Comprehensive study finds 238 genes that affect aging in yeast cells. Following an exhaustive, ten-year effort, scientists at the Buck Institute for Research on Aging and the University of Washington have identified 238 genes that, when removed, increase the replicative lifespan of S. cerevisiae yeast cells. This is the first time 189 of these genesContinue reading “Mapping Genes That Increase Lifespan”
Category Archives: genes
Causal Link Between Alzheimer’s Disease and Telomere Shortening
In a newly published study, researchers at Karolinska Institutet show that the shortening of the telomeres – the caps at each end of the chromosomes in our cells – can be linked statistically to the active mechanism responsible for Alzheimer’s disease. However, the effect is small and telomere length cannot yet be used to assessContinue reading “Causal Link Between Alzheimer’s Disease and Telomere Shortening”
A novel link between movement control and genetics
A small molecule in cells that was previously believed to have no impact on animal behaviour could in fact be responsible for controlling precise movements, according to new University of Sussex research. The team at Sussex, led by Dr Claudio Alonso, found that fruit flies had difficulty in righting themselves when placed upside down afterContinue reading “A novel link between movement control and genetics”
Autism Gene Slows Down Brain Cell Communication
Summary: Alterations in a gene associated with autism spectrum disorders changes the way in which brain cells grow and communicate, a new study reports. Source: McMaster University. Gene changes the way brain cells grow and communicate. Scientists at McMaster University’s Stem Cell and Cancer Research Institute in collaboration with Sick Children’s Hospital have discovered geneticContinue reading “Autism Gene Slows Down Brain Cell Communication”
What have been the advantages of humans acquiring Neanderthal genes?
What makes the inherited genetic material beneficial? When Neanderthal ancestors left Africa roughly 100,000 years earlier they adapted to the pathogens in their European environment, unlike modern humans who adapted to African pathogens. This transcontinental movement is known as the Out of Africa model. If contact between humans and Neanderthals occurred in Europe and AsiaContinue reading “What have been the advantages of humans acquiring Neanderthal genes?”
Brain health registry
Brief Description The purpose of the online Brain Health Registry is to recruit and observe people who are interested in promoting healthy brain function through the prevention of brain diseases, disorders, and injuries in adults. Participation involves answering questions about your health, lifestyle, and medical history and taking online brain tests. Researchers hope to buildContinue reading “Brain health registry”
Genematch for preclinical Alzheimer’s disease clinical studies
Patient Qualifications Min Age Max Age Gender Healthy Volunteers 55 Years 75 Years Both Accepts Healthy Volunteers Inclusion Criteria Willing to provide basic demographic, medical history, and contact information Consent to APOE genotyping without receiving results Resident of the United States Exclusion Criteria Unable to comply with GeneMatch requirements Self-reported diagnosis of dementia or anyContinue reading “Genematch for preclinical Alzheimer’s disease clinical studies”
Why do you need a genetic counselor?
Doctors uses the family history as the first stop in the assessment of genetic risks for any individual. For many genetic disorders, there will be no obvious signs of symptoms until significant medical problems surface, so family history may be the only way to identify individuals at risk. This in turn can lead to aContinue reading “Why do you need a genetic counselor?”
What is genetic testing?
Even when people have one copy of a dominant cancer-predisposing mutation, two copies of a recessive mutation, or, for males, one copy of an X-linked recessive mutation, they may not develop cancer. Some mutations are “incompletely penetrant,” which means that only some people will show the effects of these mutations. Mutations can also “vary inContinue reading “What is genetic testing?”
Smoking leads to disease-causing DNA damage lasting 30years
ADAM GAULT VIA GETTY IMAGESA new study has found that cigarette smoking damages users’ DNA, with its effects seen more than 30 years after they quit. Here’s one more reason to kick your smoking habit: A new study has found that cigarette smoking leads to disease-causing DNA damage that can last more than 30 years afterContinue reading “Smoking leads to disease-causing DNA damage lasting 30years”
Gene-based diet weekly schedule
Gene-based heart healthy recipe A personalized recipe recommendations to meet your dietary needs and preferences. Notes for Sunday and Saturday prep tips: Seek farmer’s market produce, cut fruits/veggies in cubes and store in portion bag in freezer for Mon-Friday smoothie, soup, or steamed veggie recipe. If you cook a big batch of chicken or beefContinue reading “Gene-based diet weekly schedule”
Epigenetic Clock Marks Age of Human Tissues and Cells
By Carol Torgan, Ph.D. The age of many human tissues and cells is reflected in chemical changes to DNA. The finding provides insights for cancer, aging, and stem cell research. We may gauge how we’re aging based on visible changes, such as wrinkles. For years, scientists have been trying to gauge aging based on changesContinue reading “Epigenetic Clock Marks Age of Human Tissues and Cells”
DNA changes predict longevity
By Harrison Wein, Ph.D. Certain DNA changes can better predict a person’s life expectancy than traditional risk factors such as age. The findings could lead to novel insights into the molecular mechanisms of aging and new ways to evaluate methods for slowing the rate of aging. “Epigenetic age” might represent a person’s biological age moreContinue reading “DNA changes predict longevity”
Longevity, genes, epigenetics, cancer and disease
Description: The study of human genetic disorders and mutant mouse models has provided evidence that genome maintenance mechanisms, DNA damage signaling and metabolic regulation cooperate to drive the ageing process. In particular, age-associated telomere damage, diminution of telomere ‘capping’ function and associated p53 activation have emerged as prime instigators of a functional decline of tissueContinue reading “Longevity, genes, epigenetics, cancer and disease”