Check your bile acid production and stress level for fat metabolism

Bile acids are synthesized from cholesterol

Bile begins its life in the liver and spends a significant amount of time somewhere between the liver, gallbladder, and gastrointestinal tract, specifically the intestines. Liver cells manufacture bile before it undergoes modification in the bile duct epithelium, and then it is transported to the gallbladder for storage and, ultimately, use. Bile acids are synthesized from cholesterol with the aid of several different enzymes.

Soup of Sulfur rich bile acids will help balance bile production:

Mix these root crops to pinch of organic chicken broth powder: rutabaga, kale, carrot, parsnip, onion, garlic and a tsp of apple cider vinegar or lemon juice added in the last boiling.

bile

Short-chain fatty acids :  The gut microbiota can ferment complex dietary residues that are resistant to digestion by enteric enzymes.

This process provides energy for the microbiota but culminates in the release of short-chain fatty acids including butyrate, which are utilized for the metabolic needs of the colon and the body.

Butyrate has a remarkable array of colonic health-promoting and antineoplastic properties:

  • It is the preferred energy source for colonocytes,
  • It maintains mucosal integrity and it suppresses inflammation and carcinogenesis through effects on immunity, gene expression and epigenetic modulation.

Note:  Protein residues and fat-stimulated bile acids are also metabolized by the microbiota to inflammatory and/or carcinogenic metabolites, which increase the risk of neoplastic progression.

The makeup of bile is largely water, at about 95%. The remaining five percent is made up of bile acids, bilirubin, amino acids, enzymes, steroid hormones including estrogen, glutathione, cholesterol, vitamins (especially vitamin D and some of the B vitamins), porphyrins, insulin, and other items, including toxins such as heavy metals, xenobiotics, medications and drugs, and environmental toxins targeted for excretion. There are also electrolytes, including sodium, potassium, chloride, calcium, magnesium, phosphate, sulfate, and bicarbonate. As you excrete more bile acid, bile flow is stimulated. There is also a circadian rhythm to the synthesis and circulation of bile acids.

In total, there are more than 50 species of bile acids in humans, but the main ones include cholic acid and chenodeoxycholic acid (CDCA). Although bile salts and bile acids are frequently used interchangeably, technically bile acids become bile salts upon conjugation with glycine or taurine. The gut bacteria metabolize bile acids to create secondary bile acids, of which there are more than 400 species. After the gut bacteria metabolize them, cholic acid becomes deoxycholic acid and CDCA becomes lithocholic acid. The amount of bile acids making their way into the colon affects the microbiome makeup. Bile acids are reabsorbed in the small intestine and colon to then come back into circulation as part of the enterohepatic circulation, which is a bidirectional pathway.

Bile acids, a key component of bile, are the main emulsifiers of fat. As such, bile ultimately finds its way into the small intestine for this function. When fat enters your small intestine, you secrete CCK (cholecystokinin), which signals your gallbladder to send bile into the small intestine to aid in digestion and absorption.

Functions of bile acid

Although this may be the function of bile most commonly known, there are actually many, many more. Some of the key functions of bile include:

  • Aids the immune system through excreting certain immune system signals, such as IgA and inflammatory cytokines
  • Elimination of certain hormones and pheromones
  • Endogenous ligand (binder to stimulate a signal) for several receptors, including nuclear receptor farnesoid X receptor (FXR), vitamin D receptor, and G protein-coupled receptor TGR5
  • Excretion of fat-soluble toxins and other waste, including endogenous substrates
  • Modulation of metabolic pathways, including lipid metabolism, glucose metabolism, and insulin sensitivity
  • Regulation of tight junction permeability
  • Removal of cholesterol
  • Signaling molecule and hormone

With so many different functions, it should come as no surprise that problems in the flow, metabolism, or synthesis of bile and/or bile acids could contribute to a variety of diseases.

Diseases such as colon and liver cancer

Problems with bile may stem from dysfunction in the synthesis of bile, an impairment in the secretion, or problems with the flow of bile. The metabolism of bile may become disturbed through problems stemming from the synthesis or conjugation with cholesterol, problems with the membrane transport, issues with the transport between the organs, or problems with the bacterial degradation of bile during the enterohepatic cycling. There may also be malabsorption of the bile acid, leading to higher concentrations in the colon, which may then negatively impact the function of the mucosal cells in the colon. Furthermore, when the concentration of bile acids is too high, it can be toxic and cause problems. Alterations to bile acids are also associated with disease.

