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Aphrodisiac foods

Cook together. Soft music, soft lights, aroma of cinnamon and garlic are all conducive for a seductive lunch or dinner.

Wine, beer or healthy smoothie are important. Do know that happy foods are chocolate, eggs, yams and beer.

Aphrodisiac Foods

  • Oysters
  • Watermelon
  • Cocoa or Chocolate
  • Asparagus
  • Avocados
  • Maca
  • Pumpkin Seeds. pumpkin seeds
  • Celery

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Match Dementia and Alzheimer studies

Alzheimer's & Related Dementia updates from the National Institute on Aging, the lead US government agency for Alzheimer's research
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Interested in volunteering for research on Alzheimer’s, related dementias, and cognitive health? Search for clinical trials and studies near you with NIA’s clinical trials finder.

Below are the newest listings. Click on the trial name for details, including contact information.

 

Biomarkers and Brain Imaging

 

Drugs and Supplements

 

Treatment Interventions

 

Observational

 

Registries

  • Alzheimer’s Prevention Registry (nationwide)—get information and updates about participating in future Alzheimer’s prevention trials.
  • GeneMatch (nationwide)—enroll to get matched to Alzheimer’s genetics studies.
  • Brain Health Registry (nationwide)—sign up for an online study of brain health and learn about possible research-study opportunities.

Get more information about these and other Alzheimer’s clinical trials. Or, callthe ADEAR Center at 1-800-438-4380 (toll-free) or email adear@nia.nih.gov.

 

Help us spread the word about Alzheimer’s and related clinical trials!

  • Forward this email to anyone who may be interested.
  • Share via social media:
    Looking for #Alzheimer’s and related dementias #clinicaltrials? Find the latest information here: http://1.usa.gov/Y1zmEN
  • Share this infographic from NIA about participating in clinical research:
    Learn how older adults can play a role in disease prevention/treatment by volunteering for research studies: http://go.usa.gov/x9sv8

Intestinal disorders , herbs and nutrition

Ulcerative Colitis Diet: Foods, Supplements & Natural Remedies that …

Aug 28, 2015 – New research continues to come out with hope for a more permanent treatment for ulcerative colitis and other inflammatory bowel diseases. A 2017 study found …. Probiotics are bacteria that line your digestive tract and support your body’s ability to absorb nutrients and fight infection. Probiotics crowd out …

Large intestine solutions through foods, herbs and nutritional …

The Doctors Book of Herbal Home Remedies – Cure Yourself With Nature’s Most Powerful Healing Agents, by the Editors of Prevention Health Books; The Food Bible, by Judith Wills; Breast Cancer, Breast Health! The Wise Woman Way, by Susun S. Weed; The Complete Guide to NutritionalSupplements – Everything You …

Eight Key Steps to Heal Crohn’s Disease Using Natural Remedies

Even if you have tried every Crohn’s treatment available without success, don’t give up hope – mynatural remedies for bowel and colon disease have helped tens of thousands of people …. Absorb Plus is a delicious elemental (pre-digested) nutrition and protein shake made of the highest qualitynatural ingredients. Absorb …

The Best Supplements for Digestive Issues – Better Nutrition Magazine …

Jul 17, 2017 – Relieve digestive distress—including heartburn, stomach cramps, and constipation—with the help of a few supplement strategies. … Herbs. Several herbs have a long history of helping with digestive disorders. Slippery elm (Ulmus fulva) contains mucilage, which is believed to coat the esophagus and …

Natural Remedies for Gastrointestinal Problems: Herbal Medicine

Jun 6, 2011 – Consider herbal medicine for gastrointestinal disorders to help naturally andholistically with issues like acid reflux, nausea, digestive problems and more.

