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It’s Not Just What You Eat, It’s What’s Eating You

It’s Not Just What You Eat, It’s What’s Eating You Summary: Autophagy allows sensory neurons and nutrient levels to work together to influence lifespan, a new study reveals. Source: Florida Atlantic University. New study provides clues for a longer lifespan. Restricting how much you eat without starving has been shown to robustly extend lifespan inContinue reading “It’s Not Just What You Eat, It’s What’s Eating You”

Binding or cross linking of glucose to protein damages tissues

The role of collagen crosslinks in ageing and diabetes – the good, the bad, and the ugly Jess G. Snedeker1 and Alfonso Gautieri2 Summary The non-enzymatic reaction of proteins with glucose (glycation) is a topic of rapidly growing importance in human health and medicine. There is increasing evidence that this reaction plays a central roleContinue reading “Binding or cross linking of glucose to protein damages tissues”

Muscling in on Development

By Dr Francis Collins Twice a week, I do an hour of weight training to maintain muscle strength and tone. Millions of Americans do the same, and there’s always a lot of attention paid to those upper arm muscles—the biceps and triceps. Less appreciated is another arm muscle that pumps right along during workouts: theContinue reading “Muscling in on Development”

Self-Perceptions of Aging and Perceived Barriers to Care

Self-Perceptions of Aging and Perceived Barriers to Care: Reasons for Health Care Delay  Jennifer K. Sun, MS; Jacqui Smith, PhD  View article Supplementary data Disrupt Aging: A Call to Action for Gerontologists  Jo Ann C. Jenkins, BS View article Age-Stereotype Paradox: Opportunity for Social Change  Becca R. Levy, PhD View article Context Influences on the SubjectiveContinue reading “Self-Perceptions of Aging and Perceived Barriers to Care”

Aging in Place in Gentrifying Neighborhoods, mental health

Aging in Place in Gentrifying Neighborhoods: Implications for Physical and Mental Health Richard J Smith, MSW, PhD Amanda J Lehning, MSW, PhD Kyeongmo Kim, MSW, PhD Gerontologist gnx105. DOI: https://doi.org/10.1093/geront/gnx105 Published: Abstract Background and Objectives In the United States, the older adult population and the proportion of neighborhoods experiencing gentrification are both growing. However, thereContinue reading “Aging in Place in Gentrifying Neighborhoods, mental health”

Lutein May Counter Cognitive Aging

Lutein May Counter Cognitive Aging Summary: People with higher levels of lutein, a nutrient commonly found in kale and eggs, were more cognitively on par with younger people than their peers with lower lutein levels, a new study reports. Source: University of Illinois. Spinach and kale are favorites of those looking to stay physically fit,Continue reading “Lutein May Counter Cognitive Aging”

The loss of SETD8 triggers cellular senescence

  The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling DOI: http://dx.doi.org/10.1016/j.celrep.2017.02.021 View all Images/Data Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 1 The Loss of SETD8/PR-Set7 Induces Senescence (A) Schematic representation of senescence models used in this study. SA-β-Gal staining of growing, oncogene-induced senescence (OIS), and replicative senescence (RS) cells are shown.Continue reading “The loss of SETD8 triggers cellular senescence”

Levels of DNA methylation reflect a person’s age

Certain DNA changes can better predict a person’s life expectancy than traditional risk factors such as age. The findings could lead to novel insights into the molecular mechanisms of aging and new ways to evaluate methods for slowing the rate of aging. “Epigenetic age” might represent a person’s biological age more accurately than the numberContinue reading “Levels of DNA methylation reflect a person’s age”

Brain Development and Aging

Summary: According to researchers, brain signals in specific brain areas change during a lifespan in ways that could be vital for maintaining flexibility. Source: University of Miami. New study by UM psychologists reveals that brain signals in specific regions change over a lifespan in ways that might be important for maintaining flexibility. The brain isContinue reading “Brain Development and Aging”

FOXO3, a gene linked to intelligence and involved in insulin signalling that might trigger apoptosis

Genes linked to intelligence Researchers discovered that the genes that were the strongest linked to intelligence are ones involved in pathways that play a part in the regulation of the nervous system’s development and apoptosis (a normal form of cell death that is needed in development). The most significant SNP was found within FOXO3, aContinue reading “FOXO3, a gene linked to intelligence and involved in insulin signalling that might trigger apoptosis”

Muscle Enzyme Explains Weight Gain in Middle Age, Cancer and Aging

By Dr. Francis Collins The struggle to maintain a healthy weight is a lifelong challenge for many of us. In fact, the average American packs on an extra 30 pounds from early adulthood to age 50. What’s responsible for this tendency toward middle-age spread? For most of us, too many calories and too little exerciseContinue reading “Muscle Enzyme Explains Weight Gain in Middle Age, Cancer and Aging”

Yoga and behavioral memory interventions for the aging brain

Yoga and behavioral memory interventions to prevent age-related cognitive decline A study examined changes in brain metabolites and structure among individuals undergoing memory training and yogic meditation. We demonstrated that memory training over 3 months is associated with decreased choline levels in bilateral hippocampus and increased gray-matter volume in dACC, suggesting that behavioral interventions likeContinue reading “Yoga and behavioral memory interventions for the aging brain”

Natural communication breakdown in aging

A naturally produced compound rewinds aspects of age-related demise in mice. Researchers have discovered a cause of aging in mammals that may be reversible. The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria. As communication breaks down, aging accelerates. By administering a moleculeContinue reading “Natural communication breakdown in aging”