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Gift for bay area family caregivers – 20% OFF for caregiving relief

This November month is family caregiver month for Veteran families.

Do you need a reliever for 2 days in caring for your family or love one in the bay area?

Get 20% OFF , code RELIEVECARE

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dietary supplements
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One Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

Researchers Identify Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes – a specific virus and two specific types of bacteria – are major causes of Alzheimer’s Disease. Their paper, which has been published online in the highly regarded peer-reviewed journal, Journal of Alzheimer’s Disease, stresses the urgent need for further research – and more importantly, for clinical trials of anti-microbial and related agents to treat the disease.

This major call for action is based on substantial published evidence into Alzheimer’s. The team’s landmark editorial summarises the abundant data implicating these microbes, but until now this work has been largely ignored or dismissed as controversial – despite the absence of evidence to the contrary. Therefore, proposals for the funding of clinical trials have been refused, despite the fact that over 400 unsuccessful clinical trials for Alzheimer’s based on other concepts were carried out over a recent 10-year period.

Opposition to the microbial concepts resembles the fierce resistance to studies some years ago which showed that viruses cause certain types of cancer, and that a bacterium causes stomach ulcers. Those concepts were ultimately proved valid, leading to successful clinical trials and the subsequent development of appropriate treatments.

Professor Douglas Kell of The University of Manchester’s School of Chemistry and Manchester Institute of Biotechnology is one of the editorial’s authors. He says that supposedly sterile red blood cells were seen to contain dormant microbes, which also has implications for blood transfusions.

“We are saying there is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component, and that this can be woken up by iron dysregulation. Removing this iron will slow down or prevent cognitive degeneration – we can’t keep ignoring all of the evidence,” Professor Douglas Kell said.

Professor Resia Pretorius of the University of Pretoria, who worked with Douglas Kell on the editorial, said “The microbial presence in blood may also play a fundamental role as causative agent of systemic inflammation, which is a characteristic of Alzheimer’s disease – particularly, the bacterial cell wall component and endotoxin, lipopolysaccharide. Furthermore, there is ample evidence that this can cause neuroinflammation and amyloid-β plaque formation.”

The findings of this editorial could also have implications for the future treatment of Parkinson’s Disease, and other progressive neurological conditions.

ABOUT THIS ALZHEIMER’S DISEASE RESEARCH

Source: University of Manchester
Image Credit: The image is adapted from the University of Manchester press release.
Original Research: Full open access editorial for “Microbes and Alzheimer’s Disease” by Itzhaki, Ruth F.; Lathe, Richard; Balin, Brian J.; Ball, Melvyn J.; Bearer, Elaine L.; Bullido, Maria J.; Carter, Chris; Clerici, Mario; Cosby, S. Louise; Field, Hugh; Fulop, Tamas; Grassi, Claudio; Griffin, W. Sue T.; Haas, Jürgen; Hudson, Alan P.; Kamer, Angela R.; Kell, Douglas B.; Licastro, Federico; Letenneur, Luc; Lövheim, Hugo; Mancuso, Roberta; Miklossy, Judith; Lagunas, Carola Otth; Palamara, Anna Teresa; Perry, George; Preston, Christopher; Pretorius, Etheresia; Strandberg, Timo; Tabet, Naji; Taylor-Robinson, Simon D.; and Whittum-Hudson, Judith A. in Journal of Alzheimer’s Disease. Published online March 8 2016 doi:10.3233/JAD-160152

Abstract

Microbes and Alzheimer’s Disease

We are researchers and clinicians working on Alzheimer’s disease (AD) or related topics, and we write to express our concern that one particular aspect of the disease has been neglected, even though treatment based on it might slow or arrest AD progression. We refer to the many studies, mainly on humans, implicating specific microbes in the elderly brain, notably herpes simplex virus type 1 (HSV1), Chlamydia pneumoniae, and several types of spirochaete, in the etiology of AD. Fungal infection of AD brain [5, 6] has also been described, as well as abnormal microbiota in AD patient blood. The first observations of HSV1 in AD brain were reported almost three decades ago]. The ever-increasing number of these studies (now about 100 on HSV1 alone) warrants re-evaluation of the infection and AD concept.

