The Toxin, Heavy Metal, and Thyroid Connection
The Toxin, Heavy Metal, and Thyroid Connection
Dr Amy Myers
This is the third article in a multi-part series on the thyroid. Follow along as we explore how the thyroid works and how you can use The Myers Way® Four Pillars of Healthto prevent, control, or reverse thyroid disease.
Toxins can wreak havoc on your body in many ways, increasing inflammation in your body, disrupting your hormones, putting you at risk for an autoimmune disease, and even causing cancer. As I discuss in my book, we are exposed to hundreds, if not thousands, of toxic chemicals on a daily basis that can accumulate in our bodies and significantly impact our health. In this article I’ll take a look at the three toxins that pose the greatest risk to your thyroid, and how you can minimize your exposure and clear them from your body.
3 Toxins that Threaten Your Thyroid
Mercury
As I’ve covered previously on my blog, mercury can be found everywhere from cosmetics, to fish, to pesticides, to vaccines, to your dental fillings. What’s more, coal-burning plants emit over 70,000 pounds of mercury in the into the air each year, where it settles into our water, meaning even if you’re taking precautions to avoid it, you’re still being exposed. I’m sure you’re well aware that mercury is a toxic chemical that is not healthy for your body, but did you know that it is particularly dangerous for the thyroid? In Part I of this series we explained that your thyroid needs iodine to produce its hormones (we will talk more about iodine later in the series). In fact, your thyroid is exceptionally good at absorbing any available iodine in your body. Unfortunately for your thyroid, mercury and iodine are chemically very similar to each other, so your thyroid is quick to absorb and store mercury too.
This creates a two-fold problem for your thyroid. First, if your thyroid is storing mercury in place of iodine, it won’t have enough iodine to produce adequate levels of T4 and T3 hormones, which can cause you to develop hypothyroidism. Second, it puts you at risk of developing an autoimmune disease. No one knows exactly how heavy metals like mercury lead to autoimmune disease, but research has shown a demonstrated link between the two, including a 2011 study that found that women with high mercury exposure were more than twice as likely to have thyroid antibodies.
One proposed reason for why this happens is that mercury damages the cells of your thyroid gland (as well as other cells in your body) so much that your immune system can no longer recognize these thyroid cells as “self” cells. Another prevailing theory is that your immune system goes on high alert to get rid of the mercury, and this chronic state of inflammation stresses your immune system so much that it starts attacking your whole thyroid.
Perchlorate
Perchlorate is a chemical used primarily to create rocket fuel, but is also used extensively to produce fireworks, and sometimes fertilizers. Due to runoff, it is commonly found in the water supply, as well as produce irrigated with perchlorate-contaminated water. Like mercury, perchlorate is chemically similar to iodine and is quickly absorbed by the thyroid, preventing it from absorbing enough iodine. Perchlorate competitively blocks iodine absorption so well that it was actually used as a treatment for Graves’ disease (to slow patients’ overproduction of thyroid hormones) in the 50’s and 60’s, but was abandoned after it was found to cause death by aplastic anemia, a condition where your bone marrow stops producing enough red blood cells.
A 2006 study by the Centers for Disease Control found that even very low levels of perchlorate exposure caused decreased thyroid function in women. The study also stated that “A combination of human activity and natural sources has led to the widespread presence of perchlorate in the environment,” yet it wasn’t until five years later, in 2011, that the Environmental Protection Agency determined that it met the criteria as a contaminant to be regulated. They still have yet to issue any actual regulations for public water systems.
Nitrates
Nitrates are a group of nitrogen and oxygen-containing chemicals that are used in fertilizer and foods. Some foods like spinach and celery naturally contain nitrate, but other foods, primarily processed or cured meats like hot dogs and bacon, have nitrates added to them as preservatives. Just like mercury and perchlorate, nitrates are similar enough to iodine to competitively block its absorption, which reduces thyroid function, but they have also been linked to increased rates of thyroid cancer.
A 2010 study examined women’s nitrate intake via their water supply and diet to determine if increased nitrate exposure coincided with thyroid problems. In the quartile of women whose nitrate-water contamination was highest (although still only 1/5 of the EPA’s maximum allowed level) thyroid cancer was 2.18 times more likely than the women in the bottom quartile. When it came to dietary nitrate, women in the top quartile were 2.9 times more likely to have thyroid cancer and 24% more likely to have hypothyroidism than women in the bottom quartile.
