Summary: Researchers report groups of brain regions that synchronize their activity during memory tasks become smaller and more numerous as people age. Source: PLOS. Groups of brain regions with coordinated activity are consistent for individuals, but shrink with age. Groups of brain regions that synchronize their activity during memory tasks become smaller and more numerousContinue reading “Missed Connections: Memory Related Brain Activity Loses Cohesion As We Age”
Tag Archives: aging
Mapping Genes That Increase Lifespan
Comprehensive study finds 238 genes that affect aging in yeast cells. Following an exhaustive, ten-year effort, scientists at the Buck Institute for Research on Aging and the University of Washington have identified 238 genes that, when removed, increase the replicative lifespan of S. cerevisiae yeast cells. This is the first time 189 of these genesContinue reading “Mapping Genes That Increase Lifespan”
Happiness factor, immune system and Brain-related Resource Links
Connections between your nervous system and immune system allow for crosstalk between them. The science that studies this is psychoneuroimmunology Pessimism promotes ill health and can shave years off your life; the tendency to always expect the worst has been linked to a 25 percent higher risk of dying before the age of 65 Sociable,Continue reading “Happiness factor, immune system and Brain-related Resource Links”
Pursuing longevity: Epigenetic clock and cellular senescence
Epigenetic clock analysis of cellular senescence According to a molecular biomarker of aging known as epigenetic clock,[14] the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are distinct because induction of replicative senescence (RS) and oncogene-induced senescence (OIS) were found to be accompanied by epigenetic aging of primaryContinue reading “Pursuing longevity: Epigenetic clock and cellular senescence”
Why does our skin causing us to age?
Epigenetics studies genetic effects notencoded in the DNA sequence of an organism, hence the prefix epi- (Greek: επί– over, outside of, around).[1][2] Such effects on cellular and physiological phenotypic traits may result from external or environmental factors that switch genes on and off and affect how cells express genes.[3][4] These alterations may or may notContinue reading “Why does our skin causing us to age?”
Epigenetic Clock Marks Age of Human Tissues and Cells
By Carol Torgan, Ph.D. The age of many human tissues and cells is reflected in chemical changes to DNA. The finding provides insights for cancer, aging, and stem cell research. We may gauge how we’re aging based on visible changes, such as wrinkles. For years, scientists have been trying to gauge aging based on changesContinue reading “Epigenetic Clock Marks Age of Human Tissues and Cells”
Epigenetic Clock Predicts Aging Rates of Racial Groups and Gender
By Samantha Blady A study published in Genome Biology in August 2016 supplies the first analysis of the epigenetic clock across different racial groups. By analyzing blood, saliva, and brain samples, epigenetic aging rates were compared among seven different racial groups and in men and women. As discovered in the study, rates of epigenetic agingContinue reading “Epigenetic Clock Predicts Aging Rates of Racial Groups and Gender”
Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes
Vitamin D metabolism is conserved between nematodes and mammals Vitamin D prevents the age-dependent accumulation of SDS-insoluble proteins Vitamin D enhances lifespan and protein homeostasis via IRE-1, XBP-1, and SKN-1 Summary Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D,Continue reading “Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes”
GWS study identifies a single major locus contributing to survival into old age – the APOE locus
Apolipoprotein E (APOE) is a class of apolipoprotein found in the chylomicron and Intermediate-density lipoprotein (IDLs) that is essential for the normal catabolism of triglyceride-rich lipoprotein constituents.[4] In peripheral tissues, APOE is primarily produced by the liver and macrophages, and mediates cholesterol metabolism in an isoform-dependent manner. In the central nervous system, APOE is mainlyContinue reading “GWS study identifies a single major locus contributing to survival into old age – the APOE locus”
Exome and whole genome sequencing in aging and longevity, an ebook
Calendar age is the major risk factor for common disease. It is therefore expected that understanding the aging process will eventually lead to promotion of better health conditions in elderly populations. Such insight may be obtained by identifying the genetic determinants of familial and exceptional longevity and age-related disease. Research of these determinants has beenContinue reading “Exome and whole genome sequencing in aging and longevity, an ebook”
Elders with negative attitude about aging may be less resilient to stress
Older adults with a positive attitude about aging may be more resilient to stress, according to a new study. “Previous research has generally found the same thing, a more positive attitude is beneficial,” said coauthor Jennifer Bellingtier, of North Carolina State University in Raleigh. “People with positive attitudes are less likely to be hospitalized andContinue reading “Elders with negative attitude about aging may be less resilient to stress”
Sleep and Alzheimer
Eric Kandel: Short-term memory had been linked to functional changes in existing synapses, while long-term memory was associated with a change in the number of synaptic connections. Researchers at MIT have confirmed that sleep is essential for long-term storage of memories. Their study showed that mice unable to “replay” their awake experiences while asleep rememberContinue reading “Sleep and Alzheimer”
Running, Cathepsin B from muscles, memory and cancer
Recent study suggests that running is good for the memory because scientist measured the presence of Cathepsin B. Cathepsin B is produced in muscle tissue during metabolism. It is capable of crossing the blood-brain barrier and is associated with neurogenesis, specifically in the mouse dentate gyrus. And more… During chronic kidney disease (CKD) there isContinue reading “Running, Cathepsin B from muscles, memory and cancer”
Diet for the elderly
A personalised nutrition approach Micronutrients such as zinc, copper and selenium play a pivotal role in a range of physiological functions and maintain immune and antioxidant systems (Eugenio Mocchegiani et al.). The complex interactions between micronutrients and genes could help in understanding how best to use nutrients as supplements in clinical practice. Further genetic andContinue reading “Diet for the elderly”