Do Parkinson’s Medications Affect Sleep?

Do Parkinson’s Medications Affect Sleep?
Some PD meds, like MAO-B inhibitors (selegiline, rasagiline, safanimide) and amantadine (a medication used to treat dyskinesia), have alerting properties and may make insomnia worse. These medications are usually taken earlier in the day, so they do not impact sleep. Sinemet does not usually have a big impact on sleep compared to dopamine agonists.

However, nighttime hallucinations can emerge with increased intake of dopaminergic drugs, especially in people with more advanced Parkinson’s.
There are other possible causes of hallucinations, so if you begin to experience this, talk to your doctor right away. For more information, get your free copy of the Parkinson’s Foundation book Psychosis by calling Helpline at 1-800-4PD-INFO (473-4636) or online at

Sleep hygiene refers to the behaviors and habits that we can control that affect our bodies day-night cycling and readiness to go to sleep or be alert at a given time of day. Follow these tips for better sleeping habits:

  1. It is especially important for individuals with sleep difficulties to set and follow regular bed/sleep and wake times with a goal of spending at least 7 but not much more than 8 hours in bed each night. Bedtimes should be chosen based on a target waking time (i.e. don’t go to bed at 8 pm if you don’t want to be up at 4 am!).
  2. The bed should be used only as a place of sleeping, reading and watching television should be done elsewhere.
  3. Daytime napping should be limited to one nap of no greater than 30 minutes, as longer naps do not seem to provide any greater benefit to daytime fatigue but do disrupt sleep drive for the coming night.
  4. Lastly it is vital that persons with these sleep disorders are exposed to as much light (preferably real daylight) and physical/mental stimulation during the day as possible. Light is an important synchronizer of the sleep-wake cycle and many elderly individuals and individuals with chronic illness have reduced exposure to bright light.

Physical and mental activity stimulates the alerting and wakefulness centers in the brain and increase blood and oxygen flow to the brain. Most importantly, maintaining good sleep and wake habits can improve many sleep issues without the need of medications.

100 points to cancer free: sleep

+1 point: Adequate sleep at night

Give yourself 1 point if you believe that adequate sleep allows you to fight cancer cells and allows you to detox or cleanse your cells from toxins.


In cold temp, with less worry and right time each night, with small protein rich food at dinner before 7pm, allow your body to get rid of toxins by getting adequate sleep. Write a journal or notes to free your mind from worries and constant thoughts and allow your body to rest and relax with calm mind.  It takes 30 minutes to digest eggs (a complete protein) while it takes 4 hours to digest red meat.


Many cancer clients have less than 4 hours of uninterrupted sleep years before they had cancer. And recent research attributes cancer growth to lack of sleep from cancer cells or microbes causing cancer not allowing the human body to sleep at night.

Related posts/keyword search in this site

sleep, magnesium, microbes, gut bacteria, meat absorption, cancer, migraine, hydration, water, exercise, cool temp


Prevalence of Short Sleep Duration (<7 hours) for Adults Aged ≥ 18 Years, by Census Tract, United States, 2014

Map displaying model-based prevalence of short sleep duration (<7 hours), by census tract in the United States, 2014. Data sources for development of model included CDC’s Behavioral Risk Factor Surveillance System (2014), the U.S. Census (2010), and the American Community Survey (2010-2014). Census tract short sleep prevalence estimates ranged from 19.8% to 59.8%.

Prevalence of Short Sleep Duration (<7 hours) for Adults Aged ≥ 18 Years, by Census Tract, United States, 2014

Map displaying model-based prevalence of short sleep duration (<7 hours), by census tract in the United States, 2014. Data sources for development of model included CDC’s Behavioral Risk Factor Surveillance System (2014), the U.S. Census (2010), and the American Community Survey (2010-2014). Census tract short sleep prevalence estimates ranged from 19.8% to 59.8%.


Sleep is profoundly altered during the course of infectious diseases. The typical response to infection includes an initial increase in nonrapid eye movement sleep (NREMS) followed by an inhibition in NREMS. REMS is inhibited during infections. Bacterial cell wall components, such as peptidoglycan and lipopolysaccharide, macrophage digests of these components, such as muramyl peptides, and viral products, such as viral double-stranded RNA, trigger sleep responses. They do so via pathogen-associated molecular pattern recognition receptors that, in turn, enhance cytokine production. Altered sleep and associated sleep-facilitated fever responses are likely adaptive responses to infection. Normal sleep in physiological conditions may also be influenced by gut microbes because the microbiota is affected by circadian rhythms, stressors, diet, and exercise. Furthermore, sleep loss enhances translocation of viable bacteria from the intestine, which provides another means by which sleep–microbe interactions impact neurobiology.

