Connie B. Dellobuono, Health author a
Is cancer increasing in the U.S.?
Connie B. Dellobuono, Health author
Metabolic related cancer (from processed foods, lifestyle) and environmental toxins have increased incidence of cancer in the USA and around the world.
Do people with higher metabolism get sick more easily?
Do people with higher metabolism get sick more easily?
Connie B. Dellobuono, Health author
The way our bodies regulate and manage energy—our metabolism—and our body’s ability to defend itself against pathogens—the immune response—are closely linked because a strong immune response relies on energy, writes Hotamisligil. But an imbalance in this relationship can put us at risk for chronic metabolic diseases. Hotamisligil writes that there is now an opportunity to translate the increased knowledge about immunometabolism into interventions that one day may reduce the global burden (https://www.hsph.harvard.edu/new…) of those diseases. Weight loss caused by a fast metabolic rate is commonly a symptom of cancer.
Slow down your metabolism:
- Have a consistent meal time.
- Get adequate sleep
- Add strength training
- Eating sufficient calories
- Stand and walk more, sit less
- Drink no alcohol and drink more water.
- Have less stress, get a massage and be with nature.
- Get adequate calcium (2:1 calcium: magnesium ratio with vitamin D)
What health problem is associated with high protein intake?
How can we reverse auto immune conditions?
Connie B. Dellobuono, Health author and blogger at http://www.clubalthea.com
$10k granny unit in the bay area is possible
1:1 Sugar to fiber ratio for healthy food
Fiber is one promising compound that has been demonstrated to alleviate metabolic syndrome.
Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.
Researchers found that the yeast that had an overactive influx of glucose caused the Ras proteins to activate too much, which would then allow the cells to grow at an accelerated rate. Our research reveals how the hyperactive sugar consumption of cancerous cells leads to a vicious cycle of continued stimulation of cancer development and growth,” said researcher Johan Thevelein from KU Leuven in Belgium.
Defective Ras signaling has been cited as a contributing factor to many other human illnesses, including diabetes and immunological and inflammatory disorders.
Over consumption of sugar affects the following organs more than others: biliary tract, lungs, colon, pancreas, prostate and skin.
A good whole food, low glycemic load diet has about a 1:1 sugar to fiber ratio. The current U.S. average is about 12:1. This is the result of both adding sugar to just about all manufactured foods and the removal of fiber during processing. The 1:1 ratio in a whole food diet comes from about 50 grams of natural sugars per day and about 45 grams of natural fiber. The average daily intake of fiber in the U.S. is about 12-15 grams, while the average sugar intake is 180-220 grams. The U.S. fiber intake doesn’t look that bad in light of the currently recommended amount of 14-15 grams. This is the disconnect between current research and typical policy and recommendations.
Sugar to fiber ration when consuming simply the natural carbohydrate with no added sugar use the table below.
Fruits Vegetables Grains
Natural sugar 5-12 gms 0.5-1gms 0.5-1gms
Fiber 1-3 gms 2-4 gms 2-4gms
Sugar to fiber ratio 1.5-10 to 1 0.1-0.5 to 1 0.1-0.5 to 1
The cupcake has a sugar to fiber ratio of greater than 18 to 1, while the cereal bar is greater than 19 to 1. Both list the fiber as less than one gram so could be 0.1 grams, or it could be 0.5 grams. These are on the order of 30 to 180 times higher than it would be without added sugar and with all of the natural fiber not refined out!
Can Alzheimer’s be prevented?
Connie B. Dellobuono, Health author and blogger at http://www.clubalthea.com and home health care organization mgt at Motherhealth LLC, bay area caregivers 408-854-1883
Alzheimer can be slowed down with nurture (massage,love,loving environment), whole foods (probiotic, sulfur rich foods), social interaction, sufficient sleep and exercise.
- Gut microbes can be balanced with whole foods, less stress, liver detox and probiotic. Avoid sugar and amino acid alanine from red meat.
- Brain cells need adequate sleep, exercise, learning new skills and sunshine to thrive and grow.
- Sulfur rich foods are cleansing and so is adequate night time sleep.
- Depression is one of the early signs of Alzheimer and social interaction can help. Limit your stress to combat its progression, Surround yourself with a loving support system and an environment close to nature.
Connie’s answers at quora.com
I need your suggestions and comments to add substance and more recent information to the topics I answered at quora.com My answers are not FDA approved but the intent is to provide a baseline info from various sources and not to replace your doctor’s advice. Doctors can use the word cure and we the patient can only be prepared to research fully well what has been added as recent information about our health.
I plan to hold a seminar as a conversation about health in libraries in the bay area and offer a free ebook about these health topics that are most important to you.
Be well.