8 Best Natural Methods to Treat Digestive Problems

Sep 25, 2016 – Poor nutrition: loads of sugars and simple carbohydrates, consumption of artificial sweeteners, caffeine and alcohol, avoiding dietary fiber and eating too … Herbal infusions have several advantages when it comes to digestive problems: they adsorb gases, reduce stress, help blood flow to the digestive …

Natural treatment options for inflammatory bowel disease

drhoffman.com/article/natural-treatment-options-for-inflammatory-bowel-disease/

Nov 8, 2014 – But supplementation is not just a matter of replacing missing nutrients in IBD; certain vitamins and minerals have therapeutic effects beyond just staving off deficiency. One such nutrient is fish oil, which some studies indicate may suppress intestinal inflammation. High doses are required, up to 9 grams per …

Nutrition Tips for Inflammatory Bowel Disease | Patient Education …

https://www.ucsfhealth.org › Patient Education

Inflammatory Bowel Disease (IBD) is a term used for two specific and separate diseases: Crohn’sdisease and ulcerative colitis. Nutritional recommendations are different for each disease and for each individual patient. It is important to discuss the treatments that are right for you with a registered dietitian and with your …

Nutrition & Homeopathy For Inflammatory Bowel Disease – Vitality …

vitalitymagazine.com/article/nutrition-homeopathy-for-inflammatory-bowel-disease/

Homeopathic remedies are gentle, have no side effects, and do not contra-indicate any medications. These medicines can drain toxins and heal the intestinal tract and supporting organs. Singlehomeopathic remedies are suited to each person’s symptoms rather than a disease name. This stimulates the person’s unique …

Natural Remedies for Tummy Troubles — Research Shows Herbs …

by RDL Blog – ‎Related articles

Natural Remedies for Tummy Troubles — Research Shows Herbs Can Relieve Symptoms in Patients With GI Diseases By Melinda Lund, MS, RD Today’s Dietitian Vol. 15 No. 9 P. 18. All illnesses that affect the gastrointestinal tract (GI) are classified as digestive diseases, including those of the esophagus, stomach, …

What sugar does to your brain – Dr Axe

What sugar does to your brain - Dr. AxeDextrose. Fructose. Lactose. Maltose. Glucose. A sugar by any other name is still sugar. In fact, there are more than 50 different names for it. But is sugar bad for you? Essentially, there are two types of sugar; there is “good” sugar that occurs naturally in fruits and vegetables and “bad” added sugar that’s added to sweeten sodas, candy, baked goods, and so on.

The “good” sugar is actually needed within the body, particularly within the brain. Following a meal, food is broken down; specifically glycogen, carbohydrates, proteins, fats and triglycerides, which are broken down into glucose. Glucose is so crucial to cell function that glucose deprivation can lead to loss of consciousness and eventual cell death. Therefore, after a meal, the body has a system in place in which excess glucose is stored as a reserve.

All cells need the energy to function; the large mass of neuron cells that make up the brain needs energy, largely in the form of glucose, to function. Did you know that the brain uses approximately 20 percent of an individual’s daily energy intake? (1)

Not only is sugar essential for your basic brain functions, but it tastes delicious too! Once you eat something with sugar in it, your taste receptors are activated, sending signals to your brain that set off an entire cascade of stimulation. In particular, the dopaminergic pathway is activated and triggers your “YUM!” signal. This pathway starts in a cluster of cells at the base of your brainstem called the ventral tegmental area (VTA) and extends through the lateral hypothalamus to the nucleus accumbens in the forebrain. Behaviors that stimulate the release of the neurotransmitter, dopamine, within this pathway have been shown to be highly motivational.

What sugar does to your brain - Dr. AxeGlucose is crucial to cell function and survival and it stimulates the reward pathway in your brain which makes everything feel like unicorns and rainbows. Life is good. Except that too much of something, is usually the opposite of good. But how many grams of sugar should you ingest per day? The American Heart Association suggests that individuals ingest a maximum daily intake of 6 teaspoons of sugar for women and 9 teaspoons for men. On average, people ingest 22 teaspoons of added sugar, which is on top of the naturally occurring sugar in our diet. (2, 3)

So as our reward pathway keeps getting stimulated, the dopamine receptors become desensitized and require more dopamine to get the same pleasant feeling.

