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Connie

Top topics on aging and health hacks 3-22-2018

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Brain can suppress feelings of chronic pain when hungry

Being Hungry Turns Off Perception of Chronic Pain

Summary: Researchers report the brain can suppress feelings of chronic pain when mice are hungry.

Source: University of Pennsylvania.

Pain can be valuable. Without it, we might let our hand linger on a hot stove, for example. But longer-lasting pain, such as the inflammatory pain that can arise after injury, can be debilitating and costly, preventing us from completing important tasks. In natural settings, the lethargy triggered by such pain could even hinder survival.

According to research by University of Pennsylvania neuroscientists, the brain has a way to suppress chronic pain when an animal is hungry, allowing it to go look for food while leaving intact the response to acute pain. Their work pinpointed a tiny population of 300 brain cells responsible for the ability to prioritize hunger over chronic pain, a group of neurons that may offer targets for novel pain therapies.

“In neuroscience we’re very good about studying one behavior at a time,” says J. Nicholas Betley, an assistant professor of biology in Penn’s School of Arts and Sciences. “My lab studies hunger, and we can find neurons that make you hungry and manipulate those neurons and monitor their activity. But in the real world, things aren’t that simple. You’re not in an isolated situation where you’re only hungry. This research was to try to understand how an animal integrates multiple needs to come to a behavioral conclusion that is optimal.”

“We didn’t set out having this expectation that hunger would influence pain sensation so significantly,” says Alhadeff, “but when we saw these behaviors unfold before us, it made sense. If you’re an animal, it doesn’t matter if you have an injury, you need to be able to overcome that in order to go find the nutrients you need to survive.”

The work will be published in the journal Cell. Betley and Alhadeff collaborated with Zhenwei Su, Elen Hernandez, Michelle L. Klima, and Sophie Z. Phillips of Penn Arts and Sciences; Ruby A. Holland and Bart C. De Jonghe of Penn’s School of Nursing; and Caiying Guo and Adam W. Hantman of the Howard Hughes Medical Institute.

Betley’s lab has focused on studying hunger, in particular how hunger can alter perception. Curious about how hunger may interact with the sensation of pain, the researchers observed how mice that hadn’t eaten for 24 hours responded to either acute pain or longer-term inflammatory pain, which is thought to involve sensitization of neural circuits in the brain.

The Penn team found that hungry mice still responded to sources of acute pain but seemed less responsive to inflammatory pain than their well-fed counterparts. Their behavior was similar to that of mice that had been given an anti-inflammatory painkiller.

In a conditioning experiment, the researchers found that hungry mice did not avoid a place where they had been exposed to inflammatory pain, while mice that were not hungry avoided the place.

That left the question of what part of the brain was processing this intersection between hunger and pain. To find out, the researchers experimentally turned on a group of neurons known to be activated by hunger, agouti-related protein (AgRP) neurons, and found that chronic pain responses subsided, while acute pain responses stayed intact.

To get more specific about the brain region involved, the team next looked at which subpopulation of AgRP neurons appeared to integrate the signals of hunger with inflammatory pain. Activating each AgRP neuron subpopulation one at a time, Betley, Alhadeff, and colleagues found that stimulation of only a few hundred AgRP neurons that project to the parabrachial nucleus significantly suppressed inflammatory pain.

“It was really striking,” Alhadeff says. “We showed that acute response to pain was perfectly intact, but inflammatory pain was suppressed to a very significant extent.”

“The really interesting thing to my mind is that out of a brain of billions of neurons, this specific behavior is mediated by 300 or so neurons,” Betley says.

Further experiments pinpointed the neurotransmitter, a molecule called NPY, responsible for selectively blocking inflammatory pain responses. Blocking receptors for NPY reversed the effects of hunger, and pain returned.

The researchers are excited by the potential clinical relevance of their findings. If they hold up in humans, this neural circuit offers a target for ameliorating the chronic pain that can linger after injuries, a type of pain that is currently often addressed by opioid medications, drugs that also inhibit acute pain.

