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Connie Dello Buono

Connie Dello Buono ; motherhealth@gmail.com

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Allergies – part 1

Skin rashes is a sign of allergy. Aloe vera and calendula are healing to the skin. Up your Vit C, A and E intake to nourish your skin. Avoid allergens if possible. Allergies tell us that the body’s immune system is in attack mode. Sometimes our meds are invading our body and rashes show up telling us that our body is not in agreement with the drugs. Connie of http://www.clubalthea.com

CALENDULA, a first rate skin healer …..

During the first year of baby’s life, I massage their bodies with calendula oil before each bath. Calendula is promoting cell growth. Connie of http://www.clubalthea.com and apricot oil especially (my 78 yr old mom used it for warts and ear ache)
I use argan oil for my hair and coconut for almost any health issues.

Connie Dello Buono ; motherhealth@gmail.com

Call for part time or full time business or job 408-854-1883 in financial planning, college planning, retirement planning and helping others with their idle money to work for them at 13%, tax free, safe and secured with free health benefits

Home made health cures from the pros

1. When diarrhea strikes his family, Gannady Raskin, MD, ND, dean of the School of Naturopathic Medicine at Bastyr University, cures it with herbal concoctions. “Tea made from pomegranate skin will help an upset stomach,” he says. Set aside the leftovers of your next purchase; you can store dried skin for up to 6 months. Then steep a tablespoon’s worth in a cup of boiling water for 3 to 4 minutes. Oak bark (available at health food stores) works, too: Boil for 3 minutes, let sit for half an hour, and then strain. Both recipes are rich in tannins, which help the body produce mucus to line the stomach and lessen irritation. Drink 2 tablespoons, 4 to 6 times a day.

2. If you suspect food poisoning, couple black tea with a few pieces of burned toast, says Georgianna Donadio, PhD, director of the National Institute of Whole Health, a holistic certification program for medical professionals. “The tannic acid in tea and charcoal in the toast will neutralize the toxins and help you get much better very quickly.” Burned rice on the pan, made into a warm drink works too.
3. In the early stages of cold or flu, try this recipe from Brian Berman, MD, director of the Center for Integrative Medicine at the University of Maryland School of Medicine: Place a whole unpeeled grapefruit, sectioned into four pieces, in a pot and cover with water; heat to just under a boil. Stir and add a tablespoon of honey, and drink the whole mixture like tea. “The simmering releases immune boosters from the grapefruit into the water–vitamin C and flavonoids hidden between the rind and the fruit,” he says. “The concoction packs more punch than store-bought grapefruit juice, plus the warmth eases a sore throat.” To beef up your body’s healing response, he swears by liquid olive leaf extract, available at health food stores. Studies suggest that its antiviral qualities can help treat cold and flu bugs. “You end up getting rid of mucus sooner, and it helps your immune system fight back as well,” Dr. Berman says. Vit C and zinc losenges work too.

4. Itchy scalp, sunburn or any skin disorder in mouth or any body part, use aloe vera.

5. Congestion and bronchitis call for an oldie but a goodie, says Woodson Merrell, MD, an assistant clinical professor of medicine at Columbia University College of Physicians and Surgeons: medicated vapor rub. Applied to the chest, it helps stuffed-up sufferers breathe easier, but Dr. Merrell prefers a cleaner approach: Boil a pot of water, let it cool for about 1 minute, and then mix in a teaspoon of vapor rub. Lean over it with your head about a foot from the steam. Use a towel over your head to make a tent, and inhale for 5 minutes. Yes for massage with vapor rub not only on chest and back but also on feet.

6. You can soothe a toothache with cloves; the old-fashioned remedy really works, says Jack Dillenberg, DDS, dean of the Arizona School of Dentistry & Oral Health. But today, not everyone has the spice handy, so he recommends eugenol–clove extract–available at your pharmacy. Soak a cotton ball and place it directly on the tooth for several minutes, and the pain should subside until you can get to a dentist. Tea tree mouth wash works too.

