Is cancer increasing in the U.S.?

 

Metabolic related cancer (from processed foods, lifestyle) and environmental toxins have increased incidence of cancer in the USA and around the world.

Statistics at a Glance: The Burden of Cancer in the United States

  • In 2018, an estimated 1,735,350 new cases of cancer will be diagnosed in the United States and 609,640 people will die from the disease.
  • The most common cancers (listed in descending order according to estimated new cases in 2018) are breast cancer, lung and bronchus cancer, prostate cancer, colon and rectum cancer, melanoma of the skin, bladder cancer, non-Hodgkin lymphoma, kidney and renal pelvis cancer, endometrial cancer, leukemia, pancreatic cancer, thyroid cancer, and liver cancer.
  • The number of new cases of cancer (cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).
  • The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).
  • Cancer mortality is higher among men than women (196.8 per 100,000 men and 139.6 per 100,000 women). When comparing groups based on race/ethnicity and sex, cancer mortality is highest in African American men (239.9 per 100,000) and lowest in Asian/Pacific Islander women (88.3 per 100,000).
  • In 2016, there were an estimated 15.5 million cancer survivors in the United States. The number of cancer survivors is expected to increase to 20.3 million by 2026.
  • Approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes (based on 2013–2015 data).
  • In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.

From WHO: 

  • Cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths is due to cancer. 
  • Approximately 70% of deaths from cancer occur in low- and middle-income countries. 
  • Around one third of deaths from cancer are due to the 5 leading behavioral and dietary risks: high body mass index, low fruit and vegetable intake, lack of physical activity, tobacco use, and alcohol use. 
  • Tobacco use is the most important risk factor for cancer and is responsible for approximately 22% of cancer deaths (2). 
  • Cancer causing infections, such as hepatitis and human papilloma virus (HPV), are responsible for up to 25% of cancer cases in low- and middle-income countries (3). 
  • Late-stage presentation and inaccessible diagnosis and treatment are common. In 2017, only 26% of low-income countries reported having pathology services generally available in the public sector. More than 90% of high-income countries reported treatment services are available compared to less than 30% of low-income countries. 
  • The economic impact of cancer is significant and is increasing. The total annual economic cost of cancer in 2010 was estimated at approximately US$ 1.16 trillion (4). 

 

Guidelines for drinking water quality in the USA 

 

Limit iron intake to limit growth of invading pathogens

iron.pngIron Limitation as an Innate Immune Defense

In addition to mitigating toxicity associated with hypo- or hyperferremia, regulation of iron distribution serves as an innate immune mechanism against invading pathogens. Even in the absence of infection, several facets of human iron metabolism ensure that iron is scarcely accessible to pathogenic microorganisms. First, the majority of iron in humans is sequestered intracellularly, complexed within hemoglobin inside erythrocytes. Some pathogens have therefore evolved mechanisms to liberate hemoglobin by lysing erythrocytes to ultimately extract iron from heme. However, hemolytic pathogens must subsequently compete with haptoglobin and hemopexin, host glycoproteins that scavenge liberated hemoglobin and heme, respectively (Figure 1D). A second factor limiting the availability of iron to invading pathogens is the paucity of free extracellular iron. Extracellular iron is bound with high affinity by transferrin, which in healthy individuals is typically less than 50% saturated with iron. When transferrin-binding capacity is exceeded, iron can also be chelated with lower affinity by a number of molecules in plasma including albumin, citrate, and amino acids (Nathan et al., 2003).

During infection, additional fortification of iron-withholding defense occurs (Figure 2). The hypoferremia of infection was documented in seminal studies by Cartwright et al. in the 1940s, who noted a precipitous drop in plasma iron levels upon intramuscular inoculation of canines with Staphylococcus aureus. A similar hypoferremic response was noted upon intravenous injection with sterile turpentine, suggesting that inflammation, rather than a specific microbial product, was responsible for declining plasma iron levels (Cartwright et al., 1946). Since these initial observations, much has been learned regarding the importance of iron withholding to the outcome of host-pathogen interactions.

https://www.sciencedirect.com/science/article/pii/S1931312813001522

 

With the oxygenation of the Earth’s atmosphere over 2 billion years ago, abundant soluble Fe2+ was oxidized to insoluble Fe3+, making bioavailable iron much more scarce. At the same time, iron became potentially more toxic since the redox cycling of iron in the presence of oxygen and hydrogen peroxide catalyzes the production of free radicals in the Fenton reaction that can damage DNA, protein, and lipids.Humans and other organisms therefore evolved specialized proteins and tightly regulated homeostatic mechanisms for the uptake, transport, storage, and export of iron to provide adequate iron for essential biologic process, but to limit the toxicity of iron excess.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977983/

