Deaths by Opioids, doctors must recognize addiction and stop it early


My senior client with Parkinson at age 79, demanded Tramadol even when she is not in pain. In front of the doctor, the doctor obliged with no plan for curving future addiction.

In the fields, high school students in Central Valley mixes over the counter meds to be high, get addicted.

Many families were broken from addiction caused by pain killers listed in the graphics above.

Avoid the following when taking medications since they double the potency of meds: alcohol and grapefruit.



10 ways to get off opiates – The Recovery Village

 Rating: 3 – ‎2 votes

May 2, 2017 – Usually, detox isn’t a treatment in and of itself, but ultra-rapid opioid detoxification(UROD) can be a successful measure on its own. Over the course of two days, a patient is sedated with general anesthesia and given Naltrexone, an opioid antagonist. This allows the symptoms and process of withdrawal to …

Opiate Addiction Detox: Don’t Poop Your Pants | Discovery Place …

In this article, I will try to raise awareness of the American opiate dilemma and offer some advice for those beginning the initial stages of treatment, specifically detox. I persevered through a nightmaredetox from opiates and heroin, and I’ve been continuously sober from the day I checked into detox at a hospital on May 24th, …

Opioids – Opiates: Addiction, Withdrawal, Crisis, Recovery Facts

Feb 7, 2018 – Suboxone is a medication used for withdrawing and detoxing from opioids. It is a combination of buprenorphine a mild opiate, and naloxone a medication that reverses the effects of opiates if taken intravenously. Buprenorphine is unlike other opioids in that it does not lead to a greater high the more you …

Opiate and opioid withdrawal: MedlinePlus Medical Encyclopedia › Medical Encyclopedia

Apr 20, 2016 – Read our article and learn more on MedlinePlus: Opiate and opioid withdrawal.

Painkiller Detox, Withdrawal Symptoms & Addiction Treatment

Jump to Why Should I Enter an Opioid Detox Program? – Anyone addicted to opioids can benefit from entering a formal detox program. However, some people have a hard time accepting that they may have developed an addiction in the first place, since the abused medication was prescribed to them by a doctor.

Opiate / Opioid Withdrawal Symptoms – Novusdetox

What are the symptoms of opiate or opioid withdrawal and how can they be controlled?

Hydrocodone Withdrawal and Detox – AddictionCenter

Clonidine and buprenorphine are the most common drugs prescribed during hydrocodone detox. These drugs ease symptoms such as anxiety, sweating, muscle pain and vomiting. Naltrexone is another medication sometimes used in hydrocodone detox. It blocks the effects of opioids and can help speeddetox. In some …

Microglia cells survey synapses by engulfing them

surveyMicroglial cells fulfill a variety of different tasks within the CNS mainly related to both immune response and maintaining homeostasis. The following are some of the major known functions carried out by these cells.[citation needed]


In addition to being very sensitive to small changes in their environment, each microglial cell also physically surveys its domain on a regular basis. This action is carried out in the ameboid and resting states. While moving through its set region, if the microglial cell finds any foreign material, damaged cells, apoptotic cells, neurofibrillary tangles, DNA fragments, or plaques it will activate and phagocytose the material or cell. In this manner microglial cells also act as “housekeepers”, cleaning up random cellular debris.[14] During developmental wiring of the brain, microglial cells play a large role regulating numbers of neural precursor cells and removing apoptotic neurons. There is also evidence that microglia can refine synaptic circuitry by engulfing and eliminating synapses[22]. Post development, the majority of dead or apoptotic cells are found in the cerebral cortex and the subcortical white matter. This may explain why the majority of ameboid microglial cells are found within the “fountains of microglia” in the cerebral cortex.[19]


The main role of microglia, phagocytosis, involves the engulfing of various materials. Engulfed materials generally consist of cellular debris, lipids, and apoptotic cells in the non-inflamed state, and invading virusbacteria, or other foreign materials in the inflamed state. Once the microglial cell is “full” it stops phagocytic activity and changes into a relatively non-reactive gitter cell.[citation needed]