How To Avoid Exposure and Reduce Your Toxic Burden
I take a two-fold approach to reducing your toxic burden. Part one is reducing your future exposure to toxins and part two is clearing your body of the toxins that have accumulated in your system over the course of your lifetime. I outline my approach to in this blog post, in a podcast episode, and you can read about it fully in my book, The Autoimmune Solution. Here we will cover those strategies specifically for the three toxins that most threaten your thyroid.
Clean Your Air
Mercury can be found in the air near coal burning plants, so to avoid breathing in mercury and increasing your risk for thyroid disease, I recommend using a HEPA filter in your home and office. The Sierra Club created an interactive map that allows you to see if there are any coal-burning power plants in your area.
Clean Your Water
Thanks to pollution and runoff, mercury, perchlorate, and nitrates can all be found in the water supply, and the EPA’s regulated levels for each are either unreasonably high or, in the case of perchlorate, nonexistent. To protect your water I recommend installing water filters on all of your taps and showerheads. Remember, chemicals can be absorbed through the skin too!
Buy Clean Food
Eating organic, grass-fed, pasture-raised food will significantly reduce your risk of exposure to toxic chemicals. Unfortunately, you can never 100% eliminate your risk of mercury and perchlorate contamination because even certified organic farming practices don’t account for public water sources being contaminated through runoff. But, if you use all of these strategies in conjunction, then the trace amounts that might get passed on through your organic food is not likely to have a large effect on you.
To further reduce your risk of mercury exposure, it is best to avoid eating fish that are particularly high in mercury, such as tuna, and instead stick with fish with lower levels of mercury, such as salmon. To reduce your nitrate exposure, purchases nitrate-free cured and processed meat products, or avoid them altogether.
Buy Clean Body Products
Like I always say, you aren’t just what you eat, you’re also what you apply to your skin! Some foreign-produced skin lightening cosmetics, including products that claim to lighten age spots and freckles, were found to have dangerous levels of mercury by the Food and Drug Administration. Although American-made products have more stringent regulations, they can still be full of harmful chemicals, many of which mimic hormones in your body and disrupt the endocrine system. The Environmental Working Group put together a helpful Dirty Dozen list of chemicals that impact the endocrine system, as well as Skin Deep®, a tool that ranks the risk level of cosmetic products and each of their component ingredients.
Know Your SNP Status
SNPs, pronounced “snips” and short for single-nucleotide polymorphisms, are genetic mutations that can affect all sorts of processes in your body. Three of these mutations in particular, two in the MTHFR gene and one in the GSTM1 gene, reduce your ability to detox heavy metals like mercury, so you need to take extra care to avoid exposure and use supplements to support your body’s detoxification process. You can test for these mutations through a regular lab or a 23andMe at-home test kit.
Examine Your Mouth
Most dentists use amalgam fillings, which contain mercury and emit mercury vapor that can leach into your bloodstream. If you have amalgam fillings I recommend seeing a biological dentist to discuss the impact it might be having on your health and your options for having them replaced.
Support Your Detox Pathways
To reduce your existing toxic burden it is important to support your liver, where most of your body’s detoxification takes place. Eating a diet rich in nutrients will support your liver, as well as eating actual animal liver. For a delicious way to incorporate animal liver into your diet, check out this week’s featured recipe: Organic Beef Liver with Bacon and Rosemary. You can also use supplements for additional detox support, such as glutathione (your body’s natural detoxifier), or a methylation support supplement to aid in heavy metal detoxification if you have an MTHFR mutation.
Visit this site for quality supplementation, AGELOC product families at:
http://www.clubalthea.pxproducts.com
To reset your gene expressions to a younger you…
Hospital-employed physicians drain Medicare
Hospital-employed physicians drain Medicare
Healthcare costs for four common procedures are rising as hospitals and health systems employ more physicians, according to a new study.
A 49% increase in hospital-employed physicians between 2012 and 2015 led to a $3.1 billion increase in Medicare costs related to four specific procedures in cardiology, orthopedics and gastroenterology, according to analysis from consulting firm Avalere Health.
Medicare paid $2.7 billion more for diagnostic cardiac catheterizations, echocardiograms, arthrocentesis and colonoscopies delivered in hospital outpatient settings than it would for treatment in independent facilities, while beneficiaries footed a $411 million higher bill.
Hospital-employed physicians performed more services in costlier hospital outpatient settings, resulting in up to 27% higher costs for Medicare and 21% for patients. For some of the procedures studied, employed physicians were seven times more likely to provide more services in a hospital outpatient setting than an independent physician’s office, which contradicts healthcare’s developing value-added mantra.
