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Brief Interactions Spur Lasting Waves of Gene Activity in the Brain

Brief Interactions Spur Lasting Waves of Gene Activity in the Brain

Summary: Researchers report they are able to see alterations in gene expression up to two hours after a stickleback fish interacts with an intruder. They speculate the changes in gene expression and chromatin modification could help set up the brain to respond to future threats. The study appears in PLOS Genetics.

Source: University of Illinois.

A five-minute encounter with an outsider spurs a cascade of changes in gene activity in the brain that can last for hours, researchers report in a study of stickleback fish.

The research, described in the journal PLOS Genetics, is one of three recent studies – the others conducted in honey bees and mice – to see waves of changes in gene expression in the brain 30 minutes to two hours after contact with an intruder.

“We are discovering that social interactions are extremely potent; they provoke big changes in gene expression in the brain,” said University of Illinois animal biology professor Alison Bell, who studies behavior in three-spined stickleback fish. “These very subtle social interactions are getting under the skin and becoming embedded in the brain. Studies like ours are beginning to show how that actually works.”

The observed changes included modifications to chromatin accessibility – a selective unpacking of the DNA that allows some genes, but not others, to be transcribed and translated into proteins.

“We used to think that DNA was so tightly packaged that it took a long time for that packaging to become unwrapped,” Bell said. “But our study shows that the unpackaging can happen fast – within minutes to hours – and we show that something really subtle, like a social interaction, can provoke dramatic changes in chromatin accessibility.”

Bell and her colleagues tracked changes in gene expression 30, 60 and 120 minutes after an encounter. They focused on two parts of the brain – the telencephalon, which is important to learning and memory; and the diencephalon, which integrates social information and hormonal influences.

“We compared experimental fish – those that had the encounter – with control fish, who remained alone in their tanks,” she said.

Hundreds of genes were expressed differently in the experimental and control fish. They also varied in the expression of numerous transcription factors, which regulate the activity of other genes.

Graduate Student Syed Abbas Bukhari, who is first author on the paper, led an analysis of the functions of groups of genes whose expression patterns paralleled one another at 30, 60 and 120 minutes.

“This revealed that the genes that change in tandem over time have similar functions,” Bell said. Such functional groups include genes that contribute to immunity, hormone activity, metabolism or homeostasis.

In the experimental fish, hormone gene expression was highest at 30 minutes, metabolism genes peaked at 60 minutes and genes linked to immune function and homeostasis were upregulated the most two hours after the encounter.

“We’re seeing changes in gene expression even two hours after the fish interacts with an intruder. Clearly, those changes are not about the animal’s initial behavior,” Bell said. “We haven’t studied learning and memory, but we think that these chromatin modifications and changes in gene expression are all about setting up their brains to respond to threats in the future.”

Previous studies suggest that the fish are learning the limits of their territory, Bell said. “Their territory basically ends where they successfully chased away an intruder,” she said.

“Our findings made me feel very humble; I really did not appreciate how much is going on in these guys’ brains,” Bell said. “If you watch sticklebacks in natural populations, they’re constantly fighting with their neighbors. Our study just looked at what happened after a five-minute interaction, once. They’re doing this all day long, over and over again.”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source: Diana Yates – University of Illinois
Image Source: NeuroscienceNews.com image is credited to Julie McMahon.
Original Research: Full open access research for “Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks” by Syed Abbas Bukhari, Michael C. Saul, Christopher H. Seward, Huimin Zhang, Miles Bensky, Noelle James, Sihai Dave Zhao, Sriram Chandrasekaran, Lisa Stubbs, and Alison M. Bell in PLOS Genetics. Published online July 13 2017 doi:10.1371/journal.pgen.1006840

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
University of Illinois “Brief Interactions Spur Lasting Waves of Gene Activity in the Brain.” NeuroscienceNews. NeuroscienceNews, 17 July 2017.
<http://neurosciencenews.com/gene-activity-interactions-7104/&gt;.

Abstract

Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks

Animals exhibit dramatic immediate behavioral plasticity in response to social interactions, and brief social interactions can shape the future social landscape. However, the molecular mechanisms contributing to behavioral plasticity are unclear. Here, we show that the genome dynamically responds to social interactions with multiple waves of transcription associated with distinct molecular functions in the brain of male threespined sticklebacks, a species famous for its behavioral repertoire and evolution. Some biological functions (e.g., hormone activity) peaked soon after a brief territorial challenge and then declined, while others (e.g., immune response) peaked hours afterwards. We identify transcription factors that are predicted to coordinate waves of transcription associated with different components of behavioral plasticity. Next, using H3K27Ac as a marker of chromatin accessibility, we show that a brief territorial intrusion was sufficient to cause rapid and dramatic changes in the epigenome. Finally, we integrate the time course brain gene expression data with a transcriptional regulatory network, and link gene expression to changes in chromatin accessibility. This study reveals rapid and dramatic epigenomic plasticity in response to a brief, highly consequential social interaction.

“Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks” by Syed Abbas Bukhari, Michael C. Saul, Christopher H. Seward, Huimin Zhang, Miles Bensky, Noelle James, Sihai Dave Zhao, Sriram Chandrasekaran, Lisa Stubbs, and Alison M. Bell in PLOS Genetics. Published online July 13 2017 doi:10.1371/journal.pgen.1006840

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Three “private American citizens” who are suing Donald Trump’s presidential campaign and his political adviser Roger Stone for data breach

The three “private American citizens” who are suing Donald Trump’s presidential campaign and his political adviser Roger Stone for conspiring with agents of Russia and WikiLeaks over the disclosure of their private information resulting from the breach of Democratic Party computers could symbolically win their case even if they ultimately lose the lawsuit.

See Also: Moving from Vulnerability Management to Effective Vulnerability Response

If a federal district judge determines the case could proceed to the discovery phase, that could require the defendants to be deposed and hand over documents, potentially revealing previously unknown facts about the hack of Democratic National Committee computers by the Russians in the run up to the 2016 U.S. presidential election. “Emails, texts and other communications from the Trump campaign would be fair game for discovery,” privacy and cybersecurity lawyer Christopher Pierson, who is not involved in the case, tells me.

“Ultimately, these particular plaintiffs may or may not care whether they get a check in the end. They care about finding out what happened.” 

The plaintiffs could declare a moral victory even if they don’t eventually prevail. “Ultimately, these particular plaintiffs may or may not care whether they get a check in the end,” says cybersecurity lawyer and author Mark Rasch. “They care about finding out what happened, publicizing it. That’s not uncommon, particularly in a highly charged political environment.”

The plaintiffs include two Democratic Party donors – Roy Cockrum, a former Episcopal monk, and Eric Schoenberg, a businessman who served in the Foreign Service during the Reagan administration – as well as Scott Comer, a mid-level staffer at the DNC. Representing the plaintiffs is Project Democracy, a watchdog group founded by former Obama administration lawyers.

The lawsuit, filed July 12 in the U.S. District Court for the District of Columbia, contends the plaintiffs’ private information – Social Security numbers, medical information and details of their private lives – was published as a calculated political strategy in which the Trump administration and Stone played a central role.

The lawsuit comes as the Justice Department special counsel, former FBI Director Robert Mueller, investigates the Russians for interfering in the 2016 presidential election and whether the Trump campaign was involved. Rasch says if Mueller feels the plaintiffs’ lawsuit would interfere with his probe, he could ask the court to stay the discovery. But he says that usually only occurs when the government is a party to the legal action, which is not the case with this lawsuit. “Private litigants have a right to litigate private matters on their own,” Rasch says.

Looming Deadline

The plaintiffs acted as a one-year statute of limitation deadline for filing privacy invasion lawsuits loomed. WikiLeaks first published stolen DNC emails last July 22.

“These plaintiffs are using the law and the American civil justice system the way it was intended: to vindicate important rights and values, such as the right to privacy and the right to participate in the political process; and to deter others who might consider colluding with a foreign government for political gain,” Project Democracy Executive Director Ian Bassin, a former associate counsel in the Obama White House, says in a statement. “Each of these victims expressed a sense of duty at various times to seek justice, even after a tumultuous year resulting from their private information being published for the world to see, and even knowing that stepping forward could bring new attacks.”

A spokesman for President Trump’s outside legal team did not respond to a request for comment, according to The New York Times. But Stone – who has said he had communications with WikiLeaks founder Julian Assange and a “completely innocuous” Twitter exchange with the DNC hacker known as Guccifer 2.0 – issued a statement, published by the online news outlet LawNewz.com, characterizing the lawsuit as baseless and completely without merit. “Essentially someone has pasted together a series of questionable media claims for which there is no evidence whatsoever,” he said.

Building a Circumstantial Case

Indeed, in making a circumstantial case of conspiracy against the defendants, the suit lists details about the Russian hacking and interference in the election that can be found in news reports, congressional testimony and government documents. One example: the email string released this past week by the president’s son, Donald Trump Jr., of the meeting he, senior presidential adviser Jared Kushner and then-Trump campaign chairman Paul Manafort held with Russian lawyer Natalia Veselnitskaya on June 9, 2016, with the purported intent of receiving political dirt on Democratic Party presidential nominee Hillary Clinton.