AD is associated with neuronal loss and progressive synaptic dysfunction, accompanied by the deposition of amyloid-β (Aβ) peptide, a cleavage product of the amyloid-β protein precursor (AβPP), and abnormal forms of tau protein, markers that have been used as diagnostic criteria for the disease. These constitute the hallmarks of AD, but whether they are causes of AD or consequences is unknown. We suggest that these are indicators of an infectious etiology. In the case of AD, it is often not realized that microbes can cause chronic as well as acute diseases; that some microbes can remain latent in the body with the potential for reactivation, the effects of which might occur years after initial infection; and that people can be infected but not necessarily affected, such that ‘controls’, even if infected, are asymptomatic

“Microbes and Alzheimer’s Disease” by Itzhaki, Ruth F.; Lathe, Richard; Balin, Brian J.; Ball, Melvyn J.; Bearer, Elaine L.; Bullido, Maria J.; Carter, Chris; Clerici, Mario; Cosby, S. Louise; Field, Hugh; Fulop, Tamas; Grassi, Claudio; Griffin, W. Sue T.; Haas, Jürgen; Hudson, Alan P.; Kamer, Angela R.; Kell, Douglas B.; Licastro, Federico; Letenneur, Luc; Lövheim, Hugo; Mancuso, Roberta; Miklossy, Judith; Lagunas, Carola Otth; Palamara, Anna Teresa; Perry, George; Preston, Christopher; Pretorius, Etheresia; Strandberg, Timo; Tabet, Naji; Taylor-Robinson, Simon D.; and Whittum-Hudson, Judith A. in Journal of Alzheimer’s Disease. Published online March 8 2016 doi:10.3233/JAD-160152

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Old Human Cells Rejuvenated – resveratrol in dark choco, berries and grapes

Old Human Cells Rejuvenated in Breakthrough Discovery on Aging

Summary: Resveratrol analogues appears to switch splicing factors back on, causing cells to look younger, start rejuvenating and behaving like young cells within hours of exposure, a new study reports.Source: University of Exeter.

A team led by Professor Lorna Harries, Professor of Molecular Genetics at the University of Exeter, has discovered a new way to rejuvenate inactive senescent cells. Within hours of treatment the older cells started to divide, and had longer telomeres – the ‘caps’ on the chromosomes which shorten as we age.

The researchers applied compounds called resveratrol analogues, chemicals based on a substance naturally found in red wine, dark chocolate, red grapes and blueberries, to cells in culture.

This discovery, funded by the Dunhill Medical Trust, builds on earlier findings from the Exeter group that showed that a class of genes called splicing factors are progressively switched off as we age. The University of Exeter research team, working with Professor Richard Faragher and Dr Elizabeth Ostler from the University of Brighton, found that splicing factors can be switched back on with chemicals, making senescent cells not only look physically younger, but start to behave more like young cells and start dividing.

The researchers applied compounds called resveratrol analogues, chemicals based on a substance naturally found in red wine, dark chocolate, red grapes and blueberries, to cells in culture.

The chemicals caused splicing factors, which are progressively switched off as we age to be switched back on. Within hours, the cells looked younger and started to rejuvenate, behaving like young cells and dividing.

The research, Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence, is published in the journal, BMC Cell Biology.

The discovery has the potential to lead to therapies which could help people age better, without experiencing some of the degenerative effects of getting old. Most people by the age of 85 have experienced some kind of chronic illness, and as people get older they are more prone to stroke, heart disease and cancer.

Professor Harries said: “This is a first step in trying to make people live normal lifespans, but with health for their entire life. Our data suggests that using chemicals to switch back on the major class of genes that are switched off as we age might provide a means to restore function to old cells.”

Dr Eva Latorre, Research Associate at the University of Exeter, who carried out the experiments, was surprised by the extent and rapidity of the changes in the cells.

