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How to have healthy blood flow to your heart?

blood flowI believe that a healthy blood flow to the heart starts with clean alkaline blood processed by a healthy liver free from toxins such as drugs, alcohol and toxic medications (narcotics).  Consumption of foods rich in nutrients such as folate, Vitamin C and B and L-arginine amino acid can prevent mitochondrial damage.  Example of foods rich in these nutrients are cage-free eggs, dairy products like cultured yogurtkefir and raw cheeses (choose organic and raw dairy whenever possible) Grass-fed beef or meat and pasture-raised poultry (including turkey and chicken) Liver and organ meats (such as chicken liver pate).

And the most important factors for a healthy heart are deep cleansing breath from calm mind, sleep, stress-free and healthy lifestyle with positive energies from sunshine, massage and grounding (walking barefoot on the beach or ground).

Connie


Sun, Earth and the Human Touch — 3 Key Principles for Healthy Blood Flow

Pollack has also clearly demonstrated there are three natural energies that result in separation of charges that create flow:

1.Sunlight charges up your blood vessels, which increases the flow of blood. When the sun’s rays penetrate your skin, it causes a massive increase of nitric oxide that acts as a vasodilator. As much as 60 percent of your blood can be shunted to the surface of your skin through the action of nitric oxide. This helps absorb solar radiation, which then causes the water in your blood to capture the energy and become structured.

This is a key component for a healthy heart. The ideal is to be exposed to the sun while grounding, meaning walking barefoot. This forms a biological circuit that makes it work even better.

2.Negative ions from the Earth, also known as earthing or grounding. This also charges up your blood vessels, creates a separation of charges, creates more positive ions and allows the blood to flow upward, against gravity.

3.The field effect or touch from another living being, such as laying on of hands.


Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is one of the family of mitochondrial cytopathies, which also include MERRF, and Leber’s hereditary optic neuropathy.

Most people with MELAS have a buildup of lactic acid in their bodies, a condition called lactic acidosis. Increased acidity in the blood can lead to vomiting, abdominal pain, extreme tiredness (fatigue), muscle weakness, loss of bowel control, and difficulty breathing. Less commonly, people with MELAS may experience involuntary muscle spasms (myoclonus), impaired muscle coordination (ataxia), hearing loss, heart and kidney problems, diabetes, epilepsy, and hormonal imbalances.

MELAS is a condition that affects many of the body’s systems, particularly the brain and nervous system (encephalo-) and muscles (myopathy). In most cases, the signs and symptoms of this disorder appear in childhood following a period of normal development.[3]Early symptoms may include muscle weakness and pain, recurrent headaches, loss of appetite, vomiting, and seizures. Most affected individuals experience stroke-like episodes beginning before age 40. These episodes often involve temporary muscle weakness on one side of the body (hemiparesis), altered consciousness, vision abnormalities, seizures, and severe headaches resembling migraines. Repeated stroke-like episodes can progressively damage the brain, leading to vision loss, problems with movement, and a loss of intellectual function (dementia). The stroke-like episodes can be mis-diagnosed as epilepsy by a doctor not aware of the MELAS condition.

Patients are managed according to what areas of the body are affected at a particular time. Enzymesamino acidsantioxidants and vitamins have been used.

Also the following supplements may help:

  • CoQ10 has been helpful for some MELAS patients.[7] Nicotinamide has been used because complex l accepts electrons from NADH and ultimately transfers electrons to CoQ10.
  • Riboflavin has been reported to improve the function of a patient with complex l deficiency and the 3250T-C mutation.[8]
  • The administration of L-arginine during the acute and interictal periods may represent a potential new therapy for this syndrome to reduce brain damage due to impairment of vasodilation in intracerebral arteries due to nitric oxide depletion

Brain, emotion, sight and sound processing, concussion and Parkinson

children

DID HANS ASPERGER ACTIVELY ASSIST THE NAZI EUTHANASIA PROGRAM?

