408-854-1883 starts at $30 per hr home care

Affordable in home care | starts at $28 per hr

Activation of Immune T Cells Leads to Behavioral Changes

Activation of Immune T Cells Leads to Behavioral Changes

Summary: A new Nature Immunology study reveals immune cells alter the body’s metabolism when activated, leading to changes in behavior.

Source: RIKEN.

Scientists from the RIKEN Center for Integrative Medical Sciences in Japan and collaborators have found that T cells — immune cells that help to protect the body from infections and cancer — change the body’s metabolism when they are activated, and that this activation actually leads to changes in behavior.

It is currently known that individual T cells change their metabolism to meet their energy needs after being activated, but the systemic metabolic effect of sustained activation of the immune system has remained unexplored. To understand the systemic effects, the group looked at T cell activation in mice designed to lack a surface receptor called PD-1, which is necessary for inhibiting the activity of T cells. T cells remain activated in mice without the receptor, similar to those in the immune systems of people with certain types of autoimmune disease. In these mice, they found that amino acids–molecules that are used to build proteins–were depleted in the blood, and that they were increased in the T cells themselves, implicating the T cells in the change.

The team tracked and imaged amino acids in many organs, and found that the depletion of amino acids from the blood was taking place due to the accumulation of amino acids in activated T cells in the lymph nodes, showing that strong or long lasting immune responses can cause metabolic changes elsewhere in the body.

The remaining question was whether this depletion of amino acids was actually having any systemic effect. By analyzing the biochemistry of the brain, they found that the systemic decrease in the amino acids tryptophan and tyrosine in blood led to lower amounts available in the brain, limiting production of the neurotransmitters serotonin and dopamine. These neurotransmitters affect emotions, motivation and fear–for example, serotonin is often a target of drugs that combat depression. The researchers found that their depletion in mice without PD-1 resulted in behavioral changes dominated by anxiety and exacerbated fear responses, which could be remedied by providing a diet rich in an essential amino acid.

This research, which was published in Nature Immunology, required teamwork and collaboration to link diverse fields of biology: immunology, neuroscience and behavior, using cutting edge metabolite measurements and imaging methods. “Together these data indicate that excessive activation of T cells causes a systemic metabolomic shift with consequences that extend beyond the immune system” says Michio Miyajima, one of the four first co-authors of this study.

t cell

According to Sidonia Fagarasan, the leader of the group, “We were fascinated to see that this happens-as it revealed the power of the immune system to influence many aspects of the body’s physiology besides infection and immunity. It will be interesting in the future to investigate whether the trigger of fear and anxiety by T cell activation is merely a side effect of the process, or whether there is an evolutionary benefit of this adaptation. We would also like to further investigate these changes, as the blockade of PD-1 is being investigated as an anti-cancer therapy, and it is important to understand if this could have behavioral changes such as increases in anxiety.”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Funding: This research was supported by the Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology (14532135 to S.F.), Japan Agency for Medical Research and Development (145208 and 16770835 to T.H.) and the Cell Science Foundation (K.C). The work was done by RIKEN in collaboration with Keio University, Kyoto University, and other institutions.

Source: Jens Wilkinson – RIKEN
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public doamin.
Original Research: Abstract for “Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior” by Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M Guerrini, Yumi Tsutsui, Mikako Maruya, Alexis Vogelzang, Kenji Chamoto, Kurara Honda, Takatoshi Hikida, Satomi Ito, Hongyan Qin, Rikako Sanuki, Keiichiro Suzuki, Takahisa Furukawa, Yasushi Ishihama, Fumihiko Matsuda, Makoto Suematsu, Tasuku Honjo & Sidonia Fagarasan in Nature Immunology. Published online October 23 2017 doi:10.1038/ni.3867

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
RIKEN “Activation of Immune T Cells Leads to Behavioral Changes.” NeuroscienceNews. NeuroscienceNews, 23 October 2017.
<http://neurosciencenews.com/t-cell-behavioral-changes-7792/&gt;.

Abstract

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

T cells reorganize their metabolic profiles after being activated, but the systemic metabolic effect of sustained activation of the immune system has remained unexplored. Here we report that augmented T cell responses in Pdcd1−/− mice, which lack the inhibitory receptor PD-1, induced a metabolic serum signature characterized by depletion of amino acids. We found that the depletion of amino acids in serum was due to the accumulation of amino acids in activated Pdcd1−/− T cells in the lymph nodes. A systemic decrease in tryptophan and tyrosine led to substantial deficiency in the neurotransmitters serotonin and dopamine in the brain, which resulted in behavioral changes dominated by anxiety-like behavior and exacerbated fear responses. Together these data indicate that excessive activation of T cells causes a systemic metabolomic shift with consequences that extend beyond the immune system.

“Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior” by Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M Guerrini, Yumi Tsutsui, Mikako Maruya, Alexis Vogelzang, Kenji Chamoto, Kurara Honda, Takatoshi Hikida, Satomi Ito, Hongyan Qin, Rikako Sanuki, Keiichiro Suzuki, Takahisa Furukawa, Yasushi Ishihama, Fumihiko Matsuda, Makoto Suematsu, Tasuku Honjo & Sidonia Fagarasan in Nature Immunology. Published online October 23 2017 doi:10.1038/ni.3867

Blocking stomach acid may promote chronic liver disease

Blocking stomach acid may promote chronic liver disease

At a Glance

  • A new study found that blocking stomach acid can lead to an overgrowth of intestinal bacteria that likely contributes to liver inflammation and damage.
  • The findings suggest that some widely used acid reflux (heartburn) medications may worsen chronic liver disease.
Woman on park bench with heartburnThe use of medications to suppress stomach acid has been on the rise. New research suggests certain kinds may have an impact on chronic liver disease.champja/iStock/Thinkstock

The liver has many important functions, including helping to digest food and process and distribute nutrients. A healthy liver is necessary for survival. The liver can regenerate after being damaged. However, repeated or long-lasting injury can cause scar tissue to form. Scarring of the liver may lead to cirrhosis, a condition in which the liver is unable to function normally. Liver cirrhosis is a leading cause of death worldwide.