The employment trend seems to have shifted care to higher-cost locations, which is concerning, said Robert Seligson, president of the Physicians Advocacy Institute, which published the study last week. But the potential impact on quality still needs to be explored, he said.
“Hospital consolidation pushes healthcare costs upward,” Seligson said. “The impact of hospitals owning outpatient practices places a greater financial burden on Medicare beneficiaries and on taxpayers.”
More physicians are joining larger organizations, in many cases major health systems, to take some of the uncertainty out of their business. Rising compliance costs related to satisfying new payment models, growing administrative burdens for managing data and documentation, and Medicare and Medicaid’s lower reimbursement levels, are unsettling independent physicians and putting their practices in jeopardy.
As employees of larger organizations, they may benefit from higher reimbursement for services performed in the system, a streamlined administrative process, an integrated model that can better tackle population health, and from potentially qualifying for the 340B program that requires pharmaceutical companies to discount drugs for providers who treat a large share of uninsured and indigent patients.
In turn, health systems have the potential to secure more referrals and spread costs over a wider patient base.
“When hospitals grow their physician network, with a subsidy of $150,000 to $200,000 per physician, they have to cover those costs by driving ancillary services and (getting more people) in hospital beds,” said Dr. Jeffrey LeBenger, CEO of Summit Health Management, an integrated, physician-led independent physician group that includes some 800 doctors. One of the main drivers of physician acquisitions is to increase referral networks, he said.
While research suggests prices will likely rise with the rapid increase of hospital-employed doctors and that referral patterns will lean toward the system that employs them, it’s been inconclusive on the impact to quality. The jury is still out on whether vertically integrated providers will yield greater efficiency, said Matthew Katz, CEO of the Connecticut State Medical Society, who is also a board member of the Physicians Advocacy Institute.
“There is a disconnect in the payment model that is presently employed. The cost of care is based on the payment model and is not driven by value or quality,” Katz said, adding that the payment models should adapt.
Between 2012 and 2015, the number of physicians employed by hospitals grew by 46,000 (49%) while the number of physician practices employed by hospitals increased by 31,000 practices, an 86% increase.
These additional costs may not be sustainable, said Joel French, CEO of SCI Solutions, which offers web-based access management products that connect patients, referring physicians and hospitals. Even though the doctors are employed, health systems run into problems with physicians’ referral patterns and can experience out-of-network leakage of 30% to 40%, he said.
“In the world’s most complicated regulatory environment, why do we believe hospital operators can somehow be confident in managing physicians? The record shows they aren’t,” French said.
Some payers have been pushing back on hospitals and systems that have profited off reimbursement rules that allow them to charge higher fees for services delivered in hospital off-campus facilities than their independent ambulatory counterparts. Anthem, for instance, will no longer pay for elective MRIs or CT scans for its fully insured members that are delivered at hospitals in nine states.
While CMS lowered these “facility fees,” there’s still an incentive for hospitals to employ more physicians, coupled with the greater leverage hospitals would have with private payers in negotiating payment rates, healthcare policy experts said.
“We do document price increases after a hospital acquires physicians and part of that are the facility fee payments,” said David Dranove, professor and co-director of health enterprise management at Northwestern University’s Kellogg School of Management.
In one instance, a colonoscopy would cost Medicare 164% more ($1,090 versus $413) if provided in a hospital outpatient setting than in an independent physician’s office, the Avalere study found.
Researchers studied Medicare payments and beneficiary responsibility using a model that assumed the same patients would receive the same procedures but in a different care setting.
While the reimbursement rules are actively changing and the march of rising healthcare costs has slowed, more physician practice consolidation is likely, experts said.
“Continued consolidation in the hospital market will absolutely increase healthcare costs in the short run,” LeBenger said.
Paternal exposure to environmental chemical stress affects male offspring’s hepatic mitochondria
Aluminum , vaccines, Alzheimer’s and detox ways
Toxic metals and BPA in babies and copper as culprit in Alzheimer’s brain
Aluminum , vaccines, Alzheimer’s and detox ways
See a doctor , chiropractor, acupuncturists, herbalist, health coach and other CAM health care pros to detox your body from metal toxins. Over time, the accumulation of aluminum in soda and vaccines can be toxic to our brain causing Alzheimer and Parkinson’s diseases.
Today we know these claims to be true, especially when acidic foods, such as tomatoes and okra, are cooked in aluminum cookware. Use of steel utensils onaluminum cookware can cause additional toxicity by scraping aluminum into food. Beer and soft drink cans are made exclusively from aluminum.