Brain iron loading impairs DNA methylation and alters GABAergic function in mice.

https://www.fasebj.org/doi/abs/10.1096/fj.201801116RR?journalCode=fasebj

The term “hemochromatosis,” introduced by von Recklinghausen at the end of the 19th century, refers to the clinical disorder that results from excess of total body iron and organ failure due to iron toxicity. The disease manifestations include cirrhosis, diabetes mellitus, hypogonadism and other endocrinopathies, cardiomyopathy, arthropathy, skin pigmentation, and, in cirrhotic patients, increased susceptibility to liver cancer.

http://www.bloodjournal.org/content/106/12/3710?sso-checked=true

Amino acid alanine from meat is food for cancer

Alanine is a hydrophobic molecule that does not mix with water. It is ambivalent, meaning that it can be inside or outside of the protein molecule.  It is a non-essential amino acid found in meat.

Both my parents who died of cancer do not eat sugar rich foods. They love BBQ meat.


Scientists have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers’ metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.


 

Pancreatic cancer cells find unique fuel sources to keep from starving

β-alanine suppresses malignant breast epithelial … – Molecular Cancer

Jan 24, 2014 – Deregulated energetics is a property of most cancer cells. … Moreover, β-alaninesignificantly increased malignant cell sensitivity to doxorubicin …

Inhibition of Alanine Aminotransferase in Silico and in Vivo Promotes http://www.jbc.org/content/286/25/22323.full

by G Beuster – ‎2011 – ‎Cited by 38 – ‎Related articles

Jun 24, 2011 – Abstract. Cancer cells commonly exhibit increased nonoxidative d-glucose metabolism whereas induction of mitochondrial metabolism may …

Evaluation of Lactate and Alanine as Metabolic Biomarkers of Prostate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613807/

The goal of this study was to investigate the use of lactate and alanine as metabolic biomarkers of prostate cancer using 1H high-resolution magic angle …

Pancreatic stellate cells support tumour metabolism through …

by CM Sousa – ‎2016 – ‎Cited by 274 – ‎Related articles

Aug 10, 2016 – Moreover, we demonstrate that alanine secretion by PSCs is dependent on PSC autophagy, a process that is stimulated by cancer cells. Thus …

Beta-alanine: Uses and Risks – WebMD
https://www.webmd.com › Vitamins and Supplements › Reference

Jan 30, 2019 – WebMD explains the uses and risks of the supplement beta-alanine.

Employing Metabolism to Improve the Diagnosis and Treatment of …

by CJ Halbrook – ‎2017 – ‎Cited by 68 – ‎Related articles

Jan 9, 2017 – Pancreatic cancer cells have extensively reprogrammed ….. PDAC cells avidly consume PSC-derived alanine (Ala) and use it to fuel diverse …

Weight loss and elevated gluconeogenesis from alanine in lung …

by S Leij-Halfwerk – ‎2000 – ‎Cited by 44 – ‎Related articles

Objective: Our aim was to study gluconeogenesis from alanine in lung cancer patients and to analyze its relation to the degree of weight loss. Design: In this …

Gluconeogenesis from Alanine in Patients with … – Cancer Research

aacrjournals.org/content/39/6_Part_1/1968

by C Waterhouse – ‎1979 – ‎Cited by 176 – ‎Related articles

The results show increased conversion of alanine to glucose in the overnight … for the patient with advanced cancer, a strong dependence for carbohydrate and …

 

Last stage of liver and lung cancer, pain and fluid build up

When my father and mother died of lung and liver cancer, there is fluid build up and pain.  My father felt the pain from lung cancer for 9 months while my mother had severe pain from liver cancer during the last month of her life.

Both experienced the signs and symptoms years before such as chronic cough, pain in the abdomen and knee, back pain, loss of appetite, loss of weight, eyes are yellowish, lack of sleep, fatigue and fast heartbeat.

Most of my clients , with Motherhealth caregivers,  would have fluid in their legs or edema a week before they die. So did my mom. Whenever I enter the room of new cancer clients, I always inspect the legs if there is fluid and if there is dark discoloration. And if the belly is hard or soft. For liver cancer, the stomach area is hard.

