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A Little Myelin Goes A Long Way To Restore Nervous System Function

A Little Myelin Goes A Long Way To Restore Nervous System Function

Source: University of Wisconsin Madison.

In the central nervous system of humans and all other mammals, a vital insulating sheath composed of lipids and proteins around nerve fibers helps speed the electrical signals or nerve impulses that direct our bodies to walk, talk, breathe, swallow or perform any routine physical act.

But diseases of the nervous system, including multiple sclerosis (MS) in people, degrade this essential insulation known as myelin, disrupting the flow of information between the brain and the body, impairing movement, dimming vision and blunting the ability to function normally.

And while scientists have long studied myelin and understand its role in disease when it degrades, they have puzzled over how myelin repairs itself naturally and whether the thinned sheaths that are a hallmark of the healing nervous system are adequate for restoring the brain’s circuitry over the long haul.

This week (Oct. 23, 2017), in a study published in the Proceedings of the National Academy of Sciences,a team of researchers from the University of Wisconsin-Madison reports that in long-lived animals, renewed but thin myelin sheaths are enough to restore the impaired nervous system and can do so for years after the onset of disease.

The team’s findings reinforce the idea that thin myelin sheaths are a valid, persistent marker of remyelination, a hypothesis challenged by other recent research. “As the only biomarker of myelin repair available this would leave us without any means of identifying or quantifying myelin repair,” explains Ian Duncan, an expert on demyelinating diseases at the UW-Madison School of Veterinary Medicine and the senior author of the new study.

Duncan and his team looked at a unique genetic disorder that naturally afflicts Weimaraners, a breed of dog that as 12- to 14-day-old pups develop a severe tremor and loss of coordination. The condition is known to occur as the development of the myelin sheath in parts of the dog’s central nervous system is delayed. The symptoms gradually diminish and in most cases disappear altogether by 3-4 months of age.

“This is a very widespread mutation in the breed,” says Duncan, noting that myelin repair mimicking what is seen in remyelination is known to occur in these dogs as the rejuvenated nerve fibers have a thinned myelin sheath.

The new Wisconsin study was made possible as 13 years ago two Weimaraner pups, littermates, were seen as patients at the School of Veterinary Medicine and Duncan was able to maintain contact with the owners after the dogs were adopted and retrieve samples of spinal tissue after the dogs lived out their lives. As they aged, the dogs exhibited few signs of tremor and were deemed ‘neurologically normal’ up to 13 years of age.

Image shows myelin.

The purpose of the study, says Duncan, was to confirm that thin myelin sheaths persisted and supported normal neurologic function.

To expand on the results, Duncan also looked at a condition in cats, another long-lived species that has been shown to fully recover nervous system function after demyelination. In particular, Duncan’s team was interested in remyelination of the optic nerves.

That element of the study, looking at remyelination two years after the onset of the condition, Duncan notes, is an example of “true demyelination and remyelination. We found that nearly every optic nerve fiber was remyelinated with a thin myelin sheath, which is important for understanding human disease because in multiple sclerosis, the optic nerve is often the first to be demyelinated.”

The new findings confirm that the gold standard for evaluating remyelination is the long-term persistence of thin myelin sheaths, which support nerve fiber function and survival, Duncan notes. The results are important for diseases like MS as it means that new therapies designed to promote myelin repair can be safely evaluated and quantified based on the presence of thin myelin sheaths.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Funding: These studies were supported in part by NMSS grant RG-1501-02876 and by a prior grant from the MS Hope for a Cure Foundation.

Source: Ian Duncan – University of Wisconsin Madison
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to the researchers.
Original Research:Abstract for “Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function” by Ian D. Duncan, Rachel L. Marik, Aimee T. Broman, and Moones Heidari in PNAS. Published online October 24 2017 doi:10.1073/pnas.1714183114

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
University of Wisconsin Madison “A Little Myelin Goes A Long Way To Restore Nervous System Function.” NeuroscienceNews. NeuroscienceNews, 24 October 2017.
<http://neurosciencenews.com/myelin-nervous-system-7802/&gt;.

