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Middle age inflammation linked to brain shrinkage decades later

MIDDLE AGE INFLAMMATION LINKED TO BRAIN SHRINKAGE DECADES LATER

NEUROSCIENCE NEWSNOVEMBER 2, 2017
According to a new study, people who have inflammation biomarkers in their blood during middle age are more likely to have increased brain shrinkage as they grow older. Researchers report the brain cell loss associated with inflammation was most prevalent in areas affected in Alzheimer’s disease.… READ MORE…
FEATUREDNEUROLOGY5 MIN READ
a brain

CHEMO BRAIN STARTS DURING CANCER’S PROGRESSION, NOT JUST AFTER TREATMENT

NEUROSCIENCE NEWSNOVEMBER 21, 2017
Chemotherapy is often blamed for memory loss and cognitive problems in cancer survivors. However, new research published in Neuroscience challenges this belief. Researchers report cognitive impairments, often referred to as Chemo Fog, may actually start as the tumor grows and develops.… READ MORE…
BRAIN CANCERFEATUREDNEUROLOGYNEUROSCIENCEPSYCHOLOGY6 MIN READ
Image shows a brain.

HERE’S WHAT WE THINK ALZHEIMER’S DOES TO THE BRAIN

NEUROSCIENCE NEWSNOVEMBER 4, 2017
A new paper explores different findings about the development of Alzheimer’s and considers how personalized treatments may help combat this complex disease.… READ MORE…
FEATUREDNEUROLOGYNEUROSCIENCE6 MIN READ
Image shows a diagram of an alzheimer's brain slice.

NEW BRAIN DEATH PATHWAY IN ALZHEIMER’S IDENTIFIED

NEUROSCIENCE NEWSJULY 24, 2017
A new Nature Neuroscience study provides evidence that necroptosis is linked to cognitive decline and severity of Alzheimer’s disease. The finding that necroptosis is activated in Alzheimer’s provides a plausible mechanism that underlies the neuron loss associated with the disease.… READ MORE…
FEATUREDGENETICSNEUROLOGYOPEN NEUROSCIENCE ARTICLES7 MIN READ
Image shows a bar of chocolate and a bottle of wine.

RESVERATROL MAY RESTORE INTEGRITY OF BLOOD-BRAIN BARRIER IN ALZHEIMER’S

NEUROSCIENCE NEWSJULY 27, 2016
Researchers report resveratrol, a naturally occurring compound found in red wine and dark chocolate, appears to improve the integrity of the blood brain barrier in patients with Alzheimer’s disease.… READ MORE…
FEATUREDNEUROLOGY5 MIN READ
The image shows hippocampal neurons and dendrites.

STUDY SUGGESTS DISRUPTIVE EFFECTS OF ANESTHESIA ON BRAIN CELL CONNECTIONS ARE TEMPORARY

NEUROSCIENCE NEWSJULY 28, 2014
A new study of brain cells from juvenile rats suggests the effects of a common anesthetic, isoflurane, on the connections between neurons are temporary.… READ MORE…
ELECTROPHYSIOLOGYFEATUREDNEUROSCIENCEOPEN NEUROSCIENCE ARTICLES8 MIN READ
This is a CT scan of a person with TBI.

SCIENTISTS DISCOVER ENVIRONMENTAL ENRICHMENT FOR TBI PATIENTS COULD COUNTER SHRINKAGE IN THE BRAIN

NEUROSCIENCE NEWSSEPTEMBER 24, 2013
For those with moderate-to-severe TBI, atrophy may be countered by participating in environmental enrichment, a new study suggests.… READ MORE…
FEATUREDNEUROLOGYOPEN NEUROSCIENCE ARTICLES4 MIN READ
Image shows a rat.

SPRINKLING OF NEURAL DUST OPENS DOOR TO ELECTROCEUTICALS

NEUROSCIENCE NEWSAUGUST 3, 2016
Researchers have developed a dust sized wireless sensor that can be implanted into the body.… READ MORE…
FEATUREDMOST POPULARNEUROSCIENCENEUROSCIENCE VIDEOSOPEN NEUROSCIENCE ARTICLES9 MIN READ
Image shows how myelin is affected in MS.

REPLACING DISEASED IMMUNE SYSTEM HALTS PROGRESS OF MULTIPLE SCLEROSIS AND ALLOWS REPAIR

NEUROSCIENCE NEWSJUNE 10, 2016
Researchers report a procedure that wipes out the immune system and then regenerates a new one using stem cells may effectively eliminate all signs of neuroinflammation in people with early, aggressive MS.… READ MORE…
FEATUREDNEUROLOGYNEUROSCIENCE VIDEOS11 MIN READ
Labelled diagram of the human brain.

RESEARCHERS SUPPRESS ALZHEIMER’S ASSOCIATED NEURONAL DEATH AND OXIDATIVE STRESS

NEUROSCIENCE NEWSFEBRUARY 26, 2016
Researchers have successfully designed mitochondria-specific ceria nanoparticles which appear to be capable of suppressing neuronal death associated with Alzheimer’s disease.… READ MORE…
FEATUREDNEUROLOGY5 MIN READ
Image shows neurons and microglia.

HIGH FAT DIETS PROMPT IMMUNE CELLS TO MUNCH AT SYNAPSES

NEUROSCIENCE NEWSNOVEMBER 23, 2015
According to researchers, high fat diets appear to prompt microglia to start consuming synapses in mice.… READ MORE…
FEATUREDNEUROSCIENCE7 MIN READ
This image shows two sections of cortex, one froma a control mouse and the other from a mouse with the presenilin-1 mutation.