Researchers have investigated Hans Asperger’s Nazi era publications and have revealed he actively cooperated with the Nazi’s euthanasia program. The Kinder-Euthanasie (child euthanasia) program resulted in the murder of thousands of physically and mentally disabled children under Nazi rule. READ MORE…

Brain, opinions, flight, fight, pain, stress, dopamine and aging

people

HAVING AN AUDIENCE MAY HELP YOU PERFORM BETTER

According to researchers, when people are aware they are being observed, brain areas associated with social awareness and reward activate a part of the brain that affects motor control, helping them to perform better at skilled tasks. READ MORE…
dna

VARIANTS IN NON-CODING DNA CONTRIBUTE TO INHERITED AUTISM RISK

Researchers report newly identified risk factors differ from currently known genetic causes of autism. The variants identified do not alter the genes directly, but disrupt the neighboring DNA control elements that turn genes on or off. Additionally, the variants do not occur as new mutations in autistic children, but are inherited from parents. READ MORE…
face

ALGORITHM WORKS TO SILENCE ONLINE CHATROOM SEX PREDATORS

A new computer algorithm may help to identify sexual predators who target children in chatrooms. The algorithm, dubbed CATT, can identify language differences and self-disclosure in conversations to provide a risk assessment of potential predators, researchers report. READ MORE…

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Iron disorders , Vit B12, toxic drugs, and donating blood

Iron Disorders: The Importance of Checking Your Iron … – Dr. Mercola

Jun 12, 2016 – My dad has betathalassemia and he gave me the gene, which is a form of hemolytic anemia (similar to sickle cell anemia). As a result of that, my red blood cells die faster than normal, and I’m prone to excess iron. My dad had a ferritin level of 800 when I diagnosed him 20 years ago. He would be dead by …

Little-Known Secrets about Optimal Iron Levels – Dr. Mercola

Jul 14, 2009 – Acute blood loss; Other nutritional anemias, such as vitamin B12 or folic acid deficiencies; Cancer; Enlarged spleen; Genetic hemolytic anemias, such as sickle cell anemia, and thalassemia (also known as Mediterranean anemia), which I have. It’s a type of genetic anemia where the hemoglobin is not well …

Jun 5, 2013 – It was because he has betathalassemia. With regular phlebotomies, his iron levels normalized and now the only side effect he has is type 1 diabetes. The high iron levels damaged his pancreatic islet cells and now he has what is called “bronze” diabetes and so requires the use of insulin. I also inherited …

Why Managing Your Iron Level Is Crucial to Your Health – Dr. Mercola

May 31, 2017 – However, keep ALL iron supplements away from children, even carbonyl iron, and do not take any kind of iron supplement if you have hemochromatosis, hemosiderosis or hemolytic anemia such as sickle cell anemia or thalassemia (aka Mediterranean anemia, a type of genetic anemia where hemoglobin …

Missing: beta

How do You Know if You Are Anemic – Dr. Mercola

Jun 25, 2007 – Macrocytic anemia (macrocytic means large red blood cells) can be a sign of vitamin B-12 deficiency, and it may also be caused by folate deficiency. Folate deficiency is not common as it is in most raw vegetables, but some drugs (methotrexate and trimethoprim) and alcohol can cause it as can intolerance …

Conventional Heart Disease Advice May Make Matters … – Dr. Mercola

Aug 2, 2015 – On a side note, a novel point about coconut oil that many are unaware of is that for those of us, including myself, who suffer from a genetic condition called beta thalassemia — or chronic low cholesterol, which can be quite harmful — coconut oil can be used instead of drugs to raise your cholesterol.

Most Common Nutrient Deficiencies – Dr. Mercola

Oct 19, 2015 – It was because he has betathalassemia. With regular phlebotomies, his iron levels normalized, but the high iron levels damaged his pancreatic islet cells and now he has what is called “bronze” diabetes that requires the use of insulin. I inherited betathalassemia from him so I’m quite familiar with this issue …

Beginner Plan: Lifestyle Changes – Dr. Mercola

Over 20 years ago, through a simple test, I discovered that my dad had extremely high ferritin levels – close to 1,000 – due to a blood disorder called betathalassemia. If this had not been addressed, it would have been extremely fatal. Through regular phlebotomies, my dad’s iron levels have normalized, and the only side …

Understanding the Risks and Benefits of Beta-Blockers – Dr. Mercola

Aug 13, 2014 – Beta-blockers are drugs used in high blood pressure and congestive heart failure treatment, but now the ESC recommends it in non-cardiac surgery as well.

Missing: thalassemia

4 Unexpected Benefits of Donating Blood – Dr. Mercola

Jul 28, 2014 – I discovered he had a ferritin level close to 1,000. It was because he has betathalassemia. With regular phlebotomies, his iron levels normalized and now the only side effect he has is type 1 diabetes. His high iron levels damaged his pancreatic islet cells triggering what is called “bronze” diabetes, and so …

Vitamin B3, Leukemia, aging and cancer

Grass fed beef, bone marrow with veggie soup, peanuts and chicken are some of the food sources of Vitamin B3.  I take Vitamin Bs when I am under stress and these vitamins help me sleep too. Vitamin B3 is a natural product found in our blood. Will sunshine help clean our blood. There are many ways to have a healthy blood: exercise with sunshine, avoidance of alcohol, drugs and environmental toxins (metals,gas), whole foods, sleep, less stress and a positive spirit (calm not full of anxiety).