The level of bile acids that reach the colon may contribute to functional bowel diseases. Elevated concentrations may contribute to diarrhea, while lower levels may play a role in constipation. In one study on children with functional constipation, the fecal bile acid profile was normal, but there were some who had the 3-sulfate version of CDCA as the dominant fecal bile acid, which could demonstrate a link for some cases.

Stress and Bile acids

Psychological stress is a risk factor for atherosclerosis, yet the pathophysiological mechanisms involved remain elusive. The transfer of cholesterol from macrophage foam cells to liver and feces (the macrophage-specific reverse cholesterol transport, m-RCT) is an important antiatherogenic pathway. Because exposure of mice to physical restraint, a model of psychological stress, increases serum levels of corticosterone, and as bile acid homeostasis is disrupted in glucocorticoid-treated animals, we investigated if chronic intermittent restraint stress would modify m-RCT by altering the enterohepatic circulation of bile acids. C57Bl/6J mice exposed to intermittent stress for 5 days exhibited increased transit through the large intestine and enhanced fecal bile acid excretion. Of the transcription factors and transporters that regulate bile acid homeostasis, the mRNA expression levels of the hepatic farnesoid X receptor (FXR), the bile salt export pump (BSEP), and the intestinal fibroblast growth factor 15 (FGF15) were reduced, whereas those of the ileal apical sodium-dependent bile acid transporter (ASBT), responsible for active bile acid absorption, remained unchanged. Neither did the hepatic expression of cholesterol 7α-hydroxylase (CYP7A1), the key enzyme regulating bile acid synthesis, change in the stressed mice. Evaluation of the functionality of the m-RCT pathway revealed increased fecal excretion of bile acids that had been synthesized from macrophage-derived cholesterol. Overall, our study reveals that chronic intermittent stress in mice accelerates m-RCT specifically by increasing fecal excretion of bile acids. This novel mechanism of m-RCT induction could have antiatherogenic potential under conditions of chronic stress.

Vinegar helps increase bile production

Polyphenols such as chlorogenic acid which is present in high levels in apple cider vinegar could inhibit oxidation of LDLs and improve health by preventing cardiovascular diseases (Laranjinha and others 1994).

Stress, fungus and weak immune system are path to cancer – vinegar, lemon and whole foods can fight cancer

 

stress and cancer

The use of vinegar (this particularly apple cider vinegar), has been effective in the treatment and the remission of many of these types of fungus.

Based on the stage of the condition and the general immunity system of the individual, whether the individual has the recuperative powers to recover with the assistance of the vinegar, the body can heal aided with less stress, adequate sleep and optimum nutrition.

High doses of Vitamin C, the use of lemon and other anti-oxidants (from whole foods) are primary cancer fighters that we can use.

Vinegar provides great benefit in countering most fungus types. Most cancer is a psychological condition, caused by free radicals within the system that have an effect upon the metabolism, creating a dissolving of the immunity system to allow these fungi, and other destructive elements (air pollution, metal toxins,stress,lack of sleep,poor nutrition, sugar) to grow in a destructive manner within the tissue.

Eggplant and garlic are rich in sulfur and other nutrients that can fight cancer.

Coramsine – Wikipedia

https://en.wikipedia.org/wiki/Coramsine

(PDF) Topical Solasodine Rhamnosyl Glycosides Derived From the …

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rhamnosyl glycosides as anticancer agents … Solasodine rhamnosyl glycosides are secondary me- ….. the promise that BEC may be potent antineoplastic bio-.

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Dr. Oz revisited – Science-Based Medicine

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Missing: wiki ‎| ‎Must include: ‎wiki

 

Alzheimer is a normal aging process that can be slowed down

Using natural healing ways, Alzheimer ‘s progression can be slowed down. It is also called Type 3  Diabetes. Is gut microbiome the culprit? Strengthen our cells with whole foods rich in omega 3, Vitamin B, A , D and C , calcium and magnesium, digestive enzymes from papaya and pineapple and pickled veggies.

Dancing, exercise, listening to music and hugs and kisses from love ones and friends will make us live long.

