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New Sign of Stimulants’ Toll on Young by Sabrina Tavernise

WASHINGTON — The number of young adults who end up in the emergency room after taking Adderall, Ritalin or other such stimulants has quadrupled in recent years, federal health officials said Thursday, fresh evidence of the unexpected consequences that can result from the wide use of medicines for conditions like attention deficit disorder.

The number of emergency room visits related to stimulants among people ages 18 to 34 increased to 23,000 in 2011, from 5,600 in 2005, according to national data from the Substance Abuse and Mental Health Services Administration, a branch of the Department of Health and Human Services. Peter J. Delany, the director of the office that oversees statistics for the administration, said the rise was particularly pronounced among 18- to 25-year-olds. He said it was part of a broader pattern of negative health effects from prescription drug abuse across American society.

Scientists have not firmly established the reasons for the rise, but Dr. Delany said one clue was the way that people who misused prescription drugs obtained them: in 2011, more than half got them at no charge from a friend or a relative, and 17 percent bought them from a friend or a relative. That suggests that a large share of the misuse is of medicines not prescribed by the abuser’s doctor.

“We have a huge issue of easy access,” said Dr. Elinore F. McCance-Katz, the chief medical officer of the substance abuse administration, adding that it applies to stimulants as well as to opioids, another category of widely abused prescription drugs.

The report focused on emergency room visits that were the result of abuse or misuse of the stimulants, like taking larger-than-prescribed doses or taking stimulants in combination with alcohol.

Misuse of these drugs has been linked to heart and blood vessel problems, as well as to drug abuse or dependence. When combined with alcohol, the stimulants can hide the effects of being drunk, which increases the risk of alcohol poisoning and alcohol-related injuries. About a third of all emergency room visits related to the stimulants among people ages 18 to 34 involve alcohol, the report said.

The stimulants measured in the report include prescription drugs, like those used to treat attention deficit hyperactivity disorder and to prevent sleepiness, as well as over-the-counter products that contain caffeine, like caffeine pills and caffeinated energy drinks. Illegal stimulants like methamphetamine, also the subject of a growing abuse problem, were not included in the report.

The use of caffeinated energy drinks did not play a major role in the increase in emergency room visits, the report said.

Connie’s comments: In the book, Holistic Pediatrician, the author wrote that diluted coffee can be a replacement instead of the medical drug,  Ritalin, for the young with ADD.

 

———Now hiring financial consultants, work from home, in USA

Please join us on Saturdays 10-11am at 400 oyster pt blvd SSF ste 120 , be a business owner helping families and you then help yourself retire in 7yrs connie 408-854-1883 in USA motherhealth@gmail.com

Where are we now, 3yrs after we created a bucket list or a wish list

This year 2013, I have learned my lessons well from all aspects: relationships, business, finances, jobs and physical needs.  My son, now 19, learned to dance ballroom and latin dances while my daughter learned from her relationships and won 2nd best artist in the bayarea. My mom is still healthy at 78, working and making friends. I have made new friends and established busineses and a blog.  I still have my passion in health and wellness. Looking back, a wish list or bucket list shows us a map of where we have moved from our first step to the next. I wish that all of us may find more actions to make and create more happy memories.

Connie’s To Do list April-August 2011

  • Transform my bedroom and bathroom into a romantic place with help of GF Noveliza
  • Learn more dance steps
  • Buy a bike for me and kids to explore other places nearby
  • Buy some weights to lose 8 lbs in 1 month and to turn back clock for my age especially my skin
  • Find more senior clients for Motherhealth caregivers for homebound bayarea seniors
  • Select friends well and company and places I hang out with and people I talk to
  • Find a permanent job in the bay area
  • Help current employer
  • Care for mom Espie, Esther and Dominic
  • Use my time well, learn my lessons well in all aspects: financial, relationships
  • Go to Melbourne Australia with love ones to visit my sister Marjorie
  • Live well and be happy and share happiness with others

———–

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Now hiring part time financial consultants; calling all former Cisco employees and retirees 408-854-1883 ; motherhealth@gmail.com

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If you are looking for Plan B, I have an opportunity for everyone:
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Motherhealth Inc caregivers for homebound seniors and care home referrals
Call Connie at 408-854-1883 motherhealth@gmail.com

 

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Be brave. Be an innovator. And be the change yourself.