7. Recurring fever blisters (you might know them as cold sores) can’t be completely cured–but they can be treated, and outbreaks prevented, with the amino acid L-lysine, found in ointments or tablets in health food stores, says Paul Horowitz, MD, medical director of the Legacy Pediatric Clinics at Emanuel Children’s Hospital in Portland, OR. If you’re among the 60 to 90% of Americans who carry the herpesvirus that causes blisters, start taking 1,000 mg three times a day with meals as soon as you feel an outbreak coming on. (The supplement may not be safe for those with high cholesterol, heart disease, or high triglycerides.)

8. After a hard workout, Declan Connolly, PhD, a professor of exercise science at the University of Vermont, drinks a bottle of tart cherry juice; he studied its antioxidant and anti-inflammatory abilities and concluded that it helps sore muscles recover. “Though you may feel fine initially after a workout, your tissues suffer tiny tears and swelling,” he says. “Tart cherries contain higher amounts of anthocyanins–antioxidants that help repair damage–than sweet cherries and most other fruits or vegetables.” Dr. Connolly tested the brand CherryPharm, available to consumers and athletes at CherryPharm.com. You can also find other brands of 100% tart cherry juice or juice concentrate in natural food supermarkets or health food stores.

9. Write your home made recipes here…..

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Collected by
Connie Dello Buono

Connie Dello Buono ; motherhealth@gmail.com

Call for part time or full time business or job 408-854-1883 in financial planning, college planning, retirement planning and helping others with their idle money to work for them at 13%, tax free, safe and secured with free health benefits

 

Bacterial signal can flip the macrophage ‘engine’ from oxidative phosphorylation to glycolysis; a New Inflammatory “Danger” Signal for chronic inflammation

microphage1
When you drive a car, sometimes it’s fine to just chug along. But if there’s a threat you might suddenly have to take action to get out of trouble. Could it be similar for front-line immune cells called macrophages when an infection tries to take hold?
A new study suggests that unthreatened macrophages tick over on one form of core metabolism, oxidative phosphorylation. But throw a bacterial threat into the mix and that metabolism switches over to a form called aerobic glycolysis, and you see an inflammatory response.

Prof Luke O’Neill from Trinity College Dublin likens the switch to what happens in a hybrid car when it changes from using electricity as a source of energy to burning petrol instead. And he and colleagues have just mapped out how a bacterial signal can flip the macrophage ‘engine’ from oxidative phosphorylation to glycolysis.

Co-author Prof Cormac Taylor, from University College Dublin, agrees that the study highlights the links between biochemical pathways that we typically associate with metabolism, immunity and disease. “What has become really important recently is the recognition of the key role of cross-talk between the pathways regulating metabolism, inflammation and tumor development,” he says. “And this is one of the clearest examples where there is a direct interface between inflammation and the type of metabolism we see in cancer.”

You could extend that hybrid-car analogy even further. Macrophages in the blood have the job of ‘sensing’ potential threats such as bacteria and then engulfing them. So perhaps they are like hybrid police cars, keeping watch and responding when there’s a threat.
The study found that if you expose macrophages to lipopolysaccharide – a signal of bacterial threat – the LPS binds to a toll-like receptor on the surface of the macrophage. This is an early signal of trouble, much like the message coming in over the police radio.

Then the core metabolism in the macrophage changes from oxidative phosphorylation to glycolysis, the equivalent of putting the boot down and switching the energy source in the hybrid engine.

“If there’s a bacterial invader threatening an infection, then you want the macrophages to become active, this is a good thing,” says O’Neill, who is Director of the Trinity Biomedical Sciences Institute.
As well as the switch to glycolysis, you also see an inflammatory response, and O’Neill believes they have found an important cog in the mechanism: succinate.

“When macrophages make that switch there is also a rise in the metabolite succinate, and this acts as a danger signal that turns on the pro-inflammatory cytokine interleukin-1ss,” he explains.
Succinate also appears to alter the shapes of several proteins in the macrophages, though it’s not known exactly what effect this has – there is plenty yet to discover. “I would anticipate that these proteins are activated through this succinylation process, but that is something we are going to look at now,” says O’Neill.

