by Shannon Firth Washington Correspondent, MedPage TodayMay 15, 2017 LAS VEGAS — A session on pharmacogenomics at the American Academy of Physician Assistants meeting here began with a lawsuit. In 2014, the Attorney General in Hawaii filed suit against drugmakers Bristol-Myers Squibb and Sanofi, charging the companies had evidence for years that clopidogrel (Plavix) wasContinue reading “Pharmacogenomics test can save life from adverse drug effects”
Tag Archives: pharmacogenetics
What is personalized medicine?
Oxycodone narcotics reduced risk with use of pharmacogenetic test
Personalized oxycodone dosing: using pharmacogenetic testing and clinical pharmacokinetics to reduce toxicity risk and increase effectiveness. Linares OA1, Daly D, Linares AD, Stefanovski D, Boston RC. Integrating pharmacogenetics goal To develop a framework for integrating pharmacogenetics with clinical pharmacokinetics for personalized oxycodone dosing based on a patient’s CYP2D6 phenotype. Design includes genotyped as CYP2D6 ultra-rapidContinue reading “Oxycodone narcotics reduced risk with use of pharmacogenetic test”
What is pharmacogenetics?
Overview: What is pharmacogenetics? Some of us respond differently than others to the same medications that we take, or we may experience different side-effects from drugs. The way we respond can be due to the genes we have inherited. With respect to drugs, our unique genetic make-up and our individual response may mean that aContinue reading “What is pharmacogenetics?”
Ethnic Differences in Cardiovascular Drug Response & Pharmacogenetics by Julie A. Johnson, PharmD
In the early 1980s, clinical differences in response to the blood pressure (BP)-lowering effects of β-blockers and, to a lesser extent, diuretics were noted between ethnic groups. The most convincing evidence at that time came from a Veterans Affairs (VA) Cooperative Trial,1 which, along with other smaller studies, suggested that whites (those of European ancestry)Continue reading “Ethnic Differences in Cardiovascular Drug Response & Pharmacogenetics by Julie A. Johnson, PharmD”
Pharmacogenetics and pain management by Maria Chianta and Maria Guevara PharmDs
Chronic pain affects approximately 100 million U.S. adults at a cost of up to $635 billion annually in direct medical costs and lost productivity. As clinicians attempt to reduce pain and improve functionality in patients with chronic pain, pharmacotherapy remains a cornerstone of treatment. Typically, several medications with different mechanisms of action are employed toContinue reading “Pharmacogenetics and pain management by Maria Chianta and Maria Guevara PharmDs”
Epigenome, a second genetic code, mapped by scientists by Sharon Begley
Scientists for the first time have mapped out the molecular “switches” that can turn on or silence individual genes in the DNA in more than 100 types of human cells, an accomplishment that reveals the complexity of genetic information and the challenges of interpreting it. Researchers unveiled the map of the “epigenome” in the journalContinue reading “Epigenome, a second genetic code, mapped by scientists by Sharon Begley”