Night owls have higher risk of dying sooner

 

Growth hormone (GH) , asthma meds and muscle quality

Growth hormone (GH) and muscle quality

GH production drops by 60% at age 60. A senior who had been taking asthma meds for a long time experienced severe neck and shoulder bone fracture from a fall.  Know that some meds can impair muscle quality.

The following factors influence GH secretion spike by the pituitary gland in the brain:

Factors Increasing GH Secretion Factors Decreasing GH Secretion
Physiological: Physiological:
Sleep Hyperglycemia
Fasting Elevated Blood Free Fatty Acids
Exercise Obesity
High Amino Acids
in the Blood
Hyper or Hypothyroidism
Low Blood Sugar  
Pharmacologic: Pharmacologic:
Any hypoglycemic agent GH itself
Estrogens Somatostatin
Alpha-agonists Alpha antagonists (yohimbine)
Beta antagonists Beta agonists (ephedrine, clenbuterol)
Serotonin Serotonin antagonists
Dopamine Dopamine antagonists
GABA  

Source: Basic and Clinical Endocrinology, 5th Edition

Muscle regeneration

Muscle growth and capacity to regenerate upon injury are faster for skeletal muscle but poor for cardiac muscle especially for young ones.

A greater capacity for regeneration of cardiac muscle is seen in fish. Fish oil, folate, Vitamin Bs, Coenzyme Q10 and omega 3 dietary supplements are important for our heart muscles.

Skeletal muscle has an excellent capacity for regeneration.  Inflammation and innervation makes regeneration suboptimal for seniors.

As we age, our cardiac muscles are easily affected even from those who have regular exercise and eat healthy.

Muscle regeneration is the process by which damaged skeletal, smooth or cardiac muscle undergoes biological repair and formation of new muscle in response to death of muscle cells.

Key Concepts:

  • Necrosis is required for muscle regeneration.
  • Inflammation is essential to remove necrotic tissue and initiate myogenesis.
  • New blood vessel formation is required after major injury of muscles.
  • Reinnervation is essential for functional recovery of skeletal muscle.

Adult skeletal muscle is a postmitotic tissue, accomplished by resident stem cells, satellite glial cells (SGCs). Current theories suggest that SGCs are important in controlling the microenvironment of the sympathetic ganglia.

SGCs role as a regulator of neuronal microenvironment is further characterized by its electrical properties which are very similar to those of astrocytes. Astrocytes have a well-studied and defined role in controlling the microenvironment within the brain.

Root causes of chronic illness

During the last 20 years, your body is exposed to inflammation such as over consumption of sugar, stress and trauma, gut bacteria/parasites/fungus/virus, lack of sleep and other chronic disease which can be prevented before it becomes Type 2 diabetes, depression, hypertension and even cancer.

  1. As we age , we are 10k times more prone to attacks from parasites and cancer.
  2. If we don’t get our 8 hour night time sleep, we are slowly breaking down the barriers in our cell mucosa making it possible for unhealthy microbes to travel to other sites from liver to blood and then brain.
  3. It takes cancer to overpower our cells at least 20 years.
  4. Know signs, detox your body starting with your liver and use whole foods such as apples with 100 million healthy bacteria to help fight invading pathogens. Do avoid these environmental toxins feeding on weakened cells invaded by parasites, fungus and virus.

 

Alzheimer clues

Sex and sleep

 

How the digestive tract communicates with the brain