“We don’t want to shut off pain altogether,” Alhadeff says, “there are adaptive reasons for pain, but it would be great to be able to target just the inflammatory pain.”

pain

Taking the next steps in this line of work, the researchers would like to map out in greater depth how the brain processes inflammatory pain, ideally identifying more targets for suppressing it. And they will continue considering how different survival behaviors integrate in the brain and how the brain processes and prioritizes them.

“We’ve initiated a new way of thinking about how behavior is prioritized,” Betley says. “It’s not that all the information is funneled up to your higher thinking centers in the brain but that there’s a hierarchy, a competition that occurs between different drives, that occurs before something like pain is even perceived.”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Funding: The study was supported by Penn’s School of Arts and Sciences, the American Heart Association, the Whitehall Foundation, and the National Institutes of Health (grants DG33400158, DK114104, DK731436, DK112561, and DK112812.)

Source: Katherine Unger Baillie – University of Pennsylvania
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Open access research in Cell.
doi:10.1016/j.cell.2018.02.057

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
University of Pennsylvania “Being Hungry Turns Off Perception of Chronic Pain.” NeuroscienceNews. NeuroscienceNews, 22 March 2018.
<http://neurosciencenews.com/hunger-pain-perception-8672/&gt;.

Abstract

A Neural Circuit for the Suppression of Pain by a Competing Need State

Highlights
•Hunger attenuates inflammatory pain without influencing acute pain responses
•Hunger-sensitive AgRP neurons projecting to the PBN suppress inflammatory pain
•Neuropeptide Y signaling in the PBN attenuates inflammatory pain during hunger

Summary
Hunger and pain are two competing signals that individuals must resolve to ensure survival. However, the neural processes that prioritize conflicting survival needs are poorly understood. We discovered that hunger attenuates behavioral responses and affective properties of inflammatory pain without altering acute nociceptive responses. This effect is centrally controlled, as activity in hunger-sensitive agouti-related protein (AgRP)-expressing neurons abrogates inflammatory pain. Systematic analysis of AgRP projection subpopulations revealed that the neural processing of hunger and inflammatory pain converge in the hindbrain parabrachial nucleus (PBN). Strikingly, activity in AgRP → PBN neurons blocked the behavioral response to inflammatory pain as effectively as hunger or analgesics. The anti-nociceptive effect of hunger is mediated by neuropeptide Y (NPY) signaling in the PBN. By investigating the intersection between hunger and pain, we have identified a neural circuit that mediates competing survival needs and uncovered NPY Y1 receptor signaling in the PBN as a target for pain suppression.

Bernie Sanders: Overturn Citizens United

Bernie Sanders

Connie –

First, the good newsOn Tuesday, with your help, the progressive community won major victories in the Illinois Democratic primaries. As the Washington Post reported, “voters resoundingly rejected Chicago-style machine politics.” Chuy Garcia, a strong progressive who worked with me during our presidential campaign, took on the Chicago Democratic machine and won a landslide victory in his primary election. He will, almost certainly, be the next congressman from the third district of Illinois.

Chuy also helped elect a number of younger progressive who we supported. Alma Anaya, 28, won her primary election for the Cook County Board of Supervisors. Beatriz Frausto-Sandoval, an immigration attorney, won her race for Cook County Circuit Court judge and Aaron Ortiz, a 26-year-old school counselor, won his race for the Illinois State House. Progressives also won a major victory when Joe Berrios, the chairman of the Cook County Democratic Party and current County Assessor, and one of the most powerful political figures in the state, lost his reelection bid to progressive candidate Fritz Kaegi.

Thank you all for bringing the political revolution to Illinois.

Now, the bad news. Late last month, the Koch Brothers and their network committed to spend up to $400 million on the 2018 election as a thank you for the Republican Party’s tax cuts for the rich, and “to change the trajectory of this country.”

Given this news, I thought it was an appropriate time to ask the question that the media and most politicians won’t ask: Who are the Koch brothers, what do they want and what are some actions we can take to stop them?

