Virus and thin blood, exercise, foods, meds

Foods that help thin the blood

Turmeric, ginger, garlic, pineapple, cayenne pepper, cinnamon, Dong Quai,  grape seed extract, gingko, Vitamin E, feverfew

Exercise that thin the blood

Standing  squat with deep slow breathing thru nose , breath IN and breath OUT thru the mouth

 

http://www.sciencedaily.com › releases › 2013/04

Apr 1, 2013 – Moreover, the absence of PAR-1 signaling was associated with a slower response to the virus of the innate immune soon after viral infection. The …


Thin blood: Causes, symptoms, and treatment

 

May 12, 2018 – Viral infections, such as HIV, hepatitis C, mumps, rubella, or the Epstein-Barr virus may cause platelet numbers to fall. Bone marrow disorders, …

Hematuria – Harvard Health

http://www.health.harvard.edu › a_to_z › hematuria-a-to-z

 

Feb 14, 2019 – Hematuria is the presence of red blood cells in the urine. … the ureters (the narrow tubes connecting each kidney to the bladder), it can cause … trauma or strenuous exercise, recent viral or bacterial infections, the medications …

Japanese Researchers to Test Blood Thinner For Virus …

http://www.bloomberg.com › news › articles › japanese-resea…

 

Mar 18, 2020 – blood thinner used to treat pancreatitis and kidney disease has been identified as a potential therapy for coronavirus patients, with clinical …

Missing: exercise ‎| Must include: exercise

13 Tips for Using Blood Thinners – WebMD

http://www.webmd.com › DVT › Feature Stories

 

Apr 21, 2015 – Ask your doctor what you should do if you accidentally miss a dose of your blood thinner. 2. Be more careful when you exercise or are doing …

Hughes syndrome – Better Health Channel

http://www.betterhealth.vic.gov.au › ConditionsAndTreatments

 

Sep 30, 2012 – Treatment includes medications to thin the blood and prevent platelets … that a percentage of patients have had a recent viral or bacterial infection, … such as quitting cigarettes, eating a healthy diet and exercising regularly.

Hughes Syndrome (Antiphospholipid Syndrome): Symptoms …

http://www.healthline.com › health › hughes-syndrome

 

Aug 31, 2018 – Hughes syndrome, also known as “sticky blood syndrome” or antiphospholipid … Having certain viral or bacterial infections, like E. coli or the … like not getting enough exercise and eating a diet high in cholesterol — and … may be prescribed a low-dose aspirin or a daily dose of the blood thinner heparin.

What You Should Know Before Taking New Blood Thinners …

health.usnews.com › Patient Advice

 

Oct 13, 2016 – Yet despite the ability of anticoagulants to prevent dangerous blood clots and stroke, … [See: 7 Signs You Should Stop Exercising Immediately.] … situations when there is a need to reverse Pradaxa’s bloodthinning effects.

Exercise on blood thinner medications- A Physical Therapist …

http://www.starspt.org › exercise-blood-thinner-medications-…

 

Blood thinner medications are prescribed to patients who suffer from deep vein thrombosis (blood clot), pulmonary embolism (blood clot has migrated to the …

Missing: virus ‎| Must include: virus

Polycythemia Vera | National Heart, Lung, and Blood Institute …

http://www.nhlbi.nih.gov › health-topics › polycythemia-vera

 

Polycythemia vera is a rare blood disease in which the body makes too many red blood cells, making the blood thicker than normal and causing blood clots.

Oxygen. Deadly cancer enemy. Deep breath

Cancer Prevention and Cure?

We don’t compete with conventional Western medicine, we compliment it. It is our intention to provide the knowledge and materials that can improve the lives of millions of human beings; to awaken the breathing consciousness of the world. I am really sick and tired of much of the the cancer industry bilking and killing millions in the name of “health”.

The modality priority depends on the person. Primary approaches we recommend are sodium bicarbonate; breathing development, fresh veggie and fruit juice combos, coffee enemas, oxygen and brain, attitude, purpose, belief systems training, and for skin I tried this CBD oil from Spain (30ML 2x Concentrate) on a diagnosed small growth cancer on my face and it WORKED; gone in a few weeks.

VIAGRA MELANOMA RISKS

Dr. Otto Warburg received the 1931 Nobel price for proving that cancer is  anaerobic. It does not survive in high concentrations of oxygen.

Dr. Warburg and cancer. Cancer all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.

All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference.

Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose. Cancer cells can flourish in low oxygen environments. They can not survive in HIGH oxygen environments.

HOW IS BREATHING RELATED TO WARBURG?

Breathing is our primary c source of oxygen. Contemporary lung volume measurements are inconsistent and guided by cross sectional criteria instead of longitudinal data and therefore do not adequately predict decline within individuals.  This lack of insight about optimal functioning can cause people to be trained to do forced inhalations that may actually be harmful in long run.