“When I saw some of the cells in the culture dish rejuvenating I couldn’t believe it. These old cells were looking like young cells. It was like magic,” she said. “I repeated the experiments several times and in each case the cells rejuvenated. I am very excited by the implications and potential for this research.”

As we age, our tissues accumulate senescent cells which are alive but do not grow or function as they should. These old cells lose the ability to correctly regulate the output of their genes. This is one reason why tissues and organs become susceptible to disease as we age. When activated, genes make a message that gives the instructions for the cell to behave in a certain way. Most genes can make more than one message, which determines how the cell acts.

Splicing factors are crucial in ensuring that genes can perform their full range of functions. One gene can send out several messages to the body to perform a function – such as the decision whether or not to grow new blood vessels – and the splicing factors make the decision about which message to make.

As people age, the splicing factors tend to work less efficiently or not at all, restricting the ability of cells to respond to challenges in their environment. Senescent cells, which can be found in most organs from older people, also have fewer splicing factors.

Professor Harries added:

“This demonstrates that when you treat old cells with molecules that restore the levels of the splicing factors, the cells regain some features of youth. They are able to grow, and their telomeres – the caps on the ends of the chromosomes that shorten as we age – are now longer, as they are in young cells. Far more research is needed now to establish the true potential for these sort of approaches to address the degenerative effects of ageing. ”

Professor Richard Faragher of the University of Brighton, will today argue for more research into the degenerative effects of ageing in a debate into whether science should be used to extend people’s lifespans.

“At a time when our capacity to translate new knowledge about the mechanisms of ageing into medicines and lifestyle advice is limited only by a chronic shortage of funds, older people are ill-served by self-indulgent science fiction. They need practical action to restore their health and they need it yesterday,” he said.

Professor Faragher added: “Our discovery of cell rejuvenation using these simple compounds shows the enormous potential of ageing research to improve the lives of older people”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Funding: Funding provided by Dunhill Medical Trust, University of Brighton, Glenn Foundation for Medical Research, BBSRC.

Source: Marie Woolf – University of Exeter
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to University of Exeter.
Original Research: Full open access research for “Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence” by Eva Latorre, Vishal C. Birar, Angela N. Sheerin, J. Charles C. Jeynes, Amy Hooper, Helen R. Dawe, David Melzer, Lynne S. Cox, Richard G. A. Faragher, Elizabeth L. Ostler and Lorna W. Harries in BMC Cell Biology. Published online October 17 2017 doi:10.1186/s12860-017-0147-7

CITE THIS NEUROSCIENCENEWS.COM ARTICLE

University of Exeter “Old Human Cells Rejuvenated in Breakthrough Discovery on Aging.” NeuroscienceNews. NeuroscienceNews, 7 November 2017.
<http://neurosciencenews.com/old-cell-aging-7890/>.

Abstract

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

Background

Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology. However, the relationship between these two processes is opaque. Accordingly we developed a novel panel of small molecules based on resveratrol, previously suggested to alter mRNA splicing, to determine whether altered splicing factor expression had potential to influence features of replicative senescence.

Results

Treatment with resveralogues was associated with altered splicing factor expression and rescue of multiple features of senescence. This rescue was independent of cell cycle traverse and also independent of SIRT1, SASP modulation or senolysis. Under growth permissive conditions, cells demonstrating restored splicing factor expression also demonstrated increased telomere length, re-entered cell cycle and resumed proliferation. These phenomena were also influenced by ERK antagonists and agonists.

Conclusions

This is the first demonstration that moderation of splicing factor levels is associated with reversal of cellular senescence in human primary fibroblasts. Small molecule modulators of such targets may therefore represent promising novel anti-degenerative therapies.

“Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence” by Eva Latorre, Vishal C. Birar, Angela N. Sheerin, J. Charles C. Jeynes, Amy Hooper, Helen R. Dawe, David Melzer, Lynne S. Cox, Richard G. A. Faragher, Elizabeth L. Ostler and Lorna W. Harries in BMC Cell Biology. Published online October 17 2017 doi:10.1186/s12860-017-0147-7

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Our most advanced anti-aging supplement ever, ageLOC Youth targets our … alpha lipoic acid, D-limonene,* CoQ10, citrus bioflavonoids, resveratrol, and vitamin K2. … ability to remind our bodies how to be young complement our many other.