Many conditions can contribute to the development of cirrhosis, including obesity, which is associated with non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH), a form of NAFLD in which you also have inflammation and liver cell damage. But alcohol misuse accounts for about half of cirrhosis-related deaths.

Changes in your gut’s microorganisms, or microbiota, can affect the progression of liver disease. Misusing alcohol alters the microbes in your gut. So can a commonly used class of heartburn medication called proton pump inhibitors (PPIs), which block stomach acid secretion. PPIs are often used by people who have chronic liver disease. However, the impact of these medications on liver disease progression has been unknown.

Bacteria growing on petri dishesIn mice, some common acid reflux medications promote growth of Enterococcus bacteria, shown here artificially glowing red, in the intestines. These bacteria can move to the liver and affect its function. UC San Diego Health

To investigate whether blocking stomach acid affects chronic liver disease, a team led by Dr. Bernd Schnabl at the University of California San Diego School of Medicine looked at PPIs in mouse models of three types of liver disease—alcohol-induced liver disease, NAFLD, and NASH—and in humans. The study was funded in part by NIH’s National Institute on Alcohol Abuse and Alcoholism (NIAAA). Results were published on October 16, 2017 in Nature Communications.

The team blocked stomach acid in the mice either by genetically deleting the gene that controls stomach acid secretion or by administering the PPI omeprazole (Prilosec). Liver conditions in all three disease models were worsened when the mice lacked stomach acid.

The researchers found that mice lacking stomach acid had higher levels of intestinal bacteria as well as imbalances among the microbes. In particular, the mice had increased levels of Enterococcus in their guts. Further experiments suggested that these bacteria can reach the liver, where they can cause liver inflammation and damage.

The team looked at whether people taking PPIs have similar microbiota changes. They collected fecal samples from healthy people before and after PPI treatment. After two weeks, those taking the PPI treatment also had a higher number of Enterococcus.

The researchers next investigated whether there might be a link between PPIs and the development of alcoholic liver disease. They looked at 4,830 patients with a diagnosis of alcohol use disorder. Among these, 36% had been using PPIs. The analysis showed that PPI use increased the 10-year risk of developing liver disease (20.7% for active users; 16.1% for previous users; 12.4% for those who had never used PPIs).

“Our findings indicate that the recent rise in use of [stomach] acid-suppressing medications might have contributed to the increased incidence of chronic liver disease,” Schnabl says. “We believe clinicians should consider withholding medications that suppress [stomach] acid unless there is a strong medical indication.”

—Tianna Hicklin, Ph.D.

