Summary: A new study reports misfolded proteins can cause circadian rhythm disruptions which contribute to cancerous tumor growth.
Source: Medical University of South Carolina.
Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina (MUSC) find. A key part of the circadian clock opposes this process, according to a paper published online Dec. 11 in Nature Cell Biology.
For tumors to grow and spread, cancer cells must make larger than normal amounts of nucleic acids and protein, so they can replicate themselves. Yet in both normal and cancer cells that increase their synthesis of protein, a small percent of those proteins do not fold properly. When that happens, the cell activates its unfolded protein response (UPR), which slows down the making of new proteins while the misfolded proteins are refolded. Eventually, the buildup of misfolded proteins becomes toxic and leads to cell death. However, cancer cells have learned to use the UPR to slow protein synthesis when needed, in order to handle the backlog of misfolded proteins. This helps them survive in conditions that would kill normal cells.
This pattern of adaptation is often seen in tumor cells, according to J. Alan Diehl, Ph.D., the SmartState Endowed Chair in Lipidomics, Pathobiology and Therapy at the MUSC Hollings Cancer Center and senior researcher on the project. “What a tumor cell is doing is taking a pathway that’s already in the cell and using it to its advantage,” said Diehl.
Yet it was not clear exactly how cancer cells were able to use UPR activity to influence circadian rhythm. Diehl’s group found that the UPR and circadian rhythm are linked together to lead the clockwork of the cell and also that cancer cells use the UPR to manipulate the circadian clock in ways that allow them to survive conditions that are toxic to normal cells.
To start, Diehl and his fellow researchers formulated a new idea based on what was known about protein synthesis in the cell. First, as they knew, the UPR is altered in tumors, and second, cells establish a circadian rhythm to regulate metabolism by producing levels of certain proteins that rise and fall in coordination with natural cycles of light and dark. Third, other scientists had observed that circadian rhythm is altered in tumor cells. Since protein production is tied to circadian rhythm, Diehl’s group asked if misfolded proteins might change circadian rhythm in cancer cells.
In their first set of experiments, Diehl’s research team used chemicals to activate the UPR in osteosarcoma cells. They found that, when activated, the UPR changes levels of an important protein called Bmal1, which is a transcription factor that rises and falls with cycles of light and dark. As it does, it regulates the expression of major circadian rhythm genes. When cells were exposed to cycles of light and dark, Bmal1 levels peaked during dark hours. But when the UPR was chemically activated, Bmal1 stayed low during both light and dark phases, which caused a phase shift in the expression of circadian genes. When one of the main parts of the UPR machinery was absent in cells, the phase shift did not happen.
Next, the group found that the UPR functions much like a “middleman” between light-dark cycles and the ability of cells to establish a circadian rhythm from those cycles. Levels of the circadian protein Bmal1 continued to decrease, as the UPR was increasingly activated. In rodents that had their light-dark cycles suddenly reversed, Bmal1 stopped rising and falling – a clear sign that their circadian rhythms were disrupted. Shifts in light exposure activated the UPR in those rodents’ cells.
But what does that mean for the development of cancer? The team found that patients with breast, gastric or lung cancers survived longer when they had higher levels of Bmal1 protein. In myc-driven cancers, the UPR was causing the loss of Bmal1 protein, which caused the tumors to grow. Myc-driven tumors lost circadian rhythm, whereas normal cells maintained it. Conversely, high levels of Bmal1 overtook the UPR, thereby allowing protein synthesis to continue, which was toxic to tumor cells. In this way, Bmal1 directly encourages protein synthesis.
This is the first study showing that human cancer suppresses circadian rhythm by controlling protein synthesis through Bmal1. Cancer cells survived longer by using the UPR to suppress Bmal1 and short-circuit their circadian rhythms. These results are important for human biology, according to Yiwen Bu, Ph.D., a postdoctoral scholar in Diehl’s laboratory and first author on the paper. “Every single normal cell in our body has circadian oscillation,” said Bu. “We showed that resetting the circadian rhythms in cancer cells slows down their proliferation.”
Still, do changes in light-dark cycles contribute to the development of cancer in humans? It is not yet clear in patients if circadian shifts contribute to changes in the UPR and if that, in turn, contributes to the development of cancer. But these results could help clinicians boost the effectiveness of current cancer treatments, Diehl said.
“Physicians are beginning to think about timing delivery of therapies in such a way that, say, if we deliver a drug at a certain time of day, we’ll get better on-target effects on the cancer and less toxicity in the normal cells,” he said.
ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE
Source: Heather Woolwine – Medical University of South Carolina Publisher: Organized by NeuroscienceNews.com. Image Source: NeuroscienceNews.com image is in the public domain. Original Research:Abstract for “A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival” by Yiwen Bu, Akihiro Yoshida, Nilesh Chitnis, Brian J. Altman, Feven Tameire, Amanda Oran, Victoria Gennaro, Kent E. Armeson, Steven B. McMahon, Gerald B. Wertheim, Chi V. Dang, Davide Ruggero, Constantinos Koumenis, Serge Y. Fuchs & J. Alan Diehl in Nature Cell Biology. Published online December 11 2017 doi:10.1038/s41556-017-0006-y
A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival
The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR signalling interfaces with the circadian clock. UPR activation induces a 10 h phase shift in circadian oscillations through induction of miR-211, a PERK-inducible microRNA that transiently suppresses both Bmal1 and Clock, core circadian regulators. Molecular investigation reveals that miR-211 directly regulates Bmal1 and Clock via distinct mechanisms. Suppression of Bmal1 and Clock has the anticipated impact on expression of select circadian genes, but we also find that repression of Bmal1 is essential for UPR-dependent inhibition of protein synthesis and cell adaptation to stresses that disrupt endoplasmic reticulum homeostasis. Our data demonstrate that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt’s lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression.