Modern cans are generally produced through a mechanical cold forming process that starts with punching a flat blank from very stiff cold-rolled sheet. This sheet is typically alloy 3104-H19 or 3004-H19, which is aluminium with about 1% manganese and 1% magnesium to give it strength and formability.
Today we know these claims to be true, especially when acidic foods, such as tomatoes and okra, are cooked in aluminum cookware. Use of steel utensils on aluminum cookware can cause additionaltoxicity by scraping aluminum into food. Beer and soft drink cans are made exclusively from aluminum.
Aluminium content of soft drinks from aluminium cans. – NCBI
The aluminium (Al) content of soft drinks from Al cans has been measured during … should not be a cause for concern in regard to Al toxicity for the human body.
News headlines: Beer and coke cans are killers – Help Free The Earth
Those aluminum coke and pepsi and beer cans leech aluminum into your drinks. … It’s dangerous andtoxic to the body…so why aren’t the regulators warning us …
Are Diet Coke Aluminum Cans Safe? | LIVESTRONG.COM
People around the world have consumed countless beverages from the convenient aluminum can, but from time to time, concerns are raised about the safety of.
Are Aluminum Cans Bad For You? – Here Is Your Answer.
Sep 19, 2016 – One concern with aluminum cans is that they might leach aluminum into their contents. Too much aluminum can cause aluminum toxicity, which …
Can Aluminum Poisoning be a Reality?
The pop manufacturers have the cans coated to prevent the leeching of aluminum into the cans, but …Pop is not the only source of potential aluminum toxicity.
Is the Can Worse Than the Soda? Study Finds Correlation Between …
Sep 18, 2012 – BPA, a chemical used in aluminum soda cans and other food packaging, was found to be associated with childhood obesity in a new study.
Why drinking from a can may be dangerous – USA Today
Dec 14, 2014 – Cans and plastic bottles are lined with a controversial chemical called BPA. … AP SODATAX FIGHT A USA CA. In this June 30, 2014 photo …
The Real Facts About Alzheimers and Aluminum – from EHSO
Question: I have heard that aluminum may be involved in the development of … Aluminum beveragecans are usually coated with a polymer to minimize such …
[PDF]Hazards of Aluminum Packaging – DigitalCommons@CalPoly
Aluminum cans such as soda cans, can be found in almost …. Besides Alzheimer’s, toxic levels ofaluminum has also been associated with Parkinson’s disease …
Aluminum Toxicity: 4 Ways to Detox Your Brain & Body
Aluminum toxicity is linked to Alzheimer’s and other serious diseases including cancer. Here are four steps you can take to protect your health.
4 Ways to Detoxify Aluminum From Your Life – Global Healing Center
Aug 28, 2014 – Ways To Detoxify Aluminum From Your Life. Purchase Whole Foods. Aluminum cans and processed food packaging — yes, even the paper looking stuff — usually contains aluminum. ChooseAluminum-Free Deodorant. The most common exposure point for most people is deodorant. Avoid Antacids. Detoxify Your Body.
Your Brain May Be Full of Toxic Aluminum. Here are 3 Ways to Detox It …
Aluminum is in many things we use every day. It’s in our antiperspirant, beauty products, the air we breathe, and even our food. (source) Aluminum is considered …
10 Ways to Detox from Vaccines – The Drs. Wolfson
Feb 21, 2017 – If I say aluminum causes dementia, it stands to reason that getting that … Before we get to 10 Ways to Detox Vaccines, let’s start with rule #1: …
How to detox aluminum and why it’s necessary – NaturalNews.com
Jan 10, 2012 – How to detox aluminum and why it’s necessary. … sure people is sick is Big Pharma’s wayof making sure the money flows their direction.
How to Detox Aluminum From the Body | Healthfully
Squeezing half of a fresh lemon in a cup of warm water twice a day is one of the best ways to help your body detoxify from metals such as aluminum. The citric …
Heavy Metal Toxicity and Detoxification Protocol – Eidon Ionic Minerals
Heavy metal detoxification can be quite difficult to accomplish. … Heavy metals such as mercury, lead, cadmium, and aluminum, are in our food, water, … They were right about that in an abstract way because the mercury that is affecting your …
4 Detox Foods for Liver Health and to Prevent Aluminum Toxicity :The …
Using aluminum foil is an inexpensive and convenient way to warm up your food. However, as many of us know by now, wrapping your food in aluminum will …
How to Do an Aluminum Detox – YouTube
Herbalix Detox Cleansing Deodorant™. … im so interested int he 30 ways thealuminium has effected us …
Heavy Metal Detox – DrAxe.com
Try this Heavy Metal Detox for healing. … considered “heavy metals” such as lead, mercury, aluminumand arsenic can cause acute or chronic toxicity. … Chelation therapy is the most effective way to reduce serious heavy metal exposure.