HOW GENETIC CHANGES LEAD TO FAMILIAL ALZHEIMER’S DISEASE

NEUROSCIENCE NEWSMARCH 11, 2015
New findings could help provide a novel approach for developing treatments for familial Alzheimer’s disease.… READ MORE..
Posted byconnie dello buonoFebruary 12, 2018Posted inMenuTags:brain, Inflammation, middle age, shrinkLeave a comment on Middle age inflammation linked to brain shrinkage decades later

Alter your life by altering your attitude

alter your life

My 21 yr old daughter over heard her dad saying the possibility of a scary scenario when in jail just by wearing pajama while driving. She said that is so negative mom and I’m glad you are not living here to hear that always.

Being positive in life will bring you good health. I have seen many seniors living in their 90s and even 100s and they are always happy and walking. Their memory might not be complete but they can walk and are always happy.

We take care of bay area seniors and provide happiness and companionship to them to live a quality life.

All cities are served by our caregivers for in home senior health care and support and referrals to care homes and nursing homes: Atherton, Menlo Park, Santa Clara county, Los Altos, Saratoga, Mountain View, Peninsula and San Mateo.

A care team involved more than 3 people who monitors the caregivers and clients.

Massage, help with exercise, light housekeeping, cooking, driving and assistance in daily living are part of the job.

And treating each client like family is important.

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Posted byconnie dello buonoFebruary 12, 2018Posted inMenuTags:bay area seniors, Caregiver, Older AdultsLeave a comment on Alter your life by altering your attitude

Sucrose, gut bacteria, toxins, and muscle integrity

Relationships between diet-related changes in the gut microbiome …

https://www.ncbi.nlm.nih.gov/pubmed/25982560

by KR Magnusson – ‎2015 – ‎Cited by 66 – ‎Related articles

May 14, 2015 – Relationships between diet-related changes in the gut microbiome and cognitive flexibility. Magnusson KR(1), Hauck L(2), Jeffrey BM(3), Elias V(4), … Western diets are high in fat andsucrose and can influence behavior and gut microbiota. There is growing evidence that altering the microbiome can …

Artificial Sweeteners May Change Our Gut Bacteria in Dangerous …

https://www.scientificamerican.com/…/artificial-sweeteners-may-change-our-gut-bacte…

Apr 1, 2015 – Bacterial gluttons. In the Israeli experiment, 10-week-old mice were fed a daily dose of aspartame, sucralose or saccharin. Another cluster of mice were given water laced with one of two natural sugars, glucose or sucrose. After 11 weeks, the mice receiving sugar were doing fine, whereas the mice fed …

Sugar Substitutes, Gut Bacteria, and Glucose Intolerance – The Scientist

https://www.the-scientist.com/?articles.view/articleNo/41033/title/…Gut-Bacteria…

Sep 17, 2014 – Four weeks of treatment with gut bacteria-depleting antibiotics reversed the glucose intolerance in mice that continued to receive saccharin. This led …. Not very many humans eat food without any sucrose or something related to it (like HFCS) so as far as I’m concerned it’s relevant impact on obesity is not …

Your Microbiome on Sugar – Hyperbiotics

https://www.hyperbiotics.com/blogs/recent-articles/your-microbiome-on-sugar

The beneficial bacteria—also called probiotics—in our gut (where most of our microbes live) are responsible for a variety of health-promoting functions, like regulating … Simple sugars—like sucrose(table sugar), fructose (naturally occurring in fruits and vegetables), and glucose—are carbohydrates found naturally in some …

Is Sugar Toxic? Health Effects Of Sucrose, Fructose Spotlighted In …

https://www.huffingtonpost.com/…/sugar-toxic-health-effects-sucrose-fructose_n_359…

Jul 16, 2013 – In contrast, the fructose in an apple does not reach the liver all at once. All the fiber in the fruit—such as cellulose that only our gut bacteria can break down—considerably slows digestion. Our enzymes must first tear apart the apple’s cells to reach the sugars sequestered within. “It’s not just about the fiber in …

Artificial Sweeteners Could Harm Gut Microbiota | Gastrointestinal …

https://www.badgut.org/…centre/a…/artificial-sweeteners-could-harm-gut-microbiota/

Nov 22, 2016 – In this study, a few weeks after researchers fed healthy mice water, or water containing sugar (either glucose or sucrose), or water containing an artificial sweetener, … Since modifying gut bacteria turned on or off glucose tolerance, they concluded that this is likely how these sweeteners have their effect.

Carbohydrates, Gut Flora, and Leaky Gut Syndrome – At the Roots …

http://www.cfnaturalhealth.com/carbohydrates-gut-flora-and-leaky-gut-syndrome.html

Our gut bacteria provide us with innumerable services that scientists are only beginning to discover, including regulating our immune systems, producing hormones …. Without these enzymes doing their jobs, carbohydrates like lactose and sucrose are no longer absorbed and so they are flushed down to the lower intestines …

High Fat and Sugar Diets May Lead to Loss of Cognitive Flexibility …

neurosciencenews.com/diet-gut-bacteria-cognition-2147/

Jun 22, 2015 – A study at Oregon State University indicates that both a high-fat and a high-sugar diet, compared to a normal diet, cause changes in gut bacteria that … Some similarities in alterations in the microbiome were seen in both the high-fat and high-sucrose diets (e.g., increased Clostridiales), as compared to the …

