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Tumor protein p53 activated by DNA damage- UV and oxidative stress

Tumor protein p53, also known as p53, cellular tumor antigen p53(UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as,Continue reading “Tumor protein p53 activated by DNA damage- UV and oxidative stress”

Pursuing longevity: Epigenetic clock and cellular senescence

Epigenetic clock analysis of cellular senescence According to a molecular biomarker of aging known as epigenetic clock,[14] the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are distinct because induction of replicative senescence (RS) and oncogene-induced senescence (OIS) were found to be accompanied by epigenetic aging of primaryContinue reading “Pursuing longevity: Epigenetic clock and cellular senescence”

Breast cancer types

There are many types of breast cancer, including noninvasive and invasive. Noninvasive Breast Cancer Types Learn about the different types of noninvasive breast cancer: Ductal carcinoma in situ (DCIS) The most common type of noninvasive breast cancer, DCIS: Begins in the lining of the milk ducts Is composed of cells that have malignant features HasContinue reading “Breast cancer types”

Molecular cancer screen at a distance

Molecular biomarkers are independent of the presence of a detectable tumor mass or even the detection of intact transformed cells. Instead, they represent detection at a distance, using molecular signals in blood or excretia to indicate the presence of a cancer or pre-invasive lesion. These molecular biomarkers fall into four groups (Table 1). Some areContinue reading “Molecular cancer screen at a distance”

7 carcinogens added to the list

Seven new substances have been added to the U.S. Department of Health and Human Services’ list of cancer-causing agents. Six of these substances are listed as “known” to cause cancer, while one is “reasonably anticipated to be a human carcinogen,” according to a statement today (Nov. 3) from the National Institutes of Health (NIH). FiveContinue reading “7 carcinogens added to the list”

WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer. Using ultrasensitive, high-speed technology, the researchers identified a suite of molecules in the feces of mice that signifies the presence of precancerous polyps. This “metabolic fingerprint” matches changes inContinue reading “WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer”

Cell type-specific properties and environment shape tissue specificity of cancer genes

One of the biggest mysteries in cancer research remains why mutations in certain genes cause cancer only at specific sites in the human body. The poor correlation between the expression level of a cancer gene and the tissues in which it causes malignant transformations raises the question of which factors determine the tissue-specific effects ofContinue reading “Cell type-specific properties and environment shape tissue specificity of cancer genes”

Prognostic biomarker is how cancer might develop for each one

Before a cancer will advance in the future, do you want to have a tests – prognostic biomarker, that will tell you how cancer will progress in the future? Would you like to know from your blood test how cancer might develop over time? All of us do not want to be in a situationContinue reading “Prognostic biomarker is how cancer might develop for each one”

Health risk factor = others + genes

Alzheimer’s disease risk factor Sex Male = 0.05 Female =0.1 Age > 55yrs=0.1 < 55yrs = 0.05 Blood sugar Normal/low =0High = 0.1 Med =0.05 Blood Pressure Normal/low=0 High = 0.1 Med =0.05 Exposure to copper,fungus,molds,toxins, smoking,alcohol,narcotics, aluminum, air pollution, medications > 5 (H,M,L)  0.2 = H,M = 0.1 Metabolic and diet: Diabetes 0.1 ExerciseContinue reading “Health risk factor = others + genes”

Thirdhand smoke consists of residual tobacco smoke pollutants that remain in the house

Thirdhand smoke consists of residual tobacco smoke pollutants that 1) remain on surfaces and in dust after tobacco has been smoked, 2) are re-emitted back into the gas phase, or 3) react with oxidants and other compounds in the environment to yield secondary … Michael Siegel of Boston University School of Public Health believes oneContinue reading “Thirdhand smoke consists of residual tobacco smoke pollutants that remain in the house”

NfKB protein as first responder to harmful toxins – infection – cancer

Nutrigenomics is the idea that studying diet-gene interactions can help identify the positive or detrimental effects of dietary compounds. For example, nutrigenomics can explain why eating rancid or oxidized omega-fats and refined sugar encourages inflammation and cancer growth. It is important to understand that a diet rich in omega-3 fats can reduce inflammation in cancer.Continue reading “NfKB protein as first responder to harmful toxins – infection – cancer”

Opioid prescription and cancer in UK

466% increase in opioid prescribing In England, the growing use of buprenorphine, oxycodone hydrochloride, and morphine sulphate increased annual costs for these three drugs by more than £10 million (US$12.98 million) between 2002 and 2013. Also, dispensing data reported by the UK National Health and Social Care Information Center show a 466% increase in opioidContinue reading “Opioid prescription and cancer in UK”

What is your molecular age? P16 protein can ID your molecular age

Aging biomarket test –  coming soon Researchers report the development of a new blood test that they say may show your “molecular age,” as opposed to your chronological age. That test measures levels of a protein called p16. A new study shows that p16 levels rise as people age, that smokers have higher levels ofContinue reading “What is your molecular age? P16 protein can ID your molecular age”