“A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival” by Yiwen Bu, Akihiro Yoshida, Nilesh Chitnis, Brian J. Altman, Feven Tameire, Amanda Oran, Victoria Gennaro, Kent E. Armeson, Steven B. McMahon, Gerald B. Wertheim, Chi V. Dang, Davide Ruggero, Constantinos Koumenis, Serge Y. Fuchs & J. Alan Diehl in Nature Cell Biology. Published online December 11 2017 doi:10.1038/s41556-017-0006-y
As main component of essential oils, terpenes can inhibit the growth of different cancer cells. Researchers from the Ruhr-University Bochum headed by Prof Dr Hanns Hatt have analysed this process in liver cancer cells in detail. They shed light upon the molecular mechanisms that resulted in cancer cells stop growing, following the application of (-)-citronellal, and they proved that the olfactory receptor OR1A2 is the crucial molecule for that purpose. In future, the olfactory receptor could serve as target for liver cancer diagnosis and therapy. The researchers report their findings in the journal Archives of Biochemistry and Biophysics.
Essential oils protect not only from bacteria, viruses and fungi
Essential oils occur in many plants, protecting them through their antibacterial, antiviral and fungicidal properties. It has been recently discovered that terpenes, the oils’ main components, can also inhibit the growth of different cancer cells, including liver cancer. Their function had not previously been fully understood.
Olfactory receptors not just in the nose
Terpenes can trigger signalling processes in cells by activating olfactory receptors. Those receptors are mainly located in the nose, but they have been proved to occur in all types of human tissue, including skin, prostate and spermatozoa. Carcinogenesis and cancer growth are likewise significantly affected by terpenes, even though it has not been understood which function exactly they fulfil.
Terpene triggers signalling pathway in the cell
In order to find this out, the researchers from Bochum utilised a cellular model of hepatocellular carcinoma, a common liver tumour. They exposed the cells to a subset of terpenes with different concentrations, and monitored their reactions. It emerged that two of the eleven terpenes tested resulted in a significant increase in calcium concentration in the cells: (-)-citronellal and citronellol. During a follow-up analysis, the researchers focused on (-)-citronellal and scanned for a receptor into which the terpene has to fit like a key into a lock. They demonstrated that the decisive olfactory receptor OR1A2 occurs in liver cells and is responsible for detection of the citrus scent and cellular reaction. If the option for producing that receptor had been removed from the cells, they did no longer react to the terpene. The researchers, moreover, succeeded in tracking the signalling pathway which the terpene uses for increasing calcium concentration inside the cells, thus reducing cell growth. “These results are yet another example for the significance of olfactory receptors outside the nose, and they give rise to hope that new drugs with no severe side effects may be developed for cancer therapy.”
ABOUT THIS CANCER AND OLFACTION RESEARCH
The hepatocellular carcinoma is the most common primary tumour of the liver. It is the third most common tumour-induced cause of death. According to current estimations, approx. 8,900 people (6,200 men, 2,700 women) contract this form of cancer in Germany every year.
Contact: Dr Hanns Hatt – Ruhr-University Bochum Source:Ruhr-University Bochum press release Image Source: The image is credited to RUB, Lehrstuhl Hatt and is adapted from the press release Original Research:Abstract for “Monoterpene (-)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor” by Désirée Maßberg, Annika Simon, Dieter Häussinger, Verena Keitel, Günter Gisselmann, Heike Conrad, and Hanns Hatt in Archives of Biochemistry and Biophysics. Published online December 13 2014 doi:10.1016/j.abb.2014.12.004
Exercise lightly before meals to stimulate appetite. Even a short walk may be invigorating.
Select enjoyable foods and foods that have a pleasant aroma.
Plan meals the day before eating them. Have someone help plan and prepare meals.
Stay well hydrated. Drink 6-12 cups of clear liquids throughout the day.
Aim for 6-8 small meals and snacks per day. Take advantage of the time of day when most hungry.
Eat meals and snacks at scheduled times, even if not hungry.
Substitute a meal with a nutritional supplement drink or a homemade smoothie made with protein powder. If you have been prescribed pancreatic enzymes, be sure to take them with these drinks.
Glucerna and/or Boost Glucose Control products may be appropriate for people with diabetes.
Benecalorie® and Beneprotein® add calories or protein when accompanying regular meals.
Place small bowls of nutritional snacks, such as nuts and fruits, in frequently-used areas of the home to encourage healthy snacking between meals.
Take anti-nausea medication at the first sign of queasiness or nausea. Delay eating favorite foods if feeling nauseous.
Arrange food attractively:
Vary the colors of foods on a plate
Use garnishes such as lemon or lime wedges
Make mealtimes pleasing:
Add color to a place setting
Watch a favorite television show or movie
Play music in the room
Use a large plate and put small portions on it. By doing this, the amount of food may appear less overwhelming.
Manage taste changes if these are contributing to decreased appetite.
Marinate red meats before cooking if they taste strong. Or, substitute red meat with fish, chicken, eggs, low-fat cheese or vegetarian alternatives.
Eat high-protein foods within an hour of taking them out of the refrigerator. High-protein foods, such as cheese, tuna, chicken, lean ham, egg salads, deviled eggs, milkshakes, eggnogs, puddings and custards, may taste better at room temperature.
Add fresh fruits to milkshakes, puddings, and custards to add flavor.
Perk up the taste and smell of food with seasonings or spices such as lemon juice, mint, basil and other herbs. Add sugar and salt to foods, if their intake is not restricted.
Music therapy uses music and sound to help express emotions and improve emotional and physical well being.
Music therapy can help you to:
express your emotions
cope with symptoms of a disease and its treatment
relax and feel comfortable
improve your emotional and physical well being
develop self confidence and self esteem
develop or rekindle a sense of creativity
You don’t need to be musically talented to get something out of music therapy. It isn’t about learning to sing, or play an instrument.
In a music therapy session, you might:
listen to music
move to music
sing
make music with simple instruments
write and discuss song lyrics
use guided imagery alongside music
Music therapists work alongside other healthcare professionals such as doctors, nurses, speech therapists, psychologists and psychiatrists.
They may work with adults and children who have:
symptoms caused by physical illness or mental illness
side effects from cancer and its treatment
a terminal illness such as cancer
There are more than 600 registered music therapists in the UK. They work in various places, including NHS hospitals, hospices and nursing homes.
Why people with cancer use music therapy
One of the main reasons people with cancer use music therapy is because it makes them feel good.
Many of us know how calming and relaxing it can be to listen to a favourite piece of music. It can help people with cancer to cope with side effects such as:
pain
anxiety
depression
sickness
Music therapy can be a safe place for people to explore fear, anxiety, anger and the range of emotional responses to living with cancer.