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Study reveals role of specific lipids in accelerating or curbing bacterial infection

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Lipids appear to play an important role in infections. According to researchers from the University of Maastricht in Maastricht, The Netherlands, and the University of Maryland, Baltimore (UMB) in Baltimore, Md., USA, specific lipids can greatly accelerate bacterial infection.

With the help of mass spectrometry imaging (MSI), researchers showed that specific mammalian lipids could also provide protection against the same infection. Their discovery offers hope for future treatment of vulnerable patients in hospitals or development of preventative treatments for travellers to risk areas in certain parts of the world.

The findings of the research team, led by American researchers Robert Ernst and Alison Scott at UMB and Maastricht University Distinguished Professor Ron Heeren, were published Nov. 6 in the journal, Proceedings of the National Academy of Sciences (PNAS).

Mass Spectrometry Imaging
Mass spectrometry imaging is an imaging technique in which molecular maps of a pathological tissue section can be compiled from a single experiment. Researchers use the technique to determine exactly where certain molecules are located and how their distribution is affected by pathogenic bacteria, for instance. “This technique enables us to analyse thousands of molecules with a single measurement,” Heeren explains. “What is special about our research is that we were able to use this method in order to capture for the first time the molecular changes which occur during a bacterial infection, mainly revealing the role of lipids in the further evolution of such an inflammation. This result means that we’ll be able in future to determine the severity of an infection accurately within half an hour. Based on the type of lipid, we’ll also know how the inflammation will behave in a patient.”

Protect or accelerate
To test their ability to use MSI to track disease progression, the scientists injected a healthy mouse with the highly pathogenic bacteria Francisella novicida (Fn). Through MSI, the researchers were then able to create an accurate molecular map of the infection’s evolution, predominantly based on lipids. In doing so, it became clear that certain lipids significantly accelerated the infection, although these lipids should never be seen as separate from their spatial context in the tissue. “The distribution of lipids in the host – the patient – appears to have a tremendous effect on the immune system. For this reason, lipids are a strong determining factor in the aggressiveness of a bacterial infection,” Heeren concludes. “It is now important to establish a kind of library, in which we can precisely identify which lipids play a role in accelerating infection and which lipids have a positive effect on the immune response.”

Alison Scott PhD, research associate professor at the University of Maryland School of Dentistry (UMSOD) and guest researcher at Maastricht University, hopes that this knowledge will help develop drugs that could be used to treat vulnerable patients and help them form the right lipids in the right places to dampen infection.

Applicability of this study
Although the researchers specifically used MSI to track Fn infection in this study, the techniques could be applied to a wide range of diseases. “The methodology underlying the study is relevant to any infection and positions us to expand work in the field of the role of lipids in both the bacteria and the host. It allows researchers to identify host-based pathways for therapeutic treatment to control bacterial infection and inflammation. I hope to start looking at airway infections such as pseudomonas,” says Scott.

This kind of research is only made possible by collaborations across disciplines. “This study shows the value of highly collaborative projects bringing together microbiologists and mass spectrometry experts to define the finite interactions between a bacteria and a host,” says Robert “Bob” Ernst, PhD, the senior investigator involved in the study and professor and vice chair of the Department of Microbial Pathogenesis at UMSOD and an adjunct professor at the University of Maryland School of Medicine (UMSOM).

The research presented here opens up many research avenues, both into the applicability of MSI for disease studies and the development of therapeutics that target lipids to treat infection, according to Ernst and colleagues, who include Kari Ann Shirey, PhD, assistant professor in UMSOM’s Department of Microbiology and Immunology.

Source:

http://www.umaryland.edu/

Trends in medical health insurance, costs and expenses by state

Employer-sponsored insurance (ESI) is the primary source of health insurance coverage for individuals under age 65

This chartbook uses data for private-sector establishments in the Medical Expenditure Panel Survey-Insurance Component (MEPS-IC) to describe trends in employer coverage, premiums, and benefits from 2003 to 2016.

