Growth hormone (GH) , asthma meds and muscle quality

Growth hormone (GH) and muscle quality

GH production drops by 60% at age 60. A senior who had been taking asthma meds for a long time experienced severe neck and shoulder bone fracture from a fall.  Know that some meds can impair muscle quality.

The following factors influence GH secretion spike by the pituitary gland in the brain:

Factors Increasing GH Secretion Factors Decreasing GH Secretion
Physiological: Physiological:
Sleep Hyperglycemia
Fasting Elevated Blood Free Fatty Acids
Exercise Obesity
High Amino Acids
in the Blood
Hyper or Hypothyroidism
Low Blood Sugar  
Pharmacologic: Pharmacologic:
Any hypoglycemic agent GH itself
Estrogens Somatostatin
Alpha-agonists Alpha antagonists (yohimbine)
Beta antagonists Beta agonists (ephedrine, clenbuterol)
Serotonin Serotonin antagonists
Dopamine Dopamine antagonists

Source: Basic and Clinical Endocrinology, 5th Edition

Muscle regeneration

Muscle growth and capacity to regenerate upon injury are faster for skeletal muscle but poor for cardiac muscle especially for young ones.

A greater capacity for regeneration of cardiac muscle is seen in fish. Fish oil, folate, Vitamin Bs, Coenzyme Q10 and omega 3 dietary supplements are important for our heart muscles.

Skeletal muscle has an excellent capacity for regeneration.  Inflammation and innervation makes regeneration suboptimal for seniors.

As we age, our cardiac muscles are easily affected even from those who have regular exercise and eat healthy.

Muscle regeneration is the process by which damaged skeletal, smooth or cardiac muscle undergoes biological repair and formation of new muscle in response to death of muscle cells.

Key Concepts:

  • Necrosis is required for muscle regeneration.
  • Inflammation is essential to remove necrotic tissue and initiate myogenesis.
  • New blood vessel formation is required after major injury of muscles.
  • Reinnervation is essential for functional recovery of skeletal muscle.

Adult skeletal muscle is a postmitotic tissue, accomplished by resident stem cells, satellite glial cells (SGCs). Current theories suggest that SGCs are important in controlling the microenvironment of the sympathetic ganglia.

SGCs role as a regulator of neuronal microenvironment is further characterized by its electrical properties which are very similar to those of astrocytes. Astrocytes have a well-studied and defined role in controlling the microenvironment within the brain.

Low glucose and low stress to go to sleep

There are many factors that will help you go to sleep. There are two most important factors.  One is that if you eat (few bites) sugary snacks (couple it with fish oil or omega 3), it should be 6 to 8 hrs before your sleep time. And the other one is that your stress level should be very low.

The pituitary gland is responsible for sleep, stress, sex hormones and food cravings.

Our gut microbiome (bacteria and microbes in our intestines) also communicates to our brain to tell us that they are busy or hungry.

When we have food cravings during the day, it is because we did not get quality sleep the night before.

When we are grumpy or stressed out that day, it also means that we did not get good sleep.

Our liver was not able to detox properly, so we have not so healthy skin as a result of poor quality sleep.

Our bedroom must be dimmed since lights tell our pituitary gland that it is not night time yet.

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So what did I do to go to sleep at 12 midnight after working making egg rolls until 9pm and eating chocolate desserts at that time? I have to wait till I calm my body and waited till 12midnight to go to sleep. I repeated some prayers to tell my brain to stop worrying or de-stress.  All these even after I took some important dietary supplements to go to sleep (melatonin, calcium and magnesium, Vit D3, zinc, Zyflamend night time caps).

Lesson: Our body needs low glucose and low stress to go to sleep.

Adrenal fatigue

Adrenal fatigue or hypoadrenia are terms used in alternative medicine to describe the unscientificbelief that the adrenal glands are exhausted and unable to produce adequate quantities of hormones, primarily the glucocorticoid cortisol, due to chronic stress or infections.[1] Adrenal fatigue should not be confused with recognized forms of adrenal dysfunction such as adrenal insufficiency or Addison’s Disease.[2]

The term “adrenal fatigue”, which was coined in 1998 by James Wilson, a chiropractor,[3] may be applied to a collection of mostly nonspecific symptoms.[1] There is no scientific evidence supporting the concept of adrenal fatigue and it is not recognized as a diagnosis by the medical community.[1][2]

Blood or salivary testing is sometimes offered but there is no evidence that adrenal fatigue exists or can be tested.

Pituitary gland

In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 grams (0.018 oz) in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The hypophysis rests upon the hypophysial fossa of the sphenoid bone in the center of the middle cranial fossa and is surrounded by a small bony cavity (sella turcica) covered by a dural fold (diaphragma sellae).[2] The anterior pituitary (or adenohypophysis) is a lobe of the gland that regulates several physiological processes (including stress, growth, reproduction, and lactation). The intermediate lobe synthesizes and secretes melanocyte-stimulating hormone. The posterior pituitary (or neurohypophysis) is a lobe of the gland that is functionally connected to the hypothalamus by the median eminence via a small tube called the pituitary stalk (also called the infundibular stalk or the infundibulum).

Hormones secreted from the pituitary gland help control: growth, blood pressure, certain functions of the sex organs, thyroid glands and metabolism as well as some aspects of pregnancy, childbirth, nursing, water/salt concentration at the kidneys, temperature regulation and pain relief.


Can methamphetamine bring on the menstrual cycle?

Can methamphetamine bring on the menstrual cycle? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Methamphetamine disrupts menstrual cycle. To regulate menstrual cycle, get good sleep, avoid plastic and hormones in foods (milk), take magnesium and calcium (Whole Foods), drink red raspberry leaf tea, detox (acidophilus,picked veggies,lemon water, avoid junk foods) and see a doctor.
Results: Long-term use of MA significantly altered the menstrual cycle, and 33.6% women suffered from abnormal uterine bleeding while using MA. Deregulation of sex hormones was observed in 73.3% of participants during abstinence. The most common patterns were simple anovular menstruation, which was caused mainly by a hypothalamic deregulation and pituitary suppression with or without ovarian suppression. Normal hormone levels were observed more frequently in participants abstinent for more than 10 months (39.5%) than in participants who were abstinent for less than 10 months (18.6%). However, no relationship was found between hormone deregulation and age or history of MA use.
Conclusions: The present data demonstrate that long-term use of MA results in the disruption of menstrual cycles and dysfunction of hypothalamic-pituitary-gonadal axis in women

Can methamphetamine bring on the menstrual cycle?