Extracellular signaling

A large part of microglial cell’s role in the brain is maintaining homeostasis in non-infected regions and promoting inflammation in infected or damaged tissue. Microglia accomplish this through an extremely complicated series of extracellular signaling molecules which allow them to communicate with other microglia, astrocytesnervesT-cells, and myeloid progenitor cells. As mentioned above the cytokine IFN-γ can be used to activate microglial cells. In addition, after becoming activated with IFN-γ, microglia also release more IFN-γ into the extracellular space. This activates more microglia and starts a cytokine induced activation cascade rapidly activating all nearby microglia. Microglia-produced TNF-α causes neural tissue to undergo apoptosis and increases inflammation. IL-8 promotes B-cell growth and differentiation, allowing it to assist microglia in fighting infection. Another cytokine, IL-1, inhibits the cytokines IL-10 and TGF-β, which downregulate antigen presentation and pro-inflammatory signaling. Additional dendritic cells and T-cells are recruited to the site of injury through the microglial production of the chemotactic molecules like MDC, IL-8, and MIP-3β. Finally, PGE2 and other prostanoids prevent chronic inflammation by inhibiting microglial pro-inflammatory response and downregulating Th1 (T-helper cell) response.[14]

Antigen presentation

As mentioned above, resident non-activated microglia act as poor antigen presenting cells due to their lack of MHC class I/II proteins. Upon activation they rapidly uptake MHC class I/II proteins and quickly become efficient antigen presenters. In some cases, microglia can also be activated by IFN-γ to present antigens, but do not function as effectively as if they had undergone uptake of MHC class I/II proteins. During inflammationT-cells cross the blood–brain barrier thanks to specialized surface markers and then directly bind to microglia in order to receive antigens. Once they have been presented with antigens, T-cells go on to fulfill a variety of roles including pro-inflammatory recruitment, formation of immunomemories, secretion of cytotoxic materials, and direct attacks on the plasma membranes of foreign cells.[6][14]


In addition to being able to destroy infectious organisms through cell to cell contact via phagocytosis, microglia can also release a variety of cytotoxic substances. Microglia in culture secrete large amounts of hydrogen peroxide and nitric oxide in a process known as ‘respiratory burst‘. Both of these chemicals can directly damage cells and lead to neuronal cell death. Proteases secreted by microglia catabolise specific proteins causing direct cellular damage, while cytokines like IL-1 promote demyelination of neuronal axons. Finally, microglia can injure neurons through NMDA receptor-mediated processes by secreting glutamateaspartate and quinolinic acid. Cytotoxic secretion is aimed at destroying infected neurons, virus, and bacteria, but can also cause large amounts of collateral neural damage. As a result, chronic inflammatory response can result in large scale neural damage as the microglia ravage the brain in an attempt to destroy the invading infection.[6]

Synaptic stripping

In a phenomenon first noticed in spinal lesions by Blinzinger and Kreutzberg in 1968, post-inflammation microglia remove the branches from nerves near damaged tissue. This helps promote regrowth and remapping of damaged neural circuitry.[6]

Promotion of repair

Post-inflammation, microglia undergo several steps to promote regrowth of neural tissue. These include synaptic stripping, secretion of anti-inflammatory cytokines, recruitment of neurons and astrocytes to the damaged area, and formation of gitter cells. Without microglial cells regrowth and remapping would be considerably slower in the resident areas of the CNS and almost impossible in many of the vascular systems surrounding the brain and eyes.

Get rid of heavy metals in your body

Once called the “poor man’s chelation therapy,” cilantro may help body release built up neurotoxins such as heavy metals. If you’d like to add more cilantro to your diet, try blending up cilantro into smoothies or juices. It also makes for a delicious salsa!

