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Starvation, diet-induced obesity (unhealthy snacks) elevated triglycerides, decreased transport of leptin to brain lead to obesity

Obesity is associated with leptin resistance as evidenced by hyperleptinemia. Resistance arises from impaired leptin transport across the blood-brain barrier (BBB), defects in leptin receptor signaling, and blockades in downstream neuronal circuitries. The mediator of this resistance is unknown. Here, we show that milk, for which fats are 98% triglycerides, immediately inhibited leptin transport asContinue reading “Starvation, diet-induced obesity (unhealthy snacks) elevated triglycerides, decreased transport of leptin to brain lead to obesity”

Alzheimer’s disease and down’s syndrome gene, serotonin receptor 4, happy neurotransmitter hormone serotonin

Function • G-protein coupled receptor activity • calmodulin-dependent protein kinase activity • serotonin receptor activity • signal transducer activity Process • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • cognition • gamma-aminobutyric acid signaling pathway • positive regulation of cAMP metabolic process • positive regulation of cell proliferation •Continue reading “Alzheimer’s disease and down’s syndrome gene, serotonin receptor 4, happy neurotransmitter hormone serotonin”

Metabolic Syndrome and Obesity in Men and Women

Males are most likely to meet the criteria for metabolic syndrome: prothrombotic state, proinflammatory state, insulin resistance, raised blood pressure, atherogenic dyslipidemia and abdominal obesity. ————————————- Aside from feeding your brain, use your memory. Use your brain or lose it. Learn new skills. If today’s jobs are either in computers or medical, learn new skills.Continue reading “Metabolic Syndrome and Obesity in Men and Women”

Pathogenetic Role of Cortisol in Metabolic Syndrome (stress and digestive health issues)

Connie’s notes: Stress can cause memory tangles, first step in Alzheimer’s disease. Stress, sugar and lack of sleep put too much load to the brain, making detox process difficult. Take your calcium and magnesium supplements during the afternoon and night time and strive to get enough sleep. Most brain disease starts with digestive issues suchContinue reading “Pathogenetic Role of Cortisol in Metabolic Syndrome (stress and digestive health issues)”

Reduce the stress hormone cortisol

When we are stressed and anxious , our immune system goes down and we are open to inflammation. So the root cause of most chronic diseases is chronic stress and anxiety. As we balance our hormones, our immune system becomes stronger. Our first step in the fight for inflammation is to reduce our stress hormone cortisol with exercise, whole foods, sleep, less stress, massage and supplementation.

Vitamin K2 +Calcium for Bone health (K2 from butterfat, organs and fat of animals consuming rapidly growing green grass

In 1945, Dr. Weston Price described   “a new vitamin-like activator” that played an influential role in the utilization of minerals, protection from tooth decay,  growth and development, reproduction, protection against heart   disease and the function of the brain. Using a chemical test, he determined that this compound—which   he called Activator X—occurred in the butterfat, organs    andContinue reading “Vitamin K2 +Calcium for Bone health (K2 from butterfat, organs and fat of animals consuming rapidly growing green grass”

Hypothetical midlife interventions in women and cutting the risk of Type 2 diabetes by half

Conclusion: A combination of dietary and non-dietary lifestyle modifications, begun in midlife or later in relatively healthy women, could have prevented at least half of the cases of type 2 diabetes in this cohort study of U.S. women. Results: The 24-year risk of diabetes was 9.6% under no intervention and 4.3% when all interventions wereContinue reading “Hypothetical midlife interventions in women and cutting the risk of Type 2 diabetes by half”

Antibodies, what they can tell us about our health

Antibodies tell us the state of health of our cells in the presence of invading pathogens and infections/viruses. We must ensure a healthy immune system and lymphatic system (cleans our blood from toxins). Pathologies of antibodies Anti-thyroid peroxidase antibodies The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility (odds ratioContinue reading “Antibodies, what they can tell us about our health”

Parasympathetic activation is involved in reducing epileptiform discharges and the recurrence rate of seizures when listening to Mozart music

CLINICAL NEUROPHYSIOLOGY, 20131388-2457Available online 27 March 2013 Publication year: 2013 Source:Clinical Neurophysiology Listening to Mozart K.448 has been demonstrated to improve spatial task scores, leading to what is known as the Mozart effect. Previous study revealed the positive effects of Mozart K.448 in reducing epileptiform discharges in children with epilepsy. However, the mechanism remains unclear.Continue reading “Parasympathetic activation is involved in reducing epileptiform discharges and the recurrence rate of seizures when listening to Mozart music”

Branched-chain amino acids supplementation for resistance exercise-based muscle damage

Branched-chain amino acids (BCAA) supplementation has been considered an interesting nutritional strategy to improve skeletal muscle protein turnover in several conditions. There is evidence that resistance exercise (RE)-derived biochemical markers of muscle soreness (creatine kinase (CK), aldolase, myoglobin), soreness, and functional strength may be modulated by BCAA supplementation to favor muscle adaptation. However, few studiesContinue reading “Branched-chain amino acids supplementation for resistance exercise-based muscle damage”