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Make a difference in people’s lives. Share healing powers of phytonutrients and measuring anti-oxidant level to prevent future chronic health issues.
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NEW YORK (GenomeWeb) – Researchers in the Netherlands have developed a diagnostic test to detect lung cancer by examining tumor RNA absorbed by circulating platelets called thrombocytes.
Published in Cancer Cell earlier today, the study investigated the potential and origin of spliced RNA profiles from tumor-educated platelets, or TEPs, for the noninvasive detection of early- and late-stage non-small cell lung cancer.
The researchers examined more than 700 blood samples using a biomarker signature detection platform called ThromboSeq, including patients diagnosed with late-stage non-small cell lung cancer, a smaller group with early stage cancer, and a control group with no known cancer.
ThromboSeq enables clinical researchers to identify different cancer types by looking at TEP-derived RNA using next-generation sequencing.
ThromboSeq’s swarm intelligence algorithm scanned approximately 5,000 different RNA molecules found in the thrombocytes and recorded the small amount that indicate a cancerous tumor. The researchers then ran the blood samples through screenings to diagnose how accurately the thrombocytes identified cancer.
According to the researchers, ThromboSeq detected early-stage cancer with 81 percent accuracy and late-stage cancer with 88 percent accuracy. The algorithm yielded an accuracy up to 91 percent in a validation control group that matched for a patient’s age, smoking status, and blood storage time.
The device’s particle-swarm optimization (PSO) algorithms allowed efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries. The gene panels then diagnosed cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostic readout of other liquid biopsy biosources.
“ThromboSeq might not only provide lung cancer diagnostics, but potentially any other tumor type as well, and may enable tumor-type stratification,” VU University Medical Center researcher Myron Best said in a statement.
He and his colleagues based their method on swarming behavior that can be found in nature, where birds, insects, and fish swarm to defend themselves against predators or to search for food.
“Birds continuously adjust their location in the swarm relative to each other, thereby increasing the flock’s coverage, and thus, the efficiency of the food-searching process,” Best said. “We applied this natural phenomenon to our algorithms, which make use of the complex RNA repertoire present in platelets.”
Researchers concluded that the ThromboSeq platform allows for robust biomarker selection for blood-based cancer diagnostics, independent of bias introduced by factors such as age and smoking status. Best and his team plan to further optimize the algorithm with patients suspected of having undiagnosed lung cancer.
“Although the tumor-educated platelets blood test does not, so far, provide perfect predictions, it may complement alternative liquid biopsy bio-sources” added Best.
Connie’s comments: Increase your anti-oxidant levels with yellow colored whole foods/supplements high in phytonutrients and greens.
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Not long ago, I took ibuprofen after a dental procedure and was amazed at how well it worked. Millions of people have had similar experiences with ibuprofen and related medications (called non-steroidal anti-inflammatory drugs, or NSAIDs) when used for a number of conditions, including arthritis, back pain, and headache. That’s why NSAIDs are among the most commonly prescribed drugs worldwide.
More than a dozen different NSAIDs are available, including naproxen (as in Naprosyn or Aleve), celecoxib (Celebrex), diclofenac (Voltaren) and indomethacin (Indocin). Aspirin is also an NSAID, though it is usually taken in small doses for its blood thinning effects (to prevent heart attack or stroke) rather than for pain.
The safety profile of NSAIDs is generally quite good, especially when taken in small doses for short periods of time. That’s why several of them, including ibuprofen and naproxen, are available in low doses over the counter in this country and elsewhere.
However, as is true for any drug, NSAIDs can cause trouble. Upset stomach, intestinal bleeding, and cardiovascular problems are among the most important and widely recognized side effects. But, the list is longer than that. The risk of heart attack may be increased among users of NSAIDs, especially among those at increased risk (such as those who have had a previous heart attack). Another important item on that longer list is kidney injury. Most of the time, NSAID-related kidney problems develop in people who already have kidney disease or who take other medications that can affect kidney function. High doses and prolonged use are also risk factors.