If we can treat the root causes, we can prevent its progression 40 years later. It takes adequate sleep, prevention of chronic stress, whole foods, exercise, sunshine and lifestyle modification.

Our brain ages but we can energized it with positive energies , frequency and vibration. Google it and this site about the brain, memory, aging, whole foods , sleep, trauma, stress, toxins and other keywords.

Connie

Preventing and Reversing Alzheimer’s Disease with Dr Perlmutter …

Jun 15, 2015 – Uploaded by Kristin Costello

Dr. Perlmutter talks with me about the possibility of preventing and reversingAlzheimer’s. Get more …

Dr. Mercola Interviews Dr. Perlmutter About Alzheimer’s Disease …

DrMercola Interviews Dr. Perlmutter About Alzheimer’s Disease Prevention – YouTube.

Podcast with Dr. Joseph Mercola – David Perlmutter M.D.

I was fortunate enough to sit down with Dr. Joseph Mercola recently to discuss the topic of Alzheimer’s prevention, an area of research about which I’m very passionate. If you’ve read Grain Brain already, you should be sure to listen, as this interview dives deeper into the arguments I make in the book.

Here is a new article on Dr. Mercola’s… – Coconut oil helps Alzheimer’s …

Here is a new article on DrMercola’s website supporting the use of coconut oil for Alzheimer’s. There is … See more of Coconut oil helps Alzheimer’s, dementia, ALS, MS on Facebook … Discover how a tablespoon of peanut butter and an intake of coconut oil may help in the diagnosis and prevention ofAlzheimer’s disease.

 

Pfizer Halts Research Into Alzheimer’s And Parkinson’s Treatments …

Jan 8, 2018 – Pfizer has announced plans to end its research efforts to discover new drugs forAlzheimer’s and Parkinson’s diseases. The pharmaceutical giant explained its decision, which will entail roughly 300 layoffs, as a move to better position itself “to bring new therapies to patients who need them.” “As a result of a …

Pfizer ends research for new Alzheimer’s, Parkinson’s drugs – Reuters

Jan 7, 2018 – NEW YORK (Reuters) – Pfizer Inc (PFE.N) is abandoning research to find new drugs aimed at treating Alzheimer’s and Parkinson’s disease, the U.S. pharmaceutical company announced on Saturday. … Pfizer is not making any changes to research and development funding for tanezumab …

Pfizer Ends Funding For Alzheimer’s, Parkinson’s Research – Newsweek

Jan 13, 2018 – Pfizer was heavily invested in Parkinson’s and Alzheimer’s research, and was part of the Dementia Discovery Fund, launched in 2015 with GlaxoSmithKline and Eli Lilly as a partnership between industry and government groups to develop treatments for the diseases. The Pfizerneuroscience group …

Commentary: Pfizer: Bad Move to Halt Alzheimer’s, Parkinson’s …

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Jan 8, 2018 – Despite promises that the big GOP corporate tax cut would lead to more corporate investment, Pfizer is steering $10 billion to its shareholders and ending its investment in Alzheimer’sresearch.

Pfizer Halts Drug Research For Alzheimer’s and Parkinson’s Because …

Jan 8, 2018 – Pfizer, one of the world’s largest drug companies, announced over the weekend that it would stop work on new drugs to fight Alzheimer’s disease and Parkinson’s disease. The reason?Pfizer believes that research on the two diseases doesn’t make sense financially.

Pfizer to Cut 300 Jobs as Alzheimer’s, Parkinson’s Research Ends …

Jan 7, 2018 – Pfizer Inc.’s decision to stop research and development into new neuroscience drugs, including its work in Alzheimer’s and Parkinson’s diseases, will lead to about 300 job cuts.