Connie Dello Buono and Michelle Benedicto are writing an ebook ‘About Cancer’, a recipe and lifestyle to fight cancer growth, stories, research and how tos from kitchen to table, from hands to healing and from exercise to cell growth.

We wanted to ask you what moves you to read a book about cancer written by the non-medical pros.


Melatonin – anti-aging and potent antioxidant

Melatonin is best for those over 50 yrs of age and should be taken an hour before sleeping. I take it with magnesium and calcium.  I turn off lights and noises to go to sleep.


Melatonin, also known as N-acetyl-5-methoxy tryptamine,[1] is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness.[Melatonin is also produced in plants where it functions as a first line of defense against oxidative stress.

In animals, melatonin is involved in the entrainment (synchronization) of the circadian rhythms including sleep-wake timing, blood pressure regulation, seasonal reproduction, and many others.[4] Many of its biological effects in animals are produced through activation of melatonin receptors,[5] while others are due to its role as an antioxidant,[6] with a particular role in the protection of nuclear and mitochondrial DNA.




Melatonin Influences Sleep and Circadian Rhythm

Melatonin is a Potent Antioxidant

  • Melatonin Protects the Mitochondria and Inhibits Programmed Cell Death
    Melatonin Protects Against Mitochondria Toxins
    Melatonin Reduces Inflammation and Promotes Healthy Immune Function

Melatonin and Sleep

  • Melatonin Helps Improves Sleep Quality
  • Melatonin Helps with Jet Lag
    Melatonin Helps with Sleep in Anxiety, Depression and Bipolar Disorders

Melatonin Protects the Brain

  • Melatonin Helps with Brain Regeneration and Neuroplasticity
  • Melatonin Strengthens the Blood-Brain Barrier
  • Melatonin Helps with Recovery from Stroke
  • Melatonin Helps with Traumatic Brain Injury
  • Melatonin Helps with Alzheimer’s
  • Melatonin Helps with Parkinson’s
  • Melatonin Helps with Amyotrophic Lateral Sclerosis (ALS)
  • Melatonin Is Important for Eye Health and Vision
  • Melatonin Help with Glaucoma
  • Melatonin Protects Nerve Cells in the Eyes from Damage from Free Radicals
  • Melatonin Relieves Noises in the Ear (Tinnitus)

Other Health Benefits of Melatonin

  • Melatonin May Help Prevent and Treat Cancer
  • Melatonin Helps Protect Against Diabetes
  • Melatonin Reduces Blood Pressure
  • Melatonin Protects the Heart
  • Melatonin Protects the Stomach
  • Melatonin Helps Treat Acid Reflux (GERD)
  • Melatonin Helps with Aging
  • Melatonin Supplementation May Help with Fertility
  • Melatonin Helps Stop Hair Loss
  • Melatonin Prevents Organ Transplant Complications

Email your experience with Melatonin.

My scientist friend asked how to detox or clean his body from toxins

Over the years, I have experienced family and friends dying of cancer. I observed their lifestyle and toxins they are exposed to. So to answer my friend’s question on how to detox and the mechanism of cleaning our body or getting rid of toxins, I listed some items for Dos and Donts.

Our lymphatic system which travels opposite our blood is responsible for cleaning our blood.  Search for lymphatic, massage and detox in this site

When we clean the many bad foods or toxins that entered our body, we must clean our liver first, our laboratory.  It is closely linked to our heart that during our last breath, our liver is the first and last signal that our heart gets to shut down.

Detox or cleaning our cells from toxins is the key to living longer, the anti-aging process we all are seeking for. In my 50s, I could have died long time ago if I was born centuries ago with no clean water, fresh produce and raising a dozen children. Each child is minus 5 years of a woman’s age.

Detox is like cleaning the toilet. The following are detox tips and anti-aging tips to clean your cells:

Dos in cleansing your body from toxin, also detoxes your liver

  • Massage
  • Adequate sleep
  • Filtered water
  • Lemon
  • Baking soda (pinch in your drinking water)
  • Activated charcoal
  • Digestive enzymes from pineapple and papaya
  • Apple cider vinegar
  • Wash produce with salt or diluted vinegar
  • No over ripe fruits and left over foods or 3-day old rice ( aflatoxin , mycotoxin )
  • No charred BBQ
  • Whole foods ; sulfur rich as they are anti-inflammatory (ginger, garlic, turmeric, coconut, walnuts)
  • Deep breathing thru nose and blow out thru mouth
  • Prayer: May God’s light energy be with you and say Amen to accept it.
  • Resveratrol from Berries, kiwi, citrus fruit
  • Fasting
  • Activated charcoal
  • Clean air

Donts are ways that when practiced or consumed can kills our nerve cells and produce toxins in our cells.