Connie
Check your bile acid production and stress level for fat metabolism
Bile acids are synthesized from cholesterol
Bile begins its life in the liver and spends a significant amount of time somewhere between the liver, gallbladder, and gastrointestinal tract, specifically the intestines. Liver cells manufacture bile before it undergoes modification in the bile duct epithelium, and then it is transported to the gallbladder for storage and, ultimately, use. Bile acids are synthesized from cholesterol with the aid of several different enzymes.
Soup of Sulfur rich bile acids will help balance bile production:
Mix these root crops to pinch of organic chicken broth powder: rutabaga, kale, carrot, parsnip, onion, garlic and a tsp of apple cider vinegar or lemon juice added in the last boiling.
Short-chain fatty acids : The gut microbiota can ferment complex dietary residues that are resistant to digestion by enteric enzymes.
This process provides energy for the microbiota but culminates in the release of short-chain fatty acids including butyrate, which are utilized for the metabolic needs of the colon and the body.
Butyrate has a remarkable array of colonic health-promoting and antineoplastic properties:
- It is the preferred energy source for colonocytes,
- It maintains mucosal integrity and it suppresses inflammation and carcinogenesis through effects on immunity, gene expression and epigenetic modulation.
Note: Protein residues and fat-stimulated bile acids are also metabolized by the microbiota to inflammatory and/or carcinogenic metabolites, which increase the risk of neoplastic progression.
The makeup of bile is largely water, at about 95%. The remaining five percent is made up of bile acids, bilirubin, amino acids, enzymes, steroid hormones including estrogen, glutathione, cholesterol, vitamins (especially vitamin D and some of the B vitamins), porphyrins, insulin, and other items, including toxins such as heavy metals, xenobiotics, medications and drugs, and environmental toxins targeted for excretion. There are also electrolytes, including sodium, potassium, chloride, calcium, magnesium, phosphate, sulfate, and bicarbonate. As you excrete more bile acid, bile flow is stimulated. There is also a circadian rhythm to the synthesis and circulation of bile acids.
In total, there are more than 50 species of bile acids in humans, but the main ones include cholic acid and chenodeoxycholic acid (CDCA). Although bile salts and bile acids are frequently used interchangeably, technically bile acids become bile salts upon conjugation with glycine or taurine. The gut bacteria metabolize bile acids to create secondary bile acids, of which there are more than 400 species. After the gut bacteria metabolize them, cholic acid becomes deoxycholic acid and CDCA becomes lithocholic acid. The amount of bile acids making their way into the colon affects the microbiome makeup. Bile acids are reabsorbed in the small intestine and colon to then come back into circulation as part of the enterohepatic circulation, which is a bidirectional pathway.
Bile acids, a key component of bile, are the main emulsifiers of fat. As such, bile ultimately finds its way into the small intestine for this function. When fat enters your small intestine, you secrete CCK (cholecystokinin), which signals your gallbladder to send bile into the small intestine to aid in digestion and absorption.
Functions of bile acid
Although this may be the function of bile most commonly known, there are actually many, many more. Some of the key functions of bile include:
- Aids the immune system through excreting certain immune system signals, such as IgA and inflammatory cytokines
- Elimination of certain hormones and pheromones
- Endogenous ligand (binder to stimulate a signal) for several receptors, including nuclear receptor farnesoid X receptor (FXR), vitamin D receptor, and G protein-coupled receptor TGR5
- Excretion of fat-soluble toxins and other waste, including endogenous substrates
- Modulation of metabolic pathways, including lipid metabolism, glucose metabolism, and insulin sensitivity
- Regulation of tight junction permeability
- Removal of cholesterol
- Signaling molecule and hormone
With so many different functions, it should come as no surprise that problems in the flow, metabolism, or synthesis of bile and/or bile acids could contribute to a variety of diseases.
Diseases such as colon and liver cancer
Problems with bile may stem from dysfunction in the synthesis of bile, an impairment in the secretion, or problems with the flow of bile. The metabolism of bile may become disturbed through problems stemming from the synthesis or conjugation with cholesterol, problems with the membrane transport, issues with the transport between the organs, or problems with the bacterial degradation of bile during the enterohepatic cycling. There may also be malabsorption of the bile acid, leading to higher concentrations in the colon, which may then negatively impact the function of the mucosal cells in the colon. Furthermore, when the concentration of bile acids is too high, it can be toxic and cause problems. Alterations to bile acids are also associated with disease.
The level of bile acids that reach the colon may contribute to functional bowel diseases. Elevated concentrations may contribute to diarrhea, while lower levels may play a role in constipation. In one study on children with functional constipation, the fecal bile acid profile was normal, but there were some who had the 3-sulfate version of CDCA as the dominant fecal bile acid, which could demonstrate a link for some cases.