Therefore, there needs to be more consumption of, in this case, the sugary food or beverage, to elicit the same response. This increase in consumption has been shown to result in obesity, including childhood obesity. An increased diet in saturated fats and sugar (also known as a high-energy diet) can have fundamental changes within the brain that in conjunction with the increased neurotransmitter release (dopamine) can have detrimental effects. Such effects include…

Learning and Memory

Studies show that a diet high in sugar and saturated fats can promote oxidative stress, leading to cell damage. In 2010 Scott Kanoski, an associate professor of biological sciences at Perdue University, demonstrated that a three-day diet of increased sugar and saturated fats resulted in impaired hippocampal function (learning and memory), causing the rats to have difficulty finding food within a maze. (4)

Other studies also illustrate that the hippocampus, in particular, is sensitive to a high-energy diet. (5)

Your brain on sugar - Dr. AxeAddiction

Sugar addiction is real. The pathway activated for addiction is the same as the reward pathway. Persistent increases in the release of the neurotransmitter, dopamine, leads to desensitization and requires more consumption for the reward. It changes gene expression and creates a consumption→ Dopamine release→ reward→ pleasure→ motivate cycle that is increasingly difficult to break. (6)

Depression & Anxiety

Attempts in trying to break the addictive cycle can lead to mood swings and irritability. Eliminating all additive sugar from your diet can lead to some of the same symptoms of drug withdrawal. Sugar withdrawal symptoms include headaches, anxiety, cravings and even chills.

Cognitive Deficits

Prolonged diets with high sugar may lead to changes in gene expression. That affects everything from neurotransmitters to receptors and the basic function of the cell. In particular, studies suggest the brain-derived neurotrophic factor (BDNF) is impacted. This is active in the hippocampus, cortex and forebrain and is vital to learning and memory, as well as supporting existing neurons while promoting the formation of new synapses. This is reduced in high sugar diets. (7)

Therefore, it’s unsurprising that a correlation between low BDNF levels and Alzheimer’s, depression and dementia has been discovered. New and continuing research in the field of neuroscience continues to provide valuable information on the effect that excessive sugar has on the brain. Further information gained from such research could also lead to changes in the way that specific cognitive disorders are treated. (8)

https://draxe.com/what-sugar-does-to-your-brain/?rs_oid_rd=376260610932895&utm_campaign=20180207_newsletter_curated_week6_eot&utm_medium=email&utm_source=smart+blast

The New Yorker 2-7-2018

Donald Trump in New York City

In an alternate universe, Trump never became President. He’s just a regular guy in New York City.

4:00 P.M.

Daily Cartoon: Wednesday, February 7th

“Yee-Haw!!!”

12:16 P.M.

Military Refuses to Participate in Trump’s Parade, Citing Bone Spurs

“Regrettably, we have no choice but to issue thousands of deferments,” a Pentagon spokesman said.

10:54 A.M.

Daily Cartoon: Tuesday, February 6th

The misadventures of Dick Trumpy.

February 6, 2018

Under Pressure from Fox News, Obama to Stop Making Stocks Plummet

“Sean Hannity has accused me of making the stock market go down,” Obama told reporters Tuesday morning. “All I have to say is, ‘Guilty as charged.’ ”

February 6, 2018

New York Times 2-7-2018

Top aging and health hacks 2-7-2018

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Disease condition and odor symptom
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Estrogen and Alzheimer
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Anti-aging Vitamin B3, Niacin
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Muscles and aging
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Prolong stress and its impact to the neuroimmune system
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MSM powder benefits – Alzheimer is a sulfur deficiency
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Resveratrol and calorie restriction activates SIRT1 , anti-aging gene
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Robert Mueller III stood up against corruption
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Melatonin counteract estrogen’s tendency to stimulate cell growth

