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What do the various neurodegenerative diseases have in common? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Gut bacteria imbalance that affects the immune system and then the brain allowing inflammatory substances to enter affecting the BBB (blood brain barrier) dopamine and serotonin pathways, tau protein destruction and other stressors – hormonal, lack of Vit D, melatonin, lack of resvetratrol, enzymes, toxins – metal and environmental)
About Tau protein:
Tau is a microtubule-associated protein linked with neurodegenerative diseases. Humans express six different isoforms of tau; the longest containing four microtubule-binding repeat motifs in the C-terminal that are vital for what is considered the major biological function of tau, to stabilize microtubules and facilitate axonal transport. The capacity of tau to maintain its normal biological function is dependent upon its phosphorylation state. In Alzheimer's and Parkinson's diseases, there is a hyperphosphorylation of tau that leads to the intracellular accumulation of tau in the form of neurofibrillary tangles. While the role of tau in Parkinson's disease has been understated for some time, here we summarize key genetic, pathological and biochemical evidence supporting a role for tau in the pathogenesis of Parkinson's disease. Toxic interactions with alpha synuclein may lead to hyperphosphorylation of tau and eventually to the deposition of both proteins in the disease.

What do the various neurodegenerative diseases have in common?

What is a quick and easy way to lose 2lb? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Calorie In/Calorie out: How to reduce your servings?
Decide for 1, 2, or 3 meals per day of your favorite happy healthy foods. Chew your food slowly. Cut your usual serving to half. When waking up, chew a protein rich food (1 tsp of peanut butter or 1 soft boiled egg or your fav breakfast cut in half). And if you have a digestive enzyme capsule or acidophilus capsule, it is best to take these in the morn and your calcium with magnesium and Vit C in the evening.
 Eat only when hungry. Have a weight loss goal.
• Do I need a specific exercise?
It depends on your lifestyle. Try to walk at least a mile a day.
• What to do in between meals?
You need a healthy sugar. Drink about 3 to 5 tablespoon of fresh squeeze orange juice or similar substitute. Use maple syrup to sweeten a home made lemon juice. Eat any sugary food -half your usual serving (healthy dessert like apples) 30 min after the meal. During the first 6 weeks, no snacking and eat your snack (not over ripe plum or apple or few walnuts/avocado slice) 30min after your meal.
Email Connie at motherhealth@gmail.com for your success story

What is a quick and easy way to lose 2lb?

How long does it take for damaged nerves to repair themselves? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Once the insulating cover of the nerve is repaired, the nerve generally begins to heal three or four weeks after the injury. Nerves usually grow one inch every month, depending on the patient's age and other factors. With an injury to a nerve in the arm above the fingertips, it may take up to a year before feeling returns to the fingertips. The feeling of pins and needles in the fingertips is common during the recovery process. While this can be uncomfortable, it usually passes and is a sign of recovery.
http://orthoinfo.aaos.org/topic.cfm?topic=A00016
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I hurt the tip of my little finger (by bumping it to a cemented wall) yesterday with a small redness by the nail bed. It healed in 12hrs as I massaged it right away (w saliva).

How long does it take for damaged nerves to repair themselves?

How can I make my nerves strong? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Nervous system health: Sleep ( > 60 ; calcium, magnesium, melatonin, Vit C), happy thoughts (anxiety is a mental disease), volunteer or give love/be generous, keep a positive spirit, Vit B complex and E, nature walk, whole foods, gardening, acidophilus capsules and digestive enzymes (fresh pineapple and papaya), and surround yourself with positive and loving people and environment. Free up your mind an hour before bedtime, do yoga or clean up your clutter. Remember that your mind is your brain in action. Fill it with positive and loving thoughts.

How can I make my nerves strong?

Calorie In/Calorie out: How to reduce your servings? Decide for 1, 2, or 3 meals per day of your favorite happy healthy foods.  Chew your food slowly. Cut your usual serving to half.  When waking u…

Source: How to succeed in losing weight in next 6weeks

Why do I get cravings at night? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

From Wiki:
There is no single explanation for food cravings, and explanations range from low serotonin levels affecting the brain centers for appetite to production of endorphins as a result of consuming fats and carbohydrates.[1] Foods with high levels of sugar glucose, such as chocolate, are more frequently craved than foods with lower sugar glucose, such as broccoli, because when glucose interacts with the opioid system in the brain an addictive [3] triggering effect occurs. The consumer of the glucose feels the urge to consume more glucose, much like an alcoholic, because the brain has become conditioned to release "happy hormones" every time glucose is present.[4] There is evidence that addiction and food craving activate some of the same brain areas. Specifically, when smokers look at pictures of people smoking it activates the same areas of the brain as when obese people look at pictures of food.
The cravings for certain types of food are linked to their ingredients. Chocolate for example, contains the neurotransmitter phenylethylamine, which is important for the regulation of the body’s release of endorphins.[6] Endorphins are released following a stressor and result in a sense of relaxation.[7] Exercise and sleep are two alternative ways to help facilitate the release of endorphins.
 Chocolate also contains large quantities of iron, which can be depleted during the menstrual cycle.[6] Another common craving is salt. Craving salt may be partly due to being dehydrated. When dehydrated the body loses water, electrolytes, and salt, and by ingesting salt, water retention can be increased.[6] Craving salt can also be a sign of diabetes, heart disease, and sickle cell anemia.[citation needed]
Carbohydrates, or particularly sugars, are yet another common craving. These cravings occur often in the middle of the afternoon when energy is at its lowest.[6]
 The craving of non-food items as food is called pica.
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The pituitary gland in the brain is responsible for food cravings, sleep, sex hormones and stress.

