Category Archives: genes
Sirtuin regulation of metabolism and stem cells
Longevity Genes
Fatty acids – Omega 3 as energy sources such as kidney, heart, cerebellum, intestine, and skeletal muscle and nuclear receptor ESRRA
Estrogen-related receptor alpha (ERRα), also known as NR3B1(nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene.[3][4] ERRα was originally cloned by DNA sequence homology to the estrogen receptor alpha (ERα, NR3A1),[4]but subsequent ligand binding and reporter-gene transfection experiments demonstratedContinue reading “Fatty acids – Omega 3 as energy sources such as kidney, heart, cerebellum, intestine, and skeletal muscle and nuclear receptor ESRRA”
Resveratrol has been claimed to be an activator of Sirtuin 1, calorie restriction and longevity gene
Mice lacking the SIRT1 gene (the sir2 biological equivalent) were smaller than normal at birth, often died early or became sterile. Lamin A is a protein that had been identified as a direct activator of Sirtuin 1 during a study on Progeria.[17] Resveratrol has been claimed to be an activator of Sirtuin 1,[18] but thisContinue reading “Resveratrol has been claimed to be an activator of Sirtuin 1, calorie restriction and longevity gene”
TP53 gene affects tumor suppression
Peto’s Paradox is the observation, due to Richard Peto, that at the species level, the incidence of cancer does not appear to correlate with the number of cells in an organism.[215] For example, the incidence of cancer in humans is much higher than the incidence of cancer in whales.[216] This is despite the fact thatContinue reading “TP53 gene affects tumor suppression”
Folate – Vit B9 deficiency or MTHFR gene mutation
Folate – Vit B9 or MTHFR deficiency has a frequency of 1 in 1.9 . Those with potentially “severe” mutations should check homocysteine with their doctor. Folate deficiency: A deficiency in folic acid (folate) could be linked to MTHFR mutation and is worth checking out. Common symptoms include extreme fatigue, light-headedness, and forgetfulness. Homocysteine is anContinue reading “Folate – Vit B9 deficiency or MTHFR gene mutation”
Carrier statistics categorized by self-reported ethnicity
The median age was 33.0 years and mean age was 33.63 years. Most (n = 17,865) of the individuals were from 21–39 years of age. A small percentage was under 21 years (1.6%) or over 45 years (2.8%). Disease carrier states Alleles associated with 96 recessive diseases (excluding mild conditions) were identified in our 23,453Continue reading “Carrier statistics categorized by self-reported ethnicity”
Genes: Terms and Definitions
Terms and Definitions A · B · C · D · E · F · G · H · I · K · L · M · N · O · P · Q · R · S · T · U · V · W · X · Z A affected Referring to anContinue reading “Genes: Terms and Definitions”
Most cancer patients want tumor profiling, even if it reveals other genetic risks
Source: Yale Cancer Center Summary: Most cancer patients would opt for tumor profiling even if the test revealed that they or their families were at risk for other genetic diseases, according to a study. The study showed that despite the risk for receiving information about other potentially serious health problems, 59% of the cancer patientsContinue reading “Most cancer patients want tumor profiling, even if it reveals other genetic risks”
Resources for doctors and health consumers about genetic tests, clinical trials
Collecting buccal or cheek swab for genetic test The following video will review proper techniques for collecting a buccal or cheek swab sample for processing in our laboratory in three easy steps. This will reduce the need for resample and is critical to yield good test results. For general information about pharmacogenomics or drug-specific resourcesContinue reading “Resources for doctors and health consumers about genetic tests, clinical trials”
Cancer Related Genes
Cancer Related Genes Gene Therapeutic Area ABL1 Chronic Myeloid Leukemia AKT1 Breast Cancer Colorectal Cancer Non-Small Cell Lung Cancer ALK Anaplastic Large Cell Lymphoma Inflammatory Myofibroblastic Tumor Neuroblastoma Non-Small Cell Lung Cancer Rhabdomyosarcoma ATM Diffuse Large B-Cell Lymphoma Mantle Cell Lymphoma Chronic Lymphocytic Leukemia AURKA Colorectal Cancer BCL2 Lymphoma BCL6 Lymphoma BCR Chronic Myeloid LeukemiaContinue reading “Cancer Related Genes”
Ovarian Cancer genes
Molecular Profiling of Epithelial Ovarian Cancer Epithelial ovarian cancer (EOC) is the most common cause of gynecological cancer death in the United States, with an estimated 22,280 new cases and 14,240 deaths estimated for 2016 (ACS 2016). The vast majority of women are diagnosed with advanced stage EOC. Current practice consists of aggressive surgical removal ofContinue reading “Ovarian Cancer genes”
Before, during and after pregnancy diet
Many tumors in young children might be influenced by the environment in utero and months before conception. Some drugs or medications linger in a woman’s body months before conception. During the first trimester, a miscarriage is possible when the embryo or fetus is not completely formed (nervous system and major organs). A study related theContinue reading “Before, during and after pregnancy diet”