GENERAL CANCER RISKS: ALL AREAS

  1. High meat and fat consumption.
  2. Coffee, tea, colas.
  3. Aflatoxins (fungal products; especially in peanuts and soy sauce).
  4. Lack of iodine, Vitamins A, C, E.
  5. Amines (such as nitrosamines) in unrefrigerated foods, processed meat, cheese.
  6. High intake of certain vitamins.
  7. Habit of overeating (associated in 35% of all cancers).
  8. Some species of mushrooms.
  9. Diet high in refined foods.
  10. Diet high in fat or protein.
  11. Diabetes
  12. Overweight
  13. High “transit time” through colon.
  14. Estrogens
  15. Hair dyes
  16. Asbestos fibers
  17. Drugs: certain antibiotics (Tetracycline, probably penicillin), aspirin, diuretics, immunosuppressants, Azolid, Butazolidin, Presamine, Tofranil, SK-Pramine, Tapazole, Methotrexate, antihistamines, amphetamines, Atromid-S, etc. (NOTE: These are associations, not implying that they are causative of cancer).
  18. Use of tobacco, alcoholic drinks, caffeinated and decaffeinated drinks.
  19. Excessive exposure to chemicals, industrial fumes, hydrocarbons, cleaning solvents, vinyl chloride.
  20. Stress
  21. Exposure to cold, heat, and radiation.
  22. public drinking water in most large cities.
  23. Long contact with sick pets.
  24. Chronic irritation or infection.
  25. All viral illnesses (flu, colds, rashes, diarrhea).
  26. Early sexual activities – cervical and fore-skin cancer.
  27. A kidney transplant.
  28. History of any previous cancer.
  29. Nonspecific factors: age, race, sex, occupation, family history of. source of the above 1-29 factors
  30. Add acid PH in urine and saliva. Think sodium bicarbonate (baking soda) to take it to alkaline. 1/2 tsp 3 x daily. Try to stay at pH 8.0 or more.
  31. Colds and flu are some of the primary gateways into cancer due to the way they inhibit oxygen uptake.
    http://www.breathing.com/articles/colds-flu

Oxygen. Deadly enemy to cancer

Latest news about Warburg’s work

Inexpensive sources of medical grade oxygen costing pennies per day.

Cancer screening too often harmful or terribly missleading Popular Science PDF

Marijuana that helps contain or reverse cancer

Cancer and cannabinoids. #6

Skin Cancer and Colloidal Silver -My personal experience with a facial problem was good but I altertated wht a CBD from Spain. Silver Armor Dina Davis 770-843-4835

The term cancer comes from the Latin word meaning crab. Cancer was characterized as a crablike disease by the Greek physician Hippocrates, who observed that cancers spread throughout the body, eventually cutting off life.

Now cancer generally is defined as the unregulated growth of abnormal cells in the body. The word cancer actually refers to over 100 different diseases, but in all cases, certain body cells multiply in an uncontrolled manner.

Cancer is anaerobic. It can not survive with the presence of adequate oxygen. That is one good reason the heart never gets cancer. The heart needs oxygen and most heart attacks are in some way linked to low oxygen to the heart. Insufficient oxygen and you die and cancer or anything else is no longer an issue.

Aside from optimal breathing right to supply adequate oxygen there are many cofactors that help ensure/support the effectiveness of adequate oxygen in the human body.

From what I know, curing and prevention of cancer often requires several of those oxygen friendly factors along with other factors that create what is an holistic approach by strengthening several factors simultaneously such as breathing improvement, strengthening antioxidants, internal cleansing, parasite elimination, changing ones self defeating thoughts and attitudes.

Excessive survival responses including those exacerbated by UDB http://www.breathing.com/articles/udb.htm  and/or poor natural hygiene stimulate and/or overtax the sympathetic nervous system (and inhibit the parasympathetic nervous system) that both vaso-constricts blood vessels and turns the body toward toxemia and acidosis, allow anaerobic organisms to dominate.

One’s thoughts (hyper-vigilance for example and or negative thinking especially including Nocebo – for example – say believing in so called expert’s prognosis of imminent death from say cancer) exacerbated by poor natural hygiene and toxic overload create an environment that invites organisms unfriendly to the body.

Eventually  the body’s immune system, biochemical and spiritual/energetic homeostasis gets overwhelmed by chaos.  Any strong enough presence of any of the preceding negatives may invite cancer or whatever to set up housekeeping.

Over the years I have come in contact with many health professionals quite successful in handling cancer. While not necessarily focusing on breathing development per se they seem to have a very good history of success.

I believe they could greatly improve their results by adding our Optimal Breathing Kit into their already successful approaches but here they are anyway. Use the form at the bottom of this page to forward to those you care about.

My top 3 choices in order of cost and simplicity.

  1. Sentient Temple in St. Petersburg Florida. I have checked it out in person. A former oncologist turned alternative.  If I had cancer I would go there. Not expensive.  click here
  2. Gerson Therapy   Thousands of successes reported. Buy “Dying to have known”  Amazon.com for approx $10.00 or free as a Netflix documentary.  Gerson protocol link Add coffee enemas.  Heal yourself heal the world
  3. Dr. Larraine Day

The Oxygen Protocol for The Treatment of Cancer, Dr. Majid Ali

Moss Cancer report

Dr. Burzinski movie  EXTREMELY EXPENSIVE but in my opinion the man deserves 2 Nobel prizes.  1 for his cancer research and results. The second for surviving the 25+ year onslaught of the FDA and Big Pharma.  Watch part of it free  See also   Iwantanp.com

  • Wigmore Institute Puerto Rico
  • Ozone University   Ozone is one of the best cancer killers.
  • Ozone oriented physicians by state or country
  • Dr. Otto Warburg
  • Alternative Cancer Centers of California
  • Prostate Cancer Majid Ali
  • cancertutor.com
  • Majidalimd.com  Breast cancer video.
  • The Hoxey Clinic  Video
  • Raymond Francis, MIT trained biochemist
  • The Moss Report
  • Cancercenter.com
  • Coffee enemas
  • Acupuncture to offset dangers of chemo
  • NETFLIX DOCUMENTARIES ABOUT FOOD THAT I HIGHLY RECOMMEND