Why do I get cravings at night?

Are short fat women stronger than tall skinny men? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Height predisposes one to cancer (tall) and (short) heart disease, stroke, Alzheimers and Diabetes
Tall people: Cancer
A new study suggests that taller women have a heightened risk for cancer, the No. 2 killer of U.S. women.
The study, published today in the Journal Cancer Epidemiology, Biomarkers and Prevention, found that taller women were more likely to develop cancers of the breasts, ovaries, kidneys, thyroid, endometrium, colon and rectum. They also had an increased risk for multiple myeloma and melanoma.
The study adds to mounting evidence connecting height and cancer risk. A 2012 study published in the journal PLoS One found that for every 5-centimeter (2-inch) increase in height above the average 5 feet, 3 inches, the risk of ovarian cancer rose 7 percent. And a 2011 study published in The Lancet found that taller women had an increased risk of 10 different cancers, including breast and skin cancer.
Short people: Heart Disease, Alzheimer’s Disease and Stroke
Heart disease is the leading cause of death in the United States, killing 616,000 people per year, according to the CDC. And, unlike cancer, it seems to affect shorter people more than their taller counterparts.
A 2010 review of 52 studies involving more than 3 million men and women found shorter people have a 50 percent higher risk of having deadly heart disease than tall people.
“It would be interesting to explore the possibility that short stature is connected with the risk of [coronary heart disease] and [heart attack] through the effect of smaller coronary artery diameter, and that smaller coronary arteries may be occluded earlier in life under similar risk conditions,” the authors wrote in their report, published in the European Heart Journal.
Stroke
Like heart disease, serious strokes are also more common among shorter people.
An Israeli study of more than 10,000 men, 364 of whom died from stroke, linked each 5-centimeter (2-inch) decrease in height with a 13 percent increase in fatal stroke risk. Men who were in the shortest quartile had a 54 percent higher risk of fatal stroke than men in the tallest quartile, according to the 2002 study published in the journal Stroke.
Alzheimer’s Disease
Alzheimer’s disease is the most common cause of dementia in older people, affecting 5.2 million Americans, according to the Alzheimer’s Association. The risk increases with age and a family history of Alzheimer’s, highlighting the disease’s genetic roots. And according to a 2007 study, the risk is also higher for shorter people.
The study, which compared 239 Alzheimer’s patients with 341 healthy controls, found men who were taller than 5 feet 10 inches had a 59 percent lower risk of developing the disease than men who were shorter than 5 feet 6 inches. The study was published in the Journal of Alzheimer’s Disease.
Both: Diabetes
“Height might represent a strong indicator of nutritional status, especially in a study such as ours, which included many subjects who had lived as persecuted minorities in their childhood,” the authors wrote. “It could also be associated with environmental conditions in childhood and adolescence.”
While Type 2 diabetes is linked to weight, Type 1 diabetes — also called juvenile diabetes — may be linked to height.
“Taller children generally seem to experience increased risk for development of diabetes mellitus type 1, except perhaps during infancy or early adolescence,” according to a 2002 study published in the journal Pediatrics.
The cause of type 1 diabetes is unknown, but it’s thought result from an autoimmune attack on the insulin-producing cells of the pancreas. Although it can occur at any age, it’s usually diagnosed in children, teens or young adults.
There is debate surrounding the link between height and diabetes, however, as other studies have suggested children with diabetes are similar in stature or even shorter than their non-diabetic peers.

Are short fat women stronger than tall skinny men?