Chlorella is a water-grown algae full of chlorophyll that may also help to reduce heavy metals in the body. However, chlorella may reduce the effectiveness of some medications, so check with your doctor if you’re curious about it.

Infrared Saunas
Unlike regular saunas, infrared saunas raise your core temperature which enhances the metabolic process. By doing so, the sauna has the power to help support natural elimination systems to help release toxins stored in the body.

While avoidance of heavy metals is nearly impossible, there are many things you can do to minimize your risk and further your detox efforts. If you suspect you are frequently exposed to heavy metals in your environment, you should speak with your physician to develop a full detox plan.

Alzheimer, feed forward cycle, neocortex, hippocampus and RNA quality


AD is a neurodegenerative disease of complex etiology (2930). The formation of neurofibrillary tangles (NFT), neuropil threads, and senile plaques have been implicated in the onset and development of the disease, but the relative causal weight of these and other factors in sporadic AD continues to be debated (3031). Although initiation and progression of AD may thus be multifactorial, it has been noted that incidence and regional distribution of NFT are most closely associated with the clinical manifestations of the disease (3233). NFT formation is the result of the accumulation of altered components of the neuronal cytoskeleton (34), and it has been suggested that “clogging” of neuronal processes and disruption of long-distance transport may underlie at least some of the cytopathological changes that characterize the disease (19).

We suggest that such cellular changes on one hand and deregulated expression and transport of dendritic RNAs on the other may be causally interrelated in AD. It has recently been speculated that non-protein-coding RNAs may be involved in AD (35), and we now show that expression of dendritic BC200 RNA, which is a translational repressor (35), is differentially regulated in normal aging and in AD. In normal aging, BC200 levels in the neocortex decrease substantially after age 50. Because BC RNAs are prominently located throughout dendrites and at synapses (128), the substantial decline of BC levels may reflect the progressive atrophy of synaptodendritic structures that has previously been observed in normal aging (233639).

In AD, synapse loss and dendritic regression are substantial (40), but these degenerative changes are accompanied by significant dendritic sprouting and remodeling, often in the same neuron (304142). Such reactive developments may be of a compensatory nature, directed at maintaining connectivity and plasticity. In one possible scenario, we therefore suggest that the substantially higher BC200 levels in AD, as compared with those in normal aging, may represent a molecular compensatory effort. If BC200 RNA is needed at the synapse for local translational control, its loss from synaptodendritic domains as the result of dendritic regression and clogging in AD may trigger compensatory mechanisms that result in the increased production of the RNA.

Increased synthesis of key synaptodendritic components may be an appropriate response in situations in which cargoes are not effectively delivered to postsynaptic sites. It may, at least initially or partially, be successful in overcoming moderate dendritic clogging that is caused by altered cytoskeletal components. Over time, however, such response may prove inadequate if further accumulation of cytoskeletal debris creates “roadblocks” that RNAs with dendritic destinations are no longer able to traverse. At this point, relative BC200 levels would begin to decrease in dendrites but increase in somata. In such cases, efforts to compensate would have failed because even increased production could no longer ensure that the RNA reaches its dendritic target sites. Transport deficits have previously been implicated in the progression of AD (1820), and impaired microtubule-dependent transport, coupled with beginning axonal and dendritic blockage, may be an early event in AD that could eventually result in the local generation of amyloid-β peptides and thus in amyloid deposition (17).

Alternative scenarios are possible or even likely. Instead of, or in addition to, being reactive–compensatory to cytoskeletal degeneration, imbalances in the somatodendritic distribution of BC200 RNA could be causative because they may lead to aberrant local translational control. BC200 RNA contains a kink turn motif of the KT-58 subtype that has been implicated in dendritic transport of BC RNAs (943). Because only slight perturbations of the kink turn motif architecture are sufficient to disrupt targeting (9), it is conceivable that single-nucleotide mutations in this region may prevent delivery of the RNA along the dendritic extent. Consequences would be twofold: compensatory elevation of BC200 transcription in an attempt to overcome dendritic delivery block and poor translational control in synaptodendritic domains. Consistent with this model, altered relative BC200 levels become manifest at a very early time point in the course of AD, possibly before clinical signs become detectable (4445).