Ozone information:

In a 1980 study done by the German Medical Society for Ozone Therapy, 644 therapists were polled regarding their 384,775 patients, comprising a total of 5,579,238 ozone treatments administered. There were only 40 cases of side effects noted out of this number which represents the incredibly low rate of .000007%, and only four fatalities, which were all attributed to operator error. Ozone has thus proven to be the safest medical therapy ever devised.”

http://www.ozoneuniversity.com  www.ozonehospital.com

http://www.oxygentherapyexperts.com  www.medicalozone.info

http://www.bloodozonation.com  http://www.youtube.com/user/ozoneresearch

An expert opinion about most cancers  “As one long-term survivor put it, “Returning to a state of health is not just about having treatment; it means dealing with the mental, emotional and the spiritual issues that tend to manifest physically. It means asking, ‘Am I on the path that I want to be on?’”

An expert opinion about most cancers  “As one long-term survivor put it, “Returning to a state of health is not just about having treatment; it means dealing with the mental, emotional and the spiritual issues that tend to manifest physically. It means asking, ‘Am I on the path that I want to be on?’”

page

NOTE from Mike: If you have poor breathing it may only add to and not cause cancer but Otto Warburg proved that cancer is anaerobic and will not survive in high concentrations of oxygen.

Breathing, oxygen and emotions. To have the best chance of success with any cancer program, make sure you develop your breathing.

Inexpensive sources of medical grade oxygen costing pennies per day..

More About Cancer

Cancer Overview – My educated guesses, opinions and facts.

Cancer screening too often harmful or terribly miss-leading Popular Science PDF

  1. Every person has cancer cells in the body. These cancer cells do not show up in the standard tests until they have multiplied to a few billion. When doctors tell cancer patients that there are no more cancer cells in their bodies after treatment, it just means the tests are unable to detect the cancer cells because they have not reached the detectable size.
  2. Cancer cells occur between 6 to more than 10 times in a person’s lifetime.
  3. When the person’s immune system is strong, the cancer cells will be destroyed and prevented from multiplying and forming tumors.
  4. When a person has cancer it indicates the person has multiple nutritional deficiencies. These could be due to genetic, environmental, food and lifestyle factors.
  5. To overcome the multiple nutritional deficiencies, changing diet and including supplements will strengthen the immune system.
  6. Chemotherapy involves poisoning the rapidly-growing cancer cells and also destroys rapidly-growing healthy cells in the bone marrow, gastro-intestinal tract etc, and can cause organ damage, like liver, kidneys, heart, lungs etc.
  7. Radiation while destroying cancer cells also burns, scars and damages healthy cells, tissues and organs.
  8. Initial treatment with chemotherapy and radiation will often reduce tumor size. However prolonged use of chemotherapy and radiation do not result in more tumor destruction.
  9. When the body has too much toxic burden from chemotherapy and radiation, the immune system is either compromised or destroyed, hence the person can succumb to various kinds of infections and complications.
  10. Chemotherapy and radiation can cause cancer cells to mutate and become resistant and difficult to destroy. Surgery can also cause cancer cells to spread to other sites.
  11. An effective way to battle cancer is to starve the cancer cells by not feeding it with the foods it needs to multiply.
  12. Marijuana/cannabis and lung and brain cancer

Cancer screening too often harmful or terribly miss-leading Popular Science PDF

Cancer Cells Feed On:

  • Sugar is a cancer-feeder. By cutting off sugar it cuts off one important food supply to the cancer cells. Sugar substitutes like NutraSweet, Equal, Spoonful, etc are made with Aspartame and it is harmful. A better natural substitute would be Manuka honey or molasses but only in very small amounts. Table salt has a chemical added to make it white in color. A better alternative is Bragg aminos or celtic or Hawaian sea salt.
  • Milk causes the body to produce mucus, especially in the gastro-intestinal tract. Cancer feeds on mucus. By cutting off milk and substituting with fresh made almond milk, the cancer cells are being starved.
  • Cancer cells thrive in an acid environment. A meat-based diet is acidic. It is best to eat fish, and a little chicken rather than beef or pork. Meat also contains livestock antibiotics, growth hormones and parasites, which are all harmful, especially to people with cancer.
  • A diet made of 80% fresh vegetables and juice, whole grains, seeds, nuts and a little fruit help put the body into an alkaline environment. About 20% can be from cooked food including beans. Fresh vegetable juices (enzymes are destroyed at temperatures above 104 degrees F (40 degrees C).) provide live enzymes that are easily absorbed and reach down to cellular levels within 15 minutes to nourish and enhance growth of healthy cells. To obtain live enzymes for building healthy cells try and drink fresh vegetable juice (most vegetables including bean sprouts) and eat some raw vegetables 2 or 3 times a day.  We use a Breville Juicer, make 2 gallons a week and preserve the juice in Mason Jars sealed with a food saver. See Gerson therapy below
  • Avoid coffee (except in enemas), tea, and chocolate, that have high caffeine. Green tea is a better alternative and has cancer-fighting properties. Water: best to drink purified, distilled, reverse osmosis or filtered, to avoid known toxins and heavy metals in tap water. Distilled water is slightly acidic; avoid it.
  • Meat protein is difficult to digest and requires a lot of digestive enzymes. Undigested meat remaining in the intestines become putrefied and leads to more toxic buildup.
  • Cancer cell walls have a tough protein covering. By refraining from or eating less meat it frees more enzymes to attack the protein walls of cancer cells and allows the body’s killer cells to destroy the cancer cells.
  • Some supplements build up the immune system (IP6, Florssence, Essiac, antioxidants, vitamins, minerals, EFAs etc.) to enable the body’s own killer cells to destroy cancer cells. Other supplements like vitamin E are known to cause apoptosis, or programmed cell death, the body’s normal method of disposing of damaged, unwanted, or unneeded cells.
  • Cancer is a disease of the mind, body, and spirit. A proactive and positive spirit will help the cancer warrior be a survivor. Anger, un-forgiveness, indifference masking resentment) and bitterness put the body into a stressful and acidic environment. Learn to have a loving and forgiving spirit. Learn to relax and enjoy life.
  • Cancer cells cannot thrive in an oxygenated environment. Exercising daily, and deep breathing help to get more oxygen down to the cellular level. Oxygen therapy is another means employed to destroy cancer cells.