As you may know, the Koch brothers are the extreme right-wing “libertarian” family. They are the third wealthiest family in the country – worth some $120 billion. They also, unbelievably, have more political power than either the Republican Party or the Democratic Party. As this country slides into oligarchy and, as a result of Citizens United, we see one family not only making huge campaign contributions, but establishing think tanks, appointing university chairs and creating a number of organizations in almost every sphere of American political life. Their goal: make the very rich richer at the expense of everyone else.

Not only did they help pass the Republican tax bill – which will provide them with about a billion dollars a year in tax breaks – they are also working aggressively to move toward the privatization of the Department of Veterans Affairs, Social Security, Medicare and public education. In fact, they want to repeal virtually every piece of major legislation passed since the 1930s designed to protect the elderly, the children, the sick, the poor and the environment.

Now, it’s hard for me to understand how you could have almost $100 billion and feel the desperate need to lower your taxes, or to take from those who are struggling, so you can have even more. I would think that with that much money you just might be able to get by. But given the news of their projected campaign spending, it doesn’t appear that they are satisfied. Their greed demands more, more and more. They never stop.

What the Koch brothers and their friends want is to spread their unique vision of “freedom” in America. They want to dismember government so as to give Americans the “freedom” to live in poverty working for $3 or $4 an hour without health care, without child care, without a pension, without the ability to afford to send their kids to college and without any hope that their children will have a higher standard of living than they do.

They also want to end – not cut – but end, Social Security, Medicare and Medicaid. One of the Koch brothers even once ran for president on a platform of “the eventual repeal of all taxation.”

Now, this isn’t personal for me. I don’t know the Koch brothers, but I do know this: the Koch brothers and billionaires like them have bought up the private sector and are now well on their way to buying up the government. And I can assure you, sisters and brothers, they aren’t spending that money with the interests of working families, women and seniors in mind – they are doing it to elect candidates who will make the rich richer and everyone else poorer.

Let’s be clear: Money dominates everything that goes on in Congress. Wall Street, the pharmaceutical industry, the coal and oil companies, agribusiness and the rest of corporate America spend billions every year not just on campaign contributions, but also on lobbying. That is why we have a government that represents the 1 percent, and ignores the needs of almost everyone else.

Do you want to know why we pay the highest prices in the world for prescription drugs, and why there are no regulations preventing the drug companies from selling their products for any price they want? It might have something to do with the fact that the pharmaceutical industry is one of the most politically powerful industries in the country and spends endless amounts of money on lobbying and campaign contributions.

In Washington, you get what you pay for, and the result is that the desires of the rich and powerful are well-attended to. The pain of working families is ignored.

This is the rigged economy held in place by a corrupt system of campaign finance that we talked about on our campaign. And it is just as important to take it on today as it was in 2015 and 2016.

If we are serious about creating jobs, gun safety, about climate change and the needs of our children and the elderly, we must be deadly serious about campaign finance reform. And Congress must know you are committed to this fight:

Sign my petition to say you support a constitutional amendment to overturn Citizens United. Congress needs to know that the American people want representatives in office who oppose the outsized influence millionaires and billionaires have on our elections.

The Koch brothers understand the importance of politics. Meanwhile, people who work for low wages, have no health insurance and live in inadequate housing don’t see a connection between the reality of their lives and what government does or does not do.

Showing people that connection is a very big part of what a true progressive movement has to do, because it is impossible to bring about real social change in this country if people are not involved in the political process.

Our vision for American democracy should be a nation in which all people, regardless of their income, can participate in the political process, can run for office without begging for contributions from the wealthy and the powerful.

Our job is not to think small in this pivotal moment in American history.

We must pass a constitutional amendment to overturn Citizens United. We need legislation that requires wealthy individuals and corporations who make large campaign contributions to disclose where their money is going. And more importantly, we need to move towards the public funding of elections.

The need for real campaign finance reform is not a progressive issue. It is not a conservative issue. It is an American issue. It is an issue that should concern all Americans – regardless of their political point of view – who wish to preserve the essence of the longest-standing democracy in the world, a government that is supposed to represent all of the people and not just a handful of powerful special interests.

