

“This research has far-reaching implications in medicine, potentially affecting the treatment of millions of patients world-wide. We hope that the results of this study encourage medical practitioners to consider the use of this method to enable people who suffer these injuries to live fuller, longer lives.”

ABOUT THIS NEUROLOGY RESEARCH ARTICLE

This research was conducted by Ellie Crompton, who graduated in Biology earlier this year, Dr Ioana Cotlarciuc, Dr Thang S. Han, and Professor Pankaj Sharma, all from the Institute of Cardiovascular Research in the School of Biological Sciences at Royal Holloway. They also worked with Irina Lubomirova (MBBS) from Imperial College London.

Source: Royal Holloway
Image Source: NeuroscienceNews.com image is credited to Royal Holloway.
Original Research: Abstract for “Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients” by Crompton, Ellie M. BSc; Lubomirova, Irina MBBS; Cotlarciuc, Ioana PhD; Han, Thang S. PhD; Sharma, Sapna D. MD; and Sharma, Pankaj PhD in Critical Care Medicine. Published online December 9 2016 doi:10.1097/CCM.0000000000002205


Abstract

Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients

Objective: Therapeutic hypothermia has been used to attenuate the effects of traumatic brain injuries. However, the required degree of hypothermia, length of its use, and its timing are uncertain. We undertook a comprehensive meta-analysis to quantify benefits of hypothermia therapy for traumatic brain injuries in adults and children by analyzing mortality rates, neurologic outcomes, and adverse effects.

Data Sources: Electronic databases PubMed, Google Scholar, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov and manual searches of studies were conducted for relevant publications up until February 2016.

Study Selection: Forty-one studies in adults (n = 3,109; age range, 18-81 yr) and eight studies in children (n = 454; age range, 3 mo to 18 yr) met eligibility criteria.

Data Extraction: Baseline patient characteristics, enrollment time, methodology of cooling, target temperature, duration of hypothermia, and rewarming protocols were extracted.

Data Synthesis: Risk ratios with 95% CIs were calculated. Compared with adults who were kept normothermic, those who underwent therapeutic hypothermia were associated with 18% reduction in mortality (risk ratio, 0.82; 95% CI, 0.70-0.96; p = 0.01) and a 35% improvement in neurologic outcome (risk ratio, 1.35; 95% CI, 1.18-1.54; p < 0.00001). The optimal management strategy for adult patients included cooling patients to a minimum of 33[degrees]C for 72 hours, followed by spontaneous, natural rewarming. In contrast, adverse outcomes were observed in children who underwent hypothermic treatment with a 66% increase in mortality (risk ratio, 1.66; 95% CI, 1.06-2.59; p = 0.03) and a marginal deterioration of neurologic outcome (risk ratio, 0.90; 95% CI, 0.80-1.01; p = 0.06).

Conclusions: Therapeutic hypothermia is likely a beneficial treatment following traumatic brain injuries in adults but cannot be recommended in children.

“Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients” by Crompton, Ellie M. BSc; Lubomirova, Irina MBBS; Cotlarciuc, Ioana PhD; Han, Thang S. PhD; Sharma, Sapna D. MD; and Sharma, Pankaj PhD in Critical Care Medicine. Published online December 9 2016 doi:10.1097/CCM.0000000000002205

Type 1 diabetes in later childhood have weaker brain connectivity in midlife

People diagnosed with type 1 diabetes in later childhood have weaker brain connectivity in midlife compared to those who were diagnosed at earlier ages according to a University of Pittsburgh Schools of the Health Sciences study.

The findings are reported in a special issue of Psychosomatic Medicine that is focused on diabetes, obesity and the brain. Sixty-six middle-aged adults (ages 32 to 58) who were diagnosed with type 1 diabetes as children participated in the study.

“Other studies have shown an association between earlier onset type 1 diabetes and cognitive difficulties, so we expected to find that people with earlier age of onset would have weaker connections between brain regions,” said John Ryan, Ph.D., assistant professor of psychiatry at Pitt. “But instead, we found that those who were diagnosed later in childhood had the weaker brain connections as they aged.”

All of the study participants had onset of type 1 diabetes before age 18 and were enrolled in the Pittsburgh Epidemiology of Diabetes Complications Study, which is an ongoing investigation led by Caterina Rosano, M.D., M.P.H., at Pitt’s Graduate School of Public Health documenting long-term complications of type 1 diabetes among patients at Children’s Hospital of Pittsburgh of UPMC between 1950 and 1980.

This image shows a neurons in the brain.