CANCER UPDATE 2 FROM JOHNS HOPKINS HOSPITAL, US – PLEASE READ

  1. No plastic containers in micro.
  2. No water bottles in freezer.
  3. No plastic wrap in microwave.

Johns Hopkins has recently sent this out in its newsletters.

This information is being circulated at Walter Reed Army Medical Center as well. Dioxin chemicals cause cancer, especially breast cancer. Dioxins are highly poisonous to the cells of our bodies. Don’t freeze your plastic bottles with water in them as this releases dioxins from the plastic.

Recently, Dr. Edward Fujimoto, Wellness Program Manager at Castle Hospital, was on a TV program to explain this health hazard. He talked about dioxins and how bad they are for us. He said that we should not be heating our food in the microwave using plastic containers. This especially applies to foods that contain fat. He said that the combination of fat, high heat, and plastics releases dioxin into the food and ultimately into the cells of the body.

Instead, he recommends using glass, such as Corning Ware, Pyrex or ceramic containers for heating food. You get the same results, only without the dioxin. So such things as TV dinners, instant ramen and soups, etc., should be removed from the container and heated in something else. Paper isn’t bad but you don’t know what is in the paper.

It’s just safer to use tempered glass, Corning Ware, etc. He reminded us that a while ago some of the fast food restaurants moved away from the foam containers to paper. The dioxin problem is one of the reasons.

Also, he pointed out that plastic wrap, such as Saran, is just as dangerous when placed over foods to be cooked in the microwave. As the food is nuked, the high heat causes poisonous toxins to actually melt out of the plastic wrap and drip into the food. Cover food with a paper towel instead.

Cancer, oxygen (think breathing) and Otto Warburg Science Daily.

A 35% decrease in cellular oxygen levels will induce cancer. Otto Warburg. The message here is INCREASE  OXYGEN

Ozone (O3) oriented physicians by state or country

To have the best chance of success with any cancer program, make sure you develop your breathing.

Inexpensive sources of medical grade oxygen costing pennies per day.

Genetically Modified ‘Serial Killer’ T-Cells Obliterate Tumors in Leukemia Patients

In a cancer treatment breakthrough 20 years in the making, researchers from the University of Pennsylvania’s Abramson Cancer Center and Perelman School of Medicine have shown sustained remissions of up to a year among a small group of advanced chronic lymphocytic leukemia (CLL) patients treated with genetically engineered versions of their own T cells.

The protocol, which involves removing patients’ cells and modifying them in Penn’s vaccine production facility, then infusing the new cells back into the patient’s body following chemotherapy, provides a tumor-attack roadmap for the treatment of other cancers including those of the lung and ovaries and myeloma and melanoma.

The findings, published simultaneously in the New England Journal of Medicine and Science Translational Medicine on August 10, are the first demonstration of the use of gene transfer therapy to create “serial killer” T cells aimed at cancerous tumors.

“Within three weeks, the tumors had been blown away, in a way that was much more violent than we ever expected,” said senior author Carl June, MD, director of Translational Research and a professor of Pathology and Laboratory Medicine in the Abramson Cancer Center, who led the work. “It worked much better than we thought it would.

” The results of the pilot trial of three patients are a stark contrast to existing therapies for CLL. The patients involved in the new study had few other treatment options. The only potential curative therapy (From Mike.

He is obviously ignorant of Gerson and Day’s approaches noted below) would have involved a bone marrow transplant, a procedure which requires a lengthy hospitalization and carries at least a 20 percent mortality risk — and even then offers only about a 50 percent chance of a cure, at best.

After removing the patients’ cells, the team reprogrammed them to attack tumor cells by genetically modifying them using a lentivirus vector. The vector encodes an antibody-like protein, called a chimeric antigen receptor (CAR), which is expressed on the surface of the T cells and designed to bind to a protein called CD19.

Once the T cells start expressing the CAR, they focus all of their killing activity on cells that express CD19, which includes CLL tumor cells and normal B cells. All of the other cells in the patient that do not express CD19 are ignored by the modified T cells, which limits side effects typically experienced during standard therapies.

The team engineered a signaling molecule into the part of the CAR that resides inside the cell. When it binds to CD19, initiating the cancer-cell death, it also tells the cell to produce cytokines that trigger other T cells to multiply — building a bigger and bigger army until all the target cells in the tumor are destroyed.

“We saw at least a 1000-fold increase in the number of modified T cells in each of the patients. Drugs don’t do that,” June says. “In addition to an extensive capacity for self-replication, the infused T cells are serial killers. On average, each infused T cell led to the killing of thousands of tumor cells — and overall, destroyed at least two pounds of tumor in each patient.