Top aging hacks 10-24-2017

Nitric Oxide Dump Exercise with nose breathing to lower blood pressure and thin blood
Eggplant and apple cider vinegar for skin cancer
Home page / Archives
Can Gout be cured permanently?
Parkinson and Exercises
Philippines Coconut Wine -Tuba
DMSO, hydrogen peroxide and Vit C fight cancer cells
Fasting, sun bathing ,Vit C, Lysine, turmeric, green tea, carrots and raw food diet to reduce tumor size
Lung cancer in the Philippines
Fatigue and Red (bloodshot) eyes from WebMD
UC biologists find link between paternal diet and offspring’s health
Damage to Blood–brain barrier (BBB) pathways leading to Alzheimer’s disease and Dementia
Anti-aging Vitamin B3, Niacin
Detox your lungs from air pollution and metal toxins and for early lung cancer
Nitric Oxide for strong blood vessels’ cells , up with exercise, melons, cucumber, Vit C, E, amino acid – L-arginine, L-citrulline
How to avoid capital gains tax
Can balsamic vinegar help with gout?
Gout, Dementia, Chelation Therapy
Blood lipids, ceramides, migraines and Parkinson
About fingerprinting, IHSS and worker’s comp in California for home care
New evidence that chronic stress predisposes brain to mental illness
Medicinal plants and uses
5 Myths About Revocable Living Trusts
New Cause of Schizophrenia Uncovered
Non pasteurized beers have more health benefits
Massage oil of fresh ginger and coconut oil relieves joint pain
Vagus nerve stimulation thru breathing, laughs and yoga
Estate Planning: Essential for the Under-40s
Dr Mercola on Knee Osteoarthritis
Top 20 Most Popular Neuroscience Articles in 2016
Welness Mama: How to Avoid the Most Common Fitness Mistakes Women Make
Philippines Coconut Wine -Tuba
Dr Mercola’s book – Fat for Fuel
Safe herbs: milk thistle, kava kava, Echinacea, black cohosh and St. John’s wort
Do you lose nerve cells when stressed?
Top health posts 8-30-2017
Protein and fat rich foods for Alzheimer’s disease prevention
Bitter gourd or bitter melon for body builders, diabetics, HIV infection
Caring for Dementia – broken brains documentary
How to be an IHSS caregiver provider
Cough remedies from Dr Mercola
Taxes 2015 – Finance Planning and Financial Strategies coupled with Business structure
5 Myths About Revocable Living Trusts
Histamine intolerance, genes and diet by Dr Lynch
Do you think politicians should be FIRED for trying to make voting more difficult for minorities?
Epidemiology of severe sepsis in the United States
Female sex hormones play a greater role than male sex hormones on neuromuscular ability for amyotrophic lateral sclerosis (ALS)
Anabolic and catabolic process, hormones and exercise
Genetic Factors in Depression
Loans for doctors and nurses
Metabolism is life sustaining and sum of all chemical reactions for growth and death of cells
Roth IRA and Index Universal Life Policy, both tax free retirement plans
How Trump Undermines Intelligence Gathering
Tryptophan – Niacin – NAD = Anti-aging
Living Near a Forest Keeps Your Amygdala Healthier
Signs of the preactive/ active phase of dying and medications for terminally ill
Anti-aging and Parkinson/Alzheimer’s prevention: Enzymes and apple cider vinegar
New evidence that chronic stress predisposes brain to mental illness
Stronger immune system, less Alzheimer’s symptoms
What are the biggest component of your metabolism?
Blind services in California
Vitamin A deficient lung – COPD – hospice in home senior care
Cardio-based body weight exercises
Growth hormone DHEA increases libido/anti-aging
Support your aging mechanisms , epigenetic way
Digestive enzymes help in healing fractures, preventing kidney stones and heart disease and more
Steve Bannon
Diet and exercise for Alzheimer’s and Parkinson
Acetylcholine/Choline Deficiency in Chronic Illness – mental, liver, kidney, heart and hormones
Support your aging mechanisms , epigenetic way
Can Adderall damage to dopamine receptors be repaired?
Boron fights radiation by Dr Mercola
Trump administration plan to cut $10.6 billion from federal education initiatives
Why is the Quora community so anti-Donald Trump?
MEDICATIONS TO AVOID that worse PD (Parkinson’s disease)
Does drinking warm water reduce cholesterol?
Top aging hacks 10-23-2017
Herbal oil for Lice, Scabies and skin issues
Are you losing $1M or more of wealth accumulation intended for retirement?
Does eating peanuts affect eczema or psoriasis?
Medicare changes for 2018 – Oct 15 to Dec 7 – 2017 Medicare enrollment
Iodine prevents cancer growth; up avocado and reduce caffeine intake to prevent Thyroid cancer
How doctors can borrow a scanner to measure anti-oxidant levels