To stand or to sit still and do nothing, we have a choice each day

We either accept or not accept the chances for the day

We take or give but choose to give when we can and take a chance if presented with an opportunity

We decide or not decide although each day counts, waiting has its value depending on the matter at hand

To live or give up on life, to make a change for others to see life with all its colors

To build a business or to work for a lifetime doing the same thing that you love or hate

To follow a dream or to follow other peoples dreams

To raise our children to our beliefs or let them go when the time is right

To follow your spirituality or leave without morals

To love or not to love, although to love is more enjoyable with fits of crying and lots of motions

To spend or save and not taste any goodness based on the value of the goods or service

To buy at thrift store or high end places

To buy a hybrid car or ordinary car

To ride a bike or walk

We choose, each day counts, so choose well and take a chance, love and live.

Connie Dello Buono, motherhealth@gmail.com , business owner

————
Rumi wrote:
Love is the bridge between you and everything.
IMG_20130808_202200

Dr. Wayne W. Dyer
Make a pact to remind yourself often of this secret: you can’t give away what you don’t have, but you can change your life by changing what’s going on inside. Then work on your personal program of self-love, self-respect, and self-empowerment, and create a huge inventory of what you wish to give away. If what you give is self-respect and self-love, the universe will return the love and respect you’ve been radiating. It’s really so simple. As the Beatles said: “The love you take is equal to the love you make.”

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To our creative spirit, invent more for it provides freedom to some. Create disruptive innovation, we need more of it.

Disruptive technology is a term coined by Harvard Business School professor Clayton M. Christensen to describe a new technology that unexpectedly displaces an established technology.

 

———Now hiring financial consultants, work from home, in USA

Please join us on Saturdays 10-11am at 400 oyster pt blvd SSF ste 120 , be a business owner helping families and you then help yourself retire in 7yrs connie 408-854-1883 in USA motherhealth@gmail.com

A 61 yr old journey to second life after a heart surgery

At 49 yrs of age, she was gasping for breath when walking 5 blocks to the convention she is suppose to attend. When she finally made it, she immediately phoned her doctor for an unscheduled medical checkup. She was not given an angiogram so at that time nothing was found that should be alarming.

One month later, she was hiking with friends and felt that she was gasping for breath again and she knows that she has to lose weight, maybe 30 lbs at her small stature. So back to the doctor’s clinic, she insisted to get an angiogram and when she had it, the doctors found out that her arteries are 90% clogged.

So a surgery was scheduled the next day to catch the doctors before they go on vacation. She called her priest and prayed about it. During the surgery, she saw her spirit leave her body and she can see how she looked in the operating room with her body cut open in the middle like a frog cut open. During that time, she felt a pink light and warm feeling of love and then she heard a warm and loving voice, “what do you choose to do now, to go back to your body or leave it. “ She decided to go back to her body.

From this experience, she appreciates life more each day when she wakes up and even when she lost everything financially 2 yrs ago, she picked up herself and started all over. A year ago, she was introduced to be an independent consultant for Rodan and Fields dermatologists, doctors of Proactiv, in direct selling of anti-aging skin care. She believed in the product and to be financially free and have her own business with low cost of entry. To be able to start the business, she needs around $600 so she worked at Panera bread to save the money needed to start as consultant and be in business with a team of people.

Now her face is glowing as she herself used the product for the first 6 months to show that it works to others and always hugging people and thankful for life. I am appreciating life to the fullest, she said.

—————

Connie Dello Buono 408-854-1883 motherhealth@gmail.com

Now hiring single mothers and single fathers in the bay area wanting to be business partners in the financial arena, no glass ceiling, start as part time but full time income, full field training support. Sharing the crusade of helping families with tax free retirement savings with health benefits, access to funds up to $1.35M when illness strikes (cancer, stroke, disability)

Call 408-854-1883 ; motherhealth@gmail.com

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Prepare for Plan B, residual and retirement income, work remotely in 50 states with  unlimited training and field support, 408-854-1883 ; motherhealth@gmail.com

Your referrals will make my day. Refer me to anyone who needs extra income in the bay area: retired, college grads, sales agents, marketers, networkers, stay at home mom and dad

Canada Health Care Wait Times: Causes and Cures

Wait Times: Causes and Cures

“Canadians could potentially have same day access to primary health care, one or two weeks access for appointments with medical specialists, and almost no waiting for tests and surgeries.”

— Dr. Brian Postl, National Wait Time advisor, CEO Winnipeg Regional Health Authority

By the Numbers

90%
The drop in wait times from first visit with an orthopaedic surgeon to surgery when Alberta implemented a project to cut wait times for orthopaedic surgeries in the public system.		 4.6 hours
The maximum amount of time spent in emergency rooms by 90% of Ontario patients with minor or uncomplicated conditions. Most emergency room visits are for minor conditions.		 16 weeks
longer to wait for cataract surgery. A Manitoba study showed that patients whose doctor worked only in public facilities waited 10 weeks, while patients whose doctors worked in both private & public facilities waited 26 weeks.		 75%
Reduction in wait times for hip and knee reconstruction surgery at B.C.’s Richmond Hospital after a pilot project to reduce wait times in the public health care system.		 2 weeks
used to be the wait time it took to see a family doctor in one area of Halifax. Improving systems has meant that most patients can get an appointment the next day.