” The importance of the T cell self-replication is illustrated in the New England Journal of Medicine paper, which describes the response of one patient, a 64-year old man. Prior to his T cell treatment, his blood and marrow were replete with tumor cells. For the first two weeks after treatment, nothing seemed to change.

Then on day 14, the patient began experiencing chills, nausea, and increasing fever, among other symptoms. Tests during that time showed an enormous increase in the number of T cells in his blood that led to a tumor lysis syndrome, which occurs when a large number of cancer cells die all at once.

By day 28, the patient had recovered from the tumor lysis syndrome — and his blood and marrow showed no evidence of leukemia. “This massive killing of tumor is a direct proof of principle of the concept,” Porter says.

Moving forward, the team plans to test the same CD19 CAR construct in patients with other types of CD19-positive tumors, including non-Hodgkin’s lymphoma and acute lymphocytic leukemia. They also plan to study the approach in pediatric leukemia patients who have failed standard therapy.

Additionally, the team has engineered a CAR vector that binds to mesothelin, a protein expressed on the surface of mesothelioma cancer cells, as well as on ovarian and pancreatic cancer cells.

Summary from Science Daily (Aug. 10, 2011)

Documentaries about eating your way to health

Valerie Warwick can be contacted via www.mywellnesstutor.com

Curaderm cream made from eggplant for basal cell and sqamous cell carcinoma www.curaderm.net

RGCC ONCOSTAT PLUS Test
Tests your cancer against 98 drugs and 45 natural compounds to see what it will respond to. Also tests 72 tumor-related genes.
www.rgcc-genlab.com/?tests

Complete list of all substances tested by ONCOSTAT PLUS test:

ONCOblot Blood Test for early detection
This test will detect a cancer of 2 million cells compared to 4.5 trillion cells for a positive mammogram.
www.oncoblotlabs.com 

Protocol for High Dose IV Vitamin C
PDFRiordan Clinic Research Institute

How to make your own liposomal vitamin C

Protocol for High Dose Oral Vitamin C

Ozone Therapy
http://www.oxygenhealingtherapies.com/Medical_Ozone_Cancer.html
The water ozonater I use can be purchased here
EWOT Exercise with Oxygen Therapy
http://www.oxygenhealingtherapies.com/exercise_with_oxygen_therapy.html

Medical Cannabis

Documentary on Cannabis Research Studies
https://www.youtube.com/channel/UCd6YT9YUqOr_aa0qVgkq0gQ
PDFList of cannabis research findings

GcMAF
GcMAF is a vitamin D binding protein that activates macrophages, which are immune cells that recognize, engulf, and destroy foreign matter and produce effector molecules. Cancer cells produce an enzyme called nagalase, which attempts to reduce macrophage activation.

GcMAF reduces nagalase and restores the integrity of the immune system allowing it to effectively eliminate cancer and restore homeostatic balance.
www.gcmaf.timsmithmd.com/book/book/4

 

https://breathing.com/pages/cancer

Serotonin Neurons Contribute to Fail Safe Mechanism that Ensures Recovery From Interrupted Breathing

Source: Harvard.

Scientists trying to identify the roots of sudden infant death syndrome (SIDS), the leading cause of death in U.S. infants between 1 month and 1 year old, have increasingly turned their attention to the neurotransmitter serotonin and the brain cells that produce it.

Studies have linked serotonin-producing neurons to the regulation of breathing, which may go awry in SIDS. In addition, tissue samples from SIDS infants often show abnormalities specifically in those neurons.

Now, a new study in mice suggests that abnormalities in serotonin-producing neurons do not simply accompany a subset of SIDS cases but could actually contribute to those premature deaths.

The findings, published Oct. 23 in eLife, show that an acute loss of normal activity in the serotonin-producing nerve cells blunts the body’s ability to recover from interrupted breathing. The results provide evidence that young animals need properly functioning serotonin neurons to maintain normal cardiorespiratory function.

“If we can determine whether serotonin-producing neurons play an active and necessary role in regulating breathing, heart rate and the recovery response to apneas in young mouse pups, it could provide a plausible biological explanation for at least some SIDS cases,” said Susan Dymecki, professor of genetics at Harvard Medical School and senior author of the study.

“This possible explanation might provide some hope, even if minutely, for the profound grief experienced by families who have lost a child to SIDS, and may one day help researchers prevent SIDS altogether,” she said.

Normally, the brain coordinates the heart and lungs to provide a continuous flow of oxygen into the body and carbon dioxide out.

In conditions such as sleep apnea, when breathing temporarily stops, oxygen levels in cells can fall too low and carbon dioxide levels can rise too high. To restore healthy levels, the brain triggers a series of gasps and raises the heart rate, a process called autoresuscitation.

But heart rate monitor readings in some SIDS infants support the hypothesis that this fail-safe mechanism doesn’t always kick in, and that its failure can lead to SIDS.

Dymecki and colleagues set out to explore the role of serotonin-producing neurons in regulating autoresuscitation in week-old mice, which the researchers estimate are within the corresponding age window that conveys highest risk of SIDS in humans.

The researchers genetically modified the mice so their serotonin neurons would quickly and temporarily be inhibited in response to an injected chemical. Other neurons remained unaffected.

Setting up this inducible neuron perturbation technique in mouse pups and coupling it with the ability to measure respiratory and heart function was the key, said Dymecki.

“Although initially technically challenging, this novel approach allowed for precise brain cell manipulation and real-time measurement of cardiac and respiratory activity,” said Ryan Dosumu-Johnson, a graduate student in the Dymecki lab and first author of the paper.