Top aging hacks 10-23-2017

View
Nitric Oxide Dump Exercise with nose breathing to lower blood pressure and thin blood
View
Home page / Archives
View
Eggplant and apple cider vinegar for skin cancer
View
DMSO, hydrogen peroxide and Vit C fight cancer cells
View
Can Gout be cured permanently?
View
Signs of the preactive/ active phase of dying and medications for terminally ill
View
Fatigue and Red (bloodshot) eyes from WebMD
View
Drug Interaction Probability Scale – DIPS
View
Philippines Coconut Wine -Tuba
View
Growth hormone DHEA increases libido/anti-aging
View
Non pasteurized beers have more health benefits
View
5
1 in 4 older adults have foot pain
View
4
Tai Chi and Qi Gong
View
4
Spices that boost testosterone
View
4
Tanglad or lemongrass to help lower blood pressure
View
3
Lung cancer in the Philippines
View
3
5 Myths About Revocable Living Trusts
View
3
Menu for the healthy plus kitchen tips
View
3
Increase the body’s oxygen carrying capacity with exercise, EPO and whole foods
View
3
Anti-aging and Parkinson/Alzheimer’s prevention: Enzymes and apple cider vinegar
View
3
1 in 4 older adults have foot pain
View
3
Caregivers $15 – 32 per hr for senior non-medical home care in the bay area
View
3
What’s a good analogy to explain the immune system?
View
2
Disease condition and odor symptom
View
2
Gout, Dementia, Chelation Therapy
View
2
5 Myths About Revocable Living Trusts
View
2
Detox your lungs from air pollution and metal toxins and for early lung cancer
View
2
MEDICATIONS TO AVOID that worse PD (Parkinson’s disease)
View
2
Revocable living trusts in California
View
2
Parkinson and Exercises
View
2
Histamine intolerance, genes and diet by Dr Lynch
View
2
Whole foods prevent inflammation
View
2
Avoid chronic bronchitis with green apple, onions, garlic, vinegar and rest
View
2
Caregivers $15 – 32 per hr for senior non-medical home care in the bay area
View
2
Reducing belly fat
View
2
What is Mitochondrial DNA depletion syndrome?
View
2
Weight loss program and stories with Jump Start
View
2
Vitamin A deficient lung – COPD – hospice in home senior care
View
2
Lower Brain Glucose Levels in Brains of People With Obesity and Type 2 Diabetes
View
2
Fight VIRUS with Enzymes from pineapple and papaya, baking soda, alkaline food, calcium and magnesium from whole foods
View
2
Chlorine rich foods are cleansing (avocado, coconut, onions, parsnips)
View
2
Massage to clean your lymps and help with attacking any virus
View
1
Drop Pain as the Fifth Vital Sign, AAFP Says
View
1
Alzheimer’s disease prevention with Vit D, Vit C and low histamine foods or raw/whole foods
View
1
Nitric Oxide for strong blood vessels’ cells , up with exercise, melons, cucumber, Vit C, E, amino acid – L-arginine, L-citrulline
View
1
Liver cleanse to help your vision and memory
View
1
How does Yakult help digestion?
View
1
Anabolic and catabolic process, hormones and exercise
View
1
Antisocial personality disorder in 70% of prison inmates
View
1
Is there a way to tell if I have a ALDH2 enzyme deficiency without drinking alcohol?
View
1
What happens if you don’t get enough dietary cholesterol?
View
1
Where do we stand on our fight for cancer causing substances around us?
View
1
Mental state and gait – walking
View
1
Dark purple berries or Black currant juice and eggs for upping up sex drive
View
1
Vagus nerve stimulation thru breathing, laughs and yoga
View
1
How the brain helps us to learn and make decisions, attention and learning
View
1
How do you treat Lewy body disease?
View
1
Can Adderall damage to dopamine receptors be repaired?
View
1
Foods to eat and avoid when you have Gout and leg pains
View
1
Paradox of Sunscreen ; Bring back the beauty in your face
View
1
Does drinking warm water reduce cholesterol?
View
1
Oldest Men and Women in the world
View
1
More than 10 reasons why we need life insurance
View
1
Falls in the Elderly: Causes, Injuries, and Management
View
1
16 Tips On How To Treat HPV Naturally And Effectively At Home
View
1
Save $5000 per year by taking care of your heart and liver
View
1
Acetylcholine/Choline Deficiency in Chronic Illness – mental, liver, kidney, heart and hormones
View
1
Health care perception and reality in the world
View
1
When will Souvenaid become available in Canada and US to treat Alzheimer’s Disease?
View
1
How long does it take for damaged nerves to repair themselves?
View
1
Skilled Nursing Facilities in the Bay area
View
1
Weird Facts about Tall and Short People by Lisa Collier Cool
View
1
News Medical – Medical & Life Sciences
View
1
Links – Senior Care in the USA
View
1
Excessive sweating and Parkinsons
View
1
The loss of SETD8 triggers cellular senescence
View
1
Non pasteurized beers have more health benefits
View
1
Health Care and Education for All
View
1
Free classes in San Jose from Qigong to Yoga for bay area cancer patients at cancercarepoint.org
View
1
Toxicology test for pregnant women
View
1
Washington Post evening edition
View
1
Iodine prevents cancer growth; up avocado and reduce caffeine intake to prevent Thyroid cancer
View
1
Stephen Colbert Monologue | 8/3/2017 The F.B.I.’s Trump-Russia Investigation
View
1
How to End America’s Opioid Addiction
View
1
Nutrients for Epilepsy
View
1
Lectin, gluten, stomach, fasting, toxins, wheat, and foods
View
1
Food and Drug Interactions
View
1
Dr Oz on nutritional biomarker
View
1
Eye Test Could Predict Alzheimer’s Years Before Symptoms Appear
View
1
How doctors can borrow a scanner to measure anti-oxidant levels
View
1
Reset gene expression of fat cells to younger you
View
1
2014 Social Security Benefit of $2642 max per month
View
1
‘Ridiculously Healthy’ Elderly Have the Same Gut Microbiome as Healthy 30 Year-Olds
View
1
Fever in Early Pregnancy Linked to Birth Defects
View
1
How to support our older adults struggling with addiction
View
1
Hospitals are housing the homeless: Will it help?
View
1
Thyme herb for toe fungus (guava and comfrey leaves and others)
View
1
Antioxidant Vitamin C in Alzheimer’s and Parkinson’s disease
View
1
You’re Probably Going to Need Medicaid
View
1
Ativan or Benzodiazepine oxidation is decreased in persons with liver disease
View
1
Can balsamic vinegar help with gout?

1 in 4 older adults have foot pain

A 92 yr old woman had foot and leg pain which always more severe at night. I have to massage the middle part of the bottom of her feet and legs. I use many kinds of oil, coconut and turmeric, coconut and MSM and/or baking soda and coconut oil alone.  In the past, I have washed seniors feet with hydrogen peroxide and salt water. I use many essential oils from eucalyptus to tea tree oil. I made sure their diet is rich in garlic, onions and the sulfur family. For supplementation, I recommend turmeric and ginger capsule, melatonin and calcium with magnesium and zinc. I always use citrus fruits such as oranges and lemon in her diet of whole foods and fish.

The position of the hospital bed is important. Exercise, sunshine and adequate sleep are important.

Connie Dello Buono

ad
caregiving

 


 

Chronic foot pain in older people

Under a Creative Commons license
open access

Highlights

Foot pain affects approximately one in four older people.

Foot pain impairs mobility and balance, and is an independent risk factor for falls.

Foot pain can be effectively managed in older people with conservative interventions such as routine foot care, footwear advice and foot orthoses.

Abstract

Foot pain is a common accompaniment of advancing age, affecting at least one in four older people. However, management of foot pain is a largely undervalued aspect of geriatric health care, resulting in many older people needlessly enduring chronic foot pain and related disability. The aim of this review is to provide an overview of (i) the prevalence and risk factors for foot pain, (ii) the impact of foot pain on mobility and quality of life, and (iii) the conservative management of foot pain. The available evidence indicates that although foot pain is common and disabling in older people, conservative interventions such as routine foot care, footwear advice and foot orthoses are effective at reducing foot pain and may also assist in maintaining mobility and independence in this age group.