In other words, succinate seems to act as the police car’s siren, spreading the news that a response is needed and triggering it in the form of inflammation.

Of course this activation and inflammation can be helpful when there’s a threat to fight off. But too much of an inflammatory response is not such good news: if it runs on for too long you can get chronic inflammation, or if the response is overzealous, it can result in potentially life-threatening sepsis.

So the researchers also looked at ways to reduce the inflammation, and found that they were able to inhibit interleukin-1ss expression in the model by interfering with the switch to glycolysis.
They were also able to tone down the inflammatory response with an anti-epilepsy medication called vigabatrin. “We tried that because the drug interferes with a pathway by which the macrophages are making succinate,” explains O’Neill. “And we saw that the drug protected mice from a serious immune reaction called sepsis.”

Dampening down the macrophage’s ability to respond might not be such a great idea for people in good health, but being able to cut the inflammatory ramp-up could point to new treatments for acute and chronic inflammatory conditions, according to O’Neill. “It’s very exciting because we now have a new way to interfere with the production of interleukin-1, which is implicated in several conditions, including diabetes,” he says.

The findings could also offer insight on the relationship between inflammation and cancer, he adds, because glycolytic metabolism is also seen in tumor cells – the Warburg effect – and cancer and inflammation go hand in glove. “There is a parallel here, the same peculiar metabolism is kicking off in tumors as we see in macrophages,” says O’Neill.

Reference: Tannahill et al., Succinate is an inflammatory signal that induces IL-1? through HIF-1?. Nature. 2013 Mar 24. doi: 10.1038/nature11986
Image: Denis Klein
Follow Scientific American on Twitter @SciAm and @SciamBlogs.
Visit ScientificAmerican.com for the latest in science, health and technology news.
© 2013 ScientificAmerican.com. All rights reserved.

About
Sepsis: blood poisoning
Glycolysis is the process in which one glucose molecule is broken down to form two molecules of pyruvic acid. The glycolysis process is a multistep metabolic pathway that occurs in the cytoplasm of animal cells, plant cells, and the cells of microorganisms. At least six enzymes operate in the metabolic pathway.
oxidative phosphorylation the formation of high-energy phosphate bonds by phosphorylation of ADP to ATP coupled to the transfer of electrons from reduced coenzymes to molecular oxygen via the electron transport chain; it occurs in the mitochondria.

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Aside from feeding your brain, use your memory.
Use your brain or lose it. Learn new skills. If today’s jobs are either in computers or medical, learn new skills.

Connie Dello Buono

Prevent vascular disease, manage inflammation, get GYV health caps to boost ATP cells performance and speedy repair of your body, email connie to get the caps and join in spreading the benefits with extra income for you at motherhealth@gmail.com and text 408-854-1883

I love you mom

Mother you have embraced me from the moment I was born.
Ensuring that I don’t get hungry, cold or unattended, you are always at my side.
As if your world stopped, you gave all your attention to me.
Giving me breastmilk, massage when I’m sick and taking care of my daily needs.
Now that I’m a teen, you are kind of overdoing it by calling my cell all the time, it seems.
But, I must admit I missed your voice.
For you are always there for me.
I love you mom.

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by
Connie Dello Buono

Connie Dello Buono ; motherhealth@gmail.com

Call for part time or full time business or job 408-854-1883 in financial planning, college planning, retirement planning and helping others with their idle money to work for them at 13%, tax free, safe and secured with free health benefits

Stem cell transplant for nerve cells, memory and learning brain cells; GABA and cholinergic neurons

For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.
A study at UW-Madison is the first to show that human stem cells can successfully implant themselves in the brain and then heal neurological deficits, says senior author Su-Chun Zhang, a professor of neuroscience and neurology.