Medical Expenditure Panel Survey Insurance Component 2016 Chartbook. Rockville, MD:
Agency for Healthcare Research and Quality; September 2017. AHRQ Publication No. 17-0034-EF. https://meps.ahrq.gov/mepsweb/data_files/publications/cb21/cb21.pdf.

The MEPS-IC is an annual survey of private employers and State and local governments and is designed to be representative of all 50 States and the District of Columbia. The large sample size (about 42,000 establishments), combined with a response rate of 67.6 percent in 2016, permits analyses of variations in ESI by firm size and across States that are not readily available from other sources.

Examining trends by firm size and across States is important because of variation in insurance markets along these dimensions. Insurance markets differ by firm size due to smaller firms’ more limited ability to pool risk and their higher administrative costs compared with larger firms. State variation in ESI markets may reflect differences in employment patterns, health care prices, and utilization, as well as differences in State approaches to regulating private insurance and
administering Medicaid.

The period presented in the chartbook, 2003 to 2016, shows trends through a period of change in national health policy that could have affected national ESI trends, as well as trends by firm size.

Starting in 2014, most people were required to either obtain health insurance or make an
individual shared responsibility payment. The employer shared responsibility provisions began to take effect for employers with 100 or more full-time-equivalent employees in 2015 and for employers with 50 or more employees in 2016.

Coinsurance Rates for Physician Office Visits

From 2003 to 2016, the percentage of enrolled employees in plans with coinsurance rates increased from 19.5 percent to 34.9 percent. There were significant year-to-year increases in the percentage of enrolled employees with a coinsurance rate from 2005 to 2006 and from 2009 to 2010 and then each year from 2011 to 2015 (Exhibit 5.7).

The percentage of enrolled employees in a health insurance plan that had a coinsurance rate for physician office visits did not change significantly from 2015 (35.0 percent) to 2016 (34.9 percent) (Exhibit 5.7).

Enrolled employees in large firms (100 or more employees) were more likely to have plans with coinsurance rates than enrolled employees in smaller firms in all years from 2003 to 2016. In 2016, 38.9 percent of enrollees in firms with 100 or more employees had
coinsurance rates compared with 20.6 percent and 21.5 percent in firms with fewer than 50 employees and with 50 to 99 employees, respectively (Exhibit 5.7).

Between 2003 and 2016, the percentage of enrolled employees in health plans with a
coinsurance rate increased for all enrollees, regardless of firm size. However, the increase was more pronounced among enrolled employees in firms with 100 or more employees (17.9 percentage points) than in smaller firms (5.4 and 6.9 percentage point increases at firms with fewer than 50 employees and with 50 to 99 employees, respectively) (Exhibit 5.7).

Among enrolled employees in plans with physician office visit coinsurance rates, average coinsurance rates increased from 18.0 percent in 2003 to 20.5 percent in 2016 (Exhibit 5.8).

Average coinsurance rates rose from 20.1 percent in 2015 to 20.5 percent in 2016, an
increase of 0.4 percentage points. This increase followed increases of 0.6 percentage points from 2013 to 2014 and 0.3 percentage points from 2014 to 2015 (p <0.10) (Exhibit 5.8).

From 2013 to 2014, average coinsurance rates for enrolled employees at firms with 100 or more employees increased from 18.8 to 19.5 percent, but there was no significant change in smaller firms. In contrast, from 2014 to 2015, average coinsurance rates for enrolled employees at firms with fewer than 50 employees increased from 21.5 to 22.6 percent, while there was no significant change at larger employers.

Click to access cb21.pdf

Brain activity ripples linked to creation of long-term memories – sleep more

Brain activity ripples linked to creation of long-term memories

At a Glance

A study in lab animals showed that communication between two brain regions may be needed for the formation of long-term memories.
The finding might help researchers discover how long-term memory formation can be enhanced.

Anatomical map showing sample ripple traces color coded by brain region.