Abstract

Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function

The presence of thin myelin sheaths in the adult CNS is recognized as a marker of remyelination, although the reason there is not a recovery from demyelination to normal myelin sheath thickness remains unknown. Remyelination is the default pathway after myelin loss in all mammalian species, in both naturally occurring and experimental disease. However, there remains uncertainty about whether these thin sheaths thicken with time and whether they remain viable for extended periods. We provide two lines of evidence here that thin myelin sheaths may persist indefinitely in long-lived animal models. In the first, we have followed thin myelin sheaths in a model of delayed myelination during a period of 13 years that we propose results in the same myelin sheath deficiencies as seen in remyelination; that is, thin myelin sheaths and short internodes. We show that the myelin sheaths remain thin and stable on many axons throughout this period with no detrimental effects on axons. In a second model system, in which there is widespread demyelination of the spinal cord and optic nerves, we also show that thinly remyelinated axons with short internodes persist for over the course of 2 y. These studies confirm the persistence and longevity of thin myelin sheaths and the importance of remyelination to the long-term health and function of the CNS.

“Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function” by Ian D. Duncan, Rachel L. Marik, Aimee T. Broman, and Moones Heidari in PNAS. Published online October 24 2017 doi:10.1073/pnas.1714183114


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Support for Populist Ideologies Linked to National Narcissism and Feelings of Disadvantage

Support for Populist Ideologies Linked to National Narcissism and Feelings of Disadvantage

Summary: University of Kent researchers report people who believe they are disadvantaged are more likely to have an unrealistic belief in the greatness of their country and support populist ideologies.

Source: University of Kent.

People who perceive they are part of a disadvantaged group are more likely to have an unrealistic belief in the greatness of their nation and support populist ideologies.

A team of psychologists and political scientists from the universities of Kent (UK), Warsaw (Poland) and Maryland (USA) found in three studies that national collective narcissism was linked to support for populism. In the UK, collective narcissism predicted support for Brexit, in the US it predicted support for Donald Trump, and in Poland it predicted support for the populist Law and Justice party.

The study found that collective narcissism, i.e. an unrealistic belief in the greatness of the nation, increased in response to group feelings of being disadvantaged, especially when this was long lasting.

The researchers suggest that the narrative of relative disadvantage, fuelled by populist leaders, might reinforce a ‘defensive and destructive’ national perspective. Narcissistic beliefs about the in-group greatness are a way to compensate for feelings of being worse off than other groups.

One of the team, Dr Aleksandra Cichocka of the University of Kent’s School of Psychology, said that the results might partially explain why populism is often linked to prejudicial attitudes and behaviours.

Image shows a group of people.

In the first study, data from Poland in 2014 was used to examine the relationship between national collective narcissism versus conventional national identification and support for the populist Law and Justice party and its leader. The researchers found that collective narcissism, rather than mere strength of national identification, was a significant predictor of support for this party.

Study two was conducted around the EU Referendum in the UK. Researchers found that a perception of long-term group disadvantage resulted in a higher willingness to adopt populist views reflected in Brexit support. They found that this link was driven by national collective narcissism.

Study three examined support for Donald Trump. Researchers found that feelings that Americans were being disadvantaged relative to immigrants was associated with national collective narcissism, which in turn predicted preference for Trump.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source: Martin Herrema – University of Kent
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Populism as Identity Politics: Perceived In-Group Disadvantage, Collective Narcissism, and Support for Populism” by Marta Marchlewska, Aleksandra Cichocka, Orestis Panayiotou, Kevin Castellanos, and Jude Batayneh in Social Psychological and Personality Science. Published online October 4 2017 doi:10.1177/1948550617732393

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
University of Kent “Support for Populist Ideologies Linked to National Narcissism and Feelings of Disadvantage.” NeuroscienceNews. NeuroscienceNews, 24 October 2017.
<http://neurosciencenews.com/populism-national-narcissism-7803/&gt;.

Abstract

Populism as Identity Politics: Perceived In-Group Disadvantage, Collective Narcissism, and Support for Populism

Self-esteem is shaped by the appraisals we receive from others. Here, we Populists combine anti-elitism with a conviction that they hold a superior vision of what it means to be a true citizen of their nation. We expected support for populism to be associated with national collective narcissism—an unrealistic belief in the greatness of the national group, which should increase in response to perceived in-group disadvantage. In Study 1 (Polish participants; n = 1,007), national collective narcissism predicted support for the populist Law and Justice party.

