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Thymosin beta 4 and Skin Repair

This hopeful message of Tb4’s potential to restore damaged human skin was voiced at the 5th International Symposium on Aging Skin, in California (May 2001), by Dr. Allan Goldstein, Chairman of the Biochemistry Department at George Washington University and founder of RegeneRX Biopharmaceuticals. RegeneRX is carrying out preclinical research on Tb4 as a wound healer, in collaboration with scientists at the National Institutes of Health.

Wounds sustained during the day heal twice as fast as those that occur at night

 Whenever you are injured, a type of skin cell known as fibroblasts, move into the region to pave the way for new cells to grow. Fibroblasts are known to “keep their own time,” writes Roni Dengler at Science, periodically changing activity depending on the time of day. But the details of the process remained largely unclear.

To better understand these rhythms, Nathaniel Hoyle and his team at the Laboratory of Molecular Biology in Cambridge took a closer look at the fibroblasts. While studying how proteins produced by the cells vary throughout the day, they discovered that proteins important to healing were most abundant when the sun was up.