Metabolic Effects of Sucralose on Environmental Bacteria – Hindawi

https://www.hindawi.com/journals/jt/2013/372986/

by A Omran – ‎2013 – ‎Cited by 13 – ‎Related articles

Nov 10, 2013 – It has been found throughout the domain Bacteria: in extremophiles, gut flora, and environmental bacterial species and has a high percent of homology between clades (9; 10; 11; 12). Invertase is an enzyme that catalyzes the breakdown of sucrose into glucose and fructose. The initial reaction rate and …

A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity – Nature

http://www.nature.com › scientific reports › articles

by KH Collins – ‎2016 – ‎Cited by 11 – ‎Related articles

Nov 17, 2016 – Furthermore, the gut microbiota may be a potential link between high-fat high-sucrose(HFS) diet, systemic chronic inflammation, and musculoskeletal integrity. ….. Specifically, others have shown that high fat diet increases gut permeability, which allows bacterial lipopolysaccharide (LPS) translocation.

Posted byconnie dello buonoFebruary 12, 2018February 12, 2018Posted inMenuTags:bacteria, cancer, disease, fat, gut, HEART, metabolism, Muscle, obesity, sucrose, sugar, toxinLeave a comment on Sucrose, gut bacteria, toxins, and muscle integrity

Smart pills

via Smart pills

Posted byconnie dello buonoFebruary 12, 2018Posted inMenuLeave a comment on Smart pills

Smart pills

Smart pills can be a product of the food, lifestyle, emotions, environment, dietary supplements and other unknown factors to prolong aging and quality of life.

I believed that health starts with the diet and lifestyle of the mother 3 months before you are concieved.

Email motherhealth@gmail.com for a personalized healthy regimen with consideration on where and how you live, dietary supplements, foods and current health issues.

I always ask if you mother breastfed you and if you are a military veteran. Your stress level and if there if filtered water in your house. Sunshine exposure and other factors I consider important in your overall health.

Virus from molds, fungus and other environmental stressors can be the root cause of many health issues. Stress and lack of exercise or sunshine can help inflammation to spread.

Inadequate sleep and diet lacking in Vitamin C , B and D can also impair the body’s ability to heal.

We train caregivers in the bay area to consider all these factors when caring for our senior population. We incorporate massage, music, exercise, gourmet cooking and a caring companion to lessen anxiety and ease the pain of older adults with health issues needed 24/7 care at home.

Connie

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This image shows an outline of a head with a+ written in pills.

THE RACE TO THE TOP: THE USE OF ‘SMART DRUGS’ TO EXCEL IN ACADEMIA AND IN THE PROFESSIONAL WORLD

NEUROSCIENCE NEWSMAY 30, 2014
Zaheera Shabbir presents her opinion about the use of nootropics as smart drugs to enhance cognitive abilities. … READ MORE…
FEATUREDNEUROETHICSNEUROSCIENCE OPINIONS10 MIN READ
Image shows a car exhaust.

TRAFFIC POLLUTION PREVENTS CHILDREN’S BRAINS FROM REACHING THEIR FULL POTENTIAL

NEUROSCIENCE NEWSOCTOBER 8, 2017
Previous research has linked traffic pollution to brain development issues in children. A new paper looks at steps being taken to improve air quality and reduce the impact of air pollution on neurodevelopment.… READ MORE…
FEATUREDNEUROSCIENCE6 MIN READ
Image shows a screen shot of the game.

NEW ONLINE GAME INVITES PUBLIC TO HELP FIGHT ALZHEIMER’S

NEUROSCIENCE NEWSOCTOBER 11, 2016
Citizen scientists can help get involved in finding a cure for Alzheimer’s disease by participating in a new online game.… READ MORE…
FEATUREDNEUROLOGY3 MIN READ
This shows a tDCS device over a brain.

TRANSCRANIAL DIRECT CURRENT BRAIN STIMULATION METHOD DETRIMENTAL TO IQ SCORES

NEUROSCIENCE NEWSMAY 5, 2015
A new study reports tDCS has mixed results when it comes to cognitive enhancement.… READ MORE…
FEATUREDPSYCHOLOGY8 MIN READ
This image shows the researchers and equipment used for the experiment.

RESEARCHERS UNTANGLE THE BIOLOGICAL EFFECTS OF BLUE LIGHT

NEUROSCIENCE NEWSOCTOBER 20, 2014
Melanopsin and S-cones battle for control of the pupil under blue light. … READ MORE…
FEATUREDNEUROSCIENCEOPEN NEUROSCIENCE ARTICLES5 MIN READ
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NEUROSCIENTISTS BOOST MEMORY USING GENETICS AND MEMORY ENHANCING DRUG

NEUROSCIENCE NEWSDECEMBER 15, 2011
When the activity of a molecule that is normally elevated during viral infections is inhibited in the brain, mice learn and remember better, researchers at Bayl… READ MORE…
Posted byconnie dello buonoFebruary 12, 2018Posted inMenuTags:smart pills2 Comments on Smart pills

Health IT News

Headlines

Rideshare-Based Transportation Services And Missed Primary Care Appointments
Tweet | JAMA

GE’s Jeff Immelt To Chair Athenahealth
Tweet | CNBC

UK Wait Times For Young Mental Health Patients Down From A Year To Six Weeks
Tweet | HeraldScotland