A gradual worsening of somatodendritic BC200 imbalances may over time set off a self-reinforcing feed–forward cycle. Inadequate translational regulation in dendrites may lead to cytoskeletal overproduction and local dysfunction (16), which in turn would hinder the transport of mRNAs and protein synthetic machinery to postsynaptic target sites. In line with this concept, levels of somatodendritic RC3 mRNA have been shown to be significantly diminished in dendritic regions of AD brains (46). Having been disrupted in this manner, the system would find itself on a slow but accelerating course toward eventual catastrophe, manifesting as synaptic or plasticity failure (17304749). At the same time, increased perikaryal levels of BC200 RNA may inappropriately repress somatic protein synthesis and thus precipitate or exacerbate degenerative changes. We anticipate that future work, directed at the understanding of neuronal RNA transport and local translational control mechanisms, will be able to establish the respective contributions of the causative and reactive–compensatory scenarios.



brain plaques

The study samples come from the Adult Changes in Thought (ACT) study, a longitudinal research effort led by Eric B. Larson, M.D., M.P.H., and Paul K. Crane, M.D., M.P.H., of the Kaiser Permanente Washington Health Research Institute (KPWHRI) (formerly known as Group Health Research Institute) and the University of Washington School of Medicine to collect data on thousands of aging adults, including detailed information on their health histories and cognitive abilities.

“This collaboration with the Allen Institute for Brain Science has allowed us to gain insights never before possible into the relationships between neuropathology, gene expression, RNA quality, and clinical features tracked in the ACT study over more than 20 years,” says Larson, who has led the National Institute of Aging-supported study from its start in 1986 and is Vice President for Research and Health Care Innovation at Kaiser Permanente Washington.


Neural Networks: Sleep and memory – ScienceDirect

by TJ Sejnowski – ‎1995 – ‎Cited by 12 – ‎Related articles

During this generative sleep stage, the strengths of the feedforward synaptic … in the sense that only small changes are made during any one wake–sleep cycle. … sleep, the visual cortex is driven by brain-stem activity and the hippocampus …

Interaction between neocortical and hippocampal networks via slow …

by A SIROTA – ‎2005 – ‎Cited by 139 – ‎Related articles

This might be caused by the removal of tonic and phasic feedforward … pool correlates with the duration of the oscillatory cycle, various brain rhythms can set …

Sleep and Brain Activity – Page 214 – Google Books Result

Marcos G. Frank – 2012 – ‎Medical

So, to the degree that the hippocampal output during ripples originates in … in the prefrontal cortex and spreading through the whole neocortex and brain issue a … a feed forward manner favors the occurrence of another slow oscillation cycle …

Disorders of Brain, Behavior, and Cognition: The Neurocomputational …

J.A. Reggia, ‎E. Ruppin, ‎D.L. Glanzman – 1999 – ‎Medical

… transmission in the piriform cortex, with a much weaker effect on feedforward … in the hippocampusgo much higher than ACh levels in neocortex (Marrosu et al., … rapid changes in modulatory dynamics within each cycle of the theta rhythm.

Microcircuits and their interactions in epilepsy: Is the focus out of focus?

by JT Paz – ‎2015 – ‎Cited by 61 – ‎Related articles

1): 1) feedforward inhibition, in which excitatory inputs from extrinsic brain regions recruit local inhibitory … Feedforward inhibition in neocortex and hippocampus …. This cycle then repeats to propagate seizure activity to the next microcircuit.