Oct 10, 2013 … Melatonin is a powerful antioxidant that helps protect you against heart disease, diabetes, migraine headaches, Alzheimer’s disease, and cancer. … When this hormone latches onto a breast cancer cell, it has been found to counteract estrogen’s tendency to stimulate cell growth. In fact, melatonin has a …
https://articles.mercola.com/…/alzheimers-dementia-treatment.aspx
Jun 13, 2013 … A study reveals that vitamins B6, B12, and folic acid, as well as cinnamon, may help slow the progression of Alzheimer’s disease.
Sep 12, 2013 … When used at extreme levels, copper can be very toxic and can increase your risk of Alzheimer’s disease.
Nov 8, 2008 … Eating the wrong diet could increase your risk of developing Alzheimer’s disease. Scientists have found a link between the degenerative brain disease and raised levels of an omega-6 fatty acid. Researchers compared the brains of mice bred with a condition that mimics Alzheimer’s to those of normal mice.
https://articles.mercola.com/…/estrogen-levels-and-cognitive-decline.aspx
Jan 2, 2008 … Another nail in the coffin for postmenopausal estrogen therapy. Last year, NEJM published a study that suggested that estrogen helps prevent Alzheimers disease in women. This information provided another false justification for traditional medicine to prescribe it. If you have not purchased Dr. Lee’s book, …
Apr 27, 2017 … Mounting research also suggests Alzheimer’s disease is intricately connected to insulin resistance; even mild elevation of blood sugar is associated with an elevated risk for dementia. Diabetes and heart disease are also known to elevate your risk, and both are rooted in insulin resistance.
Feb 11, 2010 … Copper pipes have no place in your home. Learn why installing special filters can help you avoid heart disease, Alzheimer’s disease and diabetes.
Aug 4, 2013 … Not only heart disease and stroke, but I’m thinking cancer, Alzheimer’s, multiple sclerosis, or any illness that requires good oxygenation to the tissues. … One of the mechanisms that causes this increased risk is that synthetic estrogens and progesterones increase blood viscosity, i.e., they decrease the zeta …
Feb 16, 2010 … Alzheimer’s disease is not the only reason to ditch your aluminum-containing antiperspirant and deodorant, as this metal has also been linked to cancer. A 2006 study found that aluminum salts can mimic the hormone estrogen, and chemicals that imitate that hormone are known to increase breast cancer …
Nov 6, 2014 … A six-year study reveals that those with vitamin D deficiency are more than twice as likely to develop dementia and Alzheimer’s disease.

Estrogen and Alzheimer

Estrogen and Alzheimer’s. Hormone replacement therapy does not appear to reduceAlzheimer’s symptoms, but it may help to prevent the disease in healthy women.. At menopause, the level of the hormone estrogen in women’s bodies begins to decline, marking the end of their childbearing years.

Estrogen Therapy Could Hold Back Alzheimer’s, Shrink the Brain …

Sep 3, 2015 – On a positive note, a large epidemiological study found that estrogen given early in menopause reduced Alzheimer’s risk, and results from a small cohort indicated that early treatment with the hormone may have slowed amyloid accumulation.

Hormonal Influences on Cognition and Risk for Alzheimer Disease

by SC Janicki – ‎2010 – ‎Cited by 79 – ‎Related articles

Jump to Estrogen in Men – Support for the role of estrogen in neuroprotection has come from epidemiologic studies of gender differences in risk for cognitive decline and dementia; from observational studies; from clinical trials of the effects of hormone replacement therapy; from studies of risk for cognitive decline and dementia associated …

Estrogen and Alzheimer’s – Memory Loss & the Brain

Estrogen and Alzheimer’s. Hormone replacement therapy does not appear to reduce Alzheimer’ssymptoms, but it may help to prevent the disease in healthy women.. At menopause, the level of the hormone estrogen in women’s bodies begins to decline, marking the end of their childbearing years.

New Debate on Hormone Replacement Therapy and Dementia Risk …

Mar 22, 2017 – It included over 4,500 postmenopausal women and examined the effects of estrogenplus progestin HRT on the incidence of dementia and mild cognitive … period after menopause did not have a lower risk of Alzheimer’s disease, while treatment lasting over 10 years was associated with decreased risk [9].

Estrogen & Your Brain | Cognitive Vitality | Alzheimer’s Drug Discovery …

Jul 1, 2016 – The term “estrogen” refers to a broad range of natural and synthetic molecules that affectestrogen receptors. Estrogen hormone therapy usually consists of estrogens alone or combined with a progestogen and can be used to treat symptoms of menopause. While estrogens do have some potentially …

Estrogen and Alzheimer’s Disease: What Is the Connection? – Medscape

Estrogen use was identified based on the women’s questionnaire responses at the time of entry into the retirement community. The women without AD were more likely to have taken estrogen (odds ratio 0.69; 95% CI=0.46-1.03), with the risk of Alzheimer’s decreasing as dose and duration of estrogen use increased.