Pfizer Ends Hunt for Drugs to Treat Alzheimer’s and Parkinson’s – WSJ

Jan 6, 2018 – Pfizer Inc. PFE 0.36% on Saturday said it would stop trying to discover new drugs forAlzheimer’s disease and Parkinson’s disease, abandoning costly but futile efforts to find effective treatments for the disorders. The cutback will result in layoffs of 300 employees in Cambridge and Andover in Massachusetts …

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Big Pharma efforts on Alzheimer’s tested by Pfizer exit – Financial Times

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Heal your pancreas, liver and kidney cells

Five Ways to Revitalize Your Liver, Pancreas, and Kidneys

https://steptohealth.com › Healthy habits

This natural remedy will help improve your body’s pH balance, promoting better liver, pancreatic, and kidney health. Just the simple habit of drinking this mixture on an empty stomach will do wonders for your body. It improves kidney function, helping your body detox itself, and prevents problems like the accumulation of fat …

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3 step daily skin cleaning

1. Clean your skin. Choose your skin cleanser based on whether your skin is dry or oily. If you have dry skin, choose a mild cleaning agent (such as Dove, Cetaphil, or Aveeno soaps or cleansers) and avoid products such as toners, which contain alcohol. For oily skin, choose a soap that removes the oil and clean your skin more frequently throughout the day.

I use wash water with apple cider vinegar or pinch of Vitamin C powder, left over tea bags and lemon.

2. Protect your skin from the sun. Choose a broad-spectrum sunscreen with an SPF of 30 or higher and wear it every day. Higher SPFs are useful if you plan to spend hours outdoors, but if you spend most of your time indoors, SPF 30 is generally sufficient. If you have sensitive skin, choose a sunscreen product designed for sensitive skin.

I use sunblock SPF 30.

3. Treat your skin’s particular needs. For dry skin, there are plenty of effective and inexpensive moisturizers from health food stores or you can also DIY.

I moisturize with Vitamin E, Vitamin A, and coconut.

For face mask, I mix  honey, coconut oil and baking soda.

A tsp of apple cider vinegar in your drinking water for colon cleanse

ACV in water.JPG

ACV 1.JPG

Eating foods rich in nutrients with apple cider vinegar facilitates in the absorption of these nutrients in your body. Aloe Vera and Coconut water are alkaline drinks and negates the acidity that comes with eating meat. Eating not so ripe fruits (plums,pineapple,papaya) helps in elimination.

I would drink water with tsp of apple cider vinegar before going to bed and in the morning warm water with lemon juice, aloe and coconut water, sweetened with apple juice or home made plum juice.

Connie


From wiki:

Colon cleansing (also known as colon therapy) encompasses a number of alternative medical therapies claimed to remove nonspecific toxins from the colon and intestinal tract by removing any accumulations of feces. Colon cleansing may be branded colon hydrotherapy, a colonic or colonic irrigation. During the 2000s internet marketing and infomercials of oral supplements supposedly for colon cleansing increased.[1]

Some forms of colon hydrotherapy use tubes to inject water, sometimes mixed with herbs or with other liquids, into the colon via the rectum using special equipment. Oral cleaning regimens use dietary fiber, herbs, dietary supplements, or laxatives. People who practice colon cleansing believe that accumulations of putrefied feces line the walls of the large intestine and that these accumulations harbor parasites or pathogenic gut flora, causing nonspecific symptoms and general ill-health. This “auto-intoxication” hypothesis is based on medical beliefs of the Ancient Egyptians and Greeks and was discredited in the early 20th century.[2]

No scientific evidence supports the alleged benefits of colon cleansing.[2] Certain enema preparations have been associated with heart attacks and electrolyte imbalances, and improperly prepared or used equipment can cause infection or damage to the bowel. Frequent colon cleansing can lead to dependence on enemas to defecate and some herbs may reduce the effectiveness of or increase the risks associated with the use of prescription drugs.


from Dr Mercola

Detoxification is growing increasingly popular. The basic premise is that your body accumulates more toxins in the modern world than its natural detoxification system (your liver, kidneys and lungs) can get rid of. Proponents say that chemicals from pesticides, chlorine, bleach and ammonia, and carbon monoxide build up over time and cause disease.

Dr. Tanya Edwards, director of the Cleveland Clinic’s Center for Integrative Medicine, often starts patients out with a change in diet. Because Americans tend to have diets that lead to constipation, a change in diet can accomplish the same thing as many herbal detoxification products that are really just laxatives.

People are ideally supposed to have one or two bowel movements a day, but many people go two or three days between eliminations. The normal pathway for toxins to move out of the body is through the liver, which converts harmful chemicals into water-soluble molecules that can be flushed out in the urine or feces. If there’s a delay in elimination, however, those toxins remain in your system longer.

