Two types of people Tightly coupled: Only needs to eat less to arrive at required energy level Loosely coupled: Needs to eat more to arrive at required energy level Sun energy and glucose for energy production Nucleus is energy limited Mitochondrial DNA crosstalk: 10% changes in mtDNA has a greater effect in epigenetic expression Continue reading “Energy and Anatomy = Cancer and aging”
Tag Archives: ROS
Oxidative stress and metal catalysts in depression, aging and cancer
Reactive oxygen species (ROS), byproducts of oxygen metabolism, are present in the cells as a consequence of living in an oxygen-rich atmosphere. ROS can be generated by both endogenous and exogenous sources, such as mitochondria and carcinogens, respectively. ROS contain superoxide (O2•−) and hydrogen peroxide (H2O2), and are important for the normal function of manyContinue reading “Oxidative stress and metal catalysts in depression, aging and cancer”
Acute myocardial infarction; imbalance during ischemia-reperfusion ; mitochondrial energy adaption in cancer, obesity and metabolic disorders
Acute myocardial infarction is characterized by changes in biochemical properties during ischemia and reperfusion. The heart can survive a short period of ischemia by reducing myocardial contractility, increasing glucose uptake, and switching metabolism to glycolysis. However, considering that the heart is one of the most energy-demanding tissues in the body, sustained oxygen and nutrient deprivationContinue reading “Acute myocardial infarction; imbalance during ischemia-reperfusion ; mitochondrial energy adaption in cancer, obesity and metabolic disorders”