Wait times:

Privatization is not the answer

When you are ill or in pain, there is nothing more frightening or frustrating than having to wait for treatment. Too many Canadians face long wait times for health services. Not only does this hurt the patients, it makes all Canadians wonder if our public health care system is broken.

People who want private for-profit health care use wait times as a reason to justify the introduction of a parallel private system for those who can afford to pay.

Privatization is not the answer

In fact, in places where there are for profit parallel systems, wait times are as long or longer. The good news is that wait times are fixable, and the solutions are found in the public health care system. By changing some of the ways that we now carry out important health services, we can cut wait times dramatically, improve patient care and reduce costs.

Why are we waiting?

There are many complex reasons for longer wait times, and there is not one single cause. That’s why reducing wait times will require system-wide improvements.

Here are some of the reasons for longer wait times:

  • Poorly organized services – inefficiencies, lack of coordination among all those involved in delivering services and poor planning slow down the system and create bottlenecks in providing surgeries and other services.
  • Shortages of health care workers – if patients can’t get to see a doctor quickly (or at all) they turn to emergency rooms (ERs), extending wait times in ERs.
  • Physicians don’t work in teams – most doctors offices work alone, so all appointments and procedures leading up to surgery are managed individually, leading to delays and inefficiencies at every step.
  • Cuts to hospital services — between 1988 and 2002 there were 64,000 hospital beds cut.
  • The need for more long-term care and home care – under-funding of home care and residential long-term care has increased inappropriate and preventable hospitalization and adds pressure on emergency rooms.
  • Better outcomes – when we improve services, more people can benefit from them (e.g. many patients now have surgeries that would have been too dangerous a few years ago).

Wait times:

Why for-profit is not the answer

People who own private for-profit clinics often make the case that by letting the wealthy pay for private services, it will take the pressure of the public system and reduce wait times for the rest of us. In fact, the evidence shows this is not true.
Wait times are longer where this is a parallel for profit system – In countries with parallel for-profit and public systems, wait times are longer, not shorter than wait times in countries where there is only a public system.

For-profit clinics take doctors and nurses out of the public system – there are limited resources in our health care system. A for-profit private clinic takes doctors and nurses out of the public system to care for those who can afford it, while the rest of us face longer public lines as a result.

“Cream-skimming” in for-profit care chooses easy-to- treat patients – this practice leaves the higher risk, higher cost patients to the public system while make money off the simple cases. This means longer wait times in the public system.

For-profit care isn’t as safe – Research shows that for-profit facilities are not as good for your health. One study estimated that if all Canadian hospitals were converted to for-profit, there would 2,200 additional deaths every year. That’s not the way to shorten wait times.

For-profit care costs more – costs in a parallel system are higher than in the public system. For example, knee replacement surgery in a public hospital costs $8,000; in a private facility, between $14,000 and $18,000. That’s not a cost most of us can pay.

Health care should be based on need, not on ability to pay – it’s one of the strongest beliefs of most Canadians. Our public health care reflects our Canadian values of equality and fairness. We want all Canadians to get access to quality and timely care – not just those who can afford to pay out of their own pockets.

Wait times:

The public health care solutions

To reduce wait times, we need to make important systemwide improvements in our health care system. Many of these changes have already been tried successfully in some regions of the country.

Fund the public solutions – governments need to make system-wide improvements based on the successful projects in public hospitals and clinics that are dramatically reducing wait times. We need more than isolated pilot projects.

Put patients before profits – it seems obvious, but when efficient and appropriate patient care is made a priority, administrative and clinical practices improve and wait times are shortened.

Common waiting lists – all patients waiting for certain surgeries go into a single list for the first available surgeon. Patients could still choose their surgeon, but they might have to wait longer.

Better coordination – by staggering start-time for surgery and standardizing surgical equipment and procedures including pre-screening and tests. Where this has been tried, wait times dropped 75% and the number of surgeries completed increased by 136%.

Expand team work – establishing teams of health care providers including physicians, nurses, nurse practitioners and other health professionals eliminates duplication, improves coordination and makes better use of scarce resources.

Modernizing electronic information systems – so everyone in the health care team has timely access to accurate and up-to-date patient information and there is no unnecessary waiting for patient records.