An anatomical map with raw sample traces of neocortical ripples, left, color coded to show the brain regions in which they occurred. György Buzsáki, M.D., Ph.D., NYU School of Medicine

While we’re asleep, the brain is working to store new information as long-term memories. Storing a memory likely involves interactions between the brain’s hippocampus and parts of the cortex. Scientists have been trying to determine the precise connections by examining electrical activity within these regions of the brain.

When hundreds or thousands of nerve cells, or neurons, in the brain become activated at the same moment, the high-frequency electrical activity shows up on recordings as ripples. Previous work by Dr. György Buzsáki at New York University revealed ripples of high-frequency activity in the rat hippocampus during sleep and suggested that ripples play a role in memory storage.

In the current study, Buzsáki’s team set out to record electrical activity in multiple regions of the brain for evidence of cross-talk during sleep. The work was funded in part by NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, which is managed and funded by several NIH components including NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of Mental Health (NIMH). Results were published on October 20, 2017, in Science.

The researchers created a thin, flexible array of tightly packed, tiny electrodes that can be placed on the surface of the brain. This array can record the electrical activity of single neurons. Using the device, called NeuroGrid, on top of the rat brain along with recording electrodes placed deeper into the brain, the team recorded activity in several brain regions during non-rapid eye movement (NREM) sleep. They noticed activity ripples in the association neocortex, an area on the brain’s surface involved in processing complex information. At the same time, ripples occurred in the hippocampus. The simultaneous ripples suggested that the two regions were communicating.

Six rats were given a memory training session to find water in a maze. The researchers then recorded the rats’ brain activity during NREM sleep. In these trained rats, the learning task increased the cross-talk between the association neocortex and the hippocampus. A second training session boosted the cross-talk even more. Four rats who didn’t undergo memory training were allowed to roam freely through a maze without reward. These untrained rats didn’t have synchronized ripples in the association neocortex and the hippocampus during sleep. The findings suggest that communication between these brain regions is important for the creation and storage of memories.

“Identifying the specific neural patterns that go along with memory formation provides a way to better understand memory and potentially even address disorders of memory,” says co-first author Dr. Jennifer Gelinas of New York University and Columbia University.

The researchers plan to use the NeuroGrid to study whether disrupting the ripples has an effect on memory formation in lab animals. They also plan to use the NeuroGrid to find out whether ripples occur in the same brain regions of people.

Homeless camps contrast with West Coast tech wealth

A homeless crisis of unprecedented proportions is rocking the West Coast, and its victims are being left behind by the very things that mark the region’s success: soaring housing costs, rock-bottom vacancy rates and a roaring economy. Elected officials are scrambling for solutions. Homelessness is not new on the West Coast. But interviews with local officials and those who serve the homeless – coupled with an Associated Press review of preliminary homeless data – confirm it’s getting worse.(Associated Press)

Apple found place to stash its profits, in the English Channel

Apple has accumulated more than $128 billion in profits offshore, and probably much more, that is untaxed by the United States and hardly touched by any other country. Nearly all of that was generated over the past decade. The previously undisclosed story of Apple’s search for a new island tax haven and its use of Jersey is among the revelations emerging from a cache of secret corporate records, called the “Paradise Papers,” from Appleby, a Bermuda-based law firm.(Seattle Times)

Uber tackles sex assault problem by pledging $5M to training

Uber is pledging $5 million during the next five years to fund sexual assault prevention groups as well as train its own employees. The move was announced Monday and is aimed at helping the ride-hailing service combat its own problems and society as a whole. Uber’s image has been tarnished by findings of sexual harassment of employees and multiple reports of drivers assaulting passengers.(CBS San Francisco)

Wells Fargo launches hybrid robo-adviser

Wells Fargo officially got into the digital advice market on Monday with the launch of Intuitive Investor, the bank’s new hybrid robo-adviser. The offering combines digital access to a portfolio of ETFs designed by the Wells Fargo Investment Institute with access to human advice from a team of advisers from the firm’s wealth management division, Wells Fargo Advisors. The robo integrates with Wells Fargo’s online and mobile banking services to allow for single sign-on capabilities and money transfers.(Investment News)