Spending Bill Signed Into Law: Here Are Health IT’s Biggest Wins
Tweet | Healthcare IT News

The Diseases We Aren’t Curing And Why
Tweet | Fortune

Watch: Japan Faces Superaging Population With Robots And Virtual Reality
Tweet | STAT

Oscar Health Is Having A Huge Growth Year
Tweet | Modern Healthcare

With Startup, George Church Bets Cryptocurrency Will Boost DNA Sequencing
Tweet | STAT

Rock Health in the News

Study: Virta’s Monitoring App Plus Low-Carb Diet Reverses Diabetes Progression
Tweet | MobiHealthNews

Wyoming Introduces mHealth App For Public, Population Health (Wildflower Health)
Tweet | mhealthintelligence

Posted byconnie dello buonoFebruary 12, 2018Posted inMenuLeave a comment on Health IT News

Estate plan and the new tax law

Estate plan and the new tax law

An estate plan is like a car or a house: It needs regular maintenance to function as intended. Yet unlike your car or home, external events can create the need for adjustments. Among such events is legislation like the tax bill Congress passed in late December.

So this is an important time to schedule a meeting with your estate planner and be certain your plan is up-to-date. Even if your estate plan won’t be affected by the new tax law, it’s smart to confer with your estate planner periodically to be certain your current wishes are reflected in your estate planning documents.

During this checkup, you may find that your plan no longer meets all of your needs because of changes in your life and the lives of your heirs. Or you may find that your plan didn’t cover your needs from the get-go. In my experience, many clients leave their estate planner’s office with a thick folder of documents and fail to read them carefully or discuss them in detail with their planner before signing.

When you meet with a professional for a thorough evaluation and possible updating, you might ask these key questions to assure your plan documents fully support your interests and those of your heirs.

1. Will the new federal law affect my estate tax picture?

Estate tax is the tax that estates pay governments upon death; when it applies, there’s less left for your heirs. The federal government exempts a certain amount of an estate’s value from this tax and Congress just doubled that amount, known as the exemption. The new law eliminated tax on estates for many wealthy families.

There will no longer be any federal tax on estates valued between $5.6 million and $11.2 million. Previously, the limit was $5.6 million. By exempting estates between $5.6 million and $11.2 million ($22.4 million for married couples), Congress gave substantial relief to all but the wealthiest families, since only about 5,000 estates a year are estimated to be above the new limit. So unless you’re rich (but not ultrarich), the doubling of the exemption shouldn’t affect your estate plan.

2. What does the new tax law mean by the exemption limit for married couples?

This can be confusing, since couples generally die one spouse at a time. The exemption limit for couples refers to portability — the ability of a spouse to avoid estate tax on amounts inherited from the other spouse that were within the exemption limits. The new law preserves portability, which was introduced in a revision of tax rules by Congress in 2012.

Related: The Trump tax calculator — will you pay more or less?

To assure that exemption limits from the estate of a deceased spouse are portable, estate planning documents of the surviving spouse must correctly invoke portability, using the right language. Otherwise, the estates of these spouses might be forced to create something known as a bypass trust — a costly, time-consuming route that can have the effect of reducing the amounts that heirs ultimately receive.

3. Will the new federal law affect my state estate tax?

There are 15 states that still have some form of estate tax: Minnesota, Iowa, Nebraska, Washington, Oregon, Kentucky, Tennessee, Pennsylvania, New Jersey, Massachusetts, Rhode Island, Connecticut, Delaware, Maryland and the District of Columbia.

Also read: The problems with doing your own estate planning

Some of these states yoke their exemption limits to the federal limits, so the federal increase will automatically trigger the same increase in those states. But some of these states have no such linkage, so their exemption limits will remain the same, assuming their legislatures don’t act to change them. (Some states have limits under $1 million.)

Detailed, state-by-state information on estate tax can be found on the Tax Foundation website.

4. Are my estate documents customized to fulfill my wishes and avoid unintended consequences?

Outcomes directly contrary to your intentions can result when documents aren’t specific enough because boilerplate, off-the-shelf documents were used without being customized to your situation. It’s not uncommon for this to happen with financial powers of attorney (POA), which direct how your finances are to be managed if you’re incapacitated and unable to make decisions.

Without specific provisions to assure your wishes are carried out, vague or overly general POAs — which don’t include specific provisions of wishes, limits and prohibitions — might allow the agent managing these finances (often, the person’s spouse) to:

  • Legally make gifts to whomever they wish and change beneficiaries on financial accounts — 401(k)s, IRAs, life insurance policies and annuities. In some cases, agent spouses have made gifts to themselves or their grown children from their first marriages or have designated these grown children as account beneficiaries without express permission.
  • Discontinue existing financial support for an aging parent or a disabled child
  • Manage the incapacitated individual’s assets in ways that person never would, such as taking risks that jeopardize the inheritance of heirs listed in the incapacitated person’s will

To prevent such negative outcomes, ask your estate planner to assure that your POA is specific enough.

Don’t miss: How to provide for your pet in your estate plan

5. How soon should I come in for another review of my estate plan?

Many experts advise doing a review every three years, and/or after major life changes, including: your divorce or the divorce of a grown child; the birth of a grandchild; your receipt of a significant inheritance; the sale of your business; your retirement; newly developed disabilities or chronic illnesses or a death in your family.

An estate plan should change with changing circumstances. By attending to this, you can show your loved ones that you cared about outcomes affecting them after you’re gone.