Brain repair through cell replacement is a Holy Grail of stem cell transplant, and the two cell types are both critical to brain function, Zhang says. “Cholinergic neurons are involved in Alzheimer’s and Down syndrome, but GABA neurons are involved in many additional disorders, including schizophrenia, epilepsy, depression and addiction.”Once inside the mouse brain, the implanted stem cells formed two common, vital types of neurons, which communicate with the chemicals GABA or acetylcholine. “These two neuron types are involved in many kinds of human behavior, emotions, learning, memory, addiction and many other psychiatric issues,” says Zhang.

The human embryonic stem cells were cultured in the lab, using chemicals that are known to promote development into nerve cells — a field that Zhang has helped pioneer for 15 years. The mice were a special strain that do not reject transplants from other species.
After the transplant, the mice scored significantly better on common tests of learning and memory in mice. For example, they were more adept in the water maze test, which challenged them to remember the location of a hidden platform in a pool.

The study began with deliberate damage to a part of the brain that is involved in learning and memory.
Three measures were critical to success, says Zhang: location, timing and purity. “Developing brain cells get their signals from the tissue that they reside in, and the location in the brain we chose directed these cells to form both GABA and cholinergic neurons.”
The initial destruction was in an area called the medial septum, which connects to the hippocampus by GABA and cholinergic neurons. “This circuitry is fundamental to our ability to learn and remember,” says Zhang.

The transplanted cells, however, were placed in the hippocampus — a vital memory center — at the other end of those memory circuits. After the transferred cells were implanted, in response to chemical directions from the brain, they started to specialize and connect to the appropriate cells in the hippocampus.
The study is the first to show that human stem cells can successfully implant themselves in the brain and then heal neurological deficits
The process is akin to removing a section of telephone cable, Zhang says. If you can find the correct route, you could wire the replacement from either end.
For the study, published in the current issue of Nature Biotechnology, Zhang and first author Yan Liu, a postdoctoral associate at the Waisman Center on campus, chemically directed the human embryonic stem cells to begin differentiation into neural cells, and then injected those intermediate cells. Ushering the cells through partial specialization prevented the formation of unwanted cell types in the mice.

Ensuring that nearly all of the transplanted cells became neural cells was critical, Zhang says. “That means you are able to predict what the progeny will be, and for any future use in therapy, you reduce the chance of injecting stem cells that could form tumors. In many other transplant experiments, injecting early progenitor cells resulted in masses of cells — tumors. This didn’t happen in our case because the transplanted cells are pure and committed to a particular fate so that they do not generate anything else. We need to be sure we do not inject the seeds of cancer.”
Though tantalizing, stem-cell therapy is unlikely to be the immediate benefit, Zhang notes that “for many psychiatric disorders, you don’t know which part of the brain has gone wrong.” The new study, he says, is more likely to see immediate application in creating models for drug screening and discovery.

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Use your brain or lose it. Learn new skills. If today’s jobs are either in computers or medical, learn new skills.
For example at this beta site, new skills in online ad and traffic generation can be learned:

http://addwallet.net/?id=clubalthea

Long-term stress higher among elderly men than in women as shown in hair samples from Dutch study

The Dutch study concluded that elevated long-term cortisol levels are associated with a history of cardiovascular disease. The increased cardiovascular risk we found is equivalent to the effect of traditional cardiovascular risk factors, suggesting that long-term elevated cortisol may be an important cardiovascular risk factor.

Stress is associated with an increased incidence of cardiovascular disease. The impact of chronic stress on cardiovascular risk has been studied by measuring cortisol in serum and saliva, which are measurements of only 1 time point. These studies yielded inconclusive results. The measurement of cortisol in scalp hair is a novel method that provides the opportunity to measure long-term cortisol exposure. Our aim was to study whether long-term cortisol levels, measured in scalp hair, are associated with cardiovascular diseases.

A group of 283 community-dwelling elderly participants were randomly selected from a large population-based cohort study (median age, 75 y; range, 65–85 y). Cortisol was measured in 3-cm hair segments, corresponding roughly with a period of 3 months. Self-reported data concerning coronary heart disease, stroke, peripheral arterial disease, diabetes mellitus, and other chronic non-cardiovascular diseases were collected.