Keywords

Foot
Pain
Ageing

1. Introduction

The human foot plays an essential role in all weightbearing activities as it provides the only source of contact with the ground. When walking, the foot contributes to shock absorption, adapts to uneven surfaces, and facilitates the forward propulsion of the body. In the presence of foot pain, this important biomechanical function is disrupted, leading to impaired balance, difficulty ambulating and ultimately a loss of independence [1]. Despite this, management of foot pain is a largely undervalued aspect of geriatric health care. Indeed, even older people themselves may consider foot pain to be an inevitable consequence of ageing rather than a treatable medical condition [2], resulting in many people needlessly enduring chronic foot pain and related disability.

The aim of this review paper is to provide an overview of the epidemiology, impact and conservative management of foot pain in older people.

2. Methods

A literature search was conducted in May 2016. The Ovid platform was used to explore Medline (1946 to present) and Embase (1974 to present) by applying the following title keyword search terms: foot OR foot problems OR foot disorders OR foot osteoarthritis AND elderly OR older; limited to human studies published as full journal articles in the English language. After the removal of duplicates; this search strategy yielded 194 documents. Following title and abstract review; 58 documents were removed; leaving a final yield of 136 manuscripts for consideration. The reference lists of these manuscripts were then examined for additional titles; and the most relevant manuscripts were selected for citation based on the predetermined subheadings of the review (epidemiology; impact and management). A narrative summary of the findings of these studies is provided.

3. Epidemiology of foot pain in older people

3.1. Prevalence

It has long been recognised that foot problems are common in older people [3]. However, estimating the population prevalence of foot pain in older people is difficult, as several case definitions have been used which vary according to pain frequency and time period. Nevertheless, a recent systematic review of 31 population-based studies involving 75,505 community-dwelling participants aged 45 years and over identified eight studies with comparable case definitions, from which a pooled prevalence estimate of frequent foot pain of 24% was derived. Frequent foot pain was found to most commonly affect the forefoot and the toes, to be more prevalent in women than men, and to be at least moderately disabling in two-thirds of cases [4]. Two prospective studies also indicate that foot pain is highly persistent in older people. A prospective study of 2718 people aged 50 years and over reported that of those who reported disabling foot pain at baseline, 72% had foot pain three years later, with women more likely to report persistent foot pain than men [5]. Similarly, a study of 4745 women aged 70–75 years reported that foot pain persisted in 51% over a six year follow-up period [6].

3.2. Risk factors

Cross-sectional studies have identified several potential risk factors for foot pain in older people, including female sex [7–9], obesity [8,10,11], depression [12–14] and comorbidities such as diabetes and osteoarthritis [15–17]. Of these factors, female sex and obesity appear to have the strongest associations with foot pain. Older women are significantly more likely to report foot pain than older men, which may be due to the higher prevalence of hallux valgus and lesser toe deformities [18,19] and the influence of women’s footwear, which frequently incorporates an elevated heel and narrow toe box [20,21]. The association between increased body mass index and foot pain in older people has been attributed to increased mechanical loading of the foot when walking [22] and the contribution of metabolic factors associated with excess fat mass [23].

Despite the general consensus that health status is strongly linked to socio-demographic factors, the role of education and income in the prevalence of foot pain in older people is equivocal. While some studies have reported that older people with foot problems have a lower level of income [24] others have failed to find such an association [17,25]. Similarly, lower levels of education have been found to be associated with foot problems in some studies [17,24] but not others [15,16,25]. These discrepancies are likely to reflect differences in how income levels are defined and differences in educational systems between countries.

3.3. Common foot disorders in older people

Foot pain is a complex phenomenon as it may be caused by local factors (i.e. structural disorders affecting the load-bearing function of the foot) and systemic factors (i.e. dermatological, vascular, neurological and musculoskeletal conditions that may manifest in the foot). A detailed evaluation of each of these conditions is beyond the scope of this review. However, large-scale epidemiology studies indicate that the most commonly observed and reported foot disorders resulting in foot pain in older people are keratotic lesions (corns and calluses), followed closely by nail disorders (particularly fungal nail infection) and structural deformities such as hallux valgus (‘bunions’) and lesser toe deformities (hammertoes and clawtoes) [7,18,26]. Systemic conditions most commonly associated with foot symptoms in older people include osteoarthritis [27], rheumatoid arthritis [28], gout [29] and diabetes [30]. Given that local and systemic factors often coexist, delineating a precise cause of foot pain in older people is difficult and requires a detailed systems examination in clinical practice.

4. Impact of foot pain in older people

There is strong evidence that foot pain has a significant detrimental impact on mobility and health status in older people. Several studies have demonstrated that foot pain is associated with reduced walking speed [31,32] and difficulty performing activities of daily living [16,31–34]. The majority of older people with foot pain consider it to adversely affect their ambulation on most days [4] and 20% specifically report foot pain to be the primary cause of their inability to leave their home [35]. Foot pain has also been shown to be associated with impaired balance [36,37] and is an independent risk factor for accidental falls [38,39]. More broadly, older people with foot pain report poorer health-related quality of life, as evidenced by lower scores on the Short Form 36 health survey [13,25,32].

Management of foot pain in older people accounts for a substantial number of consultations to health professionals. In the UK, primary care consultations for musculoskeletal foot and ankle problems are strongly associated with age, and peak in the 65–74 year age group [40]. Similarly, podiatry utilisation in Australia is highest among those aged 65 years and over [41], with older people accounting for 75% of all publicly-funded podiatry consultations [42]. Many older people also seek surgical intervention for their foot pain, particularly for conditions affecting the forefoot and toes [43].