David Robinson is a Certified Financial Planner and founder/CEO of RTS Private Wealth Management in Phoenix.

This article is reprinted by permission from NextAvenue.org, © 2018 Twin Cities Public Television, Inc. All rights reserved.

More from Next Avenue:

  • 9 Steps to Getting Your Estate Plan in Order
  • 5 Steps to Creating Your Digital Estate Plan
  • Do You Need a Trust for Your Estate Plan?

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Posted byconnie dello buonoFebruary 12, 2018Posted inestate planning, taxesLeave a comment on Estate plan and the new tax law

Start dating, stop swiping and texting

via Start dating, stop swiping and texting

Posted byconnie dello buonoFebruary 12, 2018Posted inMenuLeave a comment on Start dating, stop swiping and texting

Start dating, stop swiping and texting

There is meetup.com and www.thetonightapp.com (in iphones only) to find a date and suggested place to date.

Action speaks louder than words. Men who choose to text only and not meet have a disadvantage.

So meet your date in person. And get an idea of who the person is. Ask the three most important questions dear to your heart and if the answers are satisfactory based on your standards, you found the person you want to spend some time with.

Dress to impress, choose a relaxing and romantic environment. In a coffee or tea restaurant, know that chocolate can be an aphrodisiac to both sexes.

Two-way
A good conversation is where both parties get a chance to talk and to listen. Men should be aware that women expect them to take turns in the conversation, and for every question he answers, he should ask one of her.

Tone
Keep the conversation light and positive. This is not the time to complain about your job, criticize the food or grumble about traffic. Sharing problems this early can feel like complaining or neediness to the other person. The first date is your opportunity to express your best self to the other person and negativity can be a real turn-off.

Topics
Discussing very personal issues can easily scare off a prospective relationship. These include your political beliefs, your medical history and especially your past relationships. This also means you shouldn’t ask your date about these topics. Keep it light and discuss your favorite movies, music, places you have been and things you like to do

Email motherhealth@gmail.com for any suggestions on how to succeed on your first date. Success means getting a second date.

Connie

Posted byconnie dello buonoFebruary 12, 2018February 12, 2018Posted inlove, Menu1 Comment on Start dating, stop swiping and texting

Hospital aroma and smell of Rosemary can aid children’s working memory

via Hospital aroma and smell of Rosemary can aid children’s working memory

Posted byconnie dello buonoFebruary 12, 2018Posted inMenuLeave a comment on Hospital aroma and smell of Rosemary can aid children’s working memory

Hospital aroma and smell of Rosemary can aid children’s working memory

Do you like the smell of the hospital?

If you are recovering from your illness, it is best to stay at home in the company of a caring caregiver.

The brain is influenced by the smell of our environment. Some carbon monoxide poisoning and other toxic chemicals affect our brain. Some essential oils can influence our brain. Can you heal your cells from the aroma of various plants and oils?

I use lavender essential oils to our senior clients to calm them during the massage. I cooked cinnamon, vanilla and rosemary in many dishes to increase appetite.

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nasal tissue

WHEN THE NOSE DOESN’T KNOW: CAN SMELL LOSS BE REPAIRED?

NEUROSCIENCE NEWSDECEMBER 4, 2017
A study in mice reveals it is possible to regenerate stem cells of the nasal tissue.… READ MORE…
FEATUREDGENETICSNEUROLOGYNEUROSCIENCE7 MIN READ
Image shows a scared looking woman.

AUTISM AND THE SMELL OF FEAR

NEUROSCIENCE NEWSNOVEMBER 27, 2017
People on the autism spectrum appear to have different reactions to subliminal social odors, researchers report.… READ MORE…
AUTISMFEATUREDNEUROSCIENCE7 MIN READ
man smelling rose

SMELL TEST CHALLENGE SUGGESTS CLINICAL BENEFIT FOR SOME BEFORE DEVELOPMENT OF ALZHEIMER’S

NEUROSCIENCE NEWSNOVEMBER 10, 2017
Columbia researchers have identified a way in which to determine if a patient with MCI may respond to cholinesterase inhibitors.… READ MORE…
FEATUREDNEUROLOGY4 MIN READ
Image shows a clock with plots to show greatest olfaction sensitivity times.

SMELL SENSITIVITY VARIES WITH CIRCADIAN RHYTHM

NEUROSCIENCE NEWSOCTOBER 26, 2017
According to Brown researchers, our sensitivity to smells varies over the course of the day and the patterns rely on our circadian rhythm. Researchers comment the link may contribute to eating habits in teens, potentially elevating obesity risks. … READ MORE…
FEATUREDNEUROSCIENCE8 MIN READ
Image shows a C.elegans.

WORMS LEARN TO SMELL DANGER

NEUROSCIENCE NEWSOCTOBER 17, 2017
Researchers report worms can learn to activate a defense mechanism that protects cells from damage.… READ MORE…
FEATUREDNEUROSCIENCE6 MIN READ
Image shows a cartoon of a woman.

NEW SMELL TEST COULD AID EARLY DETECTION OF ALZHEIMER’S AND PARKINSON’S

NEUROSCIENCE NEWSOCTOBER 10, 2017
Rockefeller researchers have developed a new diagnostic test that could help with early detection of disorders associated with olfaction problems, such as Alzheimer’s and Parkinson’s.… READ MORE…
FEATUREDNEUROLOGY7 MIN READ
olfaction

KEY TO LOSS OF SMELL IN PARKINSON’S DISCOVERED

NEUROSCIENCE NEWSSEPTEMBER 20, 2017
Loss of the sense of smell is a common symptom of Parkinson’s disease that often precedes motor deficits. A new study may provide clues as to why the sense of smell diminishes in people with Parkinson’s.… READ MORE…
FEATUREDNEUROLOGYOPEN NEUROSCIENCE ARTICLES8 MIN READ
Image shows a woman sniffing a flower.