Stress and Bile acids
Psychological stress is a risk factor for atherosclerosis, yet the pathophysiological mechanisms involved remain elusive. The transfer of cholesterol from macrophage foam cells to liver and feces (the macrophage-specific reverse cholesterol transport, m-RCT) is an important antiatherogenic pathway. Because exposure of mice to physical restraint, a model of psychological stress, increases serum levels of corticosterone, and as bile acid homeostasis is disrupted in glucocorticoid-treated animals, we investigated if chronic intermittent restraint stress would modify m-RCT by altering the enterohepatic circulation of bile acids. C57Bl/6J mice exposed to intermittent stress for 5 days exhibited increased transit through the large intestine and enhanced fecal bile acid excretion. Of the transcription factors and transporters that regulate bile acid homeostasis, the mRNA expression levels of the hepatic farnesoid X receptor (FXR), the bile salt export pump (BSEP), and the intestinal fibroblast growth factor 15 (FGF15) were reduced, whereas those of the ileal apical sodium-dependent bile acid transporter (ASBT), responsible for active bile acid absorption, remained unchanged. Neither did the hepatic expression of cholesterol 7α-hydroxylase (CYP7A1), the key enzyme regulating bile acid synthesis, change in the stressed mice. Evaluation of the functionality of the m-RCT pathway revealed increased fecal excretion of bile acids that had been synthesized from macrophage-derived cholesterol. Overall, our study reveals that chronic intermittent stress in mice accelerates m-RCT specifically by increasing fecal excretion of bile acids. This novel mechanism of m-RCT induction could have antiatherogenic potential under conditions of chronic stress.
Vinegar helps increase bile production
Polyphenols such as chlorogenic acid which is present in high levels in apple cider vinegar could inhibit oxidation of LDLs and improve health by preventing cardiovascular diseases (Laranjinha and others 1994).
High blood glucose and homocysteine
My parents died of cancer and my other relatives of heart attack. My two grandpas of Spanish descent I believe have an iron metabolism dysfunction which was not tested. This genetic disorder make us prone to liver and heart disease. I now vow to limit my alcohol and meat consumption. I was also exposed to second-hand smoke as people around me would smoke without care for the health of others around them.
I just received my blood test today and it shows high blood glucose and homocysteine.
I eat red meat once a month and do moderate exercise. I am conscious of my daily lifestyle since I wanted to maintain a disease free state. Based on my daily food journal, I have been drinking almond milk, eating fish, veggies and been getting good sleep (<7 hours). I have to factor in stressors like starting a new job, death of my mother, and other unknowns.
I will now replace almond with soy milk and have more fiber rich whole foods.
I will now take in adequate Vitamin Bs and folate and do a regular walking exercise. I might include Yoga daily or Tai Chi in my daily routine.
I will get another blood test in a month to review my progress since it only cost me around $200 for my blood test at LifeExtension.
Connie
Limit iron intake to limit growth of invading pathogens
Iron Limitation as an Innate Immune Defense
In addition to mitigating toxicity associated with hypo- or hyperferremia, regulation of iron distribution serves as an innate immune mechanism against invading pathogens. Even in the absence of infection, several facets of human iron metabolism ensure that iron is scarcely accessible to pathogenic microorganisms. First, the majority of iron in humans is sequestered intracellularly, complexed within hemoglobin inside erythrocytes. Some pathogens have therefore evolved mechanisms to liberate hemoglobin by lysing erythrocytes to ultimately extract iron from heme. However, hemolytic pathogens must subsequently compete with haptoglobin and hemopexin, host glycoproteins that scavenge liberated hemoglobin and heme, respectively (Figure 1D). A second factor limiting the availability of iron to invading pathogens is the paucity of free extracellular iron. Extracellular iron is bound with high affinity by transferrin, which in healthy individuals is typically less than 50% saturated with iron. When transferrin-binding capacity is exceeded, iron can also be chelated with lower affinity by a number of molecules in plasma including albumin, citrate, and amino acids (Nathan et al., 2003).
During infection, additional fortification of iron-withholding defense occurs (Figure 2). The hypoferremia of infection was documented in seminal studies by Cartwright et al. in the 1940s, who noted a precipitous drop in plasma iron levels upon intramuscular inoculation of canines with Staphylococcus aureus. A similar hypoferremic response was noted upon intravenous injection with sterile turpentine, suggesting that inflammation, rather than a specific microbial product, was responsible for declining plasma iron levels (Cartwright et al., 1946). Since these initial observations, much has been learned regarding the importance of iron withholding to the outcome of host-pathogen interactions.
https://www.sciencedirect.com/science/article/pii/S1931312813001522
With the oxygenation of the Earth’s atmosphere over 2 billion years ago, abundant soluble Fe2+ was oxidized to insoluble Fe3+, making bioavailable iron much more scarce.3 At the same time, iron became potentially more toxic since the redox cycling of iron in the presence of oxygen and hydrogen peroxide catalyzes the production of free radicals in the Fenton reaction that can damage DNA, protein, and lipids.4Humans and other organisms therefore evolved specialized proteins and tightly regulated homeostatic mechanisms for the uptake, transport, storage, and export of iron to provide adequate iron for essential biologic process, but to limit the toxicity of iron excess.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977983/
Brain iron loading impairs DNA methylation and alters GABAergic function in mice.