  • Avoidance of too much caffeine, iron and sugar, these are food for cancer
  • Other metal toxins
  • TRANS fat
  • Processed
  • Plastics in food
  • Stress
  • Shift work: not sleeping from 10pm to 4 am
  • Radiation
  • Over medications, chemo, other carcinogens
  • Avoid exposure to fumes, chemicals (formaldehydes,carcinogens,toxins)



Hi Connnie,

And what is your recipe for liver detox and the mechanism by which it works to accomplish that?

From: Male friend in his late 50s whose brother died of pancreatic cancer

Poor sleep may increase your risk of disease

A poor night’s sleep not only makes getting through the day difficult, it also may increase your risk of disease, especially if you suffer from chronic lack of sleep. Inadequate sleep has been associated with obesity, diabetes, stroke, heart disease and cancer.

Studies in recent years have identified a relationship between lack of sleep and some of the top cancers in the United States: breastprostate and colorectal cancers. In addition, research suggests that people who have sleep apnea have an increased risk of developing any type of cancer.

Across the country, at least one in 10 of us experiences some kind of sleep disturbance. Stress, illness, aging and drug treatment are the main culprits. Quality sleep, though, is essential to healing, proper immune function and mental health, making it important for adults to get 7-8 hours of sleep a night.

Researchers continue to study what happens in the sleep-deprived body at a biological level to lead to cancer. They have found that lack of sleep increases inflammation and disrupts normal immune function. Both may promote cancer development. In addition, the hormone melatonin, which is produced during sleep, may have antioxidant properties that help prevent cellular damage.

Here are summaries of recent research linking lack of sleep to cancer:

Prostate cancer: Affecting more men than any other cancer, an estimated 233,000 new cases of prostate cancer are expected in 2014. Last year, a study published in Cancer Epidemiology, Biomarkers and Preventionfound that men who suffer from insomnia may be at increased risk of prostate cancer.

  • Researchers surveyed of 2,102 men and followed the 1,347 men in the group who didn’t fall asleep easily and/or experienced disrupted sleep.
  • After about five years, 135 men developed prostate cancer, with 26 of them having an aggressive form of the disease.
  • Researchers identified a twofold risk of developing prostate cancer in men with sleep insomnia.

Colorectal cancer: It’s estimated that 136,830 men and women will be diagnosed with colorectal cancer in 2014, making it the second most common cancer affecting both sexes after lung cancer. Inadequate sleep may lead to the development on colorectal cancer, according to a 2010 study published in Cancer.

  • Researchers studied the sleep quality of 1,240 people about to have a colonoscopy.
  • 338 study participants were diagnosed with colorectal cancer. Those diagnosed were more likely to average less than six hours of sleep per night.
  • Researchers calculated a 50 percent increased risk of colorectal cancer for people sleeping less than six hours per night.

Breast cancer: An estimated 232,670 women will be diagnosed with breast cancer in 2014. A 2012 studysuggests that women may develop more aggressive breast cancer if they chronically lack sleep.

  • Researchers asked 101 recently diagnosed breast cancer patients about the average amount of sleep they got two years before diagnosis.
  • They found that the post-menopausal women who slept fewer hours had a higher likelihood of cancer recurrence.
  • The study was the first to suggest more aggressive breast cancers are associated with inadequate sleep.
  • ————–

Connie’s comments: I use various herbs and supplements to go to sleep such as magnesium with calcium , Vitamin B complex, other herbs and melatonin. Room temperature of close to 60, dim lights, not so hungry and not so full before bedtime, quiet sounds and comfortable beddings help in getting to sleep.

I also use the Night Time formula from Pharmanex. Join here to order at:


For preventing diabetes, losing weight, clearing up inflammation and turning back the clock, join me at Health Care Network Alliance to measure your anti-oxidant level and supplements which impact your gene expression at :

AgeLoc Youth & lifepak Combo pack
Email Connie or join as consumer/distributor at:
Use my ID when completing the form:

  • Distributorship ID #: USW9578356

Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy

Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period.

The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40—a marker of neuroinflammation/astroglial activation—predicted poor sleep in Aβ positive older adults. Interestingly, although brain atrophy was strongly predictive of poor sleep, the relationships between CSF biomarkers and sleep were completely independent of atrophy. A joint analysis showed that unique variance in sleep was explained by P-tau and the P-tau × Aβ interaction, memory function, depressive symptoms, and brain atrophy. The results demonstrate that sleep relates to a range of different pathophysiological processes, underscoring the importance of understanding its impact on neurocognitive changes in aging and people with increased risk of Alzheimer’s disease.