Tamara MacDonald, a naturopathic physician, uses detox techniques because some people aren’t able to detoxify chemicals naturally — their systems aren’t working well for one reason or another. But MacDonald is wary of poorly researched techniques like foot baths and colonics, and thinks that people should steer clear of fasting techniques like the “Master Cleanse,” a 10-day detox plan that consists of nothing but lemon juice, maple syrup and cayenne pepper.

“One of the worst things that you can do for your body in terms of detoxification is doing a fast,” she says. “That was the idea about 20 or 30 years ago, but we know now that your body actually needs specific nutrients to be able to perform its job of detoxification.”

Late last year, I participated in a three day think-tank outside of Los Angeles with some of the top experts in autism detoxification. We explored some of the major modalities that are available. I will be presenting this information in Chicago this weekend at the Chicago Autism One Conference.

The group came up with the following consensus and priority for achieving optimal health:

  1. Healthy Living
  2. Avoiding Electromagnetic Fields (EMF)
  3. Clean Water
  4. Healthy Food
  5. Healthy Movement
  6. Emotions & Relationships
  7. Tests
  8. Organ Support
  9. Supplements
  10. Detox Tools

As you can see detoxification is an important tool, but it is not at the top of the priority list — especially if you are sick. Unfortunately, a lot of people first consider detoxing when they’re not feeling well.

It’s important to realize that if you fail to follow an orderly process and begin detoxification processes prematurely, it can deteriorate your health even further, making you very sick.

The Weston A. Price diet recommendations — which were written in 1920 and still, like all truths, hold true today — includes these timeless guidelines:

  • Eat foods that are natural, unprocessed, and organic (and contain no sugar except for the occasional bit of honey or maple syrup).
  • Eat foods that grow in your native environment. In other words, eat locally grown, seasonal foods.
  • Eat unpasteurized dairy products (such as raw milk) and fermented foods.
  • Eat at least one-third of your food raw.
  • Make sure you eat enough healthy fats, including those from animal sources like omega-3 fat, and reduce your intake of omega-6 from vegetable oils.

Additionally, it’s important to understand that if you’re deficient in essential metals, your body will actually use toxic heavy metals as “stand-ins” instead.

For example:

  • Calcium is replaced by lead, which deposits primarily in bone, and disrupts the formation of red blood cells. Lead contributes to poor bone health such as osteopenia and osteoporosis.
  • Zinc is replaced by cadmium, which tends to accumulate heavily in your kidneys. Cadmium overload is associated with peripheral neuropathy.
  • Magnesium is replaced by aluminum, which, among other things, induces neurochemical changes and has been identified as a contributing factor to developing Alzheimer’s.
  • Manganese is replaced by nickel, which is carcinogenic.

So not only do you need to make sure you’re getting vital nutrients in order to avoid this toxic metal replacement process, you also need nutrients to aid your body’s natural detoxification process.

Toxins are naturally eliminated from your body through your liver. It converts many (but not all) of the harmful chemicals you ingest or absorb into water-soluble molecules that are flushed out in your urine or feces.

Remember, Your Skin Eliminates Toxins Too

One beneficial detox method is using an infra-red sauna, particularly for slow metabolizers. It heats your tissues several inches deep, which can enhance your natural metabolic processes. It also enhances circulation and helps oxygenate your tissues.

Your skin is another major organ of elimination, but many people do not sweat on a regular basis. This may be due to wearing synthetic or tight clothing that does not breathe. Sedentary living and sun damage also inactivate your skin. Repeated use of the sauna slowly restores skin elimination, which can help reduce your toxic load quite significantly. Steam baths, sweat lodges, vigorous exercise and hot tubs are other options, but not as effective.

Your results will be best when saunas are part of an integrated program as described above. You may want to add some natural, unprocessed salt to your diet to replace minerals lost through sweating.

Cautionary Notes

 

Please remember that you should avoid starting any detox regimen when you are sick.

You need to establish a healthy lifestyle and dietary habits FIRST, so you have a reserve that your body can draw on to allow your liver to do its job properly.

If you fail to do this you can easily overwhelm your liver’s ability to process the toxic substances that are being eliminated and you will become very sick, wishing you had never done the detox in the first place. I have seen this happen many times, so please use caution and evaluate your current state of health before embarking on any kind of detoxification program.