https://www.fasebj.org/doi/abs/10.1096/fj.201801116RR?journalCode=fasebj
The term “hemochromatosis,” introduced by von Recklinghausen at the end of the 19th century, refers to the clinical disorder that results from excess of total body iron and organ failure due to iron toxicity. The disease manifestations include cirrhosis, diabetes mellitus, hypogonadism and other endocrinopathies, cardiomyopathy, arthropathy, skin pigmentation, and, in cirrhotic patients, increased susceptibility to liver cancer.
http://www.bloodjournal.org/content/106/12/3710?sso-checked=true
About Connie Dello Buono
Connie was born and raised in the Philippines. She is the eldest of the family of 6. At age 19, she has to support her family by working as a high school science and math teacher, while still completing her BS in math, minor in chemistry. She then worked at Intel and Acer and later on in various bay area biotech and medical device companies.
She has two children born at home with midwives. During the first three years of their lives, she stayed home and studied midwifery and nursing, home study. She went back to work after three years since the bay area standard of living is high and housing/day care is expensive.
She also worked for less than a year as a pharmacy technician instructor and always reminded her students the side effects of neuro meds and most medicines. She was told by one bay area school where she wanted to be a certified Nurse Midwife that she cannot enroll with 2 young children and without writing a book. She then wrote an ebook, Birthing Ways Healing Ways, a holistic childbirth ebook.
In the bay area, she moved from one biotech to medical device companies and then she started her home care organization agency in 2018 to help families with finding caregivers and caring for their home-bound loved ones who had Alzheimers, cancer, Parkinsons and other chronic health diseases.
Since 2000, she has been helping caregivers working in care homes including her mother, who was a caregiver for 18 years by driving them and helping out. She learned about senior care and care homes and had an RCFE administrator license but has no house to open a care home business at that time. She also had worked as a caregiver when in between jobs for the last six years and learned about cancer and death.
She loves dancing and learning about cancer and health.
You can find her at Motherhealth LLC, www,clubalthea.com , matching clients with caring caregivers and training caregivers.
Amino acid alanine from meat is food for cancer
Alanine is a hydrophobic molecule that does not mix with water. It is ambivalent, meaning that it can be inside or outside of the protein molecule. It is a non-essential amino acid found in meat.
Both my parents who died of cancer do not eat sugar rich foods. They love BBQ meat.
Scientists have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers’ metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.
Pancreatic cancer cells find unique fuel sources to keep from starving
β-alanine suppresses malignant breast epithelial … – Molecular Cancer
Jan 24, 2014 – Deregulated energetics is a property of most cancer cells. … Moreover, β-alaninesignificantly increased malignant cell sensitivity to doxorubicin …
Inhibition of Alanine Aminotransferase in Silico and in Vivo Promotes http://www.jbc.org/content/286/25/22323.full
Jun 24, 2011 – Abstract. Cancer cells commonly exhibit increased nonoxidative d-glucose metabolism whereas induction of mitochondrial metabolism may …
Evaluation of Lactate and Alanine as Metabolic Biomarkers of Prostate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613807/
The goal of this study was to investigate the use of lactate and alanine as metabolic biomarkers of prostate cancer using 1H high-resolution magic angle …
Pancreatic stellate cells support tumour metabolism through …
Aug 10, 2016 – Moreover, we demonstrate that alanine secretion by PSCs is dependent on PSC autophagy, a process that is stimulated by cancer cells. Thus …
Beta-alanine: Uses and Risks – WebMD
https://www.webmd.com › Vitamins and Supplements › Reference
Employing Metabolism to Improve the Diagnosis and Treatment of …
by CJ Halbrook – 2017 – Cited by 68 – Related articles
Jan 9, 2017 – Pancreatic cancer cells have extensively reprogrammed ….. PDAC cells avidly consume PSC-derived alanine (Ala) and use it to fuel diverse …
Weight loss and elevated gluconeogenesis from alanine in lung …
by S Leij-Halfwerk – 2000 – Cited by 44 – Related articles
Objective: Our aim was to study gluconeogenesis from alanine in lung cancer patients and to analyze its relation to the degree of weight loss. Design: In this …
Gluconeogenesis from Alanine in Patients with … – Cancer Research
aacrjournals.org/content/39/6_Part_1/1968
by C Waterhouse – 1979 – Cited by 176 – Related articles
The results show increased conversion of alanine to glucose in the overnight … for the patient with advanced cancer, a strong dependence for carbohydrate and