SMELL TEST COULD TRACK ALZHEIMER’S PROGRESSION

NEUROSCIENCE NEWSAUGUST 16, 2017
McGill university researchers have devised a new odor identification test that could help doctors predict those at risk of Alzheimer’s and track the progression of the disease.… READ MORE…
FEATUREDNEUROLOGY6 MIN READ
Image shows a fat mouse and a thin mouse.

CAN THE SMELL OF FOOD MAKE YOU FAT?

NEUROSCIENCE NEWSJULY 5, 2017
According to a new study, your sense of smell could be responsible for weight gain. Using mice, researchers noticed that those who lost their sense of smell also lost weight, while those mice with a super sense of smell gained more weight on a high fat diet than mice with a regular sense of smell. Findings suggest odor may play an important role in calorie burning processes; if you can’t smell your food, you may burn it rather than store it.… READ MORE…
FEATUREDNEUROSCIENCEOPEN NEUROSCIENCE ARTICLESPSYCHOLOGY9 MIN READ
Image shows a girl sniffing a flower.

HUMAN SENSE OF SMELL IS STRONGER THAN WE THINK

NEUROSCIENCE NEWSMAY 11, 2017
A new study sniffs out the myth that has existed for over 150 years, without scientific proof, and finds the sense of smell in humans is just as good as in other mammals.… READ MORE…
FEATUREDNEUROSCIENCE6 MIN READ
Image shows an old man smelling a flower.

PROBING POSSIBLE REASONS FOR SMELL LOSS

NEUROSCIENCE NEWSMAY 10, 2017
Problems with olfaction associated with Alzheimer’s could be a result of damage to neurotransmitter and neuromodulator neurons in the forebrain, a new study reports.… READ MORE…
FEATUREDNEUROLOGY6 MIN READ
Image shows a sprig of rosemary.

SMELL OF ROSEMARY CAN AID CHILDREN’S WORKING MEMORY

NEUROSCIENCE NEWSMAY 3, 2017
According to researchers, the aroma of rosemary essential oils could help enhance cognitive performance of children in a classroom setting.… READ MORE…
Posted byconnie dello buonoFebruary 12, 2018Posted inMenuTags:Alzheimer's, brain, essential oils, herb, nose, parkinson's, rosemary, smell2 Comments on Hospital aroma and smell of Rosemary can aid children’s working memory

Basic ROI Calculation

Basic ROI Calculation

A review of the basic ROI calculation and its use within IT project proposals

ROI (return on investment) is a widely used measure to compare the effectiveness of IT systems investments. It is commonly used to justify IT projects, but can measure project returns at any stage.

Definition of ROI

The basic ROI calculation is to divide the net return from an investment, by the cost of the investment and express this as a percentage. ROI, whilst a simple and extremely popular metric, it may be easily modified for different situations.

The ROI formula is:

ROI % = (Return – Cost of Investment) divided by the Cost of Investment x 100

Additional definitions:

  • The basic roi calculation is also known as: ROR (rate of return), Rate of profit.
  • The return is also known as: money gained or lost on an investment, profit or loss, gain or loss, net income or loss.
  • The cost of investment is also known as: investment, capital, principal, costs.
  • Using ROI within IT projects

Comparing the ROI of different projects / proposals provides an indication as to which IT projects to undertake. ROI proves to corporate executives / shareholders / other stakeholders that a particular project investment is beneficial for the business.

A project is more likely to proceed if its ROI is higher – the higher the better. For example, a 200% ROI over 4 years indicates a return of double the project investment, over a 4 year period.

Financially, it makes sense to choose projects with the highest ROI first, then those with lower ROI’s. Whilst there are exceptions, if a project has a negative ROI, it is questionable if it should be authorised to proceed.
Issues with using basic ROI calculations

ROI calculations can be manipulated if you are not careful.

Project savings / income and expenditures should be measurable and realistic. But sometimes they are not always easily measurable and their realism is questionable.

Project benefits may be attributable to more than one improvement – so care needs to be taken to ensure no double counting.

It is not always possible when forecasting costs and benefits, to obtain a high degree of certainty with the project costs and benefits.

Tangible benefits

IT system projects ROI should be based on tangible (or hard) benefits. Examples of tangible IT benefits (project savings / income) include:

  • travel reduction eg online meetings replacing face-to-face meetings, remote support replacing onsite support
  • time saved eg increased productivity and reduction in time to complete tasks
  • time saved eg from reduced length / number of customer service calls
  • time saved from reduced numbers of errors
  • time saved from improved system reliability and having less maintenance or fewer problems to resolve
  • time saved with improved software vendor support eg quicker responses, faster fixes

Intangible benefits

Intangible (or soft or non-financial) benefits should not be included within ROI calculations. Whilst they are often as important as tangible benefits, they are very difficult to financially quantify. Instead intangible benefits should be fully explained within the business case and where possible details given of any quantification or measurement. Examples of intangible IT benefits include:

  • increased customer satisfaction
  • ability to offer improved customer service and support
  • increased usability leading to increased sales
  • increased user satisfaction
  • improved / automated business processes that the new system supports and enables
  • faster and more accurate information
  • improved analytical solutions
  • better forecasting
  • better controls to improve data input accuracy
  • improved software vendor support and service, improved communications, better knowledge of software, system set up

Calculation criteria

The total time scale for calculating ROI for IT projects may vary. Three years is common for hardware projects, as technology is often obsolete after 3 years. However, 5 or more years may be used for a new software system. For example, a new HR system is unlikely to be completely replaced within this time scale, though likely to be kept up to date with regular maintenance. Consider calculating ROI with either quarterly or yearly timelines.