Some studies show that music therapy can help children with cancer to cope by encouraging them to cooperate and communicate.
What music therapy involves
You work with your music therapist to plan a programme that suits your needs. You decide together how often you should have the therapy and how long each session will be.
Music therapy sessions usually last between 30 to 60 minutes. Your therapist might encourage you to play or listen to music at home between sessions.
You might have regular therapy for weeks or months. You may want to see your therapist on your own, or take part in group music therapy sessions.
Your relationship with your music therapist is very important. If you don’t feel comfortable with anything your therapist is doing, do talk to them about it.
Research into music therapy in cancer care
Music therapy cannot cure, treat or prevent any type of disease, including cancer. But some research shows that music therapy can help people with cancer reduce their anxiety. It can also help to improve quality of life and reduce symptoms and side effects.
We don’t yet know about all the ways music can affect the body. But we do know that when music therapy is used in the right way for each person, it can help them to feel better. To learn more about its full benefits, we need larger trials across a wider range of cancers.
Music therapy is generally very safe and has no side effects. But very loud music or particular types of music might irritate some people or make them feel uncomfortable.
The music might trigger strong reactions or evoke memories which could range from pleasant to painful. A music therapist is trained to support patients during these processes.
How much it costs
Some cancer centres and hospitals in the UK offer music therapy free of charge. Ask if it’s available at the ward or centre where you have your treatment.
If it isn’t, your doctors or nurses might be able to direct you to voluntary organisations that do, or do so at a low cost.
You can arrange music therapy sessions privately through the British Association of Music Therapists. Sessions usually cost around £40 an hour. It is very important that you see a registered therapist.
Finding a music therapist
There are currently more than 600 music therapists in the UK. They are all trained musicians who have also studied music therapy at postgraduate level.
The title of music therapist is protected by UK law. In the UK, music therapists with a professional qualification must register with the Health and Care Professions Council (HCPC).
You can only call yourself a music therapist if you have registered with the HCPC and taken a course that they recognise.
Questions you might ask
How many years of training have you had?
How long have you been practising?
Have you had training for treating and supporting people with cancer?
Do you have indemnity insurance? (in case of negligence)
Useful links and organisations
There are a number of different organisations that music therapists can join.
Intermittent fasting is a style of eating with a few different variations that are all based on cycling through periods of fasting and eating normally. This kind of eating is most often used to boost weight loss, for which it has been proven effective. However, there are a number of additional health benefits from brain health to heart health, to protection against diabetes.
For patients with mesothelioma or another type of cancer, the benefits of intermittent fasting are hopeful. There is evidence from research that fasting in any form could slow tumor growth, boost the immune system, reduce treatment side effects, increase survival rates, and prevent recurrences. Research is ongoing, but for now, as long as done with medical guidance, intermittent fasting is safe and beneficial for cancer patients.
What is Intermittent Fasting?
Intermittent fasting refers to any one of a few different strategies of cycles of alternating eating and refraining from eating, or fasting. It isn’t really a diet, although some people use it to lose weight, because it does not indicate what kinds of foods you should eat. It is really more a pattern or style of eating that according to research has some real health benefits, including potentially helping cancer patients. Some of the different types of intermittent fasting include:
24-Hour Fasting. This type of fasting means not eating at all for 24 hours. So, for example someone practicing this may choose to not eat between dinner one day and dinner the next day. This is typically done once or twice a week.
The 5:2 Diet. The 5:2 strategy modifies 24-hour fasting. It involves restricting calories for two 24-hour periods per week. On those two days women eat 500 calories and men 600.
The 16/8 Fast. Most popular for people using intermittent fasting to lose weight, this strategy involves not eating for 16 hours every day. Most people do this by skipping breakfast, for example, and not eating between 8:00 at night and noon the next day.
Calorie Restriction. This type of diet isn’t exactly fasting because there are no designated periods of not eating. But it is similar because it reduces overall calories. Calorie restriction involves reducing daily calorie intake by 20 to 40 percent every day for an extended period of time. A general guideline is 1,200 calories per day for women and 1,400 for men.
Health Benefits of Intermittent Fasting
There are significant changes that occur in the body during fasting: human growth hormone levels increase, insulin levels drop, cell repair processes speed up, and there are changes to gene expression. These changes, and potentially others, are being used to explain some of the surprising health benefits that are seen with all types of intermittent fasting and calorie restriction.
The benefit that most people turn to intermittent fasting for is weight loss. It is proven to promote weight loss and especially fat loss. This is due to lowered calorie intake, but goes beyond that with hormone changes that promote fat loss. Intermittent fasting also increases metabolic rate, making the body burn more calories.
Research is proving that there are many benefits to this style of eating that go well beyond weight loss. It lowers blood sugar levels and helps to reduce resistance to insulin, both of which protect against diabetes. Fasting is also proven to improve cardiovascular health and to promote nerve cell growth in the brain, possibly protecting against degenerative brain diseases like Alzheimer’s. In laboratory animals, intermittent fasting has been shown to slow the aging process and extend life. For cancer patients, there may be even more exciting and hopeful benefits of practicing intermittent fasting.
Triggering the Immune System for Cancer Patients
One way in which a fasting diet may help cancer patients is by triggering the immune system. The immune system is designed to target and destroy pathogens in the body, like viruses. However, it seems to be less able to find, target, and kill the body’s own abnormal cells, like cancer cells. A lot of new cancer treatments are being developed to stimulate the immune system to do this, but new research is finding that a simple fasting diet could also do it.
Once recent study from the University of Southern California was conducted using lab mice and found that when the mice received chemotherapy and a fasted diet, the immune system was better able to target and kill breast cancer cells and skin cancer cells. The mice produced more immune system cells when on the fasted diet, including the B cells and T cells that actively target and kill tumor cells. Another discovery was that cells that normally protect tumors—called T regulatory cells—were kept out of the tumors. This may have helped chemotherapy drugs work better.
The same researchers also conducted a pilot study with human cancer patients, mainly to determine if fasting diets with chemotherapy would be safe. Both a water-only, two-day fast and a four-day, restricted-calorie diet that mimics fasting were found to be safe for cancer patients under the supervision of doctors. All of these findings indicate that fasting or a fasting-mimicked diet along with chemotherapy could be used to slow tumor growth in cancer patients.