And that starts with overturning the disastrous Citizens United decision:

Sign my petition to say you support a constitutional amendment to overturn Citizens United.

What we showed in our presidential campaign – in a way that can change politics in America forever – is that you can run a competitive national grassroots campaign without begging millionaires and billionaires for campaign contributions.

That is what we must demand of our elected leaders: a complete rejection of their influence on campaigns. And that starts with making your voice heard.

In solidarity,

Bernie Sanders
ADD YOUR NAME

 

 

 

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‘You’ve helped awaken the conscience of the nation’ Barack and Michelle Obama

Barack and Michelle Obama in letter to Parkland survivors: ‘You’ve helped awaken the conscience of the nation’

By 

Although President Obama was an outspoken advocate for gun control laws, the letter did not offer policy proscriptions.

A letter written to the survivors of the Parkland school shooting by Michelle and Barack Obama. Credit: Mic via Twitter. [Screengrab]

The former president and first lady have offered their support to the survivors of the Parkland school shooting.

In a one page letter dated March 10 and addressed to “the students of Parkland,” Barack and Michelle Obama commended high school students for speaking out in the wake of the Feb. 14 massacre.

“We wanted to let you know how inspired we have been by the resilience, resolve and solidarity that you have all shown in the wake of unspeakable tragedy,” they wrote. (The letter was first published by Mic.)

Marjory Stoneman Douglas high school students burst onto the national political scene after the shooting, demanding policy changes from state and federal lawmakers. Some have advocated for restrictions on firearm purchases, and others have focused on policies that would strengthen school safety and mental health programs.

Although President Obama is an outspoken gun control advocate, the letter did not endorse one student approach over the other.

“Not only have you supported and comforted each other, but you’ve helped awaken the conscience of the nation, and challenged decision-makers to make the safety of our children the country’s top priority,” the Obamas wrote.

The students have proven to be effective advocates for change. Sen. Marco Rubio announced Wednesday that the STOP School Violence Act, which conservative 16-year-old Douglas student Kyle Kashuv has spent weeks championing in Washington, will be included in the federal spending bill moving its way through Congress.

And student gun control advocates Jaclyn Corin, Emma González, David Hogg and Cameron Kasky — among others — have raised millions of dollars for the March 24 March for our Lives to protest gun violence. Millions are expected to attend marches all over the country.

Read the full text of the Obamas’ letter here:

“We wanted to let you know how inspired we have been by the resilience, resolve and solidarity that you have all shown in the wake of unspeakable tragedy.

Not only have you supported and comforted each other, but you’ve helped awaken the conscience of the nation, and challenged decision-makers to make the safety of our children the country’s top priority,” the Obamas wrote.

Throughout our history, young people like you have led the way in making America better. There may be setbacks; you may feel like progress is too slow in coming. But we have no doubt you are going to make an enormous difference in the days and years to come, and we will be there for you.”

How the middle class in the bay area disappeared

Two parents must work to afford housing.

One must sell their house to pay for surgery or nursing homes.

One must pay half of the paycheck for one medication.

A family must pay for half their paycheck for health insurance premiums for 3.

Day care costs a  third of their paycheck.

Single mothers must have 2 jobs to afford housing.

College students must work to pay for tuition, college expenses especially textbooks, food and housing.

More than one third of income must pay for housing.

Low wages stopped others from spending money to go back to school of higher learning and more skills.

High housing costs is making families leave their families and neighbors to look for affordable cities outside of the bay area.

Housing costs accounts for more than half of the total income of middle class.

Low wages account for less college grads in middle class household as each children must work and be employed before finishing college.

Low wages make each person go for 2-3 jobs to pay for housing and other expenses.

Low wages make it harder for families to get higher education and more skills.

High cost of college and expensive textbooks make it harder to finish college early.

High cost of housing makes it difficult to own your own house in the bay area.

But , these struggles are not roadblocks to those who will work hard, only it takes time and a lot of sacrifices.