How can ones diet affect the nervous system? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Vitamin A: (Retinol) Vision problems such as night blindness (nyctalopia). Night blindness is the inability of the eyes to adjust when a person goes from a lighted area to a dark area. changes in the skin and mucous membranes; decreased sense of taste ; Nausea, fatigue, headache; toxic in large amounts
Vitamin B1: (Thiamine) Beriberi = loss of motor coordination; paralysis; pain in arms and legs; headache. Loss of myelin sheath; attacks motor and sensory axons of the neuron. ; None known
Vitamin B2: (Riboflavin) Visual problems: burning, itching of the eyes, sensitivity to light; burning sensations around the mouth; peripheral nerve damage ; None known
Vitamin B3: (Niacin) Pellegra = mental problems (disorientation, confusion, depression, memory deficit, mania, paranoia); digestive problems; skin problems. Liver damage; flushing of the skin
Vitamin B5: (Pantothenic Acid) Although rare, fatigue, burning sensations on hands and feet, and headaches may occur None known
Vitamin B6: (Pyridoxine) Abnormal touch sensations, mania, convulsions; abnormal EEG recordings Rare problems
Vitamin B9: Folic Acid Peripheral nerve problems, memory disorder, convulsions. Involved with neural tube defects: spina bifida, anencephaly None known
Vitamin B12: Cobalamin Mainly causes blood disorders. Neurological signs include memory problems, pain, abnormal touch sensations and movement problems including weakness. can occur. Degeneration of white matter in the cerebral hemispheres, optic nerves, spinal cord. None known.
Vitamin C
(Ascorbic Acid) Scurvy = joint pain, open sores, weight loss Digestive problems
Vitamin D: (Calciferol) Help body bring in calcium, so low Vitamin D may lead to low calcium levels. This may cause seizures. Rickets = malformation of bones, sweating, restlessness ; Excessive calcification of bones and soft tissues; toxic in large amounts
Vitamin E: (Tocopherol) Affects peripheral nerves and the nerve supply to muscle. Walking and balance problems, eye movement problems.; Few effects known
Copper Wilson's disease – genetic disorder that causes a build up of copper and results in mental and movement problems.
Iron: Anemia = reduction in the amount of oxygen in the blood. Oxygen is necessary for the conversion of glucose into energy.
Magnesium: Muscle spasms, anxiety, headache, insomnia, cramps ; Respiratory problems
Manganese: Sleep problems, cramps
Selenium: Cardiac problems ; CNS damage (Oysters, liver, lobster)
Zinc: Taste and smell loss, hallucinations, depression. Zinc deficiency during pregnancy can cause brain defects. Muscle pain, headache, flu-like symptoms
Lead: Intracranial hypertension, headache, fatigue, memory and concentration problems; paralysis; gout; Lead is neurotoxic and can also damage the kidneys.
Cadmium: Neurotoxic; possible learning problems.
Biotin: Movement problems, visual problems, may be involved in Sudden Infant Death Syndrome

How can ones diet affect the nervous system?

How do I work on brain plasticity? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Sleep, strong immune system (balanced microbiome in the gut with good bacteria and microbes) and learning new movements help in brain plasticity (neuroplasticity).

How do I work on brain plasticity?

Eric Kandel:  Short-term memory had been linked to functional changes in existing synapses, while long-term memory was associated with a change in the number of synaptic connections. Researchers at…

Source: Sleep and Alzheimer

Neurology: Does drinking beer really help with creative problem solving? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Chemical analysis of the bones of ancient Sudanese Nubians who lived nearly 2000 years ago shows they were ingesting the antibiotic tetracycline on a regular basis, likely from a special brew of beer. A balance of microbial gut flora, bugs in the intestines, affects the health of the immune system and the brain.
Once the brain can detox from a balance of good bacteria/ microbiomes (healthy gut flora) from beer/fermented drinks (beer in moderation with less alcohol), sleep, healthy diet (whole foods, pickled veggies, acidophilus), and healthy lifestyle, it can do its work (cognitive, judgment , problem solving,etc).

Neurology: Does drinking beer really help with creative problem solving?

Is it a coincidence that cognition and medications for psychosis target dopamine receptors? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Dopamine and Serotonin influence mood (psychosis) and learning (cognitive function).
1. The relationship between clinically effective antipsychotic drug dosage and binding affinity to cloned dopamine (DA) and serotonin receptor subtypes was analyzed in an effort to elucidate the contribution of individual receptor subtypes to medication response. Clinically effective dose and binding affinity to D2 DA receptor were modestly correlated for typical antipsychotic medications (r=0.54, p=0.046).
http://www.nature.com/npp/journal/v32/n8/full/1301305a.html
2. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s. Most of the drugs in the second generation, known as atypical antipsychotics, have been developed more recently, although the first atypical anti-psychotic, clozapine, was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's dopamine pathways.
http://www.thefullwiki.org/Antipsychotic_drugs
3. Dopamine (DA) acts as a key neurotransmitter in the brain. Numerous studies have shown its regulatory role for motor and limbic functions. However, in the early stages of Parkinson's disease (PD), alterations of executive functions also suggest a role for DA in regulating cognitive functions. Some other diseases, which can also involve DA dysfunction, such as schizophrenia or attention deficit hyperactivity disorder (ADHD) in children, as shown from the ameliorative action of dopaminergic antagonists and agonists, respectively, also show alteration of cognitive functions. Experimental studies showed that selective lesions of the dopaminergic neurons in rats or primates can actually provide cognitive deficits, especially when the mesocorticolimbic component of the dopaminergic systems is altered. Data from the experiments also showed significant alteration in attentional processes, thus raising the question of direct involvement of DA in regulating attention. Since the dopaminergic influence is mainly exerted over the frontal lobe and basal ganglia, it has been suggested that cognitive deficits express alteration in these subcortical brain structures closely linked to cortical areas, more than simple deficit in dopaminergic transmission.
A deficiency of mesolimbic dopamine (DA) is a leading candidate for the etiology of certain symptoms of depression (e.g., anhedonia and loss of motivation).
http://www.biopsychiatry.com/dopaminecog.htm

Is it a coincidence that cognition and medications for psychosis target dopamine receptors?