Reducing Cancer Recurrence and Mortality Rates
Other studies have used intermittent fasting with cancer survivors to determine the effects. In one study, survivors of breast cancer practiced intermittent fasting by going for 13 hours per day without eating, a modification of the 16/8 fast. The results were reductions in cancer recurrence in the fasting group, by 36 percent. The fasting group also had better survival rates. Adding two hours to the fasting time gave even better results.
Fasting May Reduce Cancer Treatment Side Effects
Cancer treatments, especially chemotherapy, can cause side effects in patients that range from uncomfortable to debilitating. Studies have found that intermittent fasting can protect against these side effects. In one study, cancer patients fasted for a few days and then ate a normal diet before treatment. They did not lose a dangerous amount of weight or see any interference with the cancer treatments.
They did, however, see benefits in reduced side effects as compared to patients who did not fast. Patients who participated in the fasting diet experienced less fatigue and weakness, fewer headaches, less nausea, and no vomiting. They also saw reductions compared to the control group in dry mouth, mouth sores, cramps, and numbness.
Risks of Intermittent Fasting
Some critics of this style of eating worry that it promotes unhealthy eating patterns and even eating disorders. There may be a slight risk that someone will binge eat between fasting periods, for instance, which is not recommended and may reverse the beneficial effects of the diet. There are also concerns that some people may use fasting for health benefits but end up losing unhealthy amounts of weight, leading to malnourishment.
The research, however, does not support the concerns. Multiple studies have determined that intermittent fasting, when guided by doctors or other medical professionals, is safe. It is important to note that fasting and long-term calorie restriction can potentially be unsafe. Practicing any style of fasted eating should be done under the guidance of doctors, especially for people who are ill or have cancer.
Intermittent fasting may sound like a chore, but most people report that it is not difficult to do and that they feel better for it. If you are living with mesothelioma or another type of cancer, it may be worth giving a fasting diet a try. Just be sure to talk to your medical team and your oncologist before doing it and practice intermittent fasting only with medical guidance.
Page edited by Dave Foster
Dave has been a mesothelioma Patient Advocate for over 10 years. He consistently attends all major national and international mesothelioma meetings. In doing so, he is able to stay on top of the latest treatments, clinical trials, and research results. He also personally meets with mesothelioma patients and their families and connects them with the best medical specialists and legal representatives available.Connect with Patient Advocate Dave Foster
We don’t compete with conventional Western medicine, we compliment it. It is our intention to provide the knowledge and materials that can improve the lives of millions of human beings; to awaken the breathing consciousness of the world. I am really sick and tired of much of the the cancer industry bilking and killing millions in the name of “health”.
The modality priority depends on the person. Primary approaches we recommend are sodium bicarbonate; breathing development, fresh veggie and fruit juice combos, coffee enemas, oxygen and brain, attitude, purpose, belief systems training, and for skin I tried this CBD oil from Spain (30ML 2x Concentrate) on a diagnosed small growth cancer on my face and it WORKED; gone in a few weeks.
VIAGRA MELANOMA RISKS
Dr. Otto Warburg received the 1931 Nobel price for proving that cancer is anaerobic. It does not survive in high concentrations of oxygen.
Dr. Warburg and cancer. Cancer all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.
All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference.
Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose. Cancer cells can flourish in low oxygen environments. They can not survive in HIGH oxygen environments.
HOW IS BREATHING RELATED TO WARBURG?
Breathing is our primary c source of oxygen. Contemporary lung volume measurements are inconsistent and guided by cross sectional criteria instead of longitudinal data and therefore do not adequately predict decline within individuals. This lack of insight about optimal functioning can cause people to be trained to do forced inhalations that may actually be harmful in long run.
GENERAL CANCER RISKS: ALL AREAS
High meat and fat consumption.
Coffee, tea, colas.
Aflatoxins (fungal products; especially in peanuts and soy sauce).
Lack of iodine, Vitamins A, C, E.
Amines (such as nitrosamines) in unrefrigerated foods, processed meat, cheese.
High intake of certain vitamins.
Habit of overeating (associated in 35% of all cancers).
Some species of mushrooms.
Diet high in refined foods.
Diet high in fat or protein.
Diabetes
Overweight
High “transit time” through colon.
Estrogens
Hair dyes
Asbestos fibers
Drugs: certain antibiotics (Tetracycline, probably penicillin), aspirin, diuretics, immunosuppressants, Azolid, Butazolidin, Presamine, Tofranil, SK-Pramine, Tapazole, Methotrexate, antihistamines, amphetamines, Atromid-S, etc. (NOTE: These are associations, not implying that they are causative of cancer).
Use of tobacco, alcoholic drinks, caffeinated and decaffeinated drinks.
Inexpensive sources of medical grade oxygen costing pennies per day.
Cancer screening too often harmful or terribly missleading Popular Science PDF
Marijuana that helps contain or reverse cancer
Cancer and cannabinoids. #6
Skin Cancer and Colloidal Silver -My personal experience with a facial problem was good but I altertated wht a CBD from Spain. Silver Armor Dina Davis 770-843-4835
The term cancer comes from the Latin word meaning crab. Cancer was characterized as a crablike disease by the Greek physician Hippocrates, who observed that cancers spread throughout the body, eventually cutting off life.
Now cancer generally is defined as the unregulated growth of abnormal cells in the body. The word cancer actually refers to over 100 different diseases, but in all cases, certain body cells multiply in an uncontrolled manner.
Cancer is anaerobic. It can not survive with the presence of adequate oxygen. That is one good reason the heart never gets cancer. The heart needs oxygen and most heart attacks are in some way linked to low oxygen to the heart. Insufficient oxygen and you die and cancer or anything else is no longer an issue.
Aside from optimal breathing right to supply adequate oxygen there are many cofactors that help ensure/support the effectiveness of adequate oxygen in the human body.
From what I know, curing and prevention of cancer often requires several of those oxygen friendly factors along with other factors that create what is an holistic approach by strengthening several factors simultaneously such as breathing improvement, strengthening antioxidants, internal cleansing, parasite elimination, changing ones self defeating thoughts and attitudes.