NSAID use is common among people who deal with aches and pain during and after exercise. In fact, many marathoners and other endurance athletes take NSAIDs preventively to reduce pain and possibly improve performance. However, these same athletes are at particular risk for kidney injury. Dehydration and muscle damage are common among endurance athletes and can also contribute to kidney injury. If NSAIDs are added to the mix, might these athletes be at even higher risk for kidney damage? Should they avoid using NSAIDs? That’s the subject of a new study published in the July 2017 edition of Emergency Medicine Journal.
Researchers divided 89 ultramarathoners participating in one of several seven-day, 155-mile races into two groups: one group took 400 mg of ibuprofen (equivalent to two over-the-counter Advil) every four hours for three or four doses toward the end of the race. The other group took a placebo.
What they found was concerning:
The Yale chemical analysis (see below) found 12 carcinogens in the synthetic turf tested. High temperatures cause crumb rubber infill to outgas at a higher rate.
Artificial turf that uses infill made from recycled tires (“crumb rubber”) contains a cocktail of toxic chemicals, including benzothiazole, carbon black, and heavy metals. As the Mt. Sinai Children’s Environmental Health Center has written: “Exposures to chemicals present in crumb rubber at very high levels, typical of animal or occupational studies, are known to cause birth defects, neurologic and developmental deficits, and some can even cause cancer.
Children are particularly vulnerable to toxic threats. Children have increased exposure to toxic chemicals due to the unique way they interact with their environment. Because they are growing and developing, their bodies are also more susceptible than adults to chemical exposures.
Crumb rubber contains benzothiazole, which “exerts acute toxicity and is a respiratory irritant and a dermal sensitizer.” [ii] Carbon black, which makes up 20-40% of crumb rubber, has been identified as a cancer-causing chemical by California’s Office of Environmental Health Hazard Assessment. Another concern is allergic reactions to the latex in crumb rubber.[iii]
Unfortunately, children’s exposure to these chemicals while using artificial turf fields has not been adequately studied. The U.S. Environmental Protection Agency, in its most recent evaluation of its study of crumb rubber, determined that it was not possible for the agency to reach “comprehensive conclusions without the consideration of additional data.” The Center for Environmental Health believes that the health of our children is important enough to take action now.
Artificial turf also poses health hazards in addition to the problems caused by exposure to toxic chemicals. Fields containing crumb rubber often reach unsafe temperatures—one study at Brigham Young University recorded that their field reached a surface temperature of 200 degrees Fahrenheit on a 98 degree day.[iv] In addition, “turf burns” (abrasions) are more frequent and severe on artificial turf than grass.[v]
The California Department of Resources Recycling and Recovery bases its tire management strategy upon supporting the production and use of recycled tire products while “providing a strong and fair regulatory framework to protect public health and safety and the environment.”[vi] While we agree with and support this mission, the use of recycled tires in children’s playgrounds and playing fields runs contrary to this goal.
The Center for Environmental Health recommends that schools, when feasible, replace crumb rubber infill with infill made from natural materials. Our recommendation is similar to those in New York City, which currently uses alternatives to crumb rubber infill in its new turf installations, and the Los Angeles Unified School District, which removed crumb rubber from play areas for young children.
We asked staff at the Piedmont Unified School District to comment on the district’s artificial turf installation at Havens Elementary School using a natural infill material, Infill Pro GEO, made by Geoturf. Staff reported that “it has been a very low maintenance product” and they “can’t say enough about how well the field drains.” Staff also noted that, “unlike crumb rubber, we have had no parent complaints about infill that hitchhikes home.”
If the resources to replace infill are not available, there are a number of ways to reduce exposures. Turf fields should not be used on extremely hot days and students should be monitored for heat-induced illness and abrasions. All crumb rubber pellets should be removed from students’ clothing, bodies, and equipment after playing. Students should always wash their hands thoroughly after exposure to the crumb rubber and never lie down or eat on the field.
Please join us in minimizing the exposure to toxic chemicals to give students the best possible learning environment.
There has been concern about the safety of artificial turf for years. In 1978, experts found exposing mice to Chrysene led to a huge increase in tumours in the animals. A 1993 study into Benzo (E) Pyrene said the substance promotes tumours forming on skin.