Improve community care – by putting resources into longterm care, home care and home support, we can keep people healthier and out of hospital, and relieve the pressure on hospital beds.

Improve access to family health care – when patients can get timely access to family health care teams, through community clinics and urgent care centres, the wait time in ERs drops dramatically.

Glutathione, the body’s master antioxidant and detoxifier by Priya Shah

Glutathione, the body’s master antioxidant and detoxifier, is one of the 14 “Superfoods” listed in SuperFoods Rx : Fourteen Foods That Will Change Your Life, co-authored by Dr Steven Pratt.

Glutathione levels cannot be increased to a clinically beneficial extent by orally ingesting a single dose of glutathione. (1) This is because glutathione is manufactured inside the cell, from its precursor amino acids, glycine, glutamate and cystine.

Hence food sources or supplements that increase glutathione must either provide the precursors of glutathione, or enhance its production by some other means.

The manufacture of glutathione in cells is limited by the levels of its sulphur-containing precursor amino acid, cysteine.

Cysteine – as a free amino acid – is potentially toxic and is spontaneously catabolized or destroyed in the gastrointestinal tract and blood plasma. However, when it is present as a cysteine-cysteine dipeptide, called cystine, it is more stable than cysteine.

Consuming foods rich in sulphur-containing amino acids can help boost glutathione levels. Here are some food sources and dietary supplements that help boost glutathione levels naturally.

1. N-Acetyl-Cysteine (NAC)

It is derived from the amino acid L-Cysteine, and acts as a precursor of glutathione. NAC is quickly metabolized into glutathione once it enters the body. It has been proven in numerous scientific studies and clinical trials, to boost intracellular production of glutathione, and is approved by the FDA for treatment of accetaminophen overdose. Because of glutathione’s mucolytic action, NAC (brand name Mucomyst) is commonly used in the treatment of lung diseases like cystic fibrosis, bronchitis and asthma.

2. Milk Thistle, Silymarin

Milk thistle is a powerful antioxidant and supports the liver by preventing the depletion of glutathione. Silymarin is the active compound of milk thistle. It is a natural liver detoxifier and protects the liver from many industrial toxins such as carbon tetrachloride, and more common agents like alcohol.

3. Alpha Lipoic Acid

Made naturally in body cells as a by-product of energy release, ALA increases the levels of intra-cellular glutathione, and is a natural antioxidant with free radical scavenging abilities. It has the ability to regenerate oxidized antioxidants like Vitamin C and E and helps to make them more potent. ALA is also known for its ability to enhance glucose uptake and may help prevent the cellular damage accompanying the complications of diabetes. It also has a protective effect in the brain.

4. Natural Foods That Boost Glutathione Levels

Asparagus is a leading source of glutathione. Foods like broccoli (2), avocado and spinach are also known to boost glutathione levels. Raw eggs, garlic and fresh unprocessed meats contain high levels of sulphur-containing amino acids and help to maintain optimal glutathione levels.

5. Undenatured Whey Protein Isolate

Whey protein contains proteins like alpha-lactalbumin which is is rich in sulphur-containing amino acids. Heating or pasteurization destroys the delicate disulphide bonds that give these proteins their bioactivity. Undenatured whey protein is a non-heated product that preserves bioactive amino acids like cystine. It has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.

6. Curcumin (Turmeric)

Treatment of brain cells called astrocytes, with the Indian curry spice, curcumin (turmeric) has been found to increase expression of the glutathione S-transferase and protect neurons exposed to oxidant stress. (3)

7. Balloon Flower Root

Changkil saponins (CKS) isolated from the roots of the Chinese herbal medicine, Platycodon grandiflorum A. DC (Campanulaceae), commonly called Balloon Flower Root or Jie Geng, have been found to increase intracellular glutathione (GSH) content and significantly reduce oxidative injury to liver cells, minimise cell death and lipid peroxidation. (4)

8. Selenium

Selenium is a co-factor for the enzyme glutathione peroxidase. Selenium supplements have become popular because some studies suggest they may play a role in decreasing the risk of certain cancers, and in how the immune system and the thyroid gland function. However, too much selenium can cause some toxic effects including gastrointestinal upset, brittle nails, hair loss and mild nerve damage.

Disclaimer: The information here is not provided by medical professionals and is not intended as a substitute for medical advice. Nutritional supplements, while usually benign, can produce adverse reactions in some people. As with prescribed drugs, long-term effects from supplements are often unknown. Pregnant women and children should not take supplements except after consultation with their healthcare provider. Never exceed the recommended dosage on the container. If you observe adverse effects stop taking the supplement immediately and contact your healthcare provider.