Results: Hair cortisol levels were significantly lower in women than in men (21.0 vs 26.3 pg/mg hair). High hair cortisol levels were associated with an increased cardiovascular risk (odds ratio, 2.7) and an increased risk of type 2 diabetes mellitus (odds ratio, 3.2). There were no associations between hair cortisol levels and non-cardiovascular diseases.

Copyright © 2013 by The Endocrine Society
Laura Manenschijn, Erasmus MC, Department of Internal Medicine, Room Ee-542, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. E-mail: l.manenschijn@erasmusmc.nl.

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Acute myocardial infarction; imbalance during ischemia-reperfusion ; mitochondrial energy adaption in cancer, obesity and metabolic disorders

Acute myocardial infarction is characterized by changes in biochemical properties during ischemia and reperfusion. The heart can survive a short period of ischemia by reducing myocardial contractility, increasing glucose uptake, and switching metabolism to glycolysis.
However, considering that the heart is one of the most energy-demanding tissues in the body, sustained oxygen and nutrient deprivation results in irreversible damage. Thus, reperfusion of the ischemic heart is a prerequisite for survival.

Paradoxically, reperfusion can further increase the myocardial damage that occurs during ischemia. The severity of reperfusion injury depends on the duration of the preceding ischemia and the effectiveness of blood flow during reperfusion. Several lines of evidence demonstrate that reperfusion injury is directly associated with cardiac mitochondrial dysfunction and increased ROS and RNS generation.

An imbalance of oxidants and antioxidants resulting in increased levels of ROS, RNS, or both can result in damage to lipids, proteins, carbohydrates, and DNA.
ROS are oxygen radicals generated in the body due to exposure from polluted air

Hearse et al. noted that reperfusion of isolated hearts after ischemia resulted in abrupt cardiomyocyte death. Following this paper, several studies showed that ischemia reperfusion is associated with a burst of H2O2, O2•;−, NO•, and ONOO−, but the exact mechanism of their generation is debated.
Although some ROS may be generated by NADPH oxidase and xanthine oxidase, it is likely that complexes I and III of the mitochondrial respiratory chain are the main sources of ROS during myocardial ischemia reperfusion.

In fact, studies using mitochondrial respiratory inhibitors show that the electron leak along the oxidative phosphorylation most likely occurs at the Fe-S centers of complex I and at some components of complex III.
During the early stages of reperfusion, ROS generation levels increase drastically. Interestingly, low amounts of ROS generated by mitochondria during brief and intermittent episodes of ischemia, termed ischemic preconditioning, significantly protect the heart against prolonged ischemia.

About
Dietary antioxidants are substances that have been shown to decrease the effects of ROS and RNS in humans.
Redox (reduction-oxidation) reactions include all chemical reactions in which atoms have their oxidation state changed. This can be either a simple redox process, such as the oxidation of carbon to yield carbon dioxide (CO2) or the reduction of carbon by hydrogen to yield methane (CH4), or a complex process such as the oxidation of glucose (C6H12O6) in the human body through a series of complex electron transfer processes.

Redox reactions are concerned with the transfer of electrons between species. The term comes from the two concepts of reduction and oxidation. It can be explained in simple terms:
• Oxidation is the loss of electrons or an increase in oxidation state by a molecule, atom, or ion.
• Reduction is the gain of electrons or a decrease in oxidation state by a molecule, atom, or ion.

Although oxidation reactions are commonly associated with the formation of oxides from oxygen molecules, these are only specific examples of a more general concept of reactions involving electron transfer.

Redox reactions, or oxidation-reduction reactions, have a number of similarities to acid–base reactions. Like acid–base reactions, redox reactions are a matched set, that is, there cannot be an oxidation reaction without a reduction reaction happening simultaneously. The oxidation alone and the reduction alone are each called a half-reaction, because two half-reactions always occur together to form a whole reaction. When writing half-reactions, the gained or lost electrons are typically included explicitly in order that the half-reaction be balanced with respect to electric charge.