The participant group is one of the few in the country in which people with childhood onset type 1 diabetes have been followed throughout their lifespan. “Due to advances in treatments, people with type 1 diabetes are living longer. But we don’t yet understand how diabetes and aging interact in the brain,” Dr. Ryan noted.

“The mechanisms underlying these associations are not yet clear,” he said. “However, the relationships between age of diagnosis and connectivity was stronger in older participants, supporting a model of diabetes as accelerated aging.”

ABOUT THIS NEUROLOGY RESEARCH

Additional researchers on this project include Howard J. Aizenstein, M.D., Ph.D., Trevor J. Orchard, M.B.B.Ch., M.Med.Sci., F.A.H.A., F.A.C.E., Christopher M. Ryan, Ph.D., Judith A. Saxton, Ph.D., David F. Fine, B.S., and Karen A. Nunley, Ph.D., all of Pitt Public Health.

Funding: The study was funded by National Institutes of Health and the Rossi Memorial Fund.

Source: Ashley Trentrock – UPMC
Image Credit: Image adapted from the UPMC press release
Original Research: Full open access research for “Diabetes, Obesity, and the Brain: New Developments in Biobehavioral Medicine” by Everson-Rose, Susan A. PhD, MPH; and Ryan, John P. PhD in Psychosomatic Medicine. Published online July 2015 doi:10.1097/PSY.0000000000000223


Abstract

Diabetes, Obesity, and the Brain: New Developments in Biobehavioral Medicine

Diabetes and obesity, two major public health concerns, are associated with increased risk for problems in multiple organ systems, including the central nervous system. The adverse effects of diabetes and obesity on cognitive functioning are increasingly well recognized. This special issue of Psychosomatic Medicine features the latest research linking diabetes, obesity, and brain structure, function, and metabolism and follows a special meeting on this topic organized by the American Psychosomatic Society in October 2013. Evidence for the increased prevalence of diabetes and obesity is reviewed as it relates to cognitive decline. These articles indicate that the age of onset of Type 1 diabetes may be relevant to future cognitive function and that disease duration of Type 2 diabetes and sociocultural factors are related to cognitive decline during the aging process. The hypothalamus and other neural circuits, notably the dopaminergic system that underlies feeding and reward-related aspects of food intake, are among the key factors involved in obesity. Research on the associations between obesity and cognitive function is described using the positive effects of weight reduction following bariatric surgery or behavioral methods. This special issue concludes with a conceptual framework for linking obesity and diabetes with accelerated cognitive decline as related to the aging process. The collection of articles highlights the importance of using a life span perspective to understand the influence of both Type 1 and Type 2 diabetes on brain metabolism, function, and structure. Moreover, these studies show that distressing environmental circumstances can adversely influence neurocognitive dysfunction associated with obesity and diabetes.

“Diabetes, Obesity, and the Brain: New Developments in Biobehavioral Medicine” by Everson-Rose, Susan A. PhD, MPH; and Ryan, John P. PhD in Psychosomatic Medicine. Published online July 2015 doi:10.1097/PSY.0000000000000223

Sleep scientists’ wake-up call for later school starts

  • student sleeping on a desk

As they prepare a major study to test the idea, UK scientists have said that starting school at 10:00 could have huge benefits for teenagers.

Research suggests that society pays too little attention to our “body clock” – and adolescents in particular have a late-running biological rhythm.

This means insisting on an early start can cause sleep deprivation, which in turn can affect learning and health.

A sleep expert made the argument at the British Science Festival in Bradford.

Dr Paul Kelley said that adolescents effectively lose up to two hours of sleep per day, which is “a huge society issue”.

He and colleagues from Oxford are leading a project called Teensleep, which is currently recruiting 100 schools from around the UK to take part in what Dr Kelley called “the world’s largest randomised control trial”, due to commence in 2016.

Ups and downs

Our body clock is a daily cycle which drives the regular rise and fall of certain genes as well as the ebb and flow of our cognitive performance, our metabolism and so on.

For much of our lives – and especially in adolescence – there is a mismatch between this rhythm and the typical working day.

In fact, Dr Kelley said, the body clock of most people between age 10 and 55 is not well suited to rising early.

“Most people wake up to alarms, because they don’t naturally wake up at the time when they have to get up and go to work.

“So we’ve got a sleep deprived society – it’s just that this age group, say 14-24 in particular, is more deprived than any other sector.”

Dr Kelley and his colleagues, including well-known Oxford sleep researcher Prof Russell Foster, argue that school days should start at 10:00 and university at 11:00, to better match the circadian rhythms of adolescents and young adults.