5. Management of foot pain in older people

5.1. Routine foot care

The provision of foot health services to manage foot pain and disability in older people is primarily the domain of the podiatry profession, although a wide range of health professionals (such as general practitioners, rheumatologists, orthopaedic surgeons, nurses, physiotherapists and pedorthists) may also contribute [44]. Maintenance of foot hygiene and treatment of toenails and keratotic lesions in older people accounts for a substantial proportion of a podiatrist’s workload. Clinical audits have shown that regular podiatry treatment can maintain or improve foot health in older people [45] and that discharge from podiatry services may result in a subsequent deterioration in foot health and mobility in this age-group [46].

Difficulty cutting toenails is common in older people, as it requires not only adequate joint flexibility, but also a high level of manual dexterity and visual acuity; all of which may decline with age. Although often considered to be relatively trivial problems, nail disorders resulting from inability to maintain toenail hygiene, such as onychomycosis (fungal nail infection) and oncycryptosis (ingrown toenails) can be extremely painful and disabling [47]. In hospital or residential care settings where podiatry services are limited or unavailable, nursing staff may be required to perform this role [48]. Although there is evidence that nursing staff lack confidence in managing foot problems [49,50], educational interventions to train nursing staff have been shown to be effective at improving both foot care knowledge and practices [51,52].

Management of painful plantar calluses commonly involves scalpel debridement by a podiatrist, although the effectiveness of this approach is uncertain. Although uncontrolled studies have reported immediate reductions in pain following scalpel treatment of plantar calluses [53,54], controlled trials involving a ‘sham’ treatment group suggest that this apparent short-term improvement can be largely attributed to placebo effects [55,56]. However, these findings do not preclude the possibility of cumulative benefits over a longer time period. A recent trial has shown that scalpel debridement of plantar calluses is more effective at improving the mechanical properties of the skin than the application of topical keratolytic agents [57]. This effect may be particularly important in the management of the older person with diabetes, as regular scalpel debridement of plantar calluses has been shown to be effective in the prevention of neuropathic ulceration [58].

Treatment of corns may also require scalpel debridement, however a recent randomised trial suggests that corn plasters containing 40% salicylic acid may be more effective [59]. In this trial, 202 people were randomised to receive either scalpel debridement or corn plasters, and were followed up for a 12 month period. The use of corn plasters was associated with a higher proportion of resolved corns, a prolonged time to corn recurrence, less pain and reduced corn size over the first 6 months in comparison with scalpel treatment. However, this treatment needs to be very carefully considered in older people with poor skin integrity or peripheral neuropathy, as several cases of foot ulceration associated with corn plasters have been reported in people with diabetes [60].

5.2. Footwear considerations

Evaluation of footwear is one of the most fundamental components of effective management of foot pain in older people. Between 26 and 50% of older people wear shoes that are too short or too narrow [61–63] due to fashion influences [64,65], not measuring foot dimensions when purchasing shoes [66], and the limited availability of footwear that caters for the altered shape of the older foot [67,68]. In older people, wearing shoes substantially narrower than the foot is associated with corns on the toes, hallux valgus deformity and foot pain, whereas wearing shoes shorter than the foot is associated with lesser toe deformity [69]. Furthermore, shoes that are too tight in the forefoot or too loose in the heel may lead to reduced walking speed and gait instability [70].

The detrimental effect of high heels has been examined in two recent reviews [71,72]. Heel elevation alters the position and motion of the foot and ankle, thereby altering the biomechanics of the knee, hip and spine and predisposing to musculoskeletal pain. However, there is some evidence that the use of high heels diminishes with age. A survey of 2627 women aged 50 years and over found that the use of high heels was common between the ages of 20–29, but declined to less than 10% by the age of 40 years [73]. This may be indicative of a life-course trajectory in which the influence and perceived importance of fashion diminishes over time and is replaced with a greater emphasis on comfort and practicality. Nevertheless, in older people who continue to wear this style of footwear, heel elevation is associated with hallux valgus and plantar calluses [69] and has been shown to impair balance and increase the risk of falls [74].

Given the association between suboptimal footwear and foot pain, changing footwear could be a simple and effective intervention. Indeed, a recent randomised trial has shown that the use of appropriate footwear is effective at reducing foot pain in older people [75]. In this study, community-dwelling older people with disabling foot pain were randomly allocated to an intervention group (who received off-the-shelf, extra-depth footwear with a compliant elastane upper) or a usual care control group. At the 4 month follow-up period, the intervention group exhibited a greater reduction in foot pain and developed fewer keratotic lesions than the control group, suggesting that simply changing footwear may be an effective management strategy. However, fashion influences are a significant barrier to adherence, particularly in older women, as selection of footwear is more strongly influenced by aesthetics than functional considerations [76].

5.3. Foot orthoses

Foot orthoses are devices placed inside the shoe that alter the timing and magnitude of the forces acting on the foot during weight bearing activities. Orthotic therapy plays a major role in the conservative management of foot disorders in older people [77,78]. In the UK National Health Service, it has been estimated that £38 million is spent on orthoses each year, with foot orthoses accounting for 75% of a hospital’s total appliances budget [79]. Foot orthoses range from simple adhesive pads that can be manufactured during a routine consultation, through to more complex techniques involving the construction of custom-moulded insoles derived from plaster casts or 3-dimensional scans of the older person’s feet.