References:

1. The systemic availability of oral glutathione
Witschi A, Reddy S, Stofer B, Lauterburg BH. [Eur J Clin Pharmacol. 1992;43(6):667-9.]

2. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system
Wu L, Ashraf MH, Facci M, Wang R, Paterson PG, Ferrie A, Juurlink BH. [Proc Natl Acad Sci U S A. 2004 May 4;101(18):7094-9. Epub 2004 Apr 21.]

3. Can Curry Protect Against Alzheimer’s?
American Physiological Society (APS) Press release; 16-Apr-2004

4. Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity
Lee KJ, Choi CY, Chung YC, Kim YS, Ryu SY, Roh SH, Jeong HG. [Toxicol Lett. 2004 Mar 7;147(3):271-82.]

Others

Melatonin: This is a hormone that naturally occurs in the brain. It is made by the pineal gland. It is a derivative of the amino acid L-tryptophan and the neurotransmitter serotonin.

There are some food sources for melatonin, including the tart montmorency cherry, oats, sweet corn, rice, bananas, tomatoes, flax seed, sunflower seeds, and several leaves, such as feverfew and St. John’s Wort.

Melatonin has other roles as well, including functioning as an antioxidant, and also to effectively raise glutathione levels.

There have been many studies done on this aspect of melatonin, but as of yet, the long term safety of melatonin has not been well established, and the effect varies from person to person. If taken as a supplement, this product should only be used in conjunction with your health care professional.

Glutamine: Glutamine is the most abundant free amino acids found in the body. It is useful in raising glutathione. One of the few amino acids that crosses the blood-brain barrier, it is normally plentiful in the diet today.

There are many functions of glutamine, including it’s role in metabolizing and maintaining lean muscle. It can also build up your immune system, play a role in anti-cancer therapy, boost brain function, and detoxify the body.

Glutamine supplies the body with glutamate, one of the three amino acids that raise glutathione, and it is the second most important component after cysteine. Glutamate is found in many plant and animal sources, but is easily destroyed by cooking.

It is also found in raw spinach, parsley, and raw meat, but with the health risks associated with the latter, is not recommended. Completely healthy individuals don’t need supplemental glutamine. Any serious use of this supplement for help in how to raise glutathione should be monitored by a health care professional.

Lipoic Acid: This is also commonly referred to as Alpha-Lipoic Acid. The roles of this substance are as an antioxidant, neutralizer of toxins and heavy metals, and recycler of other antioxidants like Vitamin C and Vitamin E. It occurs naturally in the body, and is also available on the shelves of health food stores. it can also be found in small amounts in foods like spinach and broccoli.

Lipoic Acid works by keeping glutathione in its reduced state. This is good, because in its reduced stated, glutathione can do its job as an antioxidant. So they have a partnership of sorts. One reason glutathione is called the Master Antioxidant is because it also helps to keep lipoic acid in it’s reduced state as well.

There is some research demonstrating that a lipoic acid supplement is best taken along with L-Carnitine for the best results in raising glutathione.

There are promising results with lipoic acid being demonstrated with medical studies. For some, there are short term side effects, and so more research is being done on this substance to see what other benefits it may have in addition to raising glutathione.

Silymarin: Silymarin is the substance extracted from the milk thistle plant. As such, at times, these terms are used interchangeably.

This has been used by herbalists for centuries to treat a variety of liver disorders, like cirrhosis or hepatitis. It seems to stimulate the growth and regeneration of injured liver cells. It can also act as a free radical scavenger, enhancing detoxification in the liver.

There are ongoing studies demonstrating silymarin’s effectiveness in raising glutathione levels. Recommended doses vary greatly, from 50- 500 mg a day. Toxic reactions can include gas, cramps, and diarrhea.

Since it may lower blood sugar, it should be used with caution by diabetics. Liver diseases, including auto immune liver disease, should always be treated with the assistance of a health care professional.

Raising levels of glutathione

Vitamin B1, B2: These are water soluble vitamins that help to maintain glutathione and its related enzymes in their active forms.

B1 or Thiamine is found in cereal grains, yeast, pork, brown rice, certain vegetables, and eggs. B2 or Riboflavin is also essential for glutathione production and energy metabolism. vitamins and minerals
B2 can be found in dairy products, leafy green vegetables, liver, legumes, and yeast. The current recommended daily dose of these vitamins is 10-50 mg/day for most people.

However, many health professionals feel this may be too low , and so the optimum may be up to 300 mg/day. Since they are water soluble, any excess is excreted from the body and so toxicity is not normally an issue.