The researchers then induced apneas in the mice.

serotonin neurons

Those with inhibited serotonin-producing neurons had weaker breathing recovery and more instances of sudden death in the face of apneas than mice with a normally functioning serotonin production system.

“These results indicate a vital role for serotonin neurons at an early age after birth,” said Dymecki.

To the researchers’ surprise, the heart rates in mice with inhibited serotonin neurons recovered normally, at least initially, even though their breathing was impaired.

“This uncoupling of the breathing and heart-rate recovery responses was unexpected,” said Dymecki. “It suggests that these two vital physiological responses–heart rate and breathing–could be more separable at the level of brain cells and circuits than previously anticipated, despite their interwoven physiology.”

Although further studies will be needed to uncover whether the same principles hold true in humans, the current findings support the theory that defects in the functioning of serotonin neurons can render infants more vulnerable to dying from apneas and other cardiorespiratory challenges, the authors said.

If replicated in human studies, the new findings could eventually help improve screening tools to identify infants at higher SIDS risk and suggest new strategies for drug development, said Dymecki.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Additional authors of the paper were postdoctoral researcher YoonJeung Chang of HMS and Andrea Corcoran and Eugene Nattie of the Geisel School of Medicine at Dartmouth.

Funding: This study was funded by National Institutes of Health grant HD036379 as well as a Howard Hughes Medical Institute Gilliam Fellowship for Advanced Study, National Institute of General Medical Sciences award T32GM07753 and the Neuroscience Scholars Program of the Society for Neuroscience.

Source: Ekaterina Pesheva – Harvard
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Dymecki lab/Harvard Medical School.
Original Research: Open access research for “Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery” by Ryan T Dosumu-Johnson, Andrea E Cocoran, YoonJeung Chang, Eugene Nattie, and Susan M Dymecki in eLife. Published October 23 2018.
doi:10.7554/eLife.37857

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
Harvard”Serotonin Neurons Contribute to Fail Safe Mechanism that Ensures Recovery From Interrupted Breathing.” NeuroscienceNews. NeuroscienceNews, 25 October 2018.
<http://neurosciencenews.com/serotonin-neurons-breathing-10090/&gt;.

Abstract

Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

Cardiorespiratory recovery from apneas requires dynamic responses of brainstem circuitry. One implicated component is the raphe system of Pet1-expressing (largely serotonergic) neurons, however their precise requirement neonatally for homeostasis is unclear, yet central toward understanding newborn cardiorespiratory control and dysfunction. Here we show that acute in vivo perturbation of Pet1-neuron activity, via triggering cell-autonomously the synthetic inhibitory receptor hM4Di, resulted in altered baseline cardiorespiratory properties and diminished apnea survival. Respiratory more than heart rate recovery was impaired, uncoupling their normal linear relationship. Disordered gasp recovery from the initial apnea distinguished mice that would go on to die during subsequent apneas. Further, the risk likelihood of apnea-related mortality associated with suppression of Pet1 neurons was higher for animals with baseline elevated ventilatory equivalents for oxygen. These findings establish that Pet1 neurons play an active role in neonatal cardiorespiratory homeostasis and provide mechanistic plausibility for the serotonergic abnormalities associated with SIDS.

Rhythm of Breathing Affects Memory and Fear

Rhythm of Breathing Affects Memory and Fear

Source: Northwestern University.

Breathing is not just for oxygen; it’s now linked to brain function and behavior.

Northwestern Medicine scientists have discovered for the first time that the rhythm of breathing creates electrical activity in the human brain that enhances emotional judgments and memory recall.

These effects on behavior depend critically on whether you inhale or exhale and whether you breathe through the nose or mouth.

In the study, individuals were able to identify a fearful face more quickly if they encountered the face when breathing in compared to breathing out. Individuals also were more likely to remember an object if they encountered it on the inhaled breath than the exhaled one. The effect disappeared if breathing was through the mouth.

“One of the major findings in this study is that there is a dramatic difference in brain activity in the amygdala and hippocampus during inhalation compared with exhalation,” said lead author Christina Zelano, assistant professor of neurology at Northwestern University Feinberg School of Medicine. “When you breathe in, we discovered you are stimulating neurons in the olfactory cortex, amygdala and hippocampus, all across the limbic system.”

The study was published Dec. 6 in the Journal of Neuroscience.

The senior author is Jay Gottfried, professor of neurology at Feinberg.

Northwestern scientists first discovered these differences in brain activity while studying seven patients with epilepsy who were scheduled for brain surgery. A week prior to surgery, a surgeon implanted electrodes into the patients’ brains in order to identify the origin of their seizures. This allowed scientists to acquire electro-physiological data directly from their brains. The recorded electrical signals showed brain activity fluctuated with breathing. The activity occurs in brain areas where emotions, memory and smells are processed.

This discovery led scientists to ask whether cognitive functions typically associated with these brain areas — in particular fear processing and memory — could also be affected by breathing.

Image shows the location of the amygdala in the brain.

The amygdala is strongly linked to emotional processing, in particular fear-related emotions. So scientists asked about 60 subjects to make rapid decisions on emotional expressions in the lab environment while recording their breathing. Presented with pictures of faces showing expressions of either fear or surprise, the subjects had to indicate, as quickly as they could, which emotion each face was expressing.

When faces were encountered during inhalation, subjects recognized them as fearful more quickly than when faces were encountered during exhalation. This was not true for faces expressing surprise. These effects diminished when subjects performed the same task while breathing through their mouths. Thus the effect was specific to fearful stimuli during nasal breathing only.