In the last stage of my mom’s liver cancer, her abdomen becomes harder and at the end when she died, liquid goo of mixed black matter came out of her nose like the abdomen is being emptied. As I closed her eyes and massaged her face with moisturizing cream, I cried “I love you mom”. This is to help the embalmer smoothen her skin when she is placed in her casket before her body becomes so hard.

My mom’s liver cancer traveled to her brain that my cousin felt extremely hot when she was massaging my mom’s head two weeks before she died.  My dad’s lung cancer traveled to his bones that the pain become so severe.

The following factors may cause edema:

  • Cancer, especially kidney, liver, or ovarian cancers
  • Some types of chemotherapy, including cisplatin (Platinol) and docetaxel (Docefrez, Taxotere)
  • Other medications, including the following:
    • Corticosteroids, which are drugs that reduce swelling
    • Hormone replacement medications
    • Nonsteroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen or naproxen
    • Some blood pressure drugs
  • Low levels of protein in the blood, caused by poor nutrition
  • Inactivity, which can cause fluid to collect in the feet and legs
  • Problems with kidney, liver, or heart function

Signs of pain include:

  • Noisy breathing – labored, harsh, or rapid breaths
  • Making pained sounds – including groaning, moaning, or expressing hurt
  • Facial expressions – looking sad, tense, or frightened; frowning or crying
  • Body language – tension, clenched fists, knees pulled up, inflexibility, restlessness, or looking like they’re trying to get away from the hurt area
  • Body movement – changing positions to get comfortable but can’t

Cancer recruitment, collusion and collaboration with normal cells

Cancer Metastasis: Building a Framework – ScienceDirect


by GP Gupta – ‎2006 – ‎Cited by 3435 – ‎Related articles

Nov 17, 2006 – Metastasis occurs when genetically unstable cancer cells adapt to a tissue … to cancer cells and the concomitant recruitment of traits in the tumor stroma … The utter inefficiency of the metastatic process implies that healthy tissues ….. requires collusion between tumor cells and multiple nontransformed cell …

The role of the cell–cell interactions in cancer progression – NCBI


by K Kamińska – ‎2015 – ‎Cited by 45 – ‎Related articles

Interaction between cancer cells and normal cells of the primary organ … themselves, but rather conscript and corrupt resident and recruited normal cell types 9.

Missing: collusion ‎| Must include: collusion

Microenvironmental regulation of tumor progression and metastasis


by DF Quail – ‎2013 – ‎Cited by 2447 – ‎Related articles

Mar 14, 2014 – Unlike tumor cells, stromal cell types within the tumor … Bidirectional communication between cells and their microenvironment is critical for both normal tissue …. M2-to-M1 switch, recruitment of natural killer (NK) cells and subsequent tumor ….. Indeed, interruption of this interaction renders metastatic cells …

Missing: collusion ‎| Must include: collusion

Role of the tumor microenvironment in tumor progression and the …


by Y Yuan – ‎2016 – ‎Cited by 38 – ‎Related articles

Mar 7, 2016 – Through reciprocal communication, cancer cells and the microenvironment act in collusion leading to … These normal cells in the tumor microenvironment mainly consist of … The tumor cells recruit cancer-associated fibroblasts (CAFs), … the extracellular matrix (ECM) and directing cell-cell interaction (10).

Conquering the Biological Politics of Cancer: Corruption, Coercion …


Jan 3, 2018 – First, cancer cells are corrupt compared with normal cells. … They recruit cells into their midst that normally repair wounds or prevent … growing in a mouse doesn’t take this collaboration into account, giving us false hope about … we need to figure out ways to address their corruption, coercion and collusion.
[PDF]

An evolving cancer instigates clonally unrelated neighboring cells to …


biorxiv.org/cgi/reprint/085423v1

Nov 3, 2016 – colluded” by neighboring mutated cells to disseminate, and that they can even undergo de novo …. collaborate in their access to nutrients, in resistance to therapy, and in colonization in distant organs. Systemic … Direct recruitment of …. Local dispersal of normal mammary cells by growing breast tumors.
[PDF]

Reprogramming Cancer Cells – Johns Hopkins Medicine


pated but that is vitally important to how cancer cells behave. … The opportunity to expand our collaborations and partnerships has never been greater. Discoveries … deeper into the role of normalepigenetic controls in cell behavior. In normal ….. For that, Dr. Pardoll recruited the help ….. collusionin infant leukemia, one of.