Vitamin B6, B12: These too are water soluble vitamins. They play an important role in glutathione synthesis. B6 is crucial for the function of many amino acids and essential fatty acids. It also helps with glucose and lipid metabolism.

B12 helps to produce red blood cells, myelin, DNA, and other neurological tissues. For this reason, it plays a key role in the normal functioning of the brain and nervous system. B12 also helps to regenerate folate in the body.

Folic Acid: Also known as folate, helps with making DNA and transmission of nervous signals. It has also been shown to help with cardiovascular disease. Children and adults alike need folic acid to prevent anemia or iron deficiency.

For learning how to raise glutathione , folate helps to make sure available cysteine is converted into glutathione rather than homocysteine. Under normal circumstances the recommended dosage of B6 is 10-50 mg/day, B12 is 10-50 mcg, Folic acid of 400 mcg per day.

Vitamin C: Also known as ascorbic acid, this is probably the best known water soluble vitamin. Most living organisms can make their own Vitamin C, but humans cannot, so it must be supplemented.
Vitamin C has been the subject of medical studies regarding it’s role as an antioxidant for many years now. Vitamin C has a key role in glutathione metabolism. It is involved in the glutathione enzyme system which keeps Vitamin C, Vitamin E, and other antioxidants in their reduced state.

This preserves their ability to keep on working as antioxidants in the body, effectively recycling them and making them work over and over again before being disposed of by the body.

There have been many studies showing that Vitamin C supports and raises glutathione levels and activity. By the same token, when there is not enough glutathione, Vitamin C is far less effective and rapidly depleted.

So we can see why they go hand in hand with one another. There is much controversy over the adequate dose of Vitamin C needed . If glutathione levels are adequate, than 200-1,000 mg/day should be sufficient.

Vitamin E: This is a fat-soluble vitamin that comes in a close second as the most popular supplement in America today. Besides its role as an antioxidant, Vitamin E has been shown to be helpful in many areas of disease prevention today. It also plays a role in detoxification.

It also plays an important role in the glutathione enzyme system which, like Vitamin C , keeps the other antioxidants in their reduced state so they can keep doing their job mopping up free radicals.

There are two forms of Vitamin E, natural and synthetic. The natural form is denoted by d, as in d-alpha tocopherol, and the synthetic form as dl, as in dl-alpha tocopherol. The natural forms are better for you. Vitamin E can be found in avocado, nuts, seeds, spinach, vegetable oils, wheat germ, milk, asparagus, and eggs.

The recommended daily dosage for Vitamin E ranges from 25-50 IU/day, although most of us would probably experience more benefit of higher doses of 100-1200IU/day. So Vitamin E can be very helpful in finding out how to raise glutathione in your cells.

If a person has adequate levels of glutathione, 400 IU/day should be sufficient. If excessively consumed, it can provoke gastrointestinal, cardiovascular, and neurological side-effects, so caution should be exercised.

How To Raise Glutathione With Other Micronutrients: Magnesium, Vanadium, and Zinc:

Magnesium deficiency can lead to the impairment of an important glutathione enzyme needed for glutathione production.

Vanadium is a trace element that depends on glutathione to remain in a reduced state to increase it’s bioavailabiity. In high doses, Vanadium is toxic and may have an adverse effect on glutathione production.

Zinc deficiency also reduces glutathione concentration, especially in red blood cells. Zinc also is toxic in higher levels, and may also reduce glutathione if it is over-consumed.

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Safe herbs: milk thistle, kava kava, Echinacea, black cohosh and St. John’s wort

Considerable evidence from both in vitro and animal studies suggests that CYP2D6 activity can be inhibited by goldenseal [59, 60], milk thistle [61, 62], kava kava [59, 63–65], Echinacea [59], and St. John’s wort [59, 66–68]. Currently, no in vitro results are available for black cohosh’s effect on CYP2D6, although certain triterpene glycosides isolated from black cohosh modestly inhibited human CYP3A4 in vitro [69]. However, evidence of in vitro CYP450 inhibition, or that observed in animal models, may not accurately predict in vivo effects observed in humans [70]. Our purpose in this series of clinical studies was to assess whether botanical supplement formulations containing either goldenseal, milk thistle, kava kava, Echinacea, St. John’s wort, or black cohosh could modulate human CYP2D6 activity using standard phenotyping techniques.