Estrogen Patch in Newly Postmenopausal Women May Reduce …

Jul 12, 2016 – ROCHESTER, Minn. — Can estrogen preserve brain function and decrease the risk ofAlzheimer’s disease when given early in menopause? Newly postmenopausal women who receivedestrogen via a skin patch had reduced beta-amyloid deposits, the sticky plaques found in the brains of people with …

Menopause, Female Hormones, and Alzheimer’s Risk – Awakening …

Feb 23, 2017 – Estrogen and Alzheimer’s Disease. Estrogen and progesterone are steroid sex hormones that not only contribute to female fertility but also play an important role in brain functioning for both men and women. Estrogen is part of the brain’s signaling system, and it helps direct blood to parts of the brain that …

[PDF]Anti-Amyloid Therapies – Alzheimer’s Association

Hormone replacement therapy and Alzheimer’s disease. What is hormone replacement therapy? Hormone replacement therapy substitutes estrogen from a pharmaceutical source for a woman’s natural supply. Production of estrogen by the ovaries declines as women age and then virtually stops around menopause.

Estrogen supplements may protect against dementia — ScienceDaily

Jan 22, 2016 – Must start estrogen from the late 40s. Pintzka’s findings show that boosting estrogenlevels increases the volume of the hippocampus. As of yet there are no drugs that stop or prevent the course of Alzheimer’s disease, and the focus has shifted towards strategies to prevent or delay the onset of dementia.

Danazol drug and telomere-related disease

Danazol – Wikipedia

Danazol, sold under the brand names Danatrol, Danocrine, Danol, and Danoval among many others, is a synthetic steroid that is used primarily in the treatment of endometriosis. It was approved by the U.S. Food and Drug Administration in 1971 as the first drug in the country to specifically treat this condition. Although it is …

Trade names‎: ‎Danatrol, Danocrine, Danol, Da…
Biological half-life‎: ‎Acute: 3–6 hours; Chronic: …
Pregnancy category‎: ‎AU: ‎D‎; US: ‎X‎ (Contraindi…
Formula‎: ‎C22H27NO2

Danazol – DrugBank

Jul 13, 2007 – A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.

danazol – Wiktionary

Wikipedia has an article on: danazol · Wikipedia. Pronunciation[edit]. (UK) IPA: /ˈdænəzɒɫ/. Noun[edit].danazol (uncountable). A derivative of the synthetic steroid ethisterone, a modified testosterone, formerly used to treat endometriosis. Retrieved from “https://en.wiktionary.org/w/index.php?title=danazol&oldid=44982005 …

Danazol – Wikipedia Republished // WIKI 2 – wiki2.org

Danazol is a derivative of the synthetic steroid ethisterone that suppresses the production of gonadotrophins and has some weak androgenic effects. Before becoming available as a generic drug,danazol was marketed as Danocrine in the United States. It was approved by the US Food and Drug Administration (FDA) as the …

Danazol – Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol …

May 4, 2015 – Danazol – Get up-to-date information on Danazol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Danazol.

danazol | C22H27NO2 – PubChem

danazol | C22H27NO2 | CID 28417 – structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … from Wikipedia … Azol; Cyclomen; Danatrol; Danazant; Danazol; Danazol Ratiopharm; Danazol-ratiopharm; Danocrine; Danol; Danoval. Ladogal …

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To learn more about the study below, or other studies, please call us at 1-866-444-1132.

Low-dose Danazol for the Treatment of Telomere-Related Diseases

Researchers at the National Institutes of Health (NIH) are studying if the medication danazol can be used to treat people with short telomere disease who also have bone marrow failure, liver, or lung disease.

In recent studies, danazol, at high doses, showed a positive influence on telomere length. Additional research is needed to learn more about the role of different doses of danazol on telomere disease as well as its effects on secondary diseases.

Eligible participants:

  • Are 3 and older (minors must have parent/guardian consent to participate);
  • Are diagnosed with a short telomere disease;
  • Also have abnormalities affecting the bone marrow such as aplastic anemia or low blood counts OR lung disease OR liver disease

Study procedures:

  • Before starting danazol, you will have tests and evaluations including measurements of your telomere length.
  • Depending on your secondary disease you may also have a bone marrow biopsy, lung function tests, or evaluation of your liver.
  • You will then begin taking danazol either 100 mg twice a day, or 200 mg twice a day for up to a year.
  • While taking danazol you will have outpatient visits to the NIH Clinical Center after 6 months, a year, and 6 months after stopping danazol.
  • Your participation in this study will last about 2 years.