Rhythms of the Brain – Page 374 – Google Books Result

Gyorgy Buzsaki – 2006 – ‎Medical

Ahn SM, Freeman WJ (1974) Steady-state and limit cycle activity of mass of … of functionally segregated circuits linking basal ganglia and cortex. … Alger BE, Nicoll RA (1982) Feedforward dendritic inhibition in rat hippocampal pyramidal cells …

Spatially segregated feedforward and feedback neurons support … › nature neuroscience › articles
by FC Leitner – ‎2016 – ‎Cited by 13 – ‎Related articles

May 16, 2016 – The lateral entorhinal cortex (LEC) computes and transfers olfactory … Here we established LEC connectivity to upstream and downstream brain … RE+ neurons provide feedforwardprojections to the hippocampus while …… All animals were housed singly or in pairs and were kept on a 12 h light/dark cycle.

Dynamic Coordination in the Brain: From Neurons to Mind

Christoph von der Malsburg, ‎William A. Phillips, ‎Wolf Singer – 2010 – ‎Medical

From Neurons to Mind Christoph von der Malsburg, William A. Phillips, Wolf Singer … and Transfer at theHippocampus–Entorhinal– Neocortical Interface György Buzsáki … the multisynaptic feedforward loops of the entorhi- nal–hippocampal system, … In each oscillatory cycle, recruitment of principal neurons is temporally …

Handbook of Brain Microcircuits – Page 166 – Google Books Result

Gordon Shepherd, ‎Sten Grillner – 2010 – ‎Medical

(A) Multiple loops of the hippocampal-entorhinal (EC) circuits. … computation in successive layers of the EC-hippocampus (mainly) feedforward loop. … the main direction of information flow, withneocortical– hippocampal transfer taking place … Neurons that discharge within the time period of the gamma cycle (10–30 msec) …

Connie’s comments:
The plaque, clogging , RNA quality and rhythm of the brain circuits are affected by quality of life, whole foods, sleep, stress, and affected by toxins in our environment.
Knowing the effects of the clogging and plaques in our brain from stress, lack of sleep, toxins and inflammation that started in our intestines and environment (pollution, carbon monoxide poisoning, metal toxicities, others) can help us prevent Alzheimer’s. The cure is prevention 20 years before our brain can no longer clean up the plaques and clogs.

For quality supplementation to reset your gene expression to a younger you, visit:

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Kill parasites with these herbs


Garlic is anti-bad-stuff. Viruses, fungi, bacteria, parasites, cancer, and vampires all hate garlic. It’s an absolutely amazing herb and the best in the business at killing bad stuff. It even chelates heavy metals (removes them from the body). Garlic is also a very powerful deterrent for blood sucking parasites like mosquitoes, ticks, and fleas.

Black Walnut-Nuts & Hull

The nuts and green hulls of black walnut (Juglans nigra) are loved by herbalists for their ability to cleanse the blood and the intestines. Black walnut hull is used to cure fungal infections. The juice from the green hulls are used to kill parasites. Only green hulls should be used.


Wormwood (Artemisia absinthium) is a perennial herb with tiny yellow-green flowers. Leaves and flowers are used to treat stomach problems and wormwood is a powerful remedy for intestinal worms. Wormwood should be avoided by women who or nursing. Wormwood has strong antimicrobial properties and is used for other infections as well.


Clove essential oil is used to dissolve eggs found in the intestines that have been left behind by worms. It’s believed to be the only herb that actually does destroy almost all parasite eggs. When used in conjunction with black walnut and wormwood, the trio break the parasite’s life-cycles. Clove is also antibacterial, antiviral, and antifungal. Clove oil has powerful broad-spectrum antimicrobial properties.


Thyme is one of the best herbs for stimulating the thymus, a major gland of the immune system. Thyme helps stimulate the body’s natural defenses and works very well with echinacea to boost the ability of our immune system. Oil of thyme can eliminate growth of many parasites, and it kills them in the intestinal tract.