In an experiment aimed at assessing memory function — tied to the hippocampus — the same subjects were shown pictures of objects on a computer screen and told to remember them. Later, they were asked to recall those objects. Researchers found that recall was better if the images were encountered during inhalation.

The findings imply that rapid breathing may confer an advantage when someone is in a dangerous situation, Zelano said.

“If you are in a panic state, your breathing rhythm becomes faster,” Zelano said. “As a result you’ll spend proportionally more time inhaling than when in a calm state. Thus, our body’s innate response to fear with faster breathing could have a positive impact on brain function and result in faster response times to dangerous stimuli in the environment.”

Another potential insight of the research is on the basic mechanisms of meditation or focused breathing. “When you inhale, you are in a sense synchronizing brain oscillations across the limbic network,” Zelano noted.

ABOUT THIS MEMORY RESEARCH ARTICLE

Other Northwestern authors include Heidi Jiang, Guangyu Zhou, Nikita Arora, Dr. Stephan Schuele and Dr. Joshua Rosenow.

Funding: The study was supported by grants R00DC012803, R21DC012014 and R01DC013243 from the National Institute on Deafness and Communication Disorders of the National Institutes of Health.

Source: Marla Paul – Northwestern University
Image Source: NeuroscienceNews.com image is in the public domain.
Video Source: The video is credited to NorthwesternU.
Original Research: Abstract for “Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function” by Christina Zelano, Heidi Jiang, Guangyu Zhou, Nikita Arora, Stephan Schuele, Joshua Rosenow and Jay A. Gottfried in Journal of Neuroscience. Published online December 7 2016 doi:10.1523/JNEUROSCI.2586-16.2016

Abstract

Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function

The need to breathe links the mammalian olfactory system inextricably to the respiratory rhythms that draw air through the nose. In rodents and other small animals, slow oscillations of local field potential activity are driven at the rate of breathing (∼2–12 Hz) in olfactory bulb and cortex, and faster oscillatory bursts are coupled to specific phases of the respiratory cycle. These dynamic rhythms are thought to regulate cortical excitability and coordinate network interactions, helping to shape olfactory coding, memory, and behavior. However, while respiratory oscillations are a ubiquitous hallmark of olfactory system function in animals, direct evidence for such patterns is lacking in humans. In this study, we acquired intracranial EEG data from rare patients (Ps) with medically refractory epilepsy, enabling us to test the hypothesis that cortical oscillatory activity would be entrained to the human respiratory cycle, albeit at the much slower rhythm of ∼0.16–0.33 Hz.

Our results reveal that natural breathing synchronizes electrical activity in human piriform (olfactory) cortex, as well as in limbic-related brain areas, including amygdala and hippocampus. Notably, oscillatory power peaked during inspiration and dissipated when breathing was diverted from nose to mouth. Parallel behavioral experiments showed that breathing phase enhances fear discrimination and memory retrieval. Our findings provide a unique framework for understanding the pivotal role of nasal breathing in coordinating neuronal oscillations to support stimulus processing and behavior.

SIGNIFICANCE STATEMENT Animal studies have long shown that olfactory oscillatory activity emerges in line with the natural rhythm of breathing, even in the absence of an odor stimulus. Whether the breathing cycle induces cortical oscillations in the human brain is poorly understood. In this study, we collected intracranial EEG data from rare patients with medically intractable epilepsy, and found evidence for respiratory entrainment of local field potential activity in human piriform cortex, amygdala, and hippocampus. These effects diminished when breathing was diverted to the mouth, highlighting the importance of nasal airflow for generating respiratory oscillations. Finally, behavioral data in healthy subjects suggest that breathing phase systematically influences cognitive tasks related to amygdala and hippocampal functions.

“Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function” by Christina Zelano, Heidi Jiang, Guangyu Zhou, Nikita Arora, Stephan Schuele, Joshua Rosenow and Jay A. Gottfried in Journal of Neuroscience. Published online December 7 2016 doi:10.1523/JNEUROSCI.2586-16.2016

EMF and Diabetes

During the last 3 Sundays, I have been jogging and walking bare feet in Santa Cruz beach, California. I believe in nature’s help in grounding, releasing negative charges in our bodies. Email motherhealth@gmail.com if you have any research related to EMF, Diabetes and other health issues to find the root cause and empower others to a healthy body.

Connie

Dr. Magda Havas, PhD » Diabetes and Electrosensitivity

March 2010. If you have difficulty regulating your blood sugar and you are electrically sensitive you may have type 3 diabetes according to research published in the Journal Electromagnetic Biology and Medicine in 2008. Unlike Type 1 diabetes (juvenile diabetes) that is largely genetically controlled, and Type 2 diabetes …

Diabetes and EMFs | Cause of Diabetes | Type 3 Diabetes – EarthCalm

exposure to electromagnetic fields (EMFs). … Dr. Havas’s study concludes that many diabetics may be electrically-sensitive, a condition which may cause increased blood sugar in their tests. … No matter what type of Diabetes you have, you will benefit from EMF protection.

Could EMFs Cause Diabetes? – ElectricSense

Jan 13, 2011 – Studies show that diabetes can be triggered by exposure to electromagnetic fields (EMFs). It causes Type 3 diabetes. Learn the principal causes and solutions.