Excessive survival responses including those exacerbated by UDB http://www.breathing.com/articles/udb.htm and/or poor natural hygiene stimulate and/or overtax the sympathetic nervous system (and inhibit the parasympathetic nervous system) that both vaso-constricts blood vessels and turns the body toward toxemia and acidosis, allow anaerobic organisms to dominate.
One’s thoughts (hyper-vigilance for example and or negative thinking especially including Nocebo – for example – say believing in so called expert’s prognosis of imminent death from say cancer) exacerbated by poor natural hygiene and toxic overload create an environment that invites organisms unfriendly to the body.
Eventually the body’s immune system, biochemical and spiritual/energetic homeostasis gets overwhelmed by chaos. Any strong enough presence of any of the preceding negatives may invite cancer or whatever to set up housekeeping.
Over the years I have come in contact with many health professionals quite successful in handling cancer. While not necessarily focusing on breathing development per se they seem to have a very good history of success.
I believe they could greatly improve their results by adding our Optimal Breathing Kit into their already successful approaches but here they are anyway. Use the form at the bottom of this page to forward to those you care about.
My top 3 choices in order of cost and simplicity.
Sentient Temple in St. Petersburg Florida. I have checked it out in person. A former oncologist turned alternative. If I had cancer I would go there. Not expensive. click here
Gerson Therapy Thousands of successes reported. Buy “Dying to have known” Amazon.com for approx $10.00 or free as a Netflix documentary. Gerson protocol link Add coffee enemas. Heal yourself heal the world
Dr. Larraine Day
The Oxygen Protocol for The Treatment of Cancer, Dr. Majid Ali
Moss Cancer report
Dr. Burzinski movie EXTREMELY EXPENSIVE but in my opinion the man deserves 2 Nobel prizes. 1 for his cancer research and results. The second for surviving the 25+ year onslaught of the FDA and Big Pharma. Watch part of it free See also Iwantanp.com
Wigmore Institute Puerto Rico
Ozone University Ozone is one of the best cancer killers.
Ozone oriented physicians by state or country
Dr. Otto Warburg
Alternative Cancer Centers of California
Prostate Cancer Majid Ali
cancertutor.com
Majidalimd.com Breast cancer video.
The Hoxey Clinic Video
Raymond Francis, MIT trained biochemist
The Moss Report
Cancercenter.com
Coffee enemas
Acupuncture to offset dangers of chemo
NETFLIX DOCUMENTARIES ABOUT FOOD THAT I HIGHLY RECOMMEND
Ozone information:
In a 1980 study done by the German Medical Society for Ozone Therapy, 644 therapists were polled regarding their 384,775 patients, comprising a total of 5,579,238 ozone treatments administered. There were only 40 cases of side effects noted out of this number which represents the incredibly low rate of .000007%, and only four fatalities, which were all attributed to operator error. Ozone has thus proven to be the safest medical therapy ever devised.”
An expert opinion about most cancers “As one long-term survivor put it, “Returning to a state of health is not just about having treatment; it means dealing with the mental, emotional and the spiritual issues that tend to manifest physically. It means asking, ‘Am I on the path that I want to be on?’”
An expert opinion about most cancers “As one long-term survivor put it, “Returning to a state of health is not just about having treatment; it means dealing with the mental, emotional and the spiritual issues that tend to manifest physically. It means asking, ‘Am I on the path that I want to be on?’”
page
NOTE from Mike: If you have poor breathing it may only add to and not cause cancer but Otto Warburg proved that cancer is anaerobic and will not survive in high concentrations of oxygen.
Breathing, oxygen and emotions. To have the best chance of success with any cancer program, make sure you develop your breathing.
Inexpensive sources of medical grade oxygen costing pennies per day..
More About Cancer
Cancer Overview – My educated guesses, opinions and facts.
Cancer screening too often harmful or terribly miss-leading Popular Science PDF
Every person has cancer cells in the body. These cancer cells do not show up in the standard tests until they have multiplied to a few billion. When doctors tell cancer patients that there are no more cancer cells in their bodies after treatment, it just means the tests are unable to detect the cancer cells because they have not reached the detectable size.
Cancer cells occur between 6 to more than 10 times in a person’s lifetime.
When the person’s immune system is strong, the cancer cells will be destroyed and prevented from multiplying and forming tumors.
When a person has cancer it indicates the person has multiple nutritional deficiencies. These could be due to genetic, environmental, food and lifestyle factors.
To overcome the multiple nutritional deficiencies, changing diet and including supplements will strengthen the immune system.
Chemotherapy involves poisoning the rapidly-growing cancer cells and also destroys rapidly-growing healthy cells in the bone marrow, gastro-intestinal tract etc, and can cause organ damage, like liver, kidneys, heart, lungs etc.
Radiation while destroying cancer cells also burns, scars and damages healthy cells, tissues and organs.
Initial treatment with chemotherapy and radiation will often reduce tumor size. However prolonged use of chemotherapy and radiation do not result in more tumor destruction.
When the body has too much toxic burden from chemotherapy and radiation, the immune system is either compromised or destroyed, hence the person can succumb to various kinds of infections and complications.
Chemotherapy and radiation can cause cancer cells to mutate and become resistant and difficult to destroy. Surgery can also cause cancer cells to spread to other sites.
An effective way to battle cancer is to starve the cancer cells by not feeding it with the foods it needs to multiply.
Marijuana/cannabis and lung and brain cancer
Cancer screening too often harmful or terribly miss-leading Popular Science PDF
Cancer Cells Feed On:
Sugar is a cancer-feeder. By cutting off sugar it cuts off one important food supply to the cancer cells. Sugar substitutes like NutraSweet, Equal, Spoonful, etc are made with Aspartame and it is harmful. A better natural substitute would be Manuka honey or molasses but only in very small amounts. Table salt has a chemical added to make it white in color. A better alternative is Bragg aminos or celtic or Hawaian sea salt.
Milk causes the body to produce mucus, especially in the gastro-intestinal tract. Cancer feeds on mucus. By cutting off milk and substituting with fresh made almond milk, the cancer cells are being starved.
Cancer cells thrive in an acid environment. A meat-based diet is acidic. It is best to eat fish, and a little chicken rather than beef or pork. Meat also contains livestock antibiotics, growth hormones and parasites, which are all harmful, especially to people with cancer.