How Do Cytotoxic Lymphocytes Kill Cancer Cells? | Clinical Cancer …


clincancerres.aacrjournals.org/content/21/22/5047

by L Martínez-Lostao – ‎2015 – ‎Cited by 106 – ‎Related articles

Nov 15, 2015 – … are able to kill susceptible tumor cells through their interaction with their respective death receptors. …. Consequently, the oligomerized death receptors recruit the adaptor … in a wide variety of cancer cells while sparing normal cells. …… Essential complicity of perforin-granzyme and FAS-L mechanisms to …

Tumor microenvironment: angiogenesis and immunology | Abcam


Custom antibody development and commercial partnerships to advance your … The tumormicroenvironment: a cellular conspiracy … must recruit non-malignant cells from within the stromal tissue, the cellular milieu in … Just as organs within the body require constant blood supply to function normally, a growing tumor also …

Reprogramming of Tumor-Associated Macrophages with … – Frontiers


by G Genard – ‎2017 – ‎Cited by 48 – ‎Related articles

Jul 14, 2017 – Complicity of Tumor-Associated Macrophages (TAMs) in Tumor Progression. More than 50% of tumor-infiltrating cells are macrophages, named TAMs (7, 8). … In healthy tissues, macrophages offer a remarkable plasticity to …. (B) Inhibition of circulating monocyte recruitment into the tumor: two main ..

100 points to be cancer free: kill the parasites first

Liver, colorectal and lymphoid tumors may be associated with parasites. Before my mother died of liver cancer, she took out a big parasite from her anus.

Natural Ways to Purge Worms/parasites

  • Aloe vera, taken in any form, is especially helpful in eliminating worms.
  • The following herbs help expel worms: cascara sagrada, wormwood seed, cloves, Echinacea, goldenseal, burdock, and black walnut. Do not use wormwood during pregnancy.
  • Grapefruit seed extract helps destroy parasites. Take black walnut extract and chaparral tea or tablets. Eat pumpkin seeds and figs. Also drink the fig juice.
  • Take diatomaceous earth capsules for 3 weeks, to get rid of your worms. (Do not imagine you do not have some; everyone generally does.) The worms eat this, and it causes them to disintegrate.
  • Drink one cup of wormwood tea three times daily between meals.
  • Chinchona bark tea (1/2 teaspoon in 1 cup boiling water for 10 minutes) is bitter but effective.
  • Elecampane contains 2 anti-amoebic compounds. Add 1 teaspoon to 1 cup boiling water, simmer 20 minutes, and drink 1-3 cups per day.
  • Folk healers in India give turmeric for getting rid of worms, especially nematodes. It has 4 anti-parasitic compounds.

Diet

  • Eat figs and pumpkin seeds. This can be combined with black walnuts. Pumpkin seeds and extracts immobilize and aid in the expulsion of intestinal worms.
  • Because of its high tannin content, the kernel and green hull of black walnut have been used to expel various worms by Asians and American Indians. External applications kill ringworm. Chinese use it to kill tapeworms.
  • Eat garlic, onions, cabbage, and carrots. They contain natural sulphur, which helps expel worms. As you might expect, worms do not like garlic.
  • Garlic is used for pinworms, roundworms, giardia (an amoeba), and other parasitic infections. Juice 3 cloves with 4-6 oz. carrot juice and take every 2 hours.
  • Make sure you are obtaining enough water. Drink only pure water (distilled).
  • To eliminate pinworms, eat 1-2 bitter melons each day for 7-10 days. It is available in Asian markets.
  • To eliminate tapeworms, fast 3 days on raw pineapple. The bromelain in it destroys the worms.
  • Cut up two raw onions and soak them 12 hours in 1 pint water; straining while squeezing out the juice. Drink a cup of this 3 times a day. Along with this, use garlic enemas.
  • Mix tansy, bitterroot, and wormwood; and put in capsules. Take two capsules, 4 times a day.
  • Pomegranate is used to expel round worms and tapeworms. Grated raw apples, sprinkled with anise seed in a salad, is said to expel worms. Yarrow is a tonic to the bowels after worms have been expelled. Mexicans use cayenne to eliminate worms. Fresh horseradish is effective against some worms. Tansy seeds are used in Britain. Eat thyme sprigs or dried thyme mixed in food.
  • Other vermifuges include: bilberry, tarragon, European pennyroyal, quassia wood and bark, tamarind leaves, mugwort, and carline thistle.
  • For children, make senna tea, strain it, and add enough raisins to soak up the tea. Give the children 1 teaspoon of this 2-5 times a day.

No studies have yet explicitly examined how microbe-driven changes to the physical gut landscape might affect parasitic infections.