In the experimental Study 2 (British participants; n = 497), perceived long-term in-group disadvantage led to greater support for Brexit and this relationship was accounted for by national collective narcissism. In Study 3 (American participants; n = 403), group relative deprivation predicted support for Donald Trump and this relationship was accounted for by national collective narcissism. These associations were present even when we controlled for conventional national identification. We discuss implications of the link between collective narcissism and support for populism.

“Populism as Identity Politics: Perceived In-Group Disadvantage, Collective Narcissism, and Support for Populism” by Marta Marchlewska, Aleksandra Cichocka, Orestis Panayiotou, Kevin Castellanos, and Jude Batayneh in Social Psychological and Personality Science. Published online October 4 2017 doi:10.1177/1948550617732393


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Residential care options for Alzheimer’s

As Alzheimer’s disease progresses, you may no longer be able to care for the person at home. When that happens, you may want to look for a long-term care facility for the person.

Residential care options

Continuing care retirement communities (CCRCs)—a home, apartment, or room in a retirement community where people with Alzheimer’s can live and get care. Residents may move from one level of care to another—for example, from independent living to more supervised care.
Assisted living facilities—a facility with rooms or apartments for people who may need some help with daily tasks. Some assisted living facilities have special Alzheimer’s units.
Group homes—a home where several people who can’t care for themselves and two or more staff members live. At least one caregiver is on site at all times.

Nursing homes—a place for people who can’t care for themselves anymore. Some nursing homes have special Alzheimer’s disease care units.

Your own house

Your own house with hospital bed, pole (connected from floor to ceiling) to hang on to when transferring from bed to wheelchair and senior safe your  house with guide rails and other measures. And employ a private caregiver or home helper.

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Activation of Immune T Cells Leads to Behavioral Changes

Activation of Immune T Cells Leads to Behavioral Changes

Summary: A new Nature Immunology study reveals immune cells alter the body’s metabolism when activated, leading to changes in behavior.

Source: RIKEN.

Scientists from the RIKEN Center for Integrative Medical Sciences in Japan and collaborators have found that T cells — immune cells that help to protect the body from infections and cancer — change the body’s metabolism when they are activated, and that this activation actually leads to changes in behavior.

It is currently known that individual T cells change their metabolism to meet their energy needs after being activated, but the systemic metabolic effect of sustained activation of the immune system has remained unexplored. To understand the systemic effects, the group looked at T cell activation in mice designed to lack a surface receptor called PD-1, which is necessary for inhibiting the activity of T cells. T cells remain activated in mice without the receptor, similar to those in the immune systems of people with certain types of autoimmune disease. In these mice, they found that amino acids–molecules that are used to build proteins–were depleted in the blood, and that they were increased in the T cells themselves, implicating the T cells in the change.

The team tracked and imaged amino acids in many organs, and found that the depletion of amino acids from the blood was taking place due to the accumulation of amino acids in activated T cells in the lymph nodes, showing that strong or long lasting immune responses can cause metabolic changes elsewhere in the body.

The remaining question was whether this depletion of amino acids was actually having any systemic effect. By analyzing the biochemistry of the brain, they found that the systemic decrease in the amino acids tryptophan and tyrosine in blood led to lower amounts available in the brain, limiting production of the neurotransmitters serotonin and dopamine. These neurotransmitters affect emotions, motivation and fear–for example, serotonin is often a target of drugs that combat depression. The researchers found that their depletion in mice without PD-1 resulted in behavioral changes dominated by anxiety and exacerbated fear responses, which could be remedied by providing a diet rich in an essential amino acid.