Consistency: The ROI calculations should be consistently applied across all IT system projects. Consistency also applies to the assumptions behind the ROI calculations eg treatment of inflation, taxation (corporate and VAT/sales taxes).

Over-precision versus overly rounded figures. Details shown to the last $ leads users to believe in a spurious accuracy, when $’000 would be more appropriate. Equally, every figure being rounded with two or more zeros, leads users to believe that calculations are fairly inaccurate. A balance has to be struck, combined with the need to be as certain and accurate as possible.

Ways to improve the project ROI include:

  • increase project benefits / cost savings – easier to quantify, but costs can only be reduced so much
  • increase project benefits / revenues – harder, if not impossible to quantify – but can be much larger
  • decrease project costs – easy to quantify, but potentially limited
  • timing – deferring project costs or bringing project benefits forward

Whatever changes are made, they have to be realistic and measurable.

Situations when a ROI calculation may not be useful

ROI may not be useful in every IT project situation eg:

  • expenditure such as IT consumables, replacing broken PC’s
  • projects that do not produce cost savings / income – as any ROI will be zero or negative
  • projects which only have intangible benefits and no measurable financial benefits

Other ROI calculations 

Other calculations that are typically produced at the same time as calculating ROI are:

NPV (net present value) ie the return a project will make at a specified discount rate. Ideally this should be a high / positive value.

IRR (internal rate of return) ie the yearly return % of the investment – the higher, the better.

Payback years (also known as break even point) ie the number of years it takes to get the investment back. The shorter the payback, the better.

Today, no project has an automatic right to approval and a budget. Decisions to invest in IT systems projects have to compete with all other business areas and their needs / proposals. But achieving a good ROI and high NPV / IRR with a quick payback, will put IT systems proposals to the top of any choice.

Visit return on investment calculator to download a free ROI calculator for your IT system projects.

http://www.axia-consulting.co.uk/html/basic_roi_calculation.html

ROI (return on investment) is a widely used measure to compare the effectiveness of IT systems investments. It is commonly used to justify IT projects, but can measure project returns at any stage.

Definition of ROI

The basic ROI calculation is to divide the net return from an investment, by the cost of the investment and express this as a percentage. ROI, whilst a simple and extremely popular metric, it may be easily modified for different situations.

The ROI formula is:

ROI % = (Return – Cost of Investment) divided by the Cost of Investment x 100

Additional definitions:

  • The basic roi calculation is also known as: ROR (rate of return), Rate of profit.
  • The return is also known as: money gained or lost on an investment, profit or loss, gain or loss, net income or loss.
  • The cost of investment is also known as: investment, capital, principal, costs.

Using ROI within IT projects

Comparing the ROI of different projects / proposals provides an indication as to which IT projects to undertake. ROI proves to corporate executives / shareholders / other stakeholders that a particular project investment is beneficial for the business.

A project is more likely to proceed if its ROI is higher – the higher the better. For example, a 200% ROI over 4 years indicates a return of double the project investment, over a 4 year period.

Financially, it makes sense to choose projects with the highest ROI first, then those with lower ROI’s. Whilst there are exceptions, if a project has a negative ROI, it is questionable if it should be authorised to proceed.

Issues with using basic ROI calculations

ROI calculations can be manipulated if you are not careful.

Project savings / income and expenditures should be measurable and realistic. But sometimes they are not always easily measurable and their realism is questionable.

Project benefits may be attributable to more than one improvement – so care needs to be taken to ensure no double counting.

It is not always possible when forecasting costs and benefits, to obtain a high degree of certainty with the project costs and benefits.

Tangible benefits

IT system projects ROI should be based on tangible (or hard) benefits. Examples of tangible IT benefits (project savings / income) include:

  • travel reduction eg online meetings replacing face-to-face meetings, remote support replacing onsite support
  • time saved eg increased productivity and reduction in time to complete tasks
  • time saved eg from reduced length / number of customer service calls
  • time saved from reduced numbers of errors
  • time saved from improved system reliability and having less maintenance or fewer problems to resolve
  • time saved with improved software vendor support eg quicker responses, faster fixes

Intangible benefits

Intangible (or soft or non-financial) benefits should not be included within ROI calculations. Whilst they are often as important as tangible benefits, they are very difficult to financially quantify. Instead intangible benefits should be fully explained within the business case and where possible details given of any quantification or measurement. Examples of intangible IT benefits include:

  • increased customer satisfaction
  • ability to offer improved customer service and support
  • increased usability leading to increased sales
  • increased user satisfaction
  • improved / automated business processes that the new system supports and enables
  • faster and more accurate information
  • improved analytical solutions
  • better forecasting
  • better controls to improve data input accuracy
  • improved software vendor support and service, improved communications, better knowledge of software, system set up

Calculation criteria

The total time scale for calculating ROI for IT projects may vary. Three years is common for hardware projects, as technology is often obsolete after 3 years. However, 5 or more years may be used for a new software system. For example, a new HR system is unlikely to be completely replaced within this time scale, though likely to be kept up to date with regular maintenance. Consider calculating ROI with either quarterly or yearly timelines.