Five of the botanicals evaluated in these 3 studies exerted no significant effects on CYP2D6 activity as determined by DURR. These included milk thistle, kava kava, Echinacea, black cohosh and St. John’s wort. Our clinical findings run counter to many of the in vitro predictions of CYP2D6 inhibition by these supplements [59–68]. Significant divergence between in vitro predictions and in vivo realities are not uncommon. Reasons for such in vivo/in vitro discrepancies have been discussed in detail by von Moltke [70], but certain other basic pharmaceutics issues relevant to dietary supplements may also contribute; these include poor dissolution characteristics of botanical formulations and significant inter-product variability in phytochemical content [52, 71–74]. Still other considerations include extensive pre-systemic in vivo conjugation of phytochemicals via Phase II enzymes (e.g. glucuronidation, sulfation, glycination), a process that may preclude CYP inhibition by these compounds [75]. Nevertheless, our results confirm previous clinical findings that milk thistle [39], kava kava [76], Echinacea [37, 39], black cohosh [39], and St. John’s wort [29–32, 34, 38, 40] are not potent modulators of human CYP2D6 in vivo. Several of the clinical studies involving St. John’s wort, however, utilized dextromethorphan/dextrorphan urinary ratios as a phenotypic measure of CYP2D6 activity [29–31, 34, 38], and this particular approach has been recently called into question [46, 77, 78]. This uncertainty stems from the fact that normal physiological changes in urine pH can alter the dextromethorphan/dextrorphan ratio by as much as 20-fold [77]. DURR, however, is not affected by urine pH and thus appears to be a more reliable phenotypic measure of CYP2D6 activity [46, 47]. Collectively, these studies, particularly those using DURR, strongly suggest that these 5 botanicals pose little to no significant concerns regarding pharmacokinetic herb-drug interactions with drugs metabolized by CYP2D6.

Of the 6 botanical extracts evaluated in this series of clinical studies, only goldenseal appeared to have significant inhibitory effects on human CYP2D6 in vivo. The almost 50% reduction in mean post-supplementation DURR signifies that goldenseal is a potent inhibitor of human CYP2D6 in vivo. Moreover, these results corroborate an earlier report by our group, which utilized a different goldenseal formulation [76]. Our findings also bolster recent in vitro investigations demonstrating inhibition of CYP2D6-mediated biotransformations by goldenseal extracts [59, 60]. During an evaluation of a series of single-entity herbal tea extracts, Foster et al observed that Hydrastis canadensis (goldenseal) produced the greatest percent inhibition of cDNA expressed human CYP2D6 [59]. In addition, Chatterjee and Franklin observed that goldenseal extract and its principal isoquinoline alkaloids, berberine and hydrastine, inhibited CYP2D6-mediated bufuralol 1′-hydroxylation in human hepatic microsomes [60]. Of the two alkaloids, berberine exhibited a greater effect on bufuralol 1′-hydroxylation (IC50 = 45 μM) than hydrastine (IC50 = 350 μM), signifying a greater contribution of this phytochemical to CYP2D6 inhibition.

At present, little is known about the pharmacokinetics of goldenseal alkaloids in humans, but animal studies indicate that berberine bioavailablity is relatively low [79, 80]. Although the daily dose of isoquinoline alkaloids ingested in the present study was 209 mg (Table II), plasma concentrations of berberine and hydrastine were not determined; nevertheless, the significant effect observed on CYP2D6 phenotype indicates that phytochemicals present in goldenseal can cross the intestinal mucosa. Taken together, both in vitro and in vivo findings imply that goldenseal, if taken concomitantly with CYP2D6 substrates, may give rise to clinically significant herb-drug interactions.

In summary, the data presented herein supports previous clinical investigations that milk thistle, kava kava, black cohosh, Echinacea, and St. John’s wort are not potent modulators of human CYP2D6 in vivo. Thus, concomitant ingestion of these specific botanicals with drugs that are CYP2D6 substrates is not likely to result in clinically relevant herb-drug interactions. On the other hand, goldenseal significantly inhibits human CYP2D6 in vivo and may give rise to significant pharmacokinetic herb-drug interactions. Accordingly, patients should be strongly discouraged from taking goldenseal-containing supplements concomitantly with prescription medications, especially those extensively metabolized by CYP2D6.

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Acknowledgements

This work was supported by the NIH/NIGMS under grant RO1 GM71322 and by the NIH/NCRR to the General Clinical Research Center of the University of Arkansas for Medical Sciences under grant M01 RR14288

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562884/

75 yr old male, asthma and diabetes, 20 meds a day

I was observing a 75 yr old male with asthma and diabetes in a care home and  taking more than 20 medications a day. He has no appetite but when not taking any meds during the weekend, feels stronger and has appetite.  He is bed-ridden and with no food in his stomach but ingesting more acidic drugs, life is becoming more unbearable for him.

