Human Health Dangers of Bird Droppings Associated with HVAC …
Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral … – NCBI
Gut bacteria , gut flora, microbiome. Bacteria inside the small intestine, concept, representation. 3D illustration. Image Credit: Anatomy Insider / Shutterstock …
7 days ago – Altered microbiome composition in individuals with fibromyalgia. … is the first demonstration of gut microbiome alteration in non-visceral pain.
Finally, we offer a new perspective on the association of viruses with ALS, and underscore the need for multidisciplinary approaches bridging neurology and …
Researchers at Duke University were studying lung tumor samples and discovered something that didn’t quite belong. Inside the lung tumors were miniature parts of the digestive system including the stomach, duodenum and small intestine. It turns out that the lung cancer cells (and cancer cells in general) are super crafty and had turned off the expression of a gene called NKX2-1. This gene is a master switch that tells developing cells to turn into lung cells. Without this command, cells switch their identity and mature into gut tissue instead. By manipulating these master switches, cancer cells are able to develop resistance to chemotherapy and other cancer treatments.
“Cancer biologists have long suspected that cancer cells could shape shift in order to evade chemotherapy and acquire resistance, but they didn’t know the mechanisms behind such plasticity. Now that we know what we are dealing with in these tumors – we can think ahead to the possible paths these cells might take and design therapies to block them.”
For more cool photos and insights into this study, watch the Duke University video below.
Secrets to the viral-fighting ability of stem cells uncovered (Todd Dubnicoff)
I’ve been writing about stem cells for many years and thought I knew most of the basic info about these amazing cells. But up until this week, I had no idea that stem cells are known to fight off viral infections much better than other cells. It does makes sense though. Stem cells give rise to and help maintain all the organs and tissues of the body. So, it would be bad news if, let’s say, a muscle stem cell multiplied to repair damaged tissue while carrying a dangerous virus.
How exactly stem cells fend off attacking viruses is a question that has eluded researchers for decades. But this week, results published in Cell by Rockefeller University scientists may provide an answer.
The researchers found that liver cells and stem cells defend themselves against viruses differently. In the presence of a virus, liver cells and most other cells react by releasing large amounts of interferon, a protein that acts as a distress signal to other cells in the vicinity. That signal activates hundreds of genes responsible for attracting protective immune cells to the site of infection.
Stem cells, however, are always in this state of emergency. Even in the absence of interferon, the antiviral genes were activated in stem cells. And when the stem cells were genetically engineering to lack some of the antiviral genes, the cells no longer could stop viral infection.
In a press release, senior author Charles Rice explained the importance of this work:
“By understanding more about this biology in stem cells, we may learn more about antiviral mechanisms in general.”
CIRM-funded clinical trial for ALS now available next door – in Canada (Kevin McCormack)
In kindergarten we are taught that it’s good to share. So, we are delighted that a Phase 3 clinical trial for ALS – also known as Lou Gehrig’s disease – that CIRM is helping fund is now expanding its reach across the border from the U.S. into Canada.
Brainstorm Cell Therapeutics, the company behind the therapy, says it is going to open a clinical trial site in Canada because so many Canadians have asked for it.
The therapy, as we described in a recent blog post, takes mesenchymal stem cells from the patient’s own bone marrow. Those cells are then modified in the lab to be able to churn out specific proteins that can help protect the brain cells attacked by ALS. The cells are then transplanted back into the patient and the hope is they will slow down, maybe even stop the progression of the disease.
Earlier studies showed the therapy was safe and seemed to benefit some patients. Now people with ALS across our northern border will get a chance to see if it really works.
Chaim Lebovits, the president and chief executive officer of BrainStorm, said in a press release:
“Although there are thousands of patients worldwide with ALS, we initially designed the Phase 3 trial to enroll U.S.-based patients only, primarily to make it easier for patient follow-up visits at the six U.S. clinical sites. However, due to an outpouring of inquiry and support from Canadian patients wanting to enroll in the trial, we filed an amendment with the FDA [the U.S. Food and Drug Administration] to allow Canada-based ALS patients to participate.”
May 23, 2013 – Amyotrophic lateral sclerosis (ALS) is a progressive, invariably fatal … Viral infection has also long been suspected to play a role in ALS, in part because …… HIV-1 clade-C-associated “ALS”-like disorder: first report from India.
A virus infection, however one acquires it, is the final straw. No specific virus can be implicated, although the …. b) Vitamin C powder – Ascorbic acid (with a.
Monocytes, large white blood cells that turn into macrophages in tissue, help control infection by gobbling up bacteria, but have a less beneficial side. Monocytes can cause inflammation that damage tissue. In blood vessels, inflammation can damage the vessels and increase atherosclerosis, a build-up of debris inside blood vessels that can decrease blood flow to the heart. Certain foods may help keep your monocyte count within healthy limits.
Omega-3 fatty acids found in fatty fish such as salmon and mackerel and in fish oil supplements have anti-inflammatory properties that appear to protect against atherosclerosis and heart disease. Taking fish oil supplements or consuming fish high in omega-3 fatty acids daily may help decrease monocyte-activated inflammation. In a British study reported in the 2007 issue of “The Journal of Nutrition,” researchers reported that people taking fish oil supplements were less likely to have inflammatory responses in the blood vessel walls. This effect was not as pronounced in people already taking medication to treat peripheral artery disease.
Monounsaturated fats found in oils such as olive oil and foods such as seeds, nuts, vegetables, fruits and whole grains, included in the widely disseminated Mediterranean diet– may have a protective effect against inflammatory responses caused by monocytes, according to Dr. Victoria Drake of the Linus Pauling Institute. Pass on trans fats and saturated fats, often found in processed foods.
A moderate amount of alcohol daily may help reduce dangerous inflammation caused by monocytes. But in large amounts, alcohol can also stimulate inflammation. The key with alcohol consumption is to keep your intake moderate, which is one drink per day for women and no more than two drinks per day for men. Purple grape juice may have the same protective benefits as alcohol, according to the Mayo Clinic, so don’t start drinking if you don’t already consume alcohol.
Diabetes and high blood glucose levels in the blood are associated with an increase in monocyte release and inflammation, and it may make sense to cut refined sugars from your diet to decrease inflammation and the risk of heart disease. However, a study conducted by researchers from the University of California, Davis and reported in the January 2007 “American Journal of Clinical Nutrition” did not find an increase in monocyte release after meals with a high glycemic load compared to meals with a low-glycemic load in overweight women. This was contrary to expected results: that high-glycemic meals would stimulate higher release of monocytes. More research into this area is necessary, the researchers concluded, since obesity, insulin resistance and heart disease are often associated with a high-glycemic load diet, which includes refined sugars and processed foods.