TABLE 1 Examples of Reactive Oxygen and Nitrogen Species
Name Formula Comments
Superoxide O2- An oxygen-centered radical. Has limited reactivity.
Hydroxyl OH• A highly reactive oxygen-centered radical. Very reactive indeed: Attacks all molecules in the human body.
Peroxyl, alkoxyl RO2•, RO• Oxygen-centered radicals formed (among other routes) during the breakdown of organic peroxides.
Oxides of nitrogen NO•, NO2• Nitric oxide (NO•) is formed in vivo from the amino acid L-arginine. Nitrogen dioxide (NO2•) is made when NO reacts with O2 and is found in polluted air and smoke from burning organic materials (e.g., cigarette smoke).

SOURCE: Adapted from Halliwell, 1996, with permission; © International Life Sciences Institute, Washington, D.C.

About
Mitochondrial function is fundamental to metabolic homeostasis. In addition to converting the nutrient flux into the energy molecule ATP, the mitochondria generate intermediates for biosynthesis and reactive oxygen species (ROS) that serve as a secondary messenger to mediate signal transduction and metabolism.
Alterations of mitochondrial function, dynamics, and biogenesis have been observed in various metabolic disorders, including aging, cancer, diabetes, and obesity. However, the mechanisms responsible for mitochondrial changes and the pathways leading to metabolic disorders remain to be defined.
In the last few years, tremendous efforts have been devoted to addressing these complex questions and led to a significant progress. In a timely manner, the Forum on Mitochondria and Metabolic Homeostasis intends to document the latest findings in both the original research article and review articles, with the focus on addressing three major complex issues:
(1) mitochondria and mitochondrial oxidants in aging—the oxidant theory (including mitochondrial ROS) being revisited by a hyperfunction hypothesis and a novel role of SMRT in mitochondrion-mediated aging process being discussed;
(2) impaired mitochondrial capacity (e.g., fatty acid oxidation and oxidative phosphorylation [OXPHOS] for ATP synthesis) and plasticity (e.g., the response to endocrine and metabolic challenges, and to calorie restriction) in diabetes and obesity;
(3) mitochondrial energy adaption in cancer progression—a new view being provided for H+-ATP synthase in regulating cell cycle and proliferation by mediating mitochondrial OXPHOS, oxidant production, and cell death signaling.
It is anticipated that this timely Forum will advance our understanding of mitochondrial dysfunction in metabolic disorders.
Antioxidants. Redox Signal. 00, 000–000.

Measurement of Quantities in Foods
In order to meet the definition of a dietary antioxidant proposed here, the dietary intakes of the nutrient or food component must be able to be calculated from available national databases. These databases include the U.S. Department of Agriculture’s National Nutrient Databank, the Canadian Nutrient File, and other databases that contain a nationally representative sample of foods commonly eaten in the United States or Canada and that report concentrations for the antioxidant of interest and others. It is recognized that limitations exist in the use of food composition databases to accurately estimate intakes.
Decreased Adverse Effects of Some ROS and RNS
In order to meet the definition of a dietary antioxidant proposed here, the nutrient or food component must decrease the adverse effects of some ROS and RNS (see Table 1 for examples of ROS and RNS). An explanation of the biochemical and physiological mechanisms of these adverse effects follows.
Role of ROS and RNS in Health and Disease
ROS and RNS are produced metabolically by the body. It has been estimated that about 1 to 3 percent of the oxygen we utilize goes to make ROS. In addition, exposure to UV radiation or to air pollutants such as cigarette smoke (which contains oxidants) or ozone can cause the body to increase the levels of reactive radical species.