Study-related tests, procedures, and medications are at no-cost. Travel within the United States may be reimbursed by the study team.

Location: The NIH Clinical Center, America’s Research Hospital is located on the Metro red line (Medical Center stop) in Bethesda, Maryland.

For more information:
NIH Clinical Center Office of Patient Recruitment
1- 866-444-1132 (refer to study 18-H-0004)
TTY: 1-866-411-1010
https://go.usa.gov/xnPYm

Star-like cells – astrocytes – may help the brain tune breathing rhythms

Star-like cells , astrocytes,  may help the brain tune breathing rhythms

NIH study in rats suggests that support cells modulate brain circuit activity.

Traditionally, scientists thought that star-shaped brain cells called astrocytes were steady, quiet supporters of their talkative, wire-like neighbors, called neurons. Now, an NIH study suggests that astrocytes may also have their say. It showed that silencing astrocytes in the brain’s breathing center caused rats to breathe at a lower rate and tire out on a treadmill earlier than normal. These were just two examples of changes in breathing caused by manipulating the way astrocytes communicate with neighboring cells.

“For decades we thought that breathing was exclusively controlled by neurons in the brain. Our results suggest that astrocytes actively help control the rhythm of breathing,” said Jeffrey C. Smith, Ph.D., senior investigator at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and a senior author of the study published in Nature Communications. “These results add to the growing body of evidence that is changing the way we think about astrocytes and how the brain works.”

Dr. Smith’s lab investigates how breathing is controlled by the rhythmic firing of neurons in the preBötzinger complex, the brain’s breathing center that his lab helped discover. For this study, his team worked with Alexander Gourine, Ph.D., professor at University College London (UCL), whose lab found that astrocytes in neighboring parts of the brain may regulate breathing by sensing changes in blood carbon dioxide levels.

At least half of the brain is comprised of cells called glia and most of them are astrocytes. Recently scientists have shown that astrocytes may communicate like neurons by shooting off, or releasing, chemical messages, called transmitters, to neighboring cells.

In this study, the scientists tested the role of astrocytes in breathing by genetically modifying the ability of astrocytes in the preBötzinger complex to release transmitters. When they hushed the astrocytes in rats by reducing transmitter release, the rats breathed and sighed at a lower rate than normal. In contrast, if they made the astrocytes chattier by increasing transmission, the rats breathed at higher resting rates and sighed more often.

The team also tested how silencing astrocytes affected the rats’ responses to changes in oxygen and carbon dioxide levels. Although the rats’ breathing rate increased when oxygen levels were lower or carbon dioxide levels higher, it was still lower than normal. Silencing astrocytes also decreased the rate at which the rats sighed under lower oxygen levels. Moreover, the rats became exhausted much earlier than normal. They could only run half the distance that normal rats could run on a treadmill before tiring out.

“The primary goal of breathing is the exchange of carbon dioxide and oxygen that is critical for life. Our results support the idea that astrocytes help the brain translate changes in these gases into breathing,” said Shahriar Sheikhbahaei, Ph.D., formerly a doctoral student at UCL and participant in the NIH Graduate Partnership Program, and the lead author of the study.

Finally, the team showed that these astrocytes used adenosine triphosphate (ATP) to communicate with other cells in the brain. Inactivating released ATP reduced resting breathing rates and the frequency of sighs under normal and low oxygen levels.

“Our results expand our understanding of how the brain controls breathing under normal and disease conditions,” said Dr. Smith. “We plan to follow this path to understand how astrocytes help control other aspects of breathing.”

This study was supported by the Intramural Research Program at the NINDS, the Wellcome Trust, British Heart Foundation (Ref. RG/14/4/30736), BBSRC (Refs. BB/L019396/1, BB/K009192/1), the Medical Research Council (Ref. MR/L020661).

NINDS is the nation’s leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.

$64K per year Multiple sclerosis drug or a holistic healing option

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