Will.i.am’s startup raises $117M, enters enterprise market

I.am+, the tech startup founded by pop star and entrepreneur will.i.am, has raised $117 million in venture funding, the company told Reuters on Mondayas it announced its entry into the corporate computing market with a voice assistant for customer service. The company, founded in 2012, initially focused on consumer electronics devices such as headphones.(Reuters)

Facebook, WeWork and others use this startup to make swag

Swag can be important. That’s where Swag.com comes in. The company aims to be a way for companies to get quality swag to help people rep their brands. “People think of swag as junk, but it shouldn’t be,” Swag co-founder Jeremy Parker told TechCrunch. “It could be an amazing marketing tool if it’s built right.” Swag.com offers products like water bottles, umbrellas, shirts, jackets, USB drives, bags and other items from brands like Patagonia and Case Logic.(TechCrunch)

‘Frugal innovations’ could help U.S. rein in healthcare costs

Since the U.S. healthcare system still mainly operates under a fee-for-service model, adapting so-called frugal innovations from the rest of the world will be difficult, according to a new study. Frugal innovations have been defined as “ ’good enough,’ affordable products that meet the needs of resource-constrained consumers.” They can improve quality at the same cost as other solutions or can provide the same quality at lower costs, or both.(Modern Healthcare)

Cybersecurity threats pose biggest healthcare hazard, ECRI

Malware attacks in healthcare can put patient safety at risk, shutting off access to records, taking down medical devices and interrupting supply chains, according to a new report from the ECRI Institute that puts ransomware and cybersecurity threats at the top of its technology hazards list for 2018. To prevent cyberattacks, healthcare organizations must be proactive and engage their employees in safeguarding efforts, according to the ECRI Institute, a patient-safety not-for-profit.(Modern Healthcare)

NYC once repelled fast-food. Now it’s the hottest market

New York City is quickly becoming the capital of fast-food nation. More chains are moving in to replace diners and other independent restaurants forced out by relentlessly rising rents. In 2008 the Center for an Urban Future began tracking the growth of local chain retailers and restaurants, and counted about 5,400 city locations. By last year the figure had grown by more than a third, to 7,300.(Crain’s New York Business)

Urgent need for gun safety laws

Jan 27-28 2018 National Drug and Alcohol facts week

https://teens.drugabuse.gov/national-drug-facts-week/plan-your-event

Teachers, health educators, health pros and schools are welcome to host the event at your location and get free materials from the site above to showcase myths on drugs and alcohol for healthy population.

See you all at Whole Foods Cupertino on Jan 27,2018 for materials and education about drugs and alcohol myths for young and old. Email motherhealth@gmail.com

408-854-1883 starts at $30 per hr home care

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Researchers Identify Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

Old Human Cells Rejuvenated in Breakthrough Discovery on Aging

The researchers applied compounds called resveratrol analogues, chemicals based on a substance naturally found in red wine, dark chocolate, red grapes and blueberries, to cells in culture.

The researchers applied compounds called resveratrol analogues, chemicals based on a substance naturally found in red wine, dark chocolate, red grapes and blueberries, to cells in culture.

The chemicals caused splicing factors, which are progressively switched off as we age to be switched back on. Within hours, the cells looked younger and started to rejuvenate, behaving like young cells and dividing.

As people age, the splicing factors tend to work less efficiently or not at all, restricting the ability of cells to respond to challenges in their environment. Senescent cells, which can be found in most organs from older people, also have fewer splicing factors.

AGELOK Youth has resveratrol , visit

Study reveals role of specific lipids in accelerating or curbing bacterial infection

Related Stories

Employer-sponsored insurance (ESI) is the primary source of health insurance coverage for individuals under age 65

The period presented in the chartbook, 2003 to 2016, shows trends through a period of change in national health policy that could have affected national ESI trends, as well as trends by firm size.

Coinsurance Rates for Physician Office Visits

Brain activity ripples linked to creation of long-term memories

At a Glance