Yesterday, his family brought him all the sweets he liked in the past to coax him to eat, not knowing that these same sweet foods laden with preservatives brought him to his unhealthy condition.

A similar story with one of the elderly in care home who was terminally ill and so was ordered to stop taking all her medications and had survived few more years as the body tried to recover without the burden of acidic medications.

Each person is different but at times with empty stomach and only drugs, how can life be sustained.

My grandfather who died at 94 yrs of age did not take any medications and had been eating bamboo shoots and other local fresh produce only.

During the day, he chews as many other elderly, a combination of leaves and other herbal stuff that contain sulfur, cleansing compound.

Let us live well and use the natural products of the earth, whole foods and life sustaining.

How moderate exercise can help us learn

Over the past decade, in study after study in animals and people, exercise has been shown to improve the ability to learn and remember. But the specifics of that process have remained hazy. Is it better to exercise before you learn something new? What about during? And should the exercise be vigorous or gentle?

Two new studies helpfully tackle those questions, with each reaching the conclusion that the timing and intensity of even a single bout of exercise can definitely affect your ability to remember — though not always beneficially.

To reach that conclusion, scientists conducting the larger and more ambitious of the new studies, published in May in PLoS One, first recruited 81 healthy young women who were native German speakers and randomly divided them into three groups. Each group wore headphones and listened for 30 minutes to lists of paired words, one a common German noun and the other its Polish equivalent. The women were asked to memorize the unfamiliar word.

But they heard the words under quite different circumstances. One group listened after sitting quietly for 30 minutes. A second group rode a stationary bicycle at a gentle pace for 30 minutes and then sat down and donned the headphones. And the third group rode a bicycle at a mild intensity for 30 minutes while wearing the headphones and listening to the new words.

Two days later, the women completed tests of their new vocabulary. Everyone could recall some new words. But the women who had gently ridden a bicycle while hearing the new words — who had exercised lightly during the process of creating new memories —performed best. They had the most robust recall of the new information, significantly better than the group that had sat quietly and better than the group that had exercised before learning. Those women performed only slightly better than the women who had not exercised at all.

That result contrasts tellingly with the findings of another new study of memory formation and exercise, presented in May at the annual meeting of the American College of Sports Medicine in Indianapolis. During this study, 11 female collegians read a dense chapter from a college textbook on two occasions: once while sitting quietly and, on a separate day, while exercising vigorously on an elliptical machine for 30 minutes. Immediately after each session, the students were tested on the material they’d just read. They were then retested the next day.

In this study, exercise did not help the women’s memories, at least in the short term. Their test scores were actually worse on the memory test conducted immediately after they’d exercised while reading compared with their scores taken soon after they’d been sitting quietly and studying.

But the recall gap disappeared the next day, when the women were retested. At that point, there were no differences in their scores, whether they’d vigorously exercised while learning the new material or not.

The message of these studies would seem to be that exercise timing and intensity interact to affect memory formation, said Maren Schmidt-Kassow, a professor at the Institute of Medical Psychology at Goethe University in Frankfurt, Germany, who led the study of gentle bicycling and memory. Exercising during learning was, in her study, significantly more effective than exercising beforehand or not exercising at all.

But that beneficial impact probably depended on the mildness of the workout, she said. Light-intensity exercise will elicit low but noticeable levels of physiological arousal, she said, which, in turn, presumably help to prime the brain for the intake of new information and the encoding of that information into memories.

If the exercise is more vigorous, however, it may overstimulate the body and brain, she said, monopolizing more of the brain’s attentional resources and leaving fewer for the creation of robust memories.

This theory also helps to explain why, in both studies, memory recall was best a day or two after exercise, by which time, Dr. Schmidt-Kassow said, physiological arousal would have dissipated.

Of course, the mysteries of human memory remain, by and large, mysteries. These new studies don’t explain how, for instance, at a molecular level, exercise affects the creation of individual memories. It is likely that, as part of the arousal process, exercise stimulates the release of certain chemicals in the brain that affect memory formation, Dr. Schmidt-Kassow said. But that idea has yet to be proven, although she and many other scientists have applicable studies underway.

For now, though, there is some practical takeaway from the current studies, said Walter Bixby, an associate professor at Elon University in North Carolina, who oversaw the study of vigorous exercise and reading. “If you have an exam” or other activity that involves memorizing and recalling information “in a few hours, you would probably be better off sitting quietly and studying,” he says. “However, if the exam is the next day, it won’t hurt you to study while exercising.” And if your workout is gentle, it could even help.

written by GRETCHEN REYNOLDS for http://www.nytimes.com

 

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