To be successful, the plaintiffs will have to prove they were harmed by the leaks and that the Trump campaign and/or Stone were responsible. The lawsuit furnishes a lengthy list of harms it contends befell the defendants, including the outing of one of the defendants to his grandparents who did not know he was gay and emotional distress he experienced by harassing phone calls he received. Often, to succeed in such a lawsuit, the plaintiffs must show financial harm caused by defendants’ actions.

To prove a conspiracy, the plaintiffs needn’t show [that] the defendants colluded with WikiLeaks. What they must prove is that the Trump campaign and Stone plotted with the Russians who were behind the hack and that the Russians colluded with WikiLeaks to publish the stolen emails and documents. “The biggest challenge here will be proving the defendants a part of this conspiracy through a proximate cause analysis,” Pierson says. Proximate cause is an event sufficiently related to a legally recognizable injury to be held as the cause of that injury. “Was it foreseeable that the alleged actions of trying to get Russian operatives to hack and leak sensitive information to WikiLeaks .. would cause the harm that is alleged?” he asks.

Russia, WikiLeaks Not Among Defendants

The lawsuit neither names Russia nor WikiLeaks as defendants, which could suggest a political motive for the legal action. “If the suit were intended as a real effort to mitigate a harm, it would name all of the people who caused the harm,” says Paul Rosenzweig, a cybersecurity lawyer and consultant who teaches a course in cybersecurity law and policy at George Washington University. “Perhaps not Russia, which is likely immune, but certainly WikiLeaks.”

But the process of the lawsuit – seeking the truth about who should be held liable for the DNC hack and the leaking of personal information – could be as important as the final verdict. As Rasch warns: “A lawyer with subpoena power is a dangerous thing.”

Condoms don’t work, smoking doesn’t kill, GOP is saving Medicaid—the world class lies of Mike Pence

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18.6 miles for justice – we couldn’t have done it without you!

Photo by David MoriyaPhoto by David Moriya

18.6 miles for justice – we couldn’t have done it without you!

Over the weekend, Women’s March and partners marched from the NRA headquarters in Virginia to the U.S. Department of Justice in Washington, D.C. to call for civil rights charges in the tragic and senseless killing of Philando Castile, and to proudly and bravely strive for the respect of the civil and human rights of all people. Over 350 people marched the 18.6 miles through scorching heat and torrential rains, and 1,500 more joined the rallies at the beginning and end of the route. Solidarity actions were planned in dozens of locations across the nation, because we know that no one is safe until everyone is safe.

While the mobilization is over, you can still join in the growing momentum to our call for justice. Click below to send a letter to the DOJ asking for civil rights charges to be filed, as well as a letter to your member of Congress asking them to co-sponsor an important bill to end the use of racial profiling as a police tactic.

TAKE ACTION NOW

This weekend could not have been such an incredible success without you. However you participated, Women’s March has deep respect and gratitude:

Thank you for marching. The people who marched 18.6 miles endured the height of summer heat and torrential rain, in addition to blisters, broken toes, and physical discomfort. Your efforts made an immediate difference — each mile you walked inspired someone to plan a new solidarity action somewhere in the nation. Thank you to those who planned or attended one of the over 2 dozen solidarity actions! Together we stood on the right side of history.

Thank you for volunteering. It is no exaggeration to say we could not have done it without you. From handing out cold water to stocking the rest stops with snacks, keeping marchers safe and assisting those who had trouble in the heat, your labor of love made the #NRA2DOJ march the success that it was!

Thank you for donating. Thanks to your generosity and support, we met our fundraising goal to provide marchers with water, snacks, sunscreen, security and all the logistics necessary to make a safe and effective mobilization. We couldn’t have done it without you!

Thank you for showing your support on social media. Your support kept the marchers going! We read your #NRA2DOJ tweets and posts aloud throughout the 18.6 miles. And by sharing the mobilization and your reactions to it, you helped inspire dozens more solidarity actions across the country. Because of you, the message spread: No one is safe until everyone is safe. If you missed us Saturday at the DOJ, you can watch the #NRA2DOJ vigil here, and check out the great news coverage we got as well!

CNN: Women’s March organizers return to DC streets for anti-NRA march
Essence: 18 Miles: Women’s March Draws Hundreds to Protest NRA
Washington Post: At end of NRA protest march, a bit of common ground

Above all, thank you for continuing to resist!
In community,
Women’s March

Photo by David MoriyaPhoto by David Moriya

Photo by David MoriyaPhoto by David Moriya

Photo by David MoriyaPhoto by David Moriya

Photo by David MoriyaPhoto by David Moriya

Photo by David MoriyaPhoto by David Moriya

Photo by David MoriyaPhoto by David Moriya

Photo by David MoriyaPhoto by David Moriya

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Photo by David MoriyaPhoto by David Moriya

Photo by Kyle O'LearyPhoto by Kyle O’Leary

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Trump meeting may have been ‘the green light Russia was looking for’