This research, which was published in Nature Immunology, required teamwork and collaboration to link diverse fields of biology: immunology, neuroscience and behavior, using cutting edge metabolite measurements and imaging methods. “Together these data indicate that excessive activation of T cells causes a systemic metabolomic shift with consequences that extend beyond the immune system” says Michio Miyajima, one of the four first co-authors of this study.

t cell

According to Sidonia Fagarasan, the leader of the group, “We were fascinated to see that this happens-as it revealed the power of the immune system to influence many aspects of the body’s physiology besides infection and immunity. It will be interesting in the future to investigate whether the trigger of fear and anxiety by T cell activation is merely a side effect of the process, or whether there is an evolutionary benefit of this adaptation. We would also like to further investigate these changes, as the blockade of PD-1 is being investigated as an anti-cancer therapy, and it is important to understand if this could have behavioral changes such as increases in anxiety.”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Funding: This research was supported by the Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology (14532135 to S.F.), Japan Agency for Medical Research and Development (145208 and 16770835 to T.H.) and the Cell Science Foundation (K.C). The work was done by RIKEN in collaboration with Keio University, Kyoto University, and other institutions.

Source: Jens Wilkinson – RIKEN
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public doamin.
Original Research: Abstract for “Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior” by Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M Guerrini, Yumi Tsutsui, Mikako Maruya, Alexis Vogelzang, Kenji Chamoto, Kurara Honda, Takatoshi Hikida, Satomi Ito, Hongyan Qin, Rikako Sanuki, Keiichiro Suzuki, Takahisa Furukawa, Yasushi Ishihama, Fumihiko Matsuda, Makoto Suematsu, Tasuku Honjo & Sidonia Fagarasan in Nature Immunology. Published online October 23 2017 doi:10.1038/ni.3867

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
RIKEN “Activation of Immune T Cells Leads to Behavioral Changes.” NeuroscienceNews. NeuroscienceNews, 23 October 2017.
<http://neurosciencenews.com/t-cell-behavioral-changes-7792/&gt;.

Abstract

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

T cells reorganize their metabolic profiles after being activated, but the systemic metabolic effect of sustained activation of the immune system has remained unexplored. Here we report that augmented T cell responses in Pdcd1−/− mice, which lack the inhibitory receptor PD-1, induced a metabolic serum signature characterized by depletion of amino acids. We found that the depletion of amino acids in serum was due to the accumulation of amino acids in activated Pdcd1−/− T cells in the lymph nodes. A systemic decrease in tryptophan and tyrosine led to substantial deficiency in the neurotransmitters serotonin and dopamine in the brain, which resulted in behavioral changes dominated by anxiety-like behavior and exacerbated fear responses. Together these data indicate that excessive activation of T cells causes a systemic metabolomic shift with consequences that extend beyond the immune system.

“Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior” by Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M Guerrini, Yumi Tsutsui, Mikako Maruya, Alexis Vogelzang, Kenji Chamoto, Kurara Honda, Takatoshi Hikida, Satomi Ito, Hongyan Qin, Rikako Sanuki, Keiichiro Suzuki, Takahisa Furukawa, Yasushi Ishihama, Fumihiko Matsuda, Makoto Suematsu, Tasuku Honjo & Sidonia Fagarasan in Nature Immunology. Published online October 23 2017 doi:10.1038/ni.3867

Blocking stomach acid may promote chronic liver disease

Blocking stomach acid may promote chronic liver disease

At a Glance

  • A new study found that blocking stomach acid can lead to an overgrowth of intestinal bacteria that likely contributes to liver inflammation and damage.
  • The findings suggest that some widely used acid reflux (heartburn) medications may worsen chronic liver disease.
Woman on park bench with heartburnThe use of medications to suppress stomach acid has been on the rise. New research suggests certain kinds may have an impact on chronic liver disease.champja/iStock/Thinkstock

The liver has many important functions, including helping to digest food and process and distribute nutrients. A healthy liver is necessary for survival. The liver can regenerate after being damaged. However, repeated or long-lasting injury can cause scar tissue to form. Scarring of the liver may lead to cirrhosis, a condition in which the liver is unable to function normally. Liver cirrhosis is a leading cause of death worldwide.

Many conditions can contribute to the development of cirrhosis, including obesity, which is associated with non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH), a form of NAFLD in which you also have inflammation and liver cell damage. But alcohol misuse accounts for about half of cirrhosis-related deaths.

Changes in your gut’s microorganisms, or microbiota, can affect the progression of liver disease. Misusing alcohol alters the microbes in your gut. So can a commonly used class of heartburn medication called proton pump inhibitors (PPIs), which block stomach acid secretion. PPIs are often used by people who have chronic liver disease. However, the impact of these medications on liver disease progression has been unknown.