Vaccine Ingredients – Aluminum | Children’s Hospital of Philadelphia
Sep 27, 2016 – Aluminum is used in vaccines as an adjuvant. Aluminum adjuvants are used invaccines such as hepatitis A, hepatitis B, …
[PDF]Aluminum in Vaccines – Children’s Hospital of Philadelphia
of aluminum. Almost all of that accumulated aluminum comes from food. Q A Aluminum in Vaccines: What you should know. VACCINE EDUCATION CENTER.
Adjuvants | Vaccine Safety | CDC
Sep 12, 2016 – Aluminum gels or aluminum salts are vaccine ingredients that have been used invaccines since the 1930s. Small amounts of aluminum are …
The Case Against Aluminum in Vaccines – Dr Mercola articles
Mar 31, 2015 – According to some experts, including Dr. Humphries, aluminum in vaccines may pose very significant health risks.
Aluminum | Immunize for Good
You may have heard fellow parents warn about aluminum in childhood vaccines. Dr. Sears’s book TheVaccine Book has exacerbated this fear by creating an …
Study Reports Aluminum in Vaccines Poses Extremely Low Risk … – FDA
Feb 6, 2015 – The risk to infants posed by the total aluminum exposure received from the entire recommended series of childhood vaccines over the first year …
Aluminum in Vaccines: History and Toxicity – Health Freedom Idaho
Jun 23, 2017 – Aluminum in Vaccines: History and Toxicity. Here is the Toxicological Profile on Aluminum, prepared by the Agency for Toxic Substances and …
Aluminum vaccine adjuvants: are they safe? – NCBI
There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe …
Dangers of Aluminum in Vaccines vaccinepapers.org
Jan 23, 2017 – The aluminum in vaccines is dangerous. It causes brain damage. And its nanoparticulate form makes it especially harmful.
Dr Sears
The document also states on page 2, “Aluminum content in parenteral drug products could … Other injectible products aren’t required to limit aluminum, but they are … were fed a standard intravenous feeding solution that contained aluminum with …. I think vaccine manufacturers may have started wondering the same thing, …
Study Reports Aluminum in Vaccines Poses Extremely Low Risk … – FDA
Feb 6, 2015 – Aluminum is incorporated into some vaccines as an adjuvant. … products (includingvaccines) limit the amount of aluminum in the … Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, MD
[PDF]Toxicological Profile for Aluminum – Agency for Toxic Substances and …
This public health statement tells you about aluminum and the effects of exposure to it. …. Vaccinesmay contain small amounts of aluminum compounds, no …. way to limit exposure to aluminum from these sources. … Food and Drug Administration (FDA) are some federal agencies that develop regulations for toxic.
[PDF]Aluminum in Vaccines – Children’s Hospital of Philadelphia
that aluminum in vaccines might be harmful to babies. However, healthy … The Center does not receive support from pharmaceutical companies. VACCINE …
Aluminum Toxicity and Aluminum in Vaccines – Dr Thomas’s Blog
Sep 24, 2014 – In response to a document Q&A, “Aluminum in Vaccines: What you should … “The center does not receive support from pharmaceutical companies”? … injected as part of a vaccine, would only be safe by these standards if the …
20 VACCINE FACTS you need to know to make an informed decision …
Vaccine manufacturers have NO liability (National Childhood Vaccine Injury Act of … double blind goldstandard of clinical testing as other pharmaceutical drugs because … Vaccines contain neurotoxins (aluminum and mercury) far exceeding “safe … The statutory time limit for filing a claim is only 2 years after death and 3 …
[PDF]Aluminum in Childhood Vaccines Is Unsafe – Journal of the American …
… period—a 25% increase. Source: The vaccine manufacturers‘ product inserts and the CDC’s ….. School of Medicine, “Aluminum and mercury are often simultaneously …. decision to set limits onaluminum content in parenteral drug products and … for healthy people, so safety (and efficacy)standards must be impeccable.
Toxic myths about vaccines – Science-Based Medicine
Feb 18, 2008 – People don’t realize that there is aluminum, ether, antifreeze, still ….. by big drug companies that has seemed to have a default deny/lie first approach. …. with fever impacting seizurethreshold for sure for the first few years.