“All the evidence points to the same thing,” Dr Kelley told BBC News.

“There are no negative outcomes for moving [the school day] later, no positive outcomes for moving earlier.”

Silhoutted head watching a screen

The Teensleep experiment, which is funded by the Wellcome Trust and the Education Endowment Fund, will randomly assign its 100 schools into four groups.

One group of schools will shift their school days for 14- to 16-year-olds to a 10:00 start; another group will offer “sleep education” to their students.

This involves “helping students and staff realise sensible ways of making their sleep good sleep”, Dr Kelley said, such as avoiding screen-based activity in the evening.

A third group of schools will introduce both a later start and sleep education, while a fourth, control group will make no such changes.

Keenly awaited

The interventions will commence in the 2016-17 academic year, and the researchers plan to report their results in 2018.

city nightscapeThe availability of artificial light has shifted humans’ daily rhythm

Derk-Jan Dijk is a professor of sleep and physiology at the University of Surrey. He cautioned that shifting the school day might be of limited use without changing other habits that affect our sleep, especially night-time light exposure – making the education part of the trial particularly important.

“It is clear that these adolescents tend to drift later. And many of them will probably prefer to start later,” he told the BBC.

“But why do adolescents like to sleep in later and go to bed later? What is causing this?

“There is undoubtedly a biological component, but that interacts with our artificial light environment.

“And if we can’t change that, then is delaying school times the best solution? Because that way you might not solve the problem – you might shift them even later.”

Prof Dijk said the Teensleep experiment was an important one, which he would observe with interest.

“It will be very interesting to see the results.”


What’s stopping my slumber?

Sleep

A lack of sleep has been linked to weight gain, depression and reduced fertility.

Gene-based diet weekly schedule

Gene-based heart healthy recipe

A personalized recipe recommendations to meet your dietary needs and preferences.

Notes for Sunday and Saturday prep tips: Seek farmer’s market produce, cut fruits/veggies in cubes and store in portion bag in freezer for Mon-Friday smoothie, soup, or steamed veggie recipe.  If you cook a big batch of chicken or beef broth soup, store in freezer some portion (liquid) to be added to soups later.

Ingredient lists for shopping

Organic chicken or beef meat with bones, onions, garlic, carrots, celery, cilantro, yams, plantain banana, potatoes, wild salmon (broiled with rosemary and ginger), ginger, bell pepper, mushrooms,parsley,bay leaf,thyme

Heart healthy soup

heart-soup

Prep tips

Make a broth from chicken or beef bones and divide into portion and store half of the liquid for future use in soups. Add more onions, carrots, celery and garlic and use a blender for easy digestion for seniors or babies. Be sure to throw bones before serving. Always start with sauteiing garlic and onions and meat before adding other ingredients and water for the soup. Broiled wild salmon with garlic, ginger, salt and onions, serve with brown rice and chicken or beef broth soup.

Schedule tips

Saturday, Sunday and Wed

Health benefits of ingredients

Omega 3, Vit E and D, Vit C, magnesium and calcium, potassium-rich, sulfur-rich

And more…..

Gene-based immune system healthy recipe

Ingredient lists for shopping

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Prep tips

Schedule tips

Health benefits of ingredients: Sulfur-rich foods, Vit C rich, zinc and Vitamin D, greens, rich in potassium, phosporous, omega 3 and greens

Gene-based circulatory system healthy recipe

Ingredient lists for shopping

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Prep tips

Schedule tips

Health benefits of ingredients: Ginger, onions and garlic, red and green colored whole foods, good fats (avocado and walnuts),

Gene-based cleansing system for liver and kidneys healthy recipe

Ingredient lists for shopping

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Prep tips

Schedule tips: Served daily in small portions

Health benefits of ingredients: Lemon for cleansing, garlic, onions and sulfur rich (yellow) foods, more soups, less on raw foods (greens are half cooked), and all foods consumed between 11am to 8pm.

Gene-based regenerating healthy recipe

Ingredient lists for shopping

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Prep tips

Schedule tips

Health benefits of ingredients: Yellow and red colored whole foods, pickled veggies, good protein (softer), whole foods (mostly cooked-not over cooked)

Gene-based wholesome for the teens healthy recipe

Ingredient lists for shopping

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Prep tips

Schedule tips

Health benefits of ingredients: more on healthy carbs (yams), protein rich and equal amount of good fats (avocado, walnuts,others)


Please email any suggested recipes to motherhealth@gmail.com