DNA repair deficiency in neurodegeneration. Jeppesen DK, Bohr VA, Stevnsner T. SourceDanish Centre for Molecular Gerontology and Danish Aging Research Center, University of Aarhus, Department of Molecular Biology, Aarhus, Denmark. Abstract Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several neurodegenerative disorders. Many recent experimental results indicate that the post-mitoticContinue reading “DNA Damaging agents and repair, Alzheimer’s and Parkinson and other disease”
Author Archives: connie dello buono
Decreased Brain Glutamate in Alzheimer’s Disease and excitotoxic effect of Glutamate in Parkinson’s disease
Glutamate (Glu) is the most abundant excitatory neurotransmitter in the central nervous system (CNS) and is involved in the pathophysiology of Alzheimer’s disease (AD) in which there is an increased excitotoxicity. Biochemical composition of living tissues including the levels of Glu was analyzed by magnetic resonance spectroscopy (MRS). Previous reports point to decreased levels ofContinue reading “Decreased Brain Glutamate in Alzheimer’s Disease and excitotoxic effect of Glutamate in Parkinson’s disease”
Restless Legs Syndrome in Alzheimer’s and Parkinson’s Disease
Restless legs syndrome (RLS) is a neurological disorder characterized by the urge to move the legs associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved by movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer’s Disease (AD). Check out David Wimble’s site http://www.rlcure.com/ for more info on RLS.Continue reading “Restless Legs Syndrome in Alzheimer’s and Parkinson’s Disease”
Antioxidant Vitamin C in Alzheimer’s and Parkinson’s disease
Oxidative stress is suggested to play a major role in the pathogenesis of Alzheimer’s disease (AD). Among the antioxidants, vitamin C has been regarded as the most important one in neural tissue. It also decreases β-amyloid generation and acetylcholinesterase activity and prevents endothelial dysfunction by regulating nitric oxide, a newly discovered factor in the pathogenesisContinue reading “Antioxidant Vitamin C in Alzheimer’s and Parkinson’s disease”
10 Early Signs of Parkinson’s Disease That Doctors Often Miss
Avoid intensive stretching before training the lower body
A study concluded that intensive stretching such as lower-body passive static stretching (PSS) should be avoided before training the lower body or performing the 1 repetition maximum (1RM) in the squat exercise in favor of an active dynamic warm-up (AD) using resistance training equipment in the lower-body musculature. It investigated the acute effect of passiveContinue reading “Avoid intensive stretching before training the lower body”
Associations of Strength Training with Impaired Glucose Metabolism
The Australian Diabetes study concluded the importance of including strength training (ST) activity, at a frequency of at least once per week, within exercise management recommendations for the maintenance of favorable metabolic health, particularly as it may contribute to reducing the risk of developing type 2 diabetes mellitus. To examine the association of strength trainingContinue reading “Associations of Strength Training with Impaired Glucose Metabolism”
Combined light exercise after meal intake suppresses postprandial serum triglyceride
The study concluded that low-intensity exercise on the day of meal intake, particular after intake, can prevent the elevation of postprandial triglyceride concentration in healthy young subjects. The effect of exercise performed on the day of meal intake on postprandial triglyceride concentration, which is an independent risk factor for cardiovascular disease, is unclear. The presentContinue reading “Combined light exercise after meal intake suppresses postprandial serum triglyceride”
Apoptosis (cell death) induction in cancer cells exposed to dietary phytochemicals
CLINICAL EPIGENETICS, 2011 Finally, by virtue of their genetic and epigenetic mechanisms, cancer chemopreventive agents are being redefined as chemo- or radio-sensitizers. A sustained DNA damage response coupled with insufficient repair may be a pivotal mechanism for apoptosis induction in cancer cells exposed to dietary phytochemicals. A study reviews how dietary phytochemicals that affect theContinue reading “Apoptosis (cell death) induction in cancer cells exposed to dietary phytochemicals”
Vitamin D plays a beneficial role in Alzheimer’s disease (AD) /Dementia
Alzheimer’s disease (AD) is the most common form of dementia in the elderly individuals and is associated with progressive memory loss and cognitive dysfunction. A significant association between AD and low levels of vitamin D has been demonstrated. Furthermore, vitamin D supplements appear to have a beneficial clinical effect on AD by regulating micro-RNA, enhancingContinue reading “Vitamin D plays a beneficial role in Alzheimer’s disease (AD) /Dementia”
Diet high in meat promote the growth of a gut bacteria, carnitine, black walnut, pork parasitic worms
1. According to the researchers, an earlier study found that a compound called trimethylamine-N-oxide (TMAO) may promote the growth of artery-clogging plaques. TMAO is formed when bacteria from our digestive tract breaks down a compound found in meat known as carnitine. Diets high in meat promote the growth of a gut bacteria that breaks downContinue reading “Diet high in meat promote the growth of a gut bacteria, carnitine, black walnut, pork parasitic worms”
Consume more Alkaline (veggies, whole foods) than Acidic foods (meat, processed foods)
Starvation, diet-induced obesity (unhealthy snacks) elevated triglycerides, decreased transport of leptin to brain lead to obesity
Obesity is associated with leptin resistance as evidenced by hyperleptinemia. Resistance arises from impaired leptin transport across the blood-brain barrier (BBB), defects in leptin receptor signaling, and blockades in downstream neuronal circuitries. The mediator of this resistance is unknown. Here, we show that milk, for which fats are 98% triglycerides, immediately inhibited leptin transport asContinue reading “Starvation, diet-induced obesity (unhealthy snacks) elevated triglycerides, decreased transport of leptin to brain lead to obesity”
Alzheimer’s disease and down’s syndrome gene, serotonin receptor 4, happy neurotransmitter hormone serotonin
Function • G-protein coupled receptor activity • calmodulin-dependent protein kinase activity • serotonin receptor activity • signal transducer activity Process • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • cognition • gamma-aminobutyric acid signaling pathway • positive regulation of cAMP metabolic process • positive regulation of cell proliferation •Continue reading “Alzheimer’s disease and down’s syndrome gene, serotonin receptor 4, happy neurotransmitter hormone serotonin”