Bacteria growing on petri dishesIn mice, some common acid reflux medications promote growth of Enterococcus bacteria, shown here artificially glowing red, in the intestines. These bacteria can move to the liver and affect its function. UC San Diego Health

To investigate whether blocking stomach acid affects chronic liver disease, a team led by Dr. Bernd Schnabl at the University of California San Diego School of Medicine looked at PPIs in mouse models of three types of liver disease—alcohol-induced liver disease, NAFLD, and NASH—and in humans. The study was funded in part by NIH’s National Institute on Alcohol Abuse and Alcoholism (NIAAA). Results were published on October 16, 2017 in Nature Communications.

The team blocked stomach acid in the mice either by genetically deleting the gene that controls stomach acid secretion or by administering the PPI omeprazole (Prilosec). Liver conditions in all three disease models were worsened when the mice lacked stomach acid.

The researchers found that mice lacking stomach acid had higher levels of intestinal bacteria as well as imbalances among the microbes. In particular, the mice had increased levels of Enterococcus in their guts. Further experiments suggested that these bacteria can reach the liver, where they can cause liver inflammation and damage.

The team looked at whether people taking PPIs have similar microbiota changes. They collected fecal samples from healthy people before and after PPI treatment. After two weeks, those taking the PPI treatment also had a higher number of Enterococcus.

The researchers next investigated whether there might be a link between PPIs and the development of alcoholic liver disease. They looked at 4,830 patients with a diagnosis of alcohol use disorder. Among these, 36% had been using PPIs. The analysis showed that PPI use increased the 10-year risk of developing liver disease (20.7% for active users; 16.1% for previous users; 12.4% for those who had never used PPIs).

“Our findings indicate that the recent rise in use of [stomach] acid-suppressing medications might have contributed to the increased incidence of chronic liver disease,” Schnabl says. “We believe clinicians should consider withholding medications that suppress [stomach] acid unless there is a strong medical indication.”

—Tianna Hicklin, Ph.D.

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1 in 4 older adults have foot pain

A 92 yr old woman had foot and leg pain which always more severe at night. I have to massage the middle part of the bottom of her feet and legs. I use many kinds of oil, coconut and turmeric, coconut and MSM and/or baking soda and coconut oil alone.  In the past, I have washed seniors feet with hydrogen peroxide and salt water. I use many essential oils from eucalyptus to tea tree oil. I made sure their diet is rich in garlic, onions and the sulfur family. For supplementation, I recommend turmeric and ginger capsule, melatonin and calcium with magnesium and zinc. I always use citrus fruits such as oranges and lemon in her diet of whole foods and fish.

The position of the hospital bed is important. Exercise, sunshine and adequate sleep are important.

Connie Dello Buono

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Chronic foot pain in older people

Under a Creative Commons license
open access

Highlights

•

Foot pain affects approximately one in four older people.

•

Foot pain impairs mobility and balance, and is an independent risk factor for falls.

•

Foot pain can be effectively managed in older people with conservative interventions such as routine foot care, footwear advice and foot orthoses.

Abstract

Foot pain is a common accompaniment of advancing age, affecting at least one in four older people. However, management of foot pain is a largely undervalued aspect of geriatric health care, resulting in many older people needlessly enduring chronic foot pain and related disability. The aim of this review is to provide an overview of (i) the prevalence and risk factors for foot pain, (ii) the impact of foot pain on mobility and quality of life, and (iii) the conservative management of foot pain. The available evidence indicates that although foot pain is common and disabling in older people, conservative interventions such as routine foot care, footwear advice and foot orthoses are effective at reducing foot pain and may also assist in maintaining mobility and independence in this age group.

Keywords

Foot
Pain
Ageing

1. Introduction

The human foot plays an essential role in all weightbearing activities as it provides the only source of contact with the ground. When walking, the foot contributes to shock absorption, adapts to uneven surfaces, and facilitates the forward propulsion of the body. In the presence of foot pain, this important biomechanical function is disrupted, leading to impaired balance, difficulty ambulating and ultimately a loss of independence [1]. Despite this, management of foot pain is a largely undervalued aspect of geriatric health care. Indeed, even older people themselves may consider foot pain to be an inevitable consequence of ageing rather than a treatable medical condition [2], resulting in many people needlessly enduring chronic foot pain and related disability.

The aim of this review paper is to provide an overview of the epidemiology, impact and conservative management of foot pain in older people.

2. Methods

A literature search was conducted in May 2016. The Ovid platform was used to explore Medline (1946 to present) and Embase (1974 to present) by applying the following title keyword search terms: foot OR foot problems OR foot disorders OR foot osteoarthritis AND elderly OR older; limited to human studies published as full journal articles in the English language. After the removal of duplicates; this search strategy yielded 194 documents. Following title and abstract review; 58 documents were removed; leaving a final yield of 136 manuscripts for consideration. The reference lists of these manuscripts were then examined for additional titles; and the most relevant manuscripts were selected for citation based on the predetermined subheadings of the review (epidemiology; impact and management). A narrative summary of the findings of these studies is provided.

3. Epidemiology of foot pain in older people

3.1. Prevalence

It has long been recognised that foot problems are common in older people [3]. However, estimating the population prevalence of foot pain in older people is difficult, as several case definitions have been used which vary according to pain frequency and time period. Nevertheless, a recent systematic review of 31 population-based studies involving 75,505 community-dwelling participants aged 45 years and over identified eight studies with comparable case definitions, from which a pooled prevalence estimate of frequent foot pain of 24% was derived. Frequent foot pain was found to most commonly affect the forefoot and the toes, to be more prevalent in women than men, and to be at least moderately disabling in two-thirds of cases [4]. Two prospective studies also indicate that foot pain is highly persistent in older people. A prospective study of 2718 people aged 50 years and over reported that of those who reported disabling foot pain at baseline, 72% had foot pain three years later, with women more likely to report persistent foot pain than men [5]. Similarly, a study of 4745 women aged 70–75 years reported that foot pain persisted in 51% over a six year follow-up period [6].

3.2. Risk factors

Cross-sectional studies have identified several potential risk factors for foot pain in older people, including female sex [7–9], obesity [8,10,11], depression [12–14] and comorbidities such as diabetes and osteoarthritis [15–17]. Of these factors, female sex and obesity appear to have the strongest associations with foot pain. Older women are significantly more likely to report foot pain than older men, which may be due to the higher prevalence of hallux valgus and lesser toe deformities [18,19] and the influence of women’s footwear, which frequently incorporates an elevated heel and narrow toe box [20,21]. The association between increased body mass index and foot pain in older people has been attributed to increased mechanical loading of the foot when walking [22] and the contribution of metabolic factors associated with excess fat mass [23].

Despite the general consensus that health status is strongly linked to socio-demographic factors, the role of education and income in the prevalence of foot pain in older people is equivocal. While some studies have reported that older people with foot problems have a lower level of income [24] others have failed to find such an association [17,25]. Similarly, lower levels of education have been found to be associated with foot problems in some studies [17,24] but not others [15,16,25]. These discrepancies are likely to reflect differences in how income levels are defined and differences in educational systems between countries.

3.3. Common foot disorders in older people

Foot pain is a complex phenomenon as it may be caused by local factors (i.e. structural disorders affecting the load-bearing function of the foot) and systemic factors (i.e. dermatological, vascular, neurological and musculoskeletal conditions that may manifest in the foot). A detailed evaluation of each of these conditions is beyond the scope of this review. However, large-scale epidemiology studies indicate that the most commonly observed and reported foot disorders resulting in foot pain in older people are keratotic lesions (corns and calluses), followed closely by nail disorders (particularly fungal nail infection) and structural deformities such as hallux valgus (‘bunions’) and lesser toe deformities (hammertoes and clawtoes) [7,18,26]. Systemic conditions most commonly associated with foot symptoms in older people include osteoarthritis [27], rheumatoid arthritis [28], gout [29] and diabetes [30]. Given that local and systemic factors often coexist, delineating a precise cause of foot pain in older people is difficult and requires a detailed systems examination in clinical practice.

4. Impact of foot pain in older people

There is strong evidence that foot pain has a significant detrimental impact on mobility and health status in older people. Several studies have demonstrated that foot pain is associated with reduced walking speed [31,32] and difficulty performing activities of daily living [16,31–34]. The majority of older people with foot pain consider it to adversely affect their ambulation on most days [4] and 20% specifically report foot pain to be the primary cause of their inability to leave their home [35]. Foot pain has also been shown to be associated with impaired balance [36,37] and is an independent risk factor for accidental falls [38,39]. More broadly, older people with foot pain report poorer health-related quality of life, as evidenced by lower scores on the Short Form 36 health survey [13,25,32].

Management of foot pain in older people accounts for a substantial number of consultations to health professionals. In the UK, primary care consultations for musculoskeletal foot and ankle problems are strongly associated with age, and peak in the 65–74 year age group [40]. Similarly, podiatry utilisation in Australia is highest among those aged 65 years and over [41], with older people accounting for 75% of all publicly-funded podiatry consultations [42]. Many older people also seek surgical intervention for their foot pain, particularly for conditions affecting the forefoot and toes [43].

5. Management of foot pain in older people

5.1. Routine foot care

The provision of foot health services to manage foot pain and disability in older people is primarily the domain of the podiatry profession, although a wide range of health professionals (such as general practitioners, rheumatologists, orthopaedic surgeons, nurses, physiotherapists and pedorthists) may also contribute [44]. Maintenance of foot hygiene and treatment of toenails and keratotic lesions in older people accounts for a substantial proportion of a podiatrist’s workload. Clinical audits have shown that regular podiatry treatment can maintain or improve foot health in older people [45] and that discharge from podiatry services may result in a subsequent deterioration in foot health and mobility in this age-group [46].

Difficulty cutting toenails is common in older people, as it requires not only adequate joint flexibility, but also a high level of manual dexterity and visual acuity; all of which may decline with age. Although often considered to be relatively trivial problems, nail disorders resulting from inability to maintain toenail hygiene, such as onychomycosis (fungal nail infection) and oncycryptosis (ingrown toenails) can be extremely painful and disabling [47]. In hospital or residential care settings where podiatry services are limited or unavailable, nursing staff may be required to perform this role [48]. Although there is evidence that nursing staff lack confidence in managing foot problems [49,50], educational interventions to train nursing staff have been shown to be effective at improving both foot care knowledge and practices [51,52].

Management of painful plantar calluses commonly involves scalpel debridement by a podiatrist, although the effectiveness of this approach is uncertain. Although uncontrolled studies have reported immediate reductions in pain following scalpel treatment of plantar calluses [53,54], controlled trials involving a ‘sham’ treatment group suggest that this apparent short-term improvement can be largely attributed to placebo effects [55,56]. However, these findings do not preclude the possibility of cumulative benefits over a longer time period. A recent trial has shown that scalpel debridement of plantar calluses is more effective at improving the mechanical properties of the skin than the application of topical keratolytic agents [57]. This effect may be particularly important in the management of the older person with diabetes, as regular scalpel debridement of plantar calluses has been shown to be effective in the prevention of neuropathic ulceration [58].

Treatment of corns may also require scalpel debridement, however a recent randomised trial suggests that corn plasters containing 40% salicylic acid may be more effective [59]. In this trial, 202 people were randomised to receive either scalpel debridement or corn plasters, and were followed up for a 12 month period. The use of corn plasters was associated with a higher proportion of resolved corns, a prolonged time to corn recurrence, less pain and reduced corn size over the first 6 months in comparison with scalpel treatment. However, this treatment needs to be very carefully considered in older people with poor skin integrity or peripheral neuropathy, as several cases of foot ulceration associated with corn plasters have been reported in people with diabetes [60].

5.2. Footwear considerations

Evaluation of footwear is one of the most fundamental components of effective management of foot pain in older people. Between 26 and 50% of older people wear shoes that are too short or too narrow [61–63] due to fashion influences [64,65], not measuring foot dimensions when purchasing shoes [66], and the limited availability of footwear that caters for the altered shape of the older foot [67,68]. In older people, wearing shoes substantially narrower than the foot is associated with corns on the toes, hallux valgus deformity and foot pain, whereas wearing shoes shorter than the foot is associated with lesser toe deformity [69]. Furthermore, shoes that are too tight in the forefoot or too loose in the heel may lead to reduced walking speed and gait instability [70].

The detrimental effect of high heels has been examined in two recent reviews [71,72]. Heel elevation alters the position and motion of the foot and ankle, thereby altering the biomechanics of the knee, hip and spine and predisposing to musculoskeletal pain. However, there is some evidence that the use of high heels diminishes with age. A survey of 2627 women aged 50 years and over found that the use of high heels was common between the ages of 20–29, but declined to less than 10% by the age of 40 years [73]. This may be indicative of a life-course trajectory in which the influence and perceived importance of fashion diminishes over time and is replaced with a greater emphasis on comfort and practicality. Nevertheless, in older people who continue to wear this style of footwear, heel elevation is associated with hallux valgus and plantar calluses [69] and has been shown to impair balance and increase the risk of falls [74].

Given the association between suboptimal footwear and foot pain, changing footwear could be a simple and effective intervention. Indeed, a recent randomised trial has shown that the use of appropriate footwear is effective at reducing foot pain in older people [75]. In this study, community-dwelling older people with disabling foot pain were randomly allocated to an intervention group (who received off-the-shelf, extra-depth footwear with a compliant elastane upper) or a usual care control group. At the 4 month follow-up period, the intervention group exhibited a greater reduction in foot pain and developed fewer keratotic lesions than the control group, suggesting that simply changing footwear may be an effective management strategy. However, fashion influences are a significant barrier to adherence, particularly in older women, as selection of footwear is more strongly influenced by aesthetics than functional considerations [76].

5.3. Foot orthoses

Foot orthoses are devices placed inside the shoe that alter the timing and magnitude of the forces acting on the foot during weight bearing activities. Orthotic therapy plays a major role in the conservative management of foot disorders in older people [77,78]. In the UK National Health Service, it has been estimated that £38 million is spent on orthoses each year, with foot orthoses accounting for 75% of a hospital’s total appliances budget [79]. Foot orthoses range from simple adhesive pads that can be manufactured during a routine consultation, through to more complex techniques involving the construction of custom-moulded insoles derived from plaster casts or 3-dimensional scans of the older person’s feet.

Several studies have demonstrated that foot orthoses are effective at reducing pressure from painful regions of the foot (including the heel [80], forefoot [81]and toes [82]) in older people, and may also be beneficial for balance [83–85]. In relation to symptoms, two uncontrolled studies have suggested that foot orthoses can reduce foot pain in older people [85,86], and one randomised controlled trial found that foot orthoses with a medial arch support and metatarsal pad were effective at reducing foot pain and foot-related disability in older women with osteoporosis [87]. More recently, two randomised trials found that foot orthoses were effective at reducing symptoms in people with osteoarthritis of the first metatarsophalangeal joint [88] and midfoot joints [89]. These studies suggest that foot orthoses may be a useful conservative treatment for a range of foot disorders in older people. However, when prescribing orthoses in this age-group, consideration also needs to be given to whether the older person has suitable accommodative footwear, sufficient mobility to change or remove the orthoses when necessary, and sufficient skin integrity to withstand the arch contouring provided by the devices.

6. Summary and conclusions

Foot pain affects at least one in four older people, is frequently disabling, and is associated with mobility impairment and falls in this age group. The major risk factors for the development of foot pain are increasing age, female sex, obesity, depression and common chronic conditions such as diabetes and osteoarthritis, while the most commonly reported foot disorders by older people are corns and calluses, nail disorders and toe deformities. Management of foot pain is primarily the role of the podiatrist, although nurses, general practitioners, rheumatologists and orthopaedic surgeons may contribute. Conservative podiatric interventions such as regular foot care, footwear advice and foot orthoses appear to be effective at reducing foot pain in this age group, although further controlled trials are required to adequately evaluate their effectiveness.

Conflict of interest

HBM has no conflict of interest to declare.

Funding

HBM is currently a National Health and Medical Research Council of Australia Senior Research Fellow (ID: 1020925).

Contributor

HBM is the sole author of this review.

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