Connie

Nicotinamide riboside (NR) is a pyridinenucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

NR was first described in 1944 as a growth factor, termed Factor V, for Haemophilus influenza, a bacterium that lives in and depends on blood. Factor V, purified from blood was shown to exist in three forms: NAD+, NMN and NR. NR was the compound that led to the most rapid growth of this bacterium.[5] Notably, H. influenza cannot grow on nicotinic acidnicotinamidetryptophan or aspartic acid, which were the previously known precursors of NAD+.[6]

In 2000, yeast Sir2 was shown to be an NAD+-dependent protein lysine deacetylase,[7] which led several groups to probe yeast NAD+ metabolism for genes and enzymes that might regulate lifespan. Biosynthesis of NAD+ in yeast was thought to flow exclusively through NAMN (nicotinic acid mononucleotide).[8][9][10][11][12]

When NAD+ synthase (glutamine-hydrolysing) was deleted from yeast cells, NR permitted yeast cells to grow. Thus, these Dartmouth College investigators proceeded to clone yeast and human nicotinamide riboside kinases and demonstrate the conversion of NR to NMN by nicotinamide riboside kinases in vitro and in vivo. They also demonstrated that NR is a natural product, a little-noticed vitamin found in cow’s milk.[13][14]

In the 2010s. dietary supplements containing NR were brought to market by ChromaDex under the brand Niagen, which also originally provided NR to Elysium Health which uses NR as a component of its product, Basis.[15]

References

  1. Jump up^ Bogan, K.L., Brenner, C. (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”. Annu. Rev. Nutr28: 115–130. doi:10.1146/annurev.nutr.28.061807.155443.
  2. Jump up^ Chi Y, Sauve AA (November 2013). “Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection”. Curr Opin Clin Nutr Metab Care16 (6): 657–61. doi:10.1097/MCO.0b013e32836510c0PMID 24071780.
  3. Jump up to:a b c “Spherix/Chromadex GRAS submission” (PDF). March 8, 2016. See FDA GRAS index page: “GRAS Notice (GRN) No. 635”.
  4. Jump up^ “Nicotinamide Riboside”.
  5. Jump up^ Gingrich, W (1944). “Codehydrogenase I and other pyridinium compounds as V factor for Haemophilus influenzae and Haemophilus parainfluenzae”. J. Bacteriol47: 535–550.
  6. Jump up^ Belenky, P. et. al. (2007). “NAD+ Metabolism in Health and Disease”. Trends in Biochemical Sciences32: 12–19. doi:10.1016/j.tibs.2006.11.006PMID 17161604.
  7. Jump up^ Imai, S.; et al. (2000). “Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase”. Nature403 (6771): 795–800.
  8. Jump up^ Panozzo, C.; et al. (2002). “Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae”. FEBS Lett517: 97–102. doi:10.1016/s0014-5793(02)02585-1.
  9. Jump up^ Sandmeier; et al. (2002). “Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD Salvage Pathway”. Genetics160: 877–889.
  10. Jump up^ Bitterman; et al. (2002). “Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1”. J. Biol. Chem277: 45099–45107. doi:10.1074/jbc.m205670200PMID 12297502.
  11. Jump up^ Anderson; et al. (2003). “Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae”Nature423: 181–185. doi:10.1038/nature01578PMC 4802858Freely accessiblePMID 12736687.
  12. Jump up^ Gallo; et al. (2004). “Nicotinamide clearance by pnc1 directly regulates sir2-mediated silencing and longevity”. Mol. Cell. Biol24: 1301–1312. doi:10.1128/mcb.24.3.1301-1312.2004.
  13. Jump up^ Bieganowki, P. & Brenner, C. (2004). “Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans”. Cell117: 495–502. doi:10.1016/s0092-8674(04)00416-7PMID 15137942.
  14. Jump up^ Hautkooper, R.H.; et al. (2012). “Sirtuins as regulators of metabolism and healthspan”. Nat. Rev. Mol. Cell Biol13: 225–238. doi:10.1038/nrm3293.
  15. Jump up^ Zhang, Sarah (July 6, 2016). “The weird business behind a trendy “anti-aging” pill”Wired.