[PDF]Diabetes and ElectroMagnetic Fields: the evidence – Next-up

a connection between the increase in diabetes and EMF exposure, but also the effectiveness of filters on ELF electrical equipment that help to reduce the suffering and the symptoms of diabetics. “We can take a diabetic person and put them in an environment polluted by EMR and measure their sugar levels,” she explained …

Electromagnetic Fields Can Worsen Diabetes – Real Diabetes Truth …

Aug 29, 2013 – There is mounting evidence that electromagnetic fields (EMF) from the electronic equipment that constantly surrounds us are bad for our health.

EMF and Diabetes | eatgenius

eatgenius.com › Bites

Mar 17, 2017 – EMF is a risk factor for diabetes and affects diabetes management.

DoH: EMF and Diabetes / Cell Phone Radiation Standards – Institute …

geopathology-za.wikidot.com › … › Department of Health

Please WAKE-UP !!! Minister of Health and Minister of Environment !!! – Please WAKE-UP, now !!!**. Electromagnetic Fields lead to Diabetic Disasters – and not only THAT !!! See: http://www.naturalnews.com/029328_diabetes_electromagnetic_pollution.html. Talking about certain PROBLEMS does not help much, unless you …

EMF / EMR and type 3 Diabetes | Life Energy Designs

Diabetes can be caused by EMF / EMR exposure. This is the conclusion of the latest peer-reviewed research by Dr. Magda Havas PhD. In sensitive people, which she classifies as having type 3 diabetesor environmentally triggered diabetes, exposure to dirty electricity (EMF/EMR) is enough to send their blood sugar high.

Dirty electricity elevates blood sugar among electrically sensitive …

by M Havas – ‎2008 – ‎Cited by 54 – ‎Related articles

Electromagn Biol Med. 2008;27(2):135-46. doi: 10.1080/15368370802072075. Dirty electricity elevates blood sugar among electrically sensitive diabetics and may explain brittle diabetes. Havas M(1). Author information: (1)Environmental & Resource Studies, Trent University, Peterborough, Ontario, Canada.

Electromagnetic Fields Lead to Diabetic Disasters – NaturalNews.com

Jul 31, 2010 – (NewsTarget) In recent years, many of us have grown increasingly aware of the possible dangers posed by Electromagnetic Fields (EMFs) [1]. As electrical and wireless applications continue to become more ubiquitous in society, so our exposure to EMFs continues to climb. Although low levels of natural …

Star-like cells – astrocytes – may help the brain tune breathing rhythms

Star-like cells , astrocytes,  may help the brain tune breathing rhythms

NIH study in rats suggests that support cells modulate brain circuit activity.

Traditionally, scientists thought that star-shaped brain cells called astrocytes were steady, quiet supporters of their talkative, wire-like neighbors, called neurons. Now, an NIH study suggests that astrocytes may also have their say. It showed that silencing astrocytes in the brain’s breathing center caused rats to breathe at a lower rate and tire out on a treadmill earlier than normal. These were just two examples of changes in breathing caused by manipulating the way astrocytes communicate with neighboring cells.

“For decades we thought that breathing was exclusively controlled by neurons in the brain. Our results suggest that astrocytes actively help control the rhythm of breathing,” said Jeffrey C. Smith, Ph.D., senior investigator at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and a senior author of the study published in Nature Communications. “These results add to the growing body of evidence that is changing the way we think about astrocytes and how the brain works.”

Dr. Smith’s lab investigates how breathing is controlled by the rhythmic firing of neurons in the preBötzinger complex, the brain’s breathing center that his lab helped discover. For this study, his team worked with Alexander Gourine, Ph.D., professor at University College London (UCL), whose lab found that astrocytes in neighboring parts of the brain may regulate breathing by sensing changes in blood carbon dioxide levels.

At least half of the brain is comprised of cells called glia and most of them are astrocytes. Recently scientists have shown that astrocytes may communicate like neurons by shooting off, or releasing, chemical messages, called transmitters, to neighboring cells.

In this study, the scientists tested the role of astrocytes in breathing by genetically modifying the ability of astrocytes in the preBötzinger complex to release transmitters. When they hushed the astrocytes in rats by reducing transmitter release, the rats breathed and sighed at a lower rate than normal. In contrast, if they made the astrocytes chattier by increasing transmission, the rats breathed at higher resting rates and sighed more often.

The team also tested how silencing astrocytes affected the rats’ responses to changes in oxygen and carbon dioxide levels. Although the rats’ breathing rate increased when oxygen levels were lower or carbon dioxide levels higher, it was still lower than normal. Silencing astrocytes also decreased the rate at which the rats sighed under lower oxygen levels. Moreover, the rats became exhausted much earlier than normal. They could only run half the distance that normal rats could run on a treadmill before tiring out.

“The primary goal of breathing is the exchange of carbon dioxide and oxygen that is critical for life. Our results support the idea that astrocytes help the brain translate changes in these gases into breathing,” said Shahriar Sheikhbahaei, Ph.D., formerly a doctoral student at UCL and participant in the NIH Graduate Partnership Program, and the lead author of the study.

Finally, the team showed that these astrocytes used adenosine triphosphate (ATP) to communicate with other cells in the brain. Inactivating released ATP reduced resting breathing rates and the frequency of sighs under normal and low oxygen levels.

“Our results expand our understanding of how the brain controls breathing under normal and disease conditions,” said Dr. Smith. “We plan to follow this path to understand how astrocytes help control other aspects of breathing.”

This study was supported by the Intramural Research Program at the NINDS, the Wellcome Trust, British Heart Foundation (Ref. RG/14/4/30736), BBSRC (Refs. BB/L019396/1, BB/K009192/1), the Medical Research Council (Ref. MR/L020661).

NINDS is the nation’s leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.