ROS is a collective term that includes several oxygen radicals—superoxide (O2•-) and its protonated form, hydroperoxyl (HO2•), hydroxyl (OH•), peroxyl (RO2•), alkoxyl (RO•)—and nonradicals—hydrogen peroxide (H2O2), hypochlorous acid (HOCl), ozone (O3), and singlet oxygen (O2)—that are oxidizing agents or are easily converted into radicals. RNS includes nitric oxide (NO•), peroxynitrite (ONOO-), and peroxynitrous acid (ONOOH).
Various compounds in the human body generate free radicals in their metabolism. Examples are catecholamines and compounds found in the mitochondrial electron-transport chain.
In addition, activated phagocytes produce ROS as one of the defense mechanisms they use to kill microbes. Thus, in this situation, ROS are used by the body as a defense mechanism against infection.
An imbalance of oxidants and antioxidants resulting in increased levels of ROS, RNS, or both can result in damage to lipids, proteins, carbohydrates, and DNA.
A considerable body of biological evidence shows that ROS and RNS can damage cells and other body components and could in theory contribute to dysfunction and disease states.
It has been postulated that oxidative damage caused by increased levels of production of ROS or RNS may contribute to the development of many chronic diseases, including age-related eye disease, atherosclerosis, cancer, coronary heart disease, diabetes, inflammatory bowel disease, neurodegenerative diseases, respiratory disease, and rheumatoid arthritis.

Antioxidant Mechanisms
The mechanisms of antioxidant action for decreasing the adverse effects of ROS or RNS are varied. They include (1) decreasing ROS or RNS formation; (2) binding metal ions needed for catalysis of ROS generation; (3) scavenging ROS, RNS, or their precursors; (4) up-regulating endogenous antioxidant enzyme defenses; (5) repairing oxidative damage to biomolecules, such as glutathione peroxidases or specific DNA glycosylases; and (6) influencing and up-regulating repair enzymes.
Some antioxidants remove free radicals by reacting directly with them in a noncatalytic manner before the radicals react with other cell components. For example, vitamin E inhibits lipid peroxidation by scavenging radical intermediates in the radical chain reaction with polyunsaturated fatty acids.
The effectiveness of each dietary antioxidant depends on which ROS or RNS is being scavenged, how and where they are generated, the accessibility of the antioxidants to this site, and what target of damage, or oxidizable substrate, is involved.
Antioxidant defense mechanisms include not only low-molecular-weight compounds, but also some antioxidant defense systems in the human body that are enzymatic, such as: (1) superoxide dismutase enzymes, which remove superoxide (O2•-) by accelerating its conversion to H2O2 and O2; (2) glutathione peroxidases, which convert H2O2 to water and O2 and which convert various hydroperoxides to harmless compounds; and (3) catalase, which converts H2O2 to water and O2 but only functions at relatively high concentrations of the ROS.

Connie Dello Buono ; motherhealth@gmail.com

 

Acute ischemic stroke, symptoms and scoring using TCM

TCM Syndrome and Scoring of Risks for Stroke

Select the above link.

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Effect of egg white fermentation with lactobacilli on IgE binding ability of egg white proteins; reducing egg allergy by fermentation

The study demonstrated the potential of reducing egg allergy by fermentation of egg white with L. delbrueckii subsp. delbrueckii.
Egg allergy, afflicting around 1.6% to 3.2% of the total children population, is the second most common food allergy among infants and young children. The objective of the study was to determine if lactobacilli fermentation could reduce the IgE binding ability of egg white.

Acidification of egg white to pH6.0 and supplementation of tryptone are necessary to grow lactobacilli in egg white. Cell counts of Lactobacillus sanfranciscensis and Lactobacillus sakei were not affected up to 96h of incubation, while that of Lactobacillus delbrueckii subsp. delbrueckii decreased rapidly at the first 24h of incubation, increased to its inoculated level at 48h, and then leveled off afterwards.

The pH of fermented egg white was reduced to 5 after 48h of incubation with L. sanfranciscensis and/or L. sakei, and after 72h incubation with L. delbrueckii subsp. delbrueckii.
Among three strains studied, only L. delbrueckii subsp. delbrueckii fermented egg white showed 50% reduction in IgE binding ability. No obvious protein degradation in fermented egg white proteins was detected by SDS-PAGE.

The reduction of egg white IgE binding ability was attributed to ovomucoid, the dominant egg allergen, as shown the change of molecular weight analyzed by MALDI-TOF-MS, reduction of intensity of FITC labeled ovomucoid after fermentation, and the change of intensity of glycopeptides containing core+4HexNAc and core+3HexNAc.

Sen Li , Marina Offengenden , Messele Fentabil , Michael G. Gänzle , Jianping Wu. JOURNAL OF MIDWIFERY & WOMEN’S HEALTH, 20131526-9523. June 2013. Food Research International, Volume 52, Issue 1

High cost of cancer drugs; lung cancer story

High Cost Cancer Drugs

Cancer drugs constitute the second biggest category of drugs in the United States behind cholesterol-lowering medicines, and accounted for $17.8 billion of total prescription drug sales of $286.5 billion in 2007, according to IMS Health, a health care information company. Spending on drugs for cancer grew 14 percent last year, faster than for all but three other diseases.

I am voting for Bernie Sanders to lower the cost of drugs.

Connie’s comments: When my dad was diagnosed with lung cancer in 2002, last stage and was given 3 months to live, we opted for no chemotherapy and radiation.
In the comfort of his home, he used two oxygen tanks, caregiving from family members, juiced green papaya and other healing ways. He lived for 9 more months.
During my research when we found out about the cancer, some studies reported that Vit C and amino acid Lycine are beneficial in early stage of lung cancer.
My father worked in copper and nickel mines for about 10 yrs, car mechanic for 10 yrs and 2 yrs in asbestos work environment. He also smoked for 20 yrs, started it when he was only 20 yrs old. He had tuberculosis which was treated with drugs and cured 20 yrs before he died. Ten years before he died, he had quit smoking.
Without the CAT scan, we would never have found out about his lung cancer. He had chronic back pain and coughing for more than 15 yrs before he died of lung cancer. He wished to live long but we cannot afford the meds and was too late to discover his lung cancer.

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Collected by
Connie Dello Buono

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Call for live-in caregivers for homebound bayarea seniors at 408-854-1883

 

Autism Awareness

Autism Awareness by Dr Andrew Levison

Click the link above to view the article on Autism. Your brain has the power to heal and regenerate.

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Collected by
Connie Dello Buono
Connie Dello Buono ; motherhealth@gmail.com

Call for part time or full time business or job 408-854-1883 in financial planning, college planning, retirement planning and helping others with their idle money to work for them at 13%, tax free, safe and secured with free health benefits

Have a cell phone, computer and car: 10,000 sales, direct marketing work available (remote)

You strive constantly to serve the welfare of others, by devotion to selfless work to attain the supreme goal in life, with purpose and prosperity.  Wise work for those business owners, working in big or small cities surrounded by positive and happy people. The product and service is in the travel industry, going to be a trillion dollar industry and the company is a 7-yr old direct marketing company with $400M in gross sales last year and the 6th fastest growing direct marketing company with unique travel and vacation package service solutions.

 You as a business owner, work within your hours and has the stamina and engine to work for the first 2 weeks with your own and the effort of a team of people.  As a start up business owner, you will allocate time and money for cell phone, gas, food and miscellaneous (business cards, others estimated at $300).

 If you are 18 yrs old or older, please email your resume to conniedbuono@gmail.com with available time for 30min phone interview, followed by 1 hr of training and availability to start immediately with coaching and job shadowing for 3 months or more.  Bonus points (BMW car) for those who are people oriented and has connections in other countries such as Singapore, Europe, Latin America and other countries.  Please ask the 3 most important questions that you may have to say yes to this job.

 Have a blessed day.

 

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Know where your passion is. Whether in helping others generate more income thru ad traffic generation or computers/online skills, nutrition, travel savings or financial savings better than the bank, you choose your time wisely.

Use your brain or lose it. Learn new skills. If today’s jobs are either in computers or medical, learn new skills.
For example at this beta site, new skills in online ad and traffic generation can be learned:

http://addwallet.net/?id=clubalthea