Safest Anti-Inflammatories to Use for Pain Clearly the safest prescription drugs to use for pain are the non-acetylated salicylates such as: Salsalate Sodium salicylate Magnesium salicylate (i.e., Salflex, Disalcid, or Trilisate) They are the drugs of choice if there is renal insufficiency, as they minimally interfere with anticyclooxygenase and other prostaglandins. Additionally, they will notContinue reading “Rheumatoid Arthritis and drugs by Dr Mercola”