Several studies have demonstrated that foot orthoses are effective at reducing pressure from painful regions of the foot (including the heel [80], forefoot [81]and toes [82]) in older people, and may also be beneficial for balance [83–85]. In relation to symptoms, two uncontrolled studies have suggested that foot orthoses can reduce foot pain in older people [85,86], and one randomised controlled trial found that foot orthoses with a medial arch support and metatarsal pad were effective at reducing foot pain and foot-related disability in older women with osteoporosis [87]. More recently, two randomised trials found that foot orthoses were effective at reducing symptoms in people with osteoarthritis of the first metatarsophalangeal joint [88] and midfoot joints [89]. These studies suggest that foot orthoses may be a useful conservative treatment for a range of foot disorders in older people. However, when prescribing orthoses in this age-group, consideration also needs to be given to whether the older person has suitable accommodative footwear, sufficient mobility to change or remove the orthoses when necessary, and sufficient skin integrity to withstand the arch contouring provided by the devices.

6. Summary and conclusions

Foot pain affects at least one in four older people, is frequently disabling, and is associated with mobility impairment and falls in this age group. The major risk factors for the development of foot pain are increasing age, female sex, obesity, depression and common chronic conditions such as diabetes and osteoarthritis, while the most commonly reported foot disorders by older people are corns and calluses, nail disorders and toe deformities. Management of foot pain is primarily the role of the podiatrist, although nurses, general practitioners, rheumatologists and orthopaedic surgeons may contribute. Conservative podiatric interventions such as regular foot care, footwear advice and foot orthoses appear to be effective at reducing foot pain in this age group, although further controlled trials are required to adequately evaluate their effectiveness.

Conflict of interest

HBM has no conflict of interest to declare.

Funding

HBM is currently a National Health and Medical Research Council of Australia Senior Research Fellow (ID: 1020925).

Contributor

HBM is the sole author of this review.

Top Aging Hack posts 10-20-17

ad
caregiving
Nitric Oxide Dump Exercise with nose breathing to lower blood pressure and thin blood
Home page / Archives
DMSO, hydrogen peroxide and Vit C fight cancer cells
Eggplant and apple cider vinegar for skin cancer
Philippines Coconut Wine -Tuba
Signs of the preactive/ active phase of dying and medications for terminally ill
Antioxidants to increase sperm count
Can Gout be cured permanently?
Nitric Oxide for strong blood vessels’ cells , up with exercise, melons, cucumber, Vit C, E, amino acid – L-arginine, L-citrulline
MEDICATIONS TO AVOID that worse PD (Parkinson’s disease)
Detox your lungs from air pollution and metal toxins and for early lung cancer
Lower Brain Glucose Levels in Brains of People With Obesity and Type 2 Diabetes
Fasting, sun bathing ,Vit C, Lysine, turmeric, green tea, carrots and raw food diet to reduce tumor size
Lower Brain Glucose Levels in Brains of People With Obesity and Type 2 Diabetes
Whole foods prevent inflammation
Avoid chronic bronchitis with green apple, onions, garlic, vinegar and rest
Growth hormone DHEA increases libido/anti-aging
How to Stay Sane if Trump is Driving You Insane: Advice From a Therapist
Hiatal Hernia, Pancreatitis, Pancreatic Cancer and the Western Diet
Antioxidants and insulin sensitivity
Wellness assessment at Whole Foods Store Los Altos 10/21 6pm – Recipes
Hospitals are housing the homeless: Will it help?
Top health posts 8-30 and 9-22
What are risk factors for Alzheimer’s disease?
Gastroparesis, Betain HCL, diabetes and stomach health
Image viewed: gastroparesis
Fatigue and Red (bloodshot) eyes from WebMD
Non pasteurized beers have more health benefits
U.S. abortion rate fell 25 percent from 2008 to 2014; one on four women have an abortion
Eat protein-rich food when drinking alcohol to protect your stomach
Hypocretin, Insomia or Sleep Disturbances, Narcolepsy, Depression and Parkinson’s
Personalized Diet ebook
How do you solve poverty in the Philippines?
Risk Factors of Pancreatic Cancer
In Sympathetic Nervous System Why the digestion of food is slow? Where as in fight or flight we need more energy.?
Can balsamic vinegar help with gout?
Neck pain and MTHFR gene , folate , methionine
Binding of sugar to proteins undesirably modifying body tissues
If You Get the Chills From Music, you have ability to feel intense emotions
What are the benefits of eating chicken soup during pregnancy?
Portable micronutrient scan – biophotonic in the bay area
What are risk factors for Alzheimer’s disease?
Iodine prevents cancer growth; up avocado and reduce caffeine intake to prevent Thyroid cancer
How to choose the right eye nutrients , AREDS – Age-Related Eye Disease Studies
Tai Chi and Qi Gong
Dr Mercola: Tai Chi for balance and emergency prevention
Fenugreek, for diabetes/lactating moms/to boost testosterone
Age defense mechanism you cannot get in your diet
When will Souvenaid become available in Canada and US to treat Alzheimer’s Disease?
Exercise Pill Boosts Endurance, Promotes Burning of Fat
Sleep On It! Gene Responsible For Sleep Deprivation and Metabolic Disorders Identified
Pineapple, celery, carrots and Arthritis
Home health monitoring with Bluetooth connection
Pain killers damage to the liver and the heart
How doctors can borrow a scanner to measure anti-oxidant levels
Wrinkles lessen in 4 months of Jeunesse Luminesce use
12 Life Lessons along the Path to Enlightenment by David R. Hawkins, M.D. Ph.D.
Toxicology test for pregnant women
State -wide senior caregiving cost
Parasites and their effects on your immune system
Lung cancer in the Philippines
Caregivers $15 – 32 per hr for senior non-medical home care in the bay area
Metal toxins , mercury dental amalgams, Alzheimers, brain detox
Narcissistic personality disorder
Do not eat moldy foods for the sake of your kidneys
Thyme herb for toe fungus (guava and comfrey leaves and others)
Cancer statistics
Degenerative Joint Disease by Dr Axe
Raising Inspired Children by Dr Joe Dispenza
Vagus nerve stimulation thru breathing, laughs and yoga
Nominate your best doctor in the bay area
Carcinogenic TBHQ in ramen noodles
Boron fights radiation by Dr Mercola
How to Stay Sane if Trump is Driving You Insane: Advice From a Therapist
How can I increase dopamine transporters?
Can you reduce your risk of Alzheimer’s , Stroke and Parkinson’s disease?
How to support our older adults struggling with addiction
Spices that boost testosterone
Can you reduce your risk of Alzheimer’s , Stroke and Parkinson’s disease?
Blue bions – high energy whole foods kills T-bacilli cancer cells
Cancer from toxins, inhaled, small metal dusts, lack of sleep and our brain
Healing your body with Nutritional Food plan by Dr Mercola
Estimating the prevalence of diabetes mellitus and thyroid disorders using medication data in Flanders, Belgium
Racism doesn’t exist all by itself, it has support
How healthy is a diet composed almost exclusively of tuna, chicken, bread and eggs ?
Washington Post News
How important is the thymus gland in keeping your body free from diseases?
Links – Senior Care in the USA
CAM, holistic ways on cancer, depression, heart health, women and men
Lessons learned during the Big Data in Biomedicine Conference at Stanford
Restore your vision naturally y Dr. Mercola
UC biologists find link between paternal diet and offspring’s health
Gaps in women’s health insurance
Anti-aging and Parkinson/Alzheimer’s prevention: Enzymes and apple cider vinegar
How do you get rid of red lines around the stomach?
Glutathione, the body’s master antioxidant and detoxifier by Priya Shah
How to test movement in the gym using ROM as biofeedback
Vote This Evening in the House on Trump’s Tax Returns
Top aging hack posts 10-19-2017
Reducing belly fat
Why New Antidepressant Brintellix May Be a Killer
Caring for Dementia – broken brains documentary
A tsp of apple cider vinegar in your drinking water for colon cleanse