In 2014, NBC looked into the potential link between the rubber crumbs used in artificial turf and female soccer players getting cancer. The broadcast focused on Amy Griffin, associate head coach for the University of Washington’s women’s soccer team. Griffin, in her words, has discovered “a stream of kids” that have played on artificial turf and soon gotten cancer. Griffin has compiled a list of 38 American soccer players–34 of them goalies–who have been diagnosed with cancer. At least a dozen played in Washington, but the geographic spread is nationwide. Blood cancers like lymphoma and leukemia dominate the list.
In response to a NBC News investigation, the House Energy and Commerce Committee sent a letter to the EPA Administrator looking for more information about the safety of crumb rubber fields. Congress gave the EPA a November 6, 2015 deadline, which the EPA failed to meet.
Finally in February three U.S. government agencies will team up to study whether artificial turf fields and playgrounds that use bits of recycled tires are exposing children to dangerous chemicals. The Environmental Protection Agency, the Consumer Product Safety Commission and the Centers for Disease Control and Prevention announced on Friday they will study the issue, CPSC Chairman Elliot Kaye said in a statement.
In numerous studies exercise has been shown to increase both serotonin production and release. In particular, aerobic exercises, like running and biking, are the most likely to boost serotonin. Yoga boost serotonin too.
Vitamin B complex to regulate Serotonin synthesis
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Turmeric has emerged in recent years as a powerful antidepressant, in many cases equalling or even surpassing the effects of prescription antidepressants. Turns out that turmeric (or curcumin, rather) increases brain serotonin levels in a dose-dependent matter.
So maybe you need curcumin, the isolated polyphenol found in turmeric, to really affect depression. Maybe your chicken tikka masala isn’t replacing your SSRI. But absent outright depression or serotonin-based mood disorders, cooking with turmeric should help regulate normal serotonin levels.
Vitamin D—which we synthesize from UVB exposure—allows the conversion of tryptophan into serotonin.
Getting a massage boosts serotonin by 28%. ncbi.
ShinglesShingles is a disease that affects your nerves. It can cause burning, shooting pain, tingling, and/or itching, as well as a rash and blisters. You may recall having chickenpox as a child. Shingles is caused by the same virus. After you recover from chickenpox, the virus continues to live in some of your nerve cells. It is usually inactive, so you don’t even know it’s there, and most adults with the leftover virus in their bodies never get shingles. But, for about one in three adults, the virus will become active again. Instead of causing another case of chickenpox, it produces shingles. We do not totally understand what makes the virus go from inactive to active. |
Scammers pretending to be from the IRS continue to target taxpayers. These scams take many different forms. Among the most common are phone calls and fake emails. Thieves use the IRS name, logo or a fake website to try and steal money from taxpayers. Identity theft can also happen with such scams.
Taxpayers need to be cautious of phone calls or automated messages from scammers who claim to be from the IRS. These criminals often say the taxpayer owes money. They also demand immediate payment. Scammers also lie to taxpayers and say they are due a refund. They do this to lure their victims into giving their bank account information over the phone. The IRS warns taxpayers not to fall for these scams.
Below are tips that will help avoid becoming a victim during the summer months and throughout the year:
The IRS will NOT:
If a taxpayer does not owe any tax, they should:
If a taxpayer is not sure whether they owe any tax, they can view their tax account information on IRS.gov to find out.
Taxpayers should also watch out for emails and websites looking to steal personal information. An IRS phishing scam is an unsolicited, bogus email that claims to come from the IRS. Criminals often use fake refunds, phony tax bills or threats of an audit. Some emails link to fake websites that look real. The scammers’ goal is to lure victims to give up their personal and financial information. If they’re successful, they use it to steal a victim’s money and their identity.
For taxpayers who get a ‘phishing’ email, the IRS offers this advice:
More information on how to report phishing or phone scams is available on IRS.gov/phishing.
Avoid scams. The IRS does not initiate contact using social media or text message. The first contact normally comes in the mail. Those wondering if they owe money to the IRS can view their tax account information on IRS.gov to find out.
Additional IRS Resources:
IRS YouTube Videos:
Share this tip on social media — #IRSTaxTip: Be Alert to Scammers Who Pose as the IRS. https://go.usa.gov/xRpTw
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