Oil of Oregano

Oil of oregano is infused with extremely high levels of free-radical-crushing antioxidants, and it is antiparasitic, antiviral, antibacterial, and antifungal. It is a powerful, indiscriminate killer that can reset the microbial environment in the intestines. Many studies show the effectiveness of oil of oregano with everything from parasitical infections to cancer.

Chinese Goldthread

Goldthread (Coptis chinensis) has been used in traditional Chinese medicine for centuries to treat all types of infections, including bacterial, parasitic, yeast, and protozoan. It contains a substance called berberine, which is responsible for the broad-spectrum antimicrobial properties.

Diatomaceous Earth

Food grade diatomaceous earth absorbs methyl mercury, E. coli, endotoxins, viruses, organophosphate pesticide residues, and drug residues. Its positive effects include killing intestinal parasites, balancing the intestinal flora, killing viruses, and absorbing toxins. It’s great for intestinal cleanses. The only side effect known is its ability to irritate the lungs if inhaled; it is a very fine powder.

Cramp Bark Tea

Cramp bark is an herb often taken in tea form that can treat female problems like irritability and cramps associated with the menstrual cycle. The herb is hailed as a stomach cramp remedy in Russia, and helps to flush parasites from the body’s intestinal system. In addition to killing parasites, cramp bark can lower blood pressure and treat colds and coughing. Some cramp bark teas also include pumpkin seed extract, another anti-parasite herbal supplement that stunts the growth of intestinal worms. According to the University of Maryland, eating pumpkin seeds is an effective way to get rid of parasites.

Peppermint Tea

Peppermint tea is effective in treating intestinal parasites, and is also an herbal remedy for cramps and bloating. Peppermint also aids the salivary glands during the digestion process, and helps to relieve individuals suffering from bowel ailments. While peppermint has powerful antibacterial properties and can rid the body of parasites and other toxins, it’s best to consult a physician before drinking the herb tea on a regular basis, as taking conventional antifungal medications along with peppermint could cause toxic effects that intensify sickness.

Fennel Seed Tea

Fennel is a perennial herb ground into a tea; it is rich in potassium, zinc and vitamin C. Fennel tea can kill worms in the intestines and is also a natural treatment for diarrhea. According to The Brightest Hub website, fennel tea can also rid the body of infections like conjunctivitis, or pink eye. The tea will also act as a diuretic and flush excess liquid from the body, which includes toxins like parasites or worms. Fennel tea is an appetite suppressant, so some individuals use fennel along with other herbs or supplements for weight loss.

Hyssop Tea

Hyssop contains a hormone that makes the body more resistant to disease and can stop parasites from doing further damage in the body. The evergreen herb can be ground into a tea and is even mentioned several times in the Bible for its cleansing and purging properties. The tea has a minty flavor, and, aside from eliminating parasitic worms from the stomach, is an herbal remedy for fever blisters and bronchitis. Hyssop also helps to relieve anxiety and calm the nerves, and rids the body of phlegm and harmful fluids.

Raw foods

Carrots, pumpkin seeds, sesame seeds, sunflower seeds

Cooked whole foods rich in fiber

Okra, all root crops, plantain, coconut, squash

Probiotic foods

Kimchi, miso soup. soy milk, kefir, yogurt, olives, dark chocolate


Eucalyptus, tea tree

How you can use your health history form to find holistic cures with a CAM doctor

A complimentary alternative or medical doctor can help you find holistic healing ways. Knowing details of your health history will allow your health care professionals and you determine the course of action toward a healthier you.

Your determination to optimize your current health and your environment will have a greater impact on your success to achieving a healthier you.

If I become your health coach, you have to work with me to motivate yourself to wake up each day with the goal of achieving maximum health.

Examine the air your breath, the water or liquid drink you take, the time you sleep and for how long, your stress level, the texture of your skin, your eyes and your vowel.

For quality supplementation to reset your gene expression to a younger you with AGELOC family of products, visit

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