From Birth Until Sunset: Poisoned to Death: – Google Books Result
The other drug problem that keeps popping up is vaccination and the dangers that these drugs pose on our children. … One of the lies given to people by the pharmaceutical companies is, “If you had …vaccinations has 48 times the limit the FDA has set as safe limits for mercury. … with 50 percent mercury and aluminum.
The Vaccine Book: Making the Right Decision for Your Child
… the vaccines out, limit vaccine chemical overload (most notably aluminum), and … in determiningvaccine schedules is the particular pharmaceutical company …
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130/80 new guideline for blood pressure – causes of high BP
130/80 new guideline for blood pressure – causes of high BP
The latest medical evidence has proven that people with blood pressure in the 130-139 range carry a doubled risk of heart attack, stroke, heart failure and kidney failure, compared to those with lower blood pressure, said Dr. Joaquin Cigarroa, a member of the clinical guidelines task force.
There are many causes of a high BP such as trans fat, lack of sleep, carbon monoxide poisoning, metal toxicity, mold toxicity, medications and drugs, genetics, foods and other unknowns. When a person is dying, the BP is the lowest.
Trans fat foods
No more trans fats to raise blood pressure! The decision by the FDA to ban trans fats that raise blood pressure and increase risk for heart attack and stroke, is a great victory for heart health.
Sleep and blood pressure
Over time, a lack of sleep could hurt your body’s ability to regulate stress hormones, leading to high blood pressure. Sleeping seven to eight hours a night may play a role in the treatment and prevention of high blood pressure.
Carbon monoxide poisoning
Carbon monoxide poisoning often causes a victim’s blood pressure to rise.
Mold Toxicity
A conglomeration of dysfunction can set the stage for mold toxicity such as migraine headaches, elevated blood pressure and chronic recurrent infections.
Metal toxicity
Selenium antagonizes mercury toxicity. … Mercury, cadmium, and other heavymetals inactivate COMT, which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect will increase blood pressure and may be a clinical clue to heavy metal toxicity.
Medications and drugs
Certain pain and anti-inflammatory medications can cause you to retain water, creating kidney problems and increasing your blood pressure. Examples include: Indomethacin (Indocin, others) Nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen sodium (Aleve, Anaprox) and ibuprofen (Advil, Motrin IB, others)
What herbs can you add in a salmon curry to protect from inflammation
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Ischemic stroke and carbon monoxide poisoning greatest among 20-34 years
Ischemic stroke and carbon monoxide poisoning greatest among 20-34 years
Association between ischemic stroke and carbon monoxide poisoning: A population-based retrospective cohort analysis.
Abstract
BACKGROUND:
The long-term consequence of cardiovascular health has not been evaluated for patients with carbon monoxide (CO) poisoning. This study evaluated the risk of ischemic stroke using population-based data.
METHODS:
We identified 8705 inpatients with CO intoxication diagnosed from 2000 to 2011 from the Taiwan National Health Insurance Research Database. The control cohort consisted of 34,820 persons randomly identified from patients without exposure frequency matched by age, sex, and the year of hospitalization. Incidence and hazard ratio (HR) of ischemic stroke were evaluated by sociodemographic factors and comorbidities by the end of 2011.
RESULTS:
The incidence of ischemic stroke revealed a significant increase in the Carbon monoxide-poisoning cohort over the follow-up period (p<0.001). The overall incidence of ischemic stroke was near 2.5-fold greater in the Carbon monoxide-poisoned cohort than in controls (5.49 versus 2.02 per 1000 person-years), with an adjusted HR of 2.60 (95% confidence interval (CI)=2.15-3.15). The adjusted HR for those without comorbidities was slightly higher (2.76, 95% CI=2.13-3.58). The age-specific CO-poisoning to non-CO-poisoning relative risk was greatest in the youngest group (20-34 years) (adjusted HR=6.45; 95% CI=3.30-12.6).
CONCLUSION:
CO poisoning is associated with a long-term risk of increased incident ischemic stroke. Further study on the mechanism of ischemic stroke for CO poisoning affects is needed.
Copyright © 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Carbon monoxide poisoning; Cohort analysis; Stroke
Comment in
- Carbon monoxide poisoning and risk for ischemic stroke. [Eur J Intern Med. 2016]
- PMID:
- 26703428
- DOI:
- 10.1016/j.ejim.2015.11.025