Health knowledge to be disease-free – top posts 4-19-2018

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Novo-peridol , dementia , narcotics and heart failure

Haloperidol (Oral route)

Pronunciation:

hal-oh-PER-i-dol

Brand Names:

  • Haldol
  • Alti-Haloperidol
  • Apo-Haloperidol
  • Novo-Peridol
  • Peridol
  • Pms-Haloperidol
  • Ratio-Haloperidol

Dosage Forms:

  • Tablet
  • Solution

Warnings:

Oral route(Tablet)Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Haloperidol is not approved for the treatment of patients with dementia-related psychosis .

Classifications:

Therapeutic—

Antipsychotic

Pharmacologic—

Dopamine Antagonist

Chemical—

Butyrophenone

Uses of This Medicine:

Haloperidol is used to treat nervous, emotional, and mental conditions (eg, schizophrenia). It is also used to control the symptoms of Tourette’s disorder. This medicine should not be used to treat behavior problems in older adult patients who have dementia.

Haloperidol is also used to treat severe behavioral problems (eg, aggressive, impulsive behavior) or hyperactivity in children who have already been treated with psychotherapy or other medicines that did not work well.

This medicine is available only with your doctor’s prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of haloperidol in children younger than 3 years of age. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of haloperidol in the elderly. However, elderly women are more likely to have a side effect called tardive dyskinesia, and elderly patients are more likely to have age-related heart or lung problems, which may require an adjustment in the dose for patients receiving haloperidol.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (severe chest pain) or
  • Breast cancer, history of or
  • Encephalopathy or
  • Heart or blood vessel disease, severe or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Hypotension (low blood pressure) or
  • Lung or breathing problems (eg, bronchopneumonia) or
  • Mania or
  • Neuroleptic malignant syndrome, history of or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Central nervous system depression, severe or
  • Coma or
  • Dementia in elderly or
  • Parkinson’s disease—Should not be used in patients with these conditions.
  • Heart rhythm problems (eg, familial long QT-syndrome), history of or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Thyroid problems—May increase risk for more serious side effects.
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Dopamine agonists play an important role in the regulation of the central nervous-cardiovascular, renal, and hormonal systems through stimulation of dopaminergic (DA1 and DA2) and alpha- and beta-adrenergic receptors. Several studies have shown that in fat and diabetic mice. The aim of the present study was to evaluate the interaction of the dopaminergic and endocrine systems by determining the effect of the dopaminergic antagonist, metoclopramide, and dopamine on insulin secretion and cardiovascular response by blockade and activation of dopamine receptors in healthy and type 2 diabetic subjects. Healthy subjects (n =15) and subjects with type 2 diabetes (n = 15) of both genders, aged 18 to 60 years, were recruited into this study. A comparative experimental design of 90 minutes was performed in which placebo (0.9% saline) was infused intravenously for the first 30 minutes followed by metoclopramide (7.5 microg/kg/min), a dopamine receptor antagonist for 30 minutes, and then metoclopramide (7.5 microg/kg/min) plus dopamine (0.5-3 microg/kg/min) for 30 minutes.

The following clinical and biochemical parameters were measured at the beginning and then every 30 minutes of the experimental period (30′, 60′ and 90′): systolic-diastolic and mean arterial blood pressure, heart rate, serum glucose, insulin, triacylglycerides, and total cholesterol. Baseline glycosylated hemoglobin was measured and homeostasis model assessment for insulin resistance was calculated from insulin and glucose levels. Twelve-lead electrocardiograms were also obtained at these points.

Dopamine infusion induced an increase in serum insulin, systolic blood pressure, and heart rate in healthy subjects but not in subjects with type 2 diabetes. Infusion of metoclopramide induced a hypotensive effect in healthy subjects, which was blunted by inclusion of dopamine in the infusion mixture.

In subjects with diabetes, metoclopramide had no effect on blood pressure, but addition of dopamine raised systolic blood pressure. Neither metoclopramide nor dopamine altered significantly the lipid profile in healthy or diabetic subjects.

Dopaminergic drugs increase serum insulin probably by interacting with dopaminergic receptors, but stimulation of beta-adrenergic receptors cannot be ruled out. Stimulation of cardiovascular dopamine receptors also caused modifications of hemodynamic parameters in healthy subjects, but apparently these receptors are attenuated in patients with type 2 diabetes probably as a result of endothelial dysfunction and alterations in the sympathetic nervous system sensitivity.


Connie’s comments: If my father who has diabetes and dementia at 98 falls with a hairline hip fracture, I will not put him on narcotics for a long period of time.