Consistency: The ROI calculations should be consistently applied across all IT system projects. Consistency also applies to the assumptions behind the ROI calculations eg treatment of inflation, taxation (corporate and VAT/sales taxes).

Over-precision versus overly rounded figures. Details shown to the last $ leads users to believe in a spurious accuracy, when $’000 would be more appropriate. Equally, every figure being rounded with two or more zeros, leads users to believe that calculations are fairly inaccurate. A balance has to be struck, combined with the need to be as certain and accurate as possible.

Ways to improve the project ROI include:

  • increase project benefits / cost savings – easier to quantify, but costs can only be reduced so much
  • increase project benefits / revenues – harder, if not impossible to quantify – but can be much larger
  • decrease project costs – easy to quantify, but potentially limited
  • timing – deferring project costs or bringing project benefits forward

Whatever changes are made, they have to be realistic and measurable.

Situations when a ROI calculation may not be useful

ROI may not be useful in every IT project situation eg:

  • expenditure such as IT consumables, replacing broken PC’s
  • projects that do not produce cost savings / income – as any ROI will be zero or negative
  • projects which only have intangible benefits and no measurable financial benefits

Other ROI calculations 

Other calculations that are typically produced at the same time as calculating ROI are:

NPV (net present value) ie the return a project will make at a specified discount rate. Ideally this should be a high / positive value.

IRR (internal rate of return) ie the yearly return % of the investment – the higher, the better.

Payback years (also known as break even point) ie the number of years it takes to get the investment back. The shorter the payback, the better.

Today, no project has an automatic right to approval and a budget. Decisions to invest in IT systems projects have to compete with all other business areas and their needs / proposals. But achieving a good ROI and high NPV / IRR with a quick payback, will put IT systems proposals to the top of any choice.

Visit return on investment calculator to download a free ROI calculator for your IT system projects.

Posted byconnie dello buonoFebruary 12, 2018February 12, 2018Posted insuccessTags:IT, ROILeave a comment on Basic ROI Calculation

Google cloud seminar Feb 13 Santa Clara Convention Center

Cloud OnBoard
cloud
Start_Training {
Few Seats Remaining: You are invited to
Cloud OnBoard
Santa Clara
RSVP NOW
}
Hi,

Google Cloud Onboard is coming to your area next week. Make sure to secure your spot where you will receive an in-depth technical introduction to Google Cloud Platform (GCP). The training has been designed to help you understand and get started with cloud services such as Big Data and Machine Learning, Google App Engine, CloudDatastore, GCP Storage, Google Container Engine and Google Compute Engine and Networking.

This free, full-day event will be delivered by our leading technical training instructors using presentations and technical demonstrations. You will be provided with industry best practices and tips to accelerate your learning and ability to build with Google Cloud Platform.

Cloud OnBoard Santa Clara
February 13, 2018
9:00 AM – 5:30 PM

Santa Clara Convention Center
5001 Great America Pkwy, Santa Clara, CA 95054Since space is limited, we encourage you to reserve your spot early.

The Google Cloud Platform Team

RSVP NOW
Posted byconnie dello buonoFebruary 12, 2018February 12, 2018Posted insuccessTags:cloud, computing, Feb 13, Google, Santa Clara Convention CenterLeave a comment on Google cloud seminar Feb 13 Santa Clara Convention Center

Music and relaxing place help in healing

C.A.R.E. Channel provides relaxing imagery, music

a waterfall, as a part of the C.A.R.E. Channel imagery
The C.A.R.E. Channel provides a healing environment to patients and their care providers. Images can be seen on hospital TVs or downloaded from www.healinghealth.com.

Being a world class research hospital means continuously enhancing our world class environment of care. That now extends to offering specially designed, relaxing television programming called The C.A.R.E. Channel.

The channel’s name is an acronym for “Continuous Ambient Relaxation Environment.” View it for free on channel 08 anyplace the Clinical Center cable system is operable.

Running 24/7, it features nature imagery during the daytime and transitions to a moving star-filled sky during the overnight, accompanied by original instrumental music designed to be soothing and relaxing.

“When a project involves improving our patients’ experience, it’s never a hard sell to get Clinical Center staff excited to team up and make it happen,” said John Pollack, chief of the Department of Spiritual Care.

The C.A.R.E. Channel is brought to the Clinical Center through a collaboration between the Departments of Spiritual Care and Nursing. The programming runs 84 hours before repeating itself, fitting for extended stays common to the Clinical Center.

The channel is a tool that for some patients may help reduce anxiety, assist with restfulness and offer a positive focal point when in discomfort.

The relaxing images may help calm nerves in clinics and waiting rooms. Outpatients and caregivers may wish to tune in as they wind down in the Safra Lodge from a hectic appointment slate. Or inpatients may find it a welcome alternative if they don’t wish to or are unable to follow news and plot-driven shows. The possibilities are many — whether to add serenity or just drown out hospital noise.

Questions about the Clinical Center’s broadcasting of the C.A.R.E. Channel? Email John Pollack at john.pollack@nih.gov.

 


logo

Posted byconnie dello buonoFebruary 12, 2018Posted inMenuTags:environment, healing, music, relaxLeave a comment on Music and relaxing place help in healing

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