Metal toxins , mercury dental amalgams, Alzheimers, brain detox

I am caring for a 92 yr old with Dementia and she has metal dental fillings.  I started her with whole foods, exercise, sunshine and loving care with massage.  At night she has anxiety disorder.  I wish her dental metal fillings are removed as it can be toxic affecting her memory cells.  I buy cilantro, garlic, onions and healthy drinks of lemon and orange juice for her.

Soon I will start her with quality supplementation at:

http://www.clubalthea.pxproducts.com

mercury amalgam


Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan

The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older.

Methods

Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer’s disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0.

Results

Individuals exposed to amalgam fillings had higher risk of Alzheimer’s disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer’s disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women.

Conclusions

Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer’s disease than were their non-exposed counterparts.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642684/


 

Numerous studies have also demonstrated that the mercury exposure or concentration increases in the following tissues and situations

  • Due to chewing, brushing, and/or bruxism
  •  In exhaled or intra-oral air of persons with amalgam fillings
  •  In saliva of persons with amalgam fillings
  •  In blood of persons with amalgam fillings
  •  In various organs and tissues of amalgam bearers, including the kidney, liver, pituitary gland, thyroid, and brain or parts thereof
  •  In feces of amalgam bearers
  •  In amniotic fluid, cord blood, placenta, and various fetal tissues including liver, kidney and brain, in association with maternal amalgam load
  •  In colostrum and breast milk in association with maternal amalgam load

Scientific evidence confirms that in most individuals with dental mercury amalgam fillings, mercury exposure exceeds the Reference Exposure Level (REL).

[REL is a term used to denote the exposure level defined by national and international regulatory agencies at which there is an expectation of no negative health outcomes within the population.]
Also, reports from the World Health Organization (WHO) and Canada’s federal department of health (Health Canada) conclude that mercury vapor from dental amalgam is the greatest source of human exposure to mercury in non-industrial settings.

Additionally, in research published in 2011, Dr. G. Mark Richardson reported that more than 67 million Americans aged two years and older exceed the intake of mercury vapor considered “safe” by the U.S. EPA due to the presence of dental mercury amalgam fillings, whereas over 122 million Americans exceed the intake of mercury vapor considered “safe” by the California.

Click to access IAOMT-Position-Statement-Update-2016-6.16.16.pdf

Hospitals are housing the homeless: Will it help?

Hospitals are housing the homeless: Will it help?

Hospitals in Sacramento and around the country are taking steps to help homeless people find housing. Doing so, they say, will limit unnecessary ER visits and reduce wasteful healthcare spending. It also helps nonprofits such as San Francisco-based Dignity Health, Orlando-based Florida Hospital and Providence Health & Services in Portland, Ore., meet their community service obligations in exchange for tax breaks.

← Back

Thank you for your response. ✨


Looking for investors or those who wants to donate their lands to Green Research Instititute 501c3. 1708 Hallmark lane san jose ca 95124. Connie Dello Buono. 408-854-1883 motherhealth@gmail.com

A Canadian company created a modular house that can be assembled by 4 people in 2 weeks for $45k. Email Connie above for more info. These modular homes can be dropped by a helicopter in the USA or Canada.