A diet made of 80% fresh vegetables and juice, whole grains, seeds, nuts and a little fruit help put the body into an alkaline environment. About 20% can be from cooked food including beans. Fresh vegetable juices (enzymes are destroyed at temperatures above 104 degrees F (40 degrees C).) provide live enzymes that are easily absorbed and reach down to cellular levels within 15 minutes to nourish and enhance growth of healthy cells. To obtain live enzymes for building healthy cells try and drink fresh vegetable juice (most vegetables including bean sprouts) and eat some raw vegetables 2 or 3 times a day. We use a Breville Juicer, make 2 gallons a week and preserve the juice in Mason Jars sealed with a food saver. See Gerson therapy below
Avoid coffee (except in enemas), tea, and chocolate, that have high caffeine. Green tea is a better alternative and has cancer-fighting properties. Water: best to drink purified, distilled, reverse osmosis or filtered, to avoid known toxins and heavy metals in tap water. Distilled water is slightly acidic; avoid it.
Meat protein is difficult to digest and requires a lot of digestive enzymes. Undigested meat remaining in the intestines become putrefied and leads to more toxic buildup.
Cancer cell walls have a tough protein covering. By refraining from or eating less meat it frees more enzymes to attack the protein walls of cancer cells and allows the body’s killer cells to destroy the cancer cells.
Some supplements build up the immune system (IP6, Florssence, Essiac, antioxidants, vitamins, minerals, EFAs etc.) to enable the body’s own killer cells to destroy cancer cells. Other supplements like vitamin E are known to cause apoptosis, or programmed cell death, the body’s normal method of disposing of damaged, unwanted, or unneeded cells.
Cancer is a disease of the mind, body, and spirit. A proactive and positive spirit will help the cancer warrior be a survivor. Anger, un-forgiveness, indifference masking resentment) and bitterness put the body into a stressful and acidic environment. Learn to have a loving and forgiving spirit. Learn to relax and enjoy life.
Cancer cells cannot thrive in an oxygenated environment. Exercising daily, and deep breathing help to get more oxygen down to the cellular level. Oxygen therapy is another means employed to destroy cancer cells.
CANCER UPDATE 2 FROM JOHNS HOPKINS HOSPITAL, US – PLEASE READ
No plastic containers in micro.
No water bottles in freezer.
No plastic wrap in microwave.
Johns Hopkins has recently sent this out in its newsletters.
This information is being circulated at Walter Reed Army Medical Center as well. Dioxin chemicals cause cancer, especially breast cancer. Dioxins are highly poisonous to the cells of our bodies. Don’t freeze your plastic bottles with water in them as this releases dioxins from the plastic.
Recently, Dr. Edward Fujimoto, Wellness Program Manager at Castle Hospital, was on a TV program to explain this health hazard. He talked about dioxins and how bad they are for us. He said that we should not be heating our food in the microwave using plastic containers. This especially applies to foods that contain fat. He said that the combination of fat, high heat, and plastics releases dioxin into the food and ultimately into the cells of the body.
Instead, he recommends using glass, such as Corning Ware, Pyrex or ceramic containers for heating food. You get the same results, only without the dioxin. So such things as TV dinners, instant ramen and soups, etc., should be removed from the container and heated in something else. Paper isn’t bad but you don’t know what is in the paper.
It’s just safer to use tempered glass, Corning Ware, etc. He reminded us that a while ago some of the fast food restaurants moved away from the foam containers to paper. The dioxin problem is one of the reasons.
Also, he pointed out that plastic wrap, such as Saran, is just as dangerous when placed over foods to be cooked in the microwave. As the food is nuked, the high heat causes poisonous toxins to actually melt out of the plastic wrap and drip into the food. Cover food with a paper towel instead.
Cancer, oxygen (think breathing) and Otto Warburg Science Daily.
A 35% decrease in cellular oxygen levels will induce cancer. Otto Warburg. The message here is INCREASE OXYGEN
Ozone (O3) oriented physicians by state or country
To have the best chance of success with any cancer program, make sure you develop your breathing.
Inexpensive sources of medical grade oxygen costing pennies per day.
Genetically Modified ‘Serial Killer’ T-Cells Obliterate Tumors in Leukemia Patients
In a cancer treatment breakthrough 20 years in the making, researchers from the University of Pennsylvania’s Abramson Cancer Center and Perelman School of Medicine have shown sustained remissions of up to a year among a small group of advanced chronic lymphocytic leukemia (CLL) patients treated with genetically engineered versions of their own T cells.
The protocol, which involves removing patients’ cells and modifying them in Penn’s vaccine production facility, then infusing the new cells back into the patient’s body following chemotherapy, provides a tumor-attack roadmap for the treatment of other cancers including those of the lung and ovaries and myeloma and melanoma.
The findings, published simultaneously in the New England Journal of Medicine and Science Translational Medicine on August 10, are the first demonstration of the use of gene transfer therapy to create “serial killer” T cells aimed at cancerous tumors.
“Within three weeks, the tumors had been blown away, in a way that was much more violent than we ever expected,” said senior author Carl June, MD, director of Translational Research and a professor of Pathology and Laboratory Medicine in the Abramson Cancer Center, who led the work. “It worked much better than we thought it would.
” The results of the pilot trial of three patients are a stark contrast to existing therapies for CLL. The patients involved in the new study had few other treatment options. The only potential curative therapy (From Mike.
He is obviously ignorant of Gerson and Day’s approaches noted below) would have involved a bone marrow transplant, a procedure which requires a lengthy hospitalization and carries at least a 20 percent mortality risk — and even then offers only about a 50 percent chance of a cure, at best.
After removing the patients’ cells, the team reprogrammed them to attack tumor cells by genetically modifying them using a lentivirus vector. The vector encodes an antibody-like protein, called a chimeric antigen receptor (CAR), which is expressed on the surface of the T cells and designed to bind to a protein called CD19.
Once the T cells start expressing the CAR, they focus all of their killing activity on cells that express CD19, which includes CLL tumor cells and normal B cells. All of the other cells in the patient that do not express CD19 are ignored by the modified T cells, which limits side effects typically experienced during standard therapies.
The team engineered a signaling molecule into the part of the CAR that resides inside the cell. When it binds to CD19, initiating the cancer-cell death, it also tells the cell to produce cytokines that trigger other T cells to multiply — building a bigger and bigger army until all the target cells in the tumor are destroyed.
“We saw at least a 1000-fold increase in the number of modified T cells in each of the patients. Drugs don’t do that,” June says. “In addition to an extensive capacity for self-replication, the infused T cells are serial killers. On average, each infused T cell led to the killing of thousands of tumor cells — and overall, destroyed at least two pounds of tumor in each patient.
” The importance of the T cell self-replication is illustrated in the New England Journal of Medicine paper, which describes the response of one patient, a 64-year old man. Prior to his T cell treatment, his blood and marrow were replete with tumor cells. For the first two weeks after treatment, nothing seemed to change.
Then on day 14, the patient began experiencing chills, nausea, and increasing fever, among other symptoms. Tests during that time showed an enormous increase in the number of T cells in his blood that led to a tumor lysis syndrome, which occurs when a large number of cancer cells die all at once.
By day 28, the patient had recovered from the tumor lysis syndrome — and his blood and marrow showed no evidence of leukemia. “This massive killing of tumor is a direct proof of principle of the concept,” Porter says.
Moving forward, the team plans to test the same CD19 CAR construct in patients with other types of CD19-positive tumors, including non-Hodgkin’s lymphoma and acute lymphocytic leukemia. They also plan to study the approach in pediatric leukemia patients who have failed standard therapy.
Additionally, the team has engineered a CAR vector that binds to mesothelin, a protein expressed on the surface of mesothelioma cancer cells, as well as on ovarian and pancreatic cancer cells.
Curaderm cream made from eggplant for basal cell and sqamous cell carcinoma www.curaderm.net
RGCC ONCOSTAT PLUS Test
Tests your cancer against 98 drugs and 45 natural compounds to see what it will respond to. Also tests 72 tumor-related genes. www.rgcc-genlab.com/?tests
ONCOblot Blood Test for early detection
This test will detect a cancer of 2 million cells compared to 4.5 trillion cells for a positive mammogram. www.oncoblotlabs.com
GcMAF
GcMAF is a vitamin D binding protein that activates macrophages, which are immune cells that recognize, engulf, and destroy foreign matter and produce effector molecules. Cancer cells produce an enzyme called nagalase, which attempts to reduce macrophage activation.
GcMAF reduces nagalase and restores the integrity of the immune system allowing it to effectively eliminate cancer and restore homeostatic balance. www.gcmaf.timsmithmd.com/book/book/4
In American law, Scots law and under the law of some English-speaking Commonwealth nations, subornation of perjury is the crime of persuading a person to commit perjury, the swearing of a false oath to tell the truth in a legal proceeding, whether spoken or written. The term subornation of perjury further describes the circumstance wherein an attorney at lawcauses a client to lie under oath or allows another party to lie under oath.[1][2]
Whoever procures another to commit any perjury is guilty of subornation of perjury, and shall be fined under this title or imprisoned not more than five years, or both.
In California law, per the State bar Code,[3] the subornation of perjury constitutes an act of “moral turpitude” on the part of the attorney, and thus is cause for his or her disbarment, or for the suspension of his or her license to practice law.[4]
In legal practice, the condition of suborning perjury applies to a lawyer who presents either testimony or an affidavit, or both, either to a judge or to a jury, which the attorney knows to be materially false, and not factual. In civil law and in criminal law, the attorney’s knowledge that the testimony is materially false must rise above mere suspicion to what an attorney would reasonably have believed in the circumstances of the matter discussed in the testimony. Hence, the attorney cannot be wilfully blind to the fact that his or her witness is giving false, perjurious testimony.
An attorney who encourages a witness to give false testimony is suborning perjury, a crime punished either with formal disciplinary action, disbarment, jail or a combination thereof. A false statement by an attorney in court also is a crime similar to subornation of perjury and is punished accordingly. In the professional conduct of an attorney at law, there is a fine delineation between assisting a witness to recall events and encouraging him or her to give materially false testimony. The practice of ″horse shedding the witness″ (rehearsing testimony) is an example of such perjurious criminal conduct by an attorney, which is depicted in the true-crime novel Anatomy of a Murder (1958), by Robert Traver and in the eponymous film (Otto Preminger, 1959), about a rape-and-murder case wherein are explored the ethical and legal problems inherent to the subornation of perjury.[5][6][7]
For Alzheimer’s clients, it is still best to have a companion. Text 408-854-1883 for caring caregivers. Do senior-safe your house with guide rails, and other ways.
Under the Constitution, he has no right to demand such an appropriation — much less to hold vital government functions hostage to obtain it. The president is not coequal with Congress when it comes to appropriations — the power of the purse belongs to the legislative branch, not the executive.
James Madison makes this clear in Federalist 58: “the legislative department alone has access to the pockets of the people.” Trump’s claim that he can build the wall anyway is even more flagrantly unconstitutional. Article I of the Constitution is clear that “No Money shall be drawn from the Treasury, but in Consequence of Appropriations made by Law.”
Trump’s demand for an appropriation from Congress because of a security crisis on the border was anticipated by the drafters of the Constitution; they specifically refused to combine the power of the purse with the role of commander in chief. (This after all, was the specific grievance against the king of England that sparked the American Revolution itself.)
Worse, in shutting down the government to extort an appropriation he is not entitled to, Trump is violating his oath of office and breaching one of his core fiduciary duties: to “take care that the laws be faithfully executed.” (Emphasis added.) Obviously, a shutdown of one-third of the government for “months or even years” will make the execution of many laws utterly impossible – particularly since the Department of Justice is one of the shuttered agencies. Trump cannot assert that he must shut down the DOJ. The Democrats have passed an appropriation for that department, to which he concedes he has no objection. He is merely trying to use the shutdown as blackmail to force Congress to fund the wall (or at least however much of it can be built for $5 billion).
Taking as our source the very Federalist Society from which Trump gets his judicial appointee punch list, breach of fiduciary duty is the key standard for the “misdemeanors” the Constitution cites, along with criminal acts, as grounds for impeachment.
Nor does the alleged national security crisis on the border offer a justification – even an extraconstitutional one – for Trump’s hostage-taking. In fact, it makes his fiduciary breach even broader, given his willingness to shut down the Department of Homeland Security. The administration says the border, in its present state, is an unacceptable risk, because immigration officials have apprehended 3,000 “special interest” immigrants at that border. (Note – apprehended. The system apparently works.)
None of these people, let’s note, were terrorists. In fact no terrorist is ever known to have sought to cross the Mexican border. On the other hand the Department of Homeland Security did apprehend 3,700 terrorist suspects at airports and other legal points of entry not on the Mexican border. Refusing to fund the Department of Homeland Security for months or years, as the president has threatened to do, in order to stop a nonexistent threat on the border would thus greatly increase the risk of terrorists crossing into the U.S. in the way they have historically done so – that is, through other ports of entry.
So we are faced with a president who is seeking to overturn the congressional power of the purse. To achieve this unconstitutional end, he says he is ready to shut down the Justice Department — perhaps even for years. He is also willing to shut down the very agency that, since 9/11, has successfully protected the United States from terrorists entering the country – the Department of Homeland Security. This is abuse of power and fiduciary breach at its most definitive — with one important caveat.
Were the House to move articles of impeachment against Trump based on a prolonged shutdown, the president has, as of today, one powerful defense. He has not actually vetoed any bill to reopen the government, because the Senate has failed to place one before him. Since government can be funded only by legislation passed by both Houses and then signed by the president (or passed over his veto) Trump actually lacks the power to reopen the government – as long as Senate Majority Leader Mitch McConnell persists in not allowing the Senate to vote on any bill Trump says he won’t sign.
This collusion by the Senate majority with Trump is fundamental, since the heart of Trump’s fiduciary breach lies in his usurpation of the congressional power of the purse. McConnell, the leader of one chamber of Congress, is thus far fully complicit in this effort.
So solving the shutdown – without having to impeach the president – is quite simple. Enough senators – of both parties – must compel McConnell to bring bills to reopen the government before the Senate for a vote. Then, if President Trump holds the government hostage by vetoing those bills after they pass, those who wish to impeach him will have their ironclad impeachable offense. Meanwhile Congress can override the veto and restore law enforcement and other vital federal funding.
If McConnell calls Trump’s bluff, he could not only end the shutdown but also make a prolonged impeachment crisis much less likely.
Medicare coverage of genetic services. Under Medicare’s guidelines, BRCA1 and BRCA2 genetic testing is covered for people with: A personal history of breast cancer, with one or more of the following: … a close relative with a known BRCA1 or BRCA2 gene mutation.
Medicare coverage of genetic services
Under Medicare’s guidelines, BRCA1 and BRCA2 genetic testing is covered for people with:
A personal history of breast cancer, with one or more of the following:
diagnosed at or before age 45, with or without family history
diagnosed at or before age 50 or two breast primaries, with 1 or more close blood relative(s) with breast cancer diagnosed at or before age 50 or 1 or more close blood relative(s) with ovarian cancer/fallopian tube/primary peritoneal cancer
two breast primaries when first breast cancer diagnosis occurred prior to age 50
diagnosed at any age, with 2 or more close blood relatives with breast and/or epithelial ovarian/fallopian tube/primary peritoneal cancer, at any age
close male blood relative with breast cancer
personal history of epithelial ovarian/fallopian tube/primary peritoneal cancer
of a certain ethnicity associated with higher mutation frequency, (eg, founder populations of Ashkenazi Jewish, Icelandic, Swedish, Hungarian or other) no additional family history required
a close relative with a known BRCA1 or BRCA2 gene mutation
Personal history of epithelial ovarian/fallopian tube/primary peritoneal cancer.
Personal history of male breast cancer.
Medicare operates on a regional system in which Medicare Area Contractors (MACs) manage the provision of health services for a specific jurisdiction. In the spring of 2015, four MACs expanded their coverage to better align their services with National Comprehensive Cancer Network (NCCN) guidelines in a number of important areas, including:
Expanding coverage of genetic testing for individuals who have or had cancer consistent with hereditary cancer syndromes, including men diagnosed with prostate cancer and men and women diagnosed with pancreatic cancer,
Coverage of multigene testing panels if more than one mutation may be indicated, and
Clarification of the BRCA testing policy for use of the targeted therapy, Lynparza (olaparib).
It is important to note that these policy changes apply only to states covered by the four MACs:
Arkansas, Arizona, California, Hawaii, Idaho, Kentucky, Montana, Nevada, North Carolina, North Dakota, Ohio, Oregon, South Carolina, South Dakota, Utah, Virginia, Washington, West Virginia and Wyoming
Medicare does not currently cover the cost of genetic testing in individuals who do not have a personal history of cancer.
I was talking to the coordinator who facilitate the home care aid reimbursement (home care or in a facility) for California veterans/spouse of veterans and that the family member must reach out to us for info. Must have hired a home care aid first before the reimbursement process starts. The family member is best to coordinate since parents might have cognitive decline and must be internet savvy to go thru the needed documentation.
Text 408-854-1883 or email motherhealth@gmail.com if you have a heart and mind to be trained as a caregiver or experience with caring for home-bound bay area seniors.
Last week, Adam reached out after House Democrats successfully passed legislation to end Trump’s shutdown.
Since then, President Trump used the Oval Office to push for his wall in a prime time national television speech replete with falsehoods and fear mongering, and walked out of negotiations with Democratic leaders Chuck Schumer and Nancy Pelosi. Now he’s publicly weighing the declaration of an unprecedented “national emergency,” claiming it would give him the power to build his wall, no matter what Congress says.
Making matters worse, yesterday Senate Majority Leader Mitch McConnell blocked a new effort to pass a bill to reopen the government in the Senate.
As a result, today, hundreds of thousands of federal workers are receiving paychecks in the amount of $0.00, and there’s no end in sight thanks to Trump and McConnell.
We need to keep up the pressure on the GOP to end this abusive shutdown, and put people back to work. And we must fight any assertion that the failure of the president to get Mexico to pay for his pet project is some kind of “national emergency.” If we don’t resist this abuse of power, we can expect more of the same.
